ARGENX SE ARGX
SPONSORED ADR · ADR · CUSIP 04016X101 · ISIN US04016X1019
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($5.1m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $924.72. Options: 13 managers hold calls ($243.4m notional), 11 hold puts ($154.6m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 255 |
| Q4 2022 | 271 |
| Q1 2023 | 273 |
| Q2 2023 | 291 |
| Q3 2023 | 342 |
| Q4 2023 | 347 |
| Q1 2024 | 328 |
| Q2 2024 | 336 |
| Q3 2024 | 358 |
| Q4 2024 | 397 |
| Q1 2025 | 449 |
| Q2 2025 | 439 |
| Q3 2025 | 469 |
| Q4 2025 | 509 |
| Q1 2026 | 477 |
| Q2 2026 | 507 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 187 | 149 |
| Q4 2024 | 204 | 157 |
| Q1 2025 | 236 | 177 |
| Q2 2025 | 225 | 204 |
| Q3 2025 | 266 | 192 |
| Q4 2025 | 247 | 219 |
| Q1 2026 | 233 | 261 |
| Q2 2026 | 260 | 210 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $549.2m | $262.8m | 0.48 |
| Q4 2025 | $364.4m | $165.4m | 0.45 |
| Q1 2026 | $251.0m | $136.4m | 0.54 |
| Q2 2026 | $243.4m | $154.6m | 0.63 |
Biggest buyers
| FMR LLC | Added | +240.4k |
| BESSEMER GROUP INC | Added | +203.5k |
| BARCLAYS PLC | Added | +128.9k |
| Capital Research Global Investors | New | +88.5k |
| MORGAN STANLEY | Added | +82.4k |
| TWO SIGMA INVESTMENTS, LP | Added | +76.5k |
| 1832 Asset Management L.P. | Added | +73.7k |
| CANADA PENSION PLAN INVESTMENT BOARD | New | +60.6k |
| WESTFIELD CAPITAL MANAGEMENT CO LP | New | +57.1k |
| Woodline Partners LP | New | +55.0k |
Biggest sellers
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -696.9k |
| Invesco Ltd. | Reduced | -150.7k |
| Fiera Capital Corp | Reduced | -126.8k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -90.9k |
| BRAIDWELL LP | Reduced | -67.2k |
| Capital World Investors | Reduced | -56.4k |
| TD Asset Management Inc | Reduced | -56.1k |
| GOLDMAN SACHS GROUP INC | Reduced | -54.1k |
| Rock Springs Capital Management LP | Reduced | -45.8k |
| ORBIMED ADVISORS LLC | Reduced | -44.0k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $66.2m71.3k shares |
| D. E. Shaw & Co., Inc. | Reduced | $54.1m58.3k shares |
| CITADEL ADVISORS LLC | Reduced | $34.0m36.7k shares |
| JANE STREET GROUP, LLC | Added | $32.8m35.4k shares |
| LMR Partners LLP | Added | $18.9m20.4k shares |
| IMC-Chicago, LLC | Reduced | $16.1m17.3k shares |
| HRT FINANCIAL LP | New | $8.6m9.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $5.1m5.5k shares |
| Point72 Asset Management, L.P. | Reduced | $3.3m3.6k shares |
| PEAK6 LLC | New | $2.8m3.0k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $78.9m85.0k shares |
| CITADEL ADVISORS LLC | Reduced | $22.5m24.2k shares |
| IMC-Chicago, LLC | Reduced | $20.7m22.3k shares |
| JANE STREET GROUP, LLC | Added | $11.1m12.0k shares |
| HRT FINANCIAL LP | New | $8.6m9.3k shares |
| D. E. Shaw & Co., Inc. | Reduced | $4.5m4.8k shares |
| LMR Partners LLP | New | $3.1m3.3k shares |
| Point72 Asset Management, L.P. | Reduced | $2.0m2.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $1.9m2.1k shares |
| Walleye Capital LLC | Added | $742.2k800 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
No one currently above 5% in the filings since 19 Dec 2024.
