UNIQURE NV QURