Frazier Life Sciences Management, L.P.

PALO ALTO, CA · CIK 1892134 · 13F filing filed 2024-08-15

SEC-registered investment adviser since 2021 · limited partnership

Assets managed$7.0bn
Staff64 · 47 in investment roles
Main clients (by assets)Private funds 100%
Private funds8 (1 hedge) · $7.0bn gross assets
Websitefrazierls.com
Form ADV · 2026-03-31SEC adviser record

Legal entityFrazier Life Sciences Management, L.P. (US)

Kindhedge funds, private equity, venture
Others nearbyPalo Alto, CA, San Diego, CA

As an employer

Offices in1 country
Private fundsventure capital 4, hedge 1, private equity 3

Where they work

people there (dot area)number not reportedmain officeHover or tap a dot. Australian and UK companies are placed at their business or registered address, with their staff across the whole country.

Offices

From Form ADV: the main office and the other offices where it does advisory work (at most the 25 largest), with the people doing investment work at each. “About” is worked out: the firm's investment staff less its other offices. Each city links to the other managers there.

City	Country	People
Palo Alto, CA (main office)United States	United States	about 44
San Diego, CAUnited States	United States	3

Map: places from GeoNames (CC BY 4.0), outlines from Natural Earth.

$2.1bn reported value -9.8% vs Q1 2024

49positions

62.0%in top 10

8 new 13 added 4 reduced 9 sold out vs Q1 2024

Holdings, Q2 2024

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES NAMS	NAMS	12,226,943	$234.9m10.99%	10.99%	Unchanged
2	MIRUM PHARMACEUTICALS INC COM MIRM	MIRM	6,495,392	$222.1m10.39%	10.39%	Unchanged
3	KRYSTAL BIOTECH INC COM KRYS	KRYS	988,460	$181.5m8.49%	8.49%	Unchanged
4	HILLEVAX INC COM COM		10,617,062	$153.5m7.18%	7.18%	Added +835.6k	+835,590 8.5%
5	PHATHOM PHARMACEUTICALS INC COM PHAT	PHAT	10,109,279	$104.1m4.87%	4.87%	Unchanged
6	RHYTHM PHARMACEUTICALS INC COM RYTM	RYTM	2,371,304	$97.4m4.55%	4.55%	Added +181.1k	+181,125 8.3%
7	BRIDGEBIO PHARMA INC COM BBIO	BBIO	3,632,604	$92.0m4.30%	4.30%	Added +217.0k	+217,000 6.3%
8	ARCUTIS BIOTHERAPEUTICS INC COM ARQT	ARQT	8,785,284	$81.7m3.82%	3.82%	Unchanged
9	DISC MEDICINE INC COM IRON	IRON	1,754,834	$79.1m3.70%	3.70%	Added +969.8k	+969,834 123.5%
10	VAXCYTE INC COM PCVX	PCVX	1,039,405	$78.5m3.67%	3.67%	Reduced -100.0k	-100,000 -8.8%
11	EDGEWISE THERAPEUTICS INC COM EWTX	EWTX	3,731,067	$67.2m3.14%	3.14%	Added +427.5k	+427,500 12.9%
12	ANAPTYSBIO INC COM ANAB	ANAB	2,165,591	$54.3m2.54%	2.54%	Added +1.3m	+1,265,891 140.7%
13	VERONA PHARMA PLC SPONSORED ADS VRNA	VRNA	3,314,349	$47.9m2.24%	2.24%	Added +300.0k	+300,000 9.9%
14	KALVISTA PHARMACEUTICALS INC COM KALV	KALV	3,687,867	$43.4m2.03%	2.03%	Unchanged
15	TARSUS PHARMACEUTICALS INC COM TARS	TARS	1,587,527	$43.1m2.02%	2.02%	Reduced -200.0k	-200,000 -11.2%
16	REVOLUTION MEDICINES INC COM RVMD	RVMD	997,455	$38.7m1.81%	1.81%	Unchanged
17	ERASCA INC COM ERAS	ERAS	16,216,216	$38.3m1.79%	1.79%	New
18	AGIOS PHARMACEUTICALS INC COM AGIO	AGIO	871,974	$37.6m1.76%	1.76%	Added +348.8k	+348,808 66.7%
19	SOLENO THERAPEUTICS INC COM SLNO	SLNO	875,667	$35.7m1.67%	1.67%	Unchanged
20	ROCKET PHARMACEUTICALS INC COM RCKT	RCKT	1,561,230	$33.6m1.57%	1.57%	Unchanged
21	SAVARA INC COM SVRA	SVRA	8,157,385	$32.9m1.54%	1.54%	Added +4.2m	+4,157,385 103.9%
22	ORIC PHARMACEUTICALS INC COM ORIC	ORIC	4,142,855	$29.3m1.37%	1.37%	Unchanged
23	CG ONCOLOGY INC COM CGON	CGON	770,000	$24.3m1.14%	1.14%	Unchanged
24	PEPGEN INC COM PEPG	PEPG	1,502,788	$24.0m1.12%	1.12%	Unchanged
25	MERUS N V COM MRUS	MRUS	373,100	$22.1m1.03%	1.03%	Reduced -373.4k	-373,379 -50.0%
26	TREVI THERAPEUTICS INC COM TRVI	TRVI	7,381,090	$22.0m1.03%	1.03%	Unchanged
27	SILENCE THERAPEUTICS PLC ADS SLN	SLN	1,148,591	$21.8m1.02%	1.02%	Unchanged
28	ULTRAGENYX PHARMACEUTICAL IN COM RARE	RARE	425,000	$17.5m0.82%	0.82%	New
29	AUTOLUS THERAPEUTICS PLC SPON ADS AUTL	AUTL	4,623,324	$16.1m0.75%	0.75%	Unchanged
30	CEREVEL THERAPEUTICS HLDNG I COM CERE	CERE	393,000	$16.1m0.75%	0.75%	Unchanged
31	MEREO BIOPHARMA GROUP PLC SPON ADS MREO	MREO	4,401,371	$15.8m0.74%	0.74%	New
32	IMMATICS N.V SHS IMTX	IMTX	1,152,456	$13.4m0.63%	0.63%	New
33	TYRA BIOSCIENCES INC COM TYRA	TYRA	832,220	$13.3m0.62%	0.62%	Unchanged
34	MACROGENICS INC COM MGNX	MGNX	3,010,727	$12.8m0.60%	0.60%	Added +539.0k	+539,023 21.8%
35	APPLIED THERAPEUTICS INC COM APLT	APLT	2,286,135	$10.7m0.50%	0.50%	Added +333.3k	+333,278 17.1%
36	PUMA BIOTECHNOLOGY INC COM PBYI	PBYI	3,062,558	$10.0m0.47%	0.47%	Added +246.3k	+246,264 8.7%
37	89BIO INC COM ETNB	ETNB	1,000,000	$8.0m0.37%	0.37%	Unchanged
38	ELEVATION ONCOLOGY INC COM COM		2,958,579	$8.0m0.37%	0.37%	New
39	COGENT BIOSCIENCES INC COM COGT	COGT	936,576	$7.9m0.37%	0.37%	Unchanged
40	ACADIA PHARMACEUTICALS INC COM ACAD	ACAD	470,338	$7.6m0.36%	0.36%	Unchanged
41	ARVINAS INC COM ARVN	ARVN	285,331	$7.6m0.36%	0.36%	Unchanged
42	ADVERUM BIOTECHNOLOGIES INC COM NEW ADVM	ADVM	1,069,244	$7.3m0.34%	0.34%	New
43	ALLOGENE THERAPEUTICS INC COM ALLO	ALLO	2,867,750	$6.7m0.31%	0.31%	Unchanged
44	AN2 THERAPEUTICS INC COM ANTX	ANTX	2,088,889	$4.5m0.21%	0.21%	Added +700.0k	+700,000 50.4%
45	NEWAMSTERDAM PHARMA COMPANY *W EXP 11/22/202 NAMSW	NAMSW	500,333	$4.4m0.20%	0.20%	Unchanged
46	DESIGN THERAPEUTICS INC COM DSGN	DSGN	1,195,179	$4.0m0.19%	0.19%	New
47	IMMUNOCORE HLDGS PLC ADS IMCR	IMCR	108,762	$3.7m0.17%	0.17%	New
48	METAGENOMI INC COM MGX	MGX	245,692	$1.0m0.05%	0.05%	Reduced -33.3k	-33,333 -11.9%
49	ACLARIS THERAPEUTICS INC COM ACRS	ACRS	264,377	$290.8k0.01%	0.01%	Unchanged

Sold out since Q1 2024

Security	Ticker	Shares held before	Value then
ALPINE IMMUNE SCIENCES INC NVLS	NVLS	3,131,008	$124.1m3.1m shares
APELLIS PHARMACEUTICALS INC APLS	APLS	885,165	$52.0m885.2k shares
AEROVATE THERAPEUTICS INC		1,204,867	$35.6m1.2m shares
STRUCTURE THERAPEUTICS INC GPCR	GPCR	629,194	$27.0m629.2k shares
DECIPHERA PHARMACEUTICALS IN DCPH	DCPH	1,455,837	$22.9m1.5m shares
ADVERUM BIOTECHNOLOGIES INC		1,069,244	$15.1m1.1m shares
INTELLIA THERAPEUTICS INC NTLA	NTLA	203,684	$5.6m203.7k shares
GRITSTONE BIO INC GRTS	GRTS	1,030,878	$2.6m1.0m shares
BLUEBIRD BIO INC		1,709,907	$2.2m1.7m shares