Fell to 5% or below in the last year: PRICE T ROWE ASSOCIATES INC /MD/ (4.3%, 2026-08-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.21% of their portfolio | 5.2m $4.9bn | Added +240.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.25% of their portfolio | 2.7m $2.5bn | Reduced -696.9k |
| Jupiter Topco LLC 0.94% of their portfolio | 2.5m $2.3bn | First filing |
| Capital World Investors 0.24% of their portfolio | 2.2m $2.0bn | Reduced -56.4k |
| Artisan Partners Limited Partnership 2.28% of their portfolio | 1.5m $1.4bn | Added +40.8k |
| Avoro Capital Advisors LLC 8.33% of their portfolio | 1.0m $927.8m | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP 0.15% of their portfolio | 930.5k $863.3m | Reduced -90.9k |
| BlackRock, Inc. 0.01% of their portfolio | 777.2k $721.1m | Reduced -31.1k |
| RTW INVESTMENTS, LP 5.62% of their portfolio | 709.4k $658.2m | Unchanged |
| MORGAN STANLEY 0.03% of their portfolio | 643.1k $596.7m | Added +82.4k |
| Invesco Ltd. 0.03% of their portfolio | 444.0k $411.9m | Reduced -150.7k |
| BANK OF AMERICA CORP /DE/ 0.02% of their portfolio | 400.2k $371.3m | Added +117 |
| ALLIANCEBERNSTEIN L.P. 0.10% of their portfolio | 395.7k $288.9m | Reduced -26.6k |
| Bellevue Group AG 5.88% of their portfolio | 301.0k $279.3m | Reduced -12.0k |
| SANDS CAPITAL MANAGEMENT, LLC 1.03% of their portfolio | 298.6k $277.0m | Reduced -41.7k |
| BESSEMER GROUP INC 0.34% of their portfolio | 267.8k $248.4m | Added +203.5k |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.74% of their portfolio | 264.6k $245.5m | Reduced -1.4k |
| SEI INVESTMENTS CO 0.21% of their portfolio | 255.1k $236.7m | Reduced -31.9k |
| Clearbridge Investments, LLC 0.19% of their portfolio | 253.8k $235.4m | Added +22.4k |
| JENNISON ASSOCIATES LLC 0.13% of their portfolio | 226.2k $209.9m | Reduced -11.3k |
| FRANKLIN RESOURCES INC 0.05% of their portfolio | 224.9k $208.7m | Reduced -8.6k |
| CITADEL ADVISORS LLC 0.11% of their portfolio | 212.4k $197.1m | Reduced -6.7k |
| Pictet Asset Management Holding SA 0.18% of their portfolio | 198.3k $183.8m | Added +50.0k |
| TWO SIGMA INVESTMENTS, LP 0.13% of their portfolio | 185.6k $172.2m | Added +76.5k |
| AMERIPRISE FINANCIAL INC 0.03% of their portfolio | 181.5k $168.4m | Reduced -34.4k |
| GOLDMAN SACHS GROUP INC 0.02% of their portfolio | 177.8k $165.0m | Reduced -54.1k |
| Legal & General Group Plc 0.03% of their portfolio | 177.2k $164.4m | Added +26.3k |
| AMERICAN CENTURY COMPANIES INC 0.07% of their portfolio | 173.2k $160.7m | Reduced -507 |
| Allspring Global Investments Holdings, LLC 0.24% of their portfolio | 170.8k $155.4m | Reduced -4.5k |
| BNP PARIBAS FINANCIAL MARKETS 0.08% of their portfolio | 158.0k $146.5m | Reduced -19.9k |
| 1832 Asset Management L.P. 0.18% of their portfolio | 157.9k $146.5m | Added +73.7k |
| DEUTSCHE BANK AG\ 0.04% of their portfolio | 137.3k $127.4m | Reduced -2.0k |
| BAMCO INC /NY/ 0.19% of their portfolio | 136.7k $126.8m | Reduced -2.0k |
| BARCLAYS PLC 0.04% of their portfolio | 134.4k $124.7m | Added +128.9k |
| LAZARD ASSET MANAGEMENT LLC 0.19% of their portfolio | 132.0k $122.5m | Reduced -1.4k |
| Checkpoint Capital L.P. 31.25% of their portfolio | 131.3k $121.8m | Reduced -21.7k |
| EVENTIDE ASSET MANAGEMENT, LLC 1.56% of their portfolio | 125.7k $116.6m | Added +11 |
| AGF MANAGEMENT LTD 0.45% of their portfolio | 125.5k $116.4m | Added +412 |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.11% of their portfolio | 121.8k $113.0m | Reduced -7.4k |
| LORD, ABBETT & CO. LLC 0.29% of their portfolio | 108.3k $100.4m | Reduced -43.8k |
| FIRST TRUST ADVISORS LP 0.06% of their portfolio | 101.4k $94.1m | Reduced -5.8k |
| PGGM Investments 2.20% of their portfolio | 96.5k $89.5m | Added +25.0k |
| MILLENNIUM MANAGEMENT LLC 0.06% of their portfolio | 94.4k $87.6m | Added +22.0k |
| ORBIMED ADVISORS LLC 1.63% of their portfolio | 92.9k $86.2m | Reduced -44.0k |
| Fiera Capital Corp 0.30% of their portfolio | 90.4k $83.9m | Reduced -126.8k |
| Capital Research Global Investors 0.01% of their portfolio | 88.5k $82.1m | New |
| FEDERATED HERMES, INC. 0.12% of their portfolio | 87.3k $81.0m | Reduced -8.0k |
| PINEBRIDGE INVESTMENTS LLC 0.67% of their portfolio | 87.0k $80.8m | Reduced -16.8k |
| Public Sector Pension Investment Board 0.21% of their portfolio | 84.3k $78.2m | Added +11.0k |
