STRUCTURE THERAPEUTICS INC GPCR
SPONSORED ADS · ADR · CUSIP 86366E106
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSouth San Francisco, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($685.5k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $39.27. Options: 21 managers hold calls ($71.0m notional), 15 hold puts ($25.1m).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q1 2023 | 38 |
| Q2 2023 | 49 |
| Q3 2023 | 85 |
| Q4 2023 | 123 |
| Q1 2024 | 121 |
| Q2 2024 | 167 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q2 2023 | 26 | 14 |
| Q3 2023 | 71 | 12 |
| Q4 2023 | 84 | 41 |
| Q1 2024 | 71 | 61 |
| Q2 2024 | 123 | 46 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $0 | $0 | — |
| Q4 2023 | $70.3m | $24.2m | 0.34 |
| Q1 2024 | $61.4m | $19.8m | 0.32 |
| Q2 2024 | $71.0m | $25.1m | 0.35 |
Biggest buyers
| FMR LLC | Added | +2.8m |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +1.7m |
| BVF INC/IL | Added | +1.7m |
| Capital Research Global Investors | Added | +1.6m |
| Logos Global Management LP | Added | +1.5m |
| JANUS HENDERSON GROUP PLC | Added | +1.3m |
| FIL Ltd | Added | +1.3m |
| MILLENNIUM MANAGEMENT LLC | Added | +1.0m |
| Deep Track Capital, LP | Added | +909.9k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +752.6k |
Biggest sellers
| TCG Crossover Management, LLC | Reduced | -903.9k |
| HSG Holding Ltd | Reduced | -798.9k |
| MORGAN STANLEY | Reduced | -748.6k |
| Frazier Life Sciences Management, L.P. | Sold out | -629.2k |
| Alyeska Investment Group, L.P. | Reduced | -593.6k |
| T. Rowe Price Investment Management, Inc. | Reduced | -519.8k |
| BRAIDWELL LP | Sold out | -435.8k |
| Casdin Capital, LLC | Reduced | -416.9k |
| Capital World Investors | Reduced | -310.4k |
| Altitude Crest Partners Inc. | Sold out | -205.2k |
Biggest calls
| Logos Global Management LP | Added | $35.3m900.0k shares |
| JANE STREET GROUP, LLC | Added | $7.5m192.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $6.9m176.0k shares |
| MILLENNIUM MANAGEMENT LLC | New | $3.2m82.5k shares |
| Caption Management, LLC | Reduced | $2.8m72.5k shares |
| CITADEL ADVISORS LLC | Reduced | $2.7m68.0k shares |
| SIMPLEX TRADING, LLC | Added | $2.6m66.7k shares |
| Rock Springs Capital Management LP | New | $2.6m65.6k shares |
| Point72 Asset Management, L.P. | New | $2.0m50.0k shares |
| GROUP ONE TRADING LLC | Added | $1.8m45.2k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $6.7m171.7k shares |
| JANE STREET GROUP, LLC | Added | $4.5m115.0k shares |
| CITADEL ADVISORS LLC | Added | $3.7m93.4k shares |
| GROUP ONE TRADING LLC | Added | $3.2m82.3k shares |
| SIMPLEX TRADING, LLC | Added | $1.9m48.5k shares |
| MILLENNIUM MANAGEMENT LLC | New | $1.5m38.6k shares |
| Ikarian Capital, LLC | Reduced | $1.1m290 shares |
| GTS SECURITIES LLC | New | $585.1k14.9k shares |
| J. Goldman & Co LP | Reduced | $530.1k13.5k shares |
| Caption Management, LLC | New | $467.3k11.9k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · passive investor -1.8 pts · filed 2026-08-06 | 13.2% |
| WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.8 pts · filed 2026-02-10 | 10.1% |
| Avoro Capital Advisors LLC 13G · institution new · filed 2025-11-14 | 9.4% |
| JANUS HENDERSON GROUP PLC 13G · institution -0.3 pts · filed 2025-11-14 | 7.7% |
| Deep Track Capital, LP 13G · passive investor -1.4 pts · filed 2026-02-13 | 6.0% |
Fell to 5% or below in the last year: BIOTECHNOLOGY VALUE FUND L P (4.9%, 2026-02-17)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported in Q2 2024.
