APELLIS PHARMACEUTICALS INC APLS
COM · Common Stock · CUSIP 03753U106 · ISIN US03753U1060
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $41.03.
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 251 |
| Q4 2022 | 245 |
| Q1 2023 | 284 |
| Q2 2023 | 319 |
| Q3 2023 | 257 |
| Q4 2023 | 284 |
| Q1 2024 | 304 |
| Q2 2024 | 264 |
| Q3 2024 | 267 |
| Q4 2024 | 262 |
| Q1 2025 | 258 |
| Q2 2025 | 248 |
| Q3 2025 | 273 |
| Q4 2025 | 280 |
| Q1 2026 | 325 |
| Q2 2026 | 1 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 135 | 132 |
| Q4 2024 | 146 | 134 |
| Q1 2025 | 134 | 130 |
| Q2 2025 | 147 | 118 |
| Q3 2025 | 151 | 119 |
| Q4 2025 | 137 | 149 |
| Q1 2026 | 201 | 150 |
| Q2 2026 | 0 | 311 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $102.3m | $21.1m | 0.21 |
| Q4 2025 | $105.5m | $27.7m | 0.26 |
| Q1 2026 | $52.1m | $36.5m | 0.70 |
| Q2 2026 | $0 | $0 | — |
Biggest buyers
| None |
Biggest sellers
| BlackRock, Inc. | Sold out | -13.5m |
| Avoro Capital Advisors LLC | Sold out | -12.2m |
| MORGAN STANLEY | Sold out | -10.0m |
| STATE STREET CORP | Sold out | -6.8m |
| UBS Group AG | Sold out | -6.2m |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Sold out | -5.4m |
| Pentwater Capital Management LP | Sold out | -5.2m |
| VANGUARD CAPITAL MANAGEMENT LLC | Sold out | -4.8m |
| Deep Track Capital, LP | Sold out | -4.5m |
| Point72 Asset Management, L.P. | Sold out | -4.2m |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution +6.0 pts · filed 2026-02-06 | 10.5% |
| STATE STREET CORP 13G · institution new · filed 2026-05-12 | 5.4% |
Fell to 5% or below in the last year: MORGAN STANLEY (0.0%, 2026-06-05), RTW INVESTMENTS, LP (2.9%, 2026-05-15), Deep Track Capital, LP (3.5%, 2026-05-15), BIOGEN INC. (0.0%, 2026-05-14), WELLINGTON MANAGEMENT GROUP LLP (0.2%, 2026-04-07), VANGUARD GROUP INC (0.0%, 2026-03-26)
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| IFP Advisors, Inc 0.00% of their portfolio | 248 $10.2k | Reduced -223 |