Avoro Capital Advisors LLC

NEW YORK, NY · CIK 1633313 · 13F filing filed 2026-08-14

SEC-registered investment adviser since 2012 · limited liability company

Assets managed$13.6bn
Staff19 · 11 in investment roles
Main clients (by assets)Private funds 100%
Private funds2 (1 hedge) · $13.6bn gross assets
Websiteavorocapital.com
Form ADV · 2026-03-05SEC adviser record

Legal entityAVORO CAPITAL ADVISORS LLC (US)

$11.1bn reported value +9.7% vs Q1 2026

26positions

79.5%in top 10

3 new 11 added 3 reduced 7 sold out vs Q1 2026

Holdings, Q2 2026

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	UNITED THERAPEUTICS CORP DEL COM UTHR	UTHR	2,777,777	$1.5bn13.52%	13.52%	Added +147.8k	+147,777 5.6%
2	ASCENDIS PHARMA A/S ORD SHS ASND	ASND	5,111,111	$1.4bn12.24%	12.24%	New
3	KRYSTAL BIOTECH INC COM KRYS	KRYS	2,888,888	$1.1bn9.64%	9.64%	Unchanged
4	MADRIGAL PHARMACEUTICALS INC COM MDGL	MDGL	1,833,333	$984.4m8.84%	8.84%	Added +15.2k	+15,152 0.8%
5	ARGENX SE SPONSORED ADR ARGX	ARGX	1,000,000	$927.8m8.33%	8.33%	Unchanged
6	ARROWHEAD PHARMACEUTICALS IN COM ARWR	ARWR	11,355,555	$925.6m8.31%	8.31%	Added +655.6k	+655,556 6.1%
7	KYMERA THERAPEUTICS INC COM KYMR	KYMR	7,474,747	$857.1m7.70%	7.70%	Unchanged
8	REVOLUTION MEDICINES INC COM RVMD	RVMD	2,297,000	$430.2m3.86%	3.86%	Reduced -47.4k	-47,444 -2.0%
9	CYTOKINETICS INC COM NEW CYTK	CYTK	4,999,999	$425.9m3.82%	3.82%	Added +1.7m	+1,666,666 50.0%
10	CELCUITY INC COM CELC	CELC	3,400,000	$355.7m3.19%	3.19%	Added +25.0k	+25,000 0.7%
11	STRUCTURE THERAPEUTICS INC SPONSORED ADS GPCR	GPCR	6,555,555	$351.8m3.16%	3.16%	Unchanged
12	XENON PHARMACEUTICALS INC COM XENE	XENE	5,777,777	$348.7m3.13%	3.13%	Unchanged
13	DEFINIUM THERAPEUTICS INC COM SHS DFTX	DFTX	7,188,888	$338.2m3.04%	3.04%	Added +2.2m	+2,188,888 43.8%
14	UNIQURE NV SHS QURE	QURE	6,727,777	$309.9m2.78%	2.78%	Added +768.2k	+768,182 12.9%
15	VERA THERAPEUTICS INC CL A VERA	VERA	5,723,888	$245.6m2.21%	2.21%	Reduced -165.0k	-165,000 -2.8%
16	TAYSHA GENE THERAPIES INC COM SHS TSHA	TSHA	23,888,888	$162.7m1.46%	1.46%	Added +2.2m	+2,188,888 10.1%
17	OCULAR THERAPEUTIX INC COM OCUL	OCUL	12,540,000	$123.1m1.11%	1.11%	Added +225.0k	+225,000 1.8%
18	DAMORA THERAPEUTICS INC COM NEW COM NEW		3,783,000	$98.4m0.88%	0.88%	Unchanged
19	HEMAB THERAPEUTICS HLDGS INC COM SHS COAG	COAG	1,925,150	$70.7m0.63%	0.63%	New
20	GH RESEARCH PLC ORDINARY SHARES GHRS	GHRS	1,800,000	$48.4m0.43%	0.43%	Unchanged
21	VIRIDIAN THERAPEUTICS INC COM VRDN	VRDN	2,500,000	$45.9m0.41%	0.41%	Added +1.0m	+1,000,000 66.7%
22	SEPTERNA INC COM SEPN	SEPN	1,337,500	$44.8m0.40%	0.40%	Unchanged
23	AVALO THERAPEUTICS INC COM NEW AVTX	AVTX	2,333,333	$43.1m0.39%	0.39%	Added +923.3k	+923,333 65.5%
24	FAETH THERAPEUTICS INC COM NEW FTH	FTH	1,444,039	$36.1m0.32%	0.32%	New
25	AADI BIOSCIENCE INC COM WHWK	WHWK	2,849,402	$13.1m0.12%	0.12%	Unchanged
26	LEXEO THERAPEUTICS INC COM LXEO	LXEO	1,489,189	$6.9m0.06%	0.06%	Reduced -385.8k	-385,811 -20.6%