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP 0.05% of their portfolio | 7.5m $296.4m | Added +1.7m |
| FMR LLC 0.01% of their portfolio | 5.7m $225.6m | Added +2.8m |
| JANUS HENDERSON GROUP PLC 0.07% of their portfolio | 3.4m $131.6m | Added +1.3m |
| Capital Research Global Investors 0.03% of their portfolio | 3.1m $123.0m | Added +1.6m |
| Driehaus Capital Management LLC 0.98% of their portfolio | 2.6m $101.2m | Added +86.8k |
| BVF INC/IL 2.74% of their portfolio | 2.5m $97.7m | Added +1.7m |
| FEDERATED HERMES, INC. 0.22% of their portfolio | 2.4m $94.5m | Added +150.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 2.3m $90.9m | Added +752.6k |
| Logos Global Management LP 5.01% of their portfolio | 2.2m $86.4m | Added +1.5m |
| RA CAPITAL MANAGEMENT, L.P. 0.99% of their portfolio | 1.9m $74.5m | Added +386.4k |
| Capital International Investors 0.01% of their portfolio | 1.5m $58.9m | Added +217.1k |
| CITADEL ADVISORS LLC 0.05% of their portfolio | 1.4m $55.3m | Added +132.5k |
| FIL Ltd 0.05% of their portfolio | 1.3m $51.4m | Added +1.3m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.09% of their portfolio | 1.2m $47.6m | Added +402.5k |
| Octagon Capital Advisors LP 7.39% of their portfolio | 1.1m $44.8m | Added +633.5k |
| MILLENNIUM MANAGEMENT LLC 0.04% of their portfolio | 1.1m $44.7m | Added +1.0m |
| Avidity Partners Management LP 1.79% of their portfolio | 1.1m $42.2m | Added +211.0k |
| Rock Springs Capital Management LP 1.18% of their portfolio | 999.9k $39.3m | Added +587.2k |
| Deep Track Capital, LP 1.11% of their portfolio | 950.0k $37.3m | Added +909.9k |
| BlackRock Inc. 0.00% of their portfolio | 943.0k $37.0m | Reduced -143.4k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.55% of their portfolio | 844.4k $33.2m | Reduced -189.3k |
| Alyeska Investment Group, L.P. 0.16% of their portfolio | 707.4k $27.8m | Reduced -593.6k |
| Casdin Capital, LLC 2.10% of their portfolio | 700.0k $27.5m | Reduced -416.9k |
| T. Rowe Price Investment Management, Inc. 0.02% of their portfolio | 696.5k $27.4m | Reduced -519.8k |
| TCG Crossover Management, LLC 2.84% of their portfolio | 694.5k $27.3m | Reduced -903.9k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 682.4k $26.8m | Added +233.7k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 645.7k $25.4m | Added +110.0k |
| First Light Asset Management, LLC 2.03% of their portfolio | 590.6k $23.2m | Added +441.5k |
| Vestal Point Capital, LP 1.64% of their portfolio | 560.0k $22.0m | New |
| Bellevue Group AG 0.36% of their portfolio | 557.3k $21.9m | Added +193.4k |
| AMERICAN CENTURY COMPANIES INC 0.01% of their portfolio | 435.0k $17.1m | Added +173.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 406.8k $16.0m | Added +316.2k |
| MONEY CONCEPTS CAPITAL CORP 1.32% of their portfolio | 401.0k $15.7m | Added +24.4k |
| Boxer Capital, LLC 0.83% of their portfolio | 400.0k $15.7m | Unchanged |
| Point72 Asset Management, L.P. 0.05% of their portfolio | 367.7k $14.4m | New |
| Woodline Partners LP 0.13% of their portfolio | 337.4k $13.2m | Added +157.5k |
| Capital World Investors 0.00% of their portfolio | 323.8k $12.7m | Reduced -310.4k |
| JENNISON ASSOCIATES LLC 0.01% of their portfolio | 314.5k $12.4m | New |
| FRED ALGER MANAGEMENT, LLC 0.05% of their portfolio | 287.6k $11.3m | Reduced -125.7k |
| HSG Holding Ltd 0.38% of their portfolio | 266.1k $10.3m | Reduced -798.9k |
| ArrowMark Colorado Holdings LLC 0.11% of their portfolio | 242.9k $9.5m | Reduced -12.3k |
| Invesco Ltd. 0.00% of their portfolio | 238.0k $9.3m | Added +25.9k |
| Schonfeld Strategic Advisors LLC 0.07% of their portfolio | 216.4k $8.5m | New |
| TD Asset Management Inc 0.01% of their portfolio | 211.6k $8.3m | Added +68.5k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 183.8k $7.2m | New |
| Zimmer Partners, LP 0.13% of their portfolio | 177.1k $7.0m | New |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 165.2k $6.5m | New |
| TANG CAPITAL MANAGEMENT LLC 0.58% of their portfolio | 144.5k $5.7m | Added +44.5k |