| Aberdeen Group plc 0.11% of their portfolio | 83.8k $77.8m | Added +1.7k |
| TimesSquare Capital Management, LLC 1.13% of their portfolio | 83.1k $77.1m | Reduced -3 |
| Candriam S.C.A. 0.33% of their portfolio | 80.1k $74.3m | Added +26.0k |
| BANK OF MONTREAL /CAN/ 0.03% of their portfolio | 77.2k $71.6m | Reduced -8.1k |
| Eagle Health Investments LP 11.75% of their portfolio | 76.4k $70.9m | Added +81 |
| Nuveen, LLC 0.02% of their portfolio | 74.1k $68.8m | Added +7.9k |
| Amundi 0.01% of their portfolio | 65.1k $60.4m | Added +3.7k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 62.2k $57.7m | Added +3.5k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 61.3k $56.9m | Added +33.8k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.03% of their portfolio | 60.6k $56.2m | New |
| Squarepoint Ops LLC 0.11% of their portfolio | 58.4k $54.2m | Added +39.7k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.08% of their portfolio | 58.3k $54.1m | Reduced -107 |
| USS Investment Management Ltd 0.21% of their portfolio | 57.9k $53.8m | Added +45.8k |
| WESTFIELD CAPITAL MANAGEMENT CO LP 0.17% of their portfolio | 57.1k $53.0m | New |
| ENVESTNET ASSET MANAGEMENT INC 0.01% of their portfolio | 55.3k $51.3m | Reduced -6.1k |
| Woodline Partners LP 0.16% of their portfolio | 55.0k $51.1m | New |
| Rock Springs Capital Management LP 2.39% of their portfolio | 52.8k $48.9m | Reduced -45.8k |
| Handelsbanken Fonder AB 0.14% of their portfolio | 52.7k $48.9m | Reduced -2.3k |
| Ensign Peak Advisors, Inc 0.08% of their portfolio | 52.0k $48.3m | Reduced -19.6k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.07% of their portfolio | 50.6k $47.0m | Reduced -39.4k |
| NOMURA ASSET MANAGEMENT CO LTD 0.10% of their portfolio | 49.2k $45.6m | Reduced -127 |
| Jefferies Financial Group Inc. 0.38% of their portfolio | 45.1k $41.8m | Added +15.1k |
| DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio | 44.4k $41.2m | Added +5.6k |
| Tri Locum Partners LP 4.75% of their portfolio | 41.6k $38.6m | Added +10.0k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.02% of their portfolio | 40.1k $37.2m | New |
| Point72 Asset Management, L.P. 0.06% of their portfolio | 40.0k $37.1m | New |
| UBS Group AG 0.01% of their portfolio | 36.6k $33.9m | Added +4.9k |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 34.8k $32.2m | Reduced -2.0k |
| WELLS FARGO & COMPANY/MN 0.01% of their portfolio | 34.5k $32.0m | Reduced -3.7k |
| Assenagon Asset Management S.A. 0.02% of their portfolio | 33.1k $30.7m | Added +18.3k |
| VICTORY CAPITAL MANAGEMENT INC 0.02% of their portfolio | 30.9k $28.6m | Reduced -1.4k |
| Mediolanum International Funds Ltd 0.23% of their portfolio | 29.8k $27.2m | New |
| Artia Global Partners LP 5.25% of their portfolio | 29.7k $27.6m | Unchanged |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.90% of their portfolio | 29.7k $27.6m | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 28.6k $26.5m | Reduced -4.4k |
| Perpetual Ltd 0.37% of their portfolio | 28.2k $26.2m | Reduced -113 |
| BLAIR WILLIAM & CO/IL 0.07% of their portfolio | 27.7k $25.7m | Added +5.3k |
| ODDO BHF ASSET MANAGEMENT SAS 1.07% of their portfolio | 25.0k $23.2m | Unchanged |
| TD Asset Management Inc 0.02% of their portfolio | 24.7k $22.9m | Reduced -56.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 23.9k $22.1m | Added +292 |
| Patient Square Capital LP 3.31% of their portfolio | 23.0k $21.3m | Reduced -13.7k |
| Life Cycle Investment Partners Ltd 0.10% of their portfolio | 22.5k $20.9m | Reduced -36.4k |
| VAN ECK ASSOCIATES CORP 0.01% of their portfolio | 22.2k $20.6m | Reduced -18.2k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.03% of their portfolio | 22.1k $20.5m | Reduced -17.4k |
| Soleus Capital Management, L.P. 0.64% of their portfolio | 20.0k $18.5m | Added +16.5k |
| LPL Financial LLC 0.00% of their portfolio | 19.5k $18.1m | Reduced -3.7k |
| NATIXIS ADVISORS, LLC 0.02% of their portfolio | 19.1k $17.7m | Reduced -1.3k |
| Jain Global LLC 0.21% of their portfolio | 18.9k $17.5m | Added +14.3k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.07% of their portfolio | 18.8k $17.4m | Reduced -3.9k |
| BRAIDWELL LP 0.61% of their portfolio | 17.7k $16.4m | Reduced -67.2k |
| HRT FINANCIAL LP 0.04% of their portfolio | 17.5k $16.2m | Reduced -1.3k |