Sold out since Q1 2026

Security	Ticker	Shares held before	Value then
ASCENDIS PHARMA A/S		5,062,500	$1.2bn5.1m shares
APELLIS PHARMACEUTICALS INC APLS	APLS	12,222,222	$491.7m12.2m shares
CENTESSA PHARMACEUTICALS PLC		11,430,455	$454.0m11.4m shares
TERNS PHARMACEUTICALS INC		5,695,000	$300.2m5.7m shares
SOLENO THERAPEUTICS INC SLNO	SLNO	2,300,000	$77.0m2.3m shares
ALKERMES PLC ALKS	ALKS	1,200,000	$42.4m1.2m shares
MANNKIND CORP MNKD	MNKD	2,200,000	$5.4m2.2m shares

Stakes above 5%

Companies where this manager has reported owning more than 5% of a class of shares, on Schedule 13D (may seek influence) or 13G (passive): its latest filing for each, from 19 Dec 2024 on.

Company	Ticker	Stake	Change	Schedule	Last filed
AADI BIOSCIENCE INC WHWK · 13D · filed 2026-05-14	WHWK	20.0%≈ $57.4m	no change	13D	2026-05-14
TOURMALINE BIO INC TRML · 13G · filed 2025-08-14	TRML	9.9%		13G	2025-08-14
UNIQURE NV QURE · 13G · filed 2026-02-17	QURE	9.9%≈ $283.3m	+3.3 pts	13G	2026-02-17
ARROWHEAD PHARMACEUTICALS IN ARWR · 13G · filed 2026-08-14	ARWR	9.6%≈ $1.1bn	+1.3 pts	13G	2026-08-14
STRUCTURE THERAPEUTICS INC GPCR · 13G · filed 2025-11-14	GPCR	9.4%	new	13G	2025-11-14
VERA THERAPEUTICS INC VERA · 13G · filed 2025-02-14	VERA	8.9%≈ $240.7m		13G	2025-02-14
CENTESSA PHARMACEUTICALS PLC 13G · filed 2026-05-15		7.4%	-2.6 pts	13G	2026-05-15
HEMAB THERAPEUTICS HLDGS INC COAG · 13G · filed 2026-08-14	COAG	7.1%≈ $121.1m	new	13G	2026-08-14
CELCUITY INC CELC · 13G · filed 2026-02-17	CELC	6.7%≈ $325.5m	new	13G	2026-02-17
DAMORA THERAPEUTICS INC 13G · filed 2026-05-15		6.3%≈ $98.4m	new	13G	2026-05-15
XENON PHARMACEUTICALS INC XENE · 13G · filed 2026-05-15	XENE	6.3%≈ $348.7m		13G	2026-05-15
AVIDITY BIOSCIENCES INC RNA · 13G · filed 2026-02-17	RNA	5.5%		13G	2026-02-17
DEFINIUM THERAPEUTICS INC DFTX · 13G · filed 2026-02-17	DFTX	5.1%≈ $235.2m	new	13G	2026-02-17