| Candriam S.C.A. 0.03% of their portfolio | 135.0k $5.3m | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 132.3k $5.2m | Reduced -748.6k |
| ORBIMED ADVISORS LLC 0.10% of their portfolio | 125.0k $4.9m | New |
| RTW INVESTMENTS, LP 0.08% of their portfolio | 125.0k $4.9m | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio | 119.6k $4.7m | Added +37.8k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 109.2k $4.3m | Added +101.5k |
| Pier Capital, LLC 0.59% of their portfolio | 101.2k $4.0m | Added +3.6k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 94.4k $3.7m | Added +32.8k |
| Aberdeen Group plc 0.01% of their portfolio | 93.3k $3.7m | New |
| WEXFORD CAPITAL LP 0.93% of their portfolio | 93.2k $3.7m | Added +60.8k |
| Melqart Asset Management (UK) Ltd 0.34% of their portfolio | 92.3k $3.6m | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 84.4k $3.3m | Added +46.2k |
| LMR Partners LLP 0.07% of their portfolio | 80.6k $3.2m | New |
| MARSHALL WACE, LLP 0.00% of their portfolio | 75.9k $3.0m | Added +40.7k |
| Hudson Bay Capital Management LP 0.02% of their portfolio | 74.1k $2.9m | New |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.68% of their portfolio | 70.5k $2.8m | Added +60.5k |
| Caption Management, LLC 0.28% of their portfolio | 67.9k $2.7m | Reduced -2.1k |
| Trexquant Investment LP 0.04% of their portfolio | 63.5k $2.5m | Added +33.5k |
| Jump Financial, LLC 0.05% of their portfolio | 63.0k $2.5m | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 61.7k $2.4m | New |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 58.0k $2.3m | Unchanged |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.09% of their portfolio | 57.2k $2.2m | Reduced -19.9k |
| Blue Owl Capital Holdings LP 0.60% of their portfolio | 55.0k $2.2m | New |
| Monashee Investment Management LLC 0.25% of their portfolio | 50.0k $2.0m | Reduced -44.7k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 48.6k $1.9m | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 44.9k $1.8m | Added +16.0k |
| Allspring Global Investments Holdings, LLC 0.00% of their portfolio | 44.5k $1.7m | Reduced -2.8k |
| Engineers Gate Manager LP 0.04% of their portfolio | 43.5k $1.7m | New |
| TWINBEECH CAPITAL LP 0.03% of their portfolio | 42.7k $1.7m | New |
| BARCLAYS PLC 0.00% of their portfolio | 40.2k $1.6m | Reduced -41.0k |
| Duquesne Family Office LLC 0.05% of their portfolio | 37.7k $1.5m | New |
| SIMPLEX TRADING, LLC 0.05% of their portfolio | 37.3k $1.5m | Added +14.4k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 35.7k $1.4m | New |
| HighVista Strategies LLC 0.50% of their portfolio | 35.1k $1.4m | Reduced -2.3k |
| PERCEPTIVE ADVISORS LLC 0.03% of their portfolio | 34.9k $1.4m | New |
| SEVEN EIGHT CAPITAL, LP 0.14% of their portfolio | 34.3k $1.3m | New |
| AWM Investment Company, Inc. 0.16% of their portfolio | 30.0k $1.2m | New |
| Lighthouse Investment Partners, LLC 0.07% of their portfolio | 30.0k $1.2m | New |
| TrueMark Investments, LLC 0.40% of their portfolio | 29.9k $1.2m | Unchanged |
| Moody Aldrich Partners LLC 0.21% of their portfolio | 27.7k $1.1m | New |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 27.1k $1.4m | New |
| HAP Trading, LLC 0.45% of their portfolio | 26.3k $1.0m | Reduced -14.6k |
| AlphaCentric Advisors LLC 0.75% of their portfolio | 26.0k $1.0m | Reduced -1.5k |
| NOMURA ASSET MANAGEMENT CO LTD 0.00% of their portfolio | 21.7k $852.6k | Added +3.9k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 21.5k $843.0k | Reduced -38 |
| NATIXIS ADVISORS, LLC 0.00% of their portfolio | 19.0k $746.0k | Added +4.3k |
| Scientech Research LLC 0.15% of their portfolio | 18.8k $738.4k | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 18.6k $729.9k | Reduced -3.1k |
| M&T Bank Corp 0.00% of their portfolio | 18.1k $711.9k | Added +2.0k |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio | 17.7k $693.0k | Added +3.9k |
| Point72 Europe (London) LLP 0.06% of their portfolio | 17.5k $685.5k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 16.9k $662.6k | Reduced -32.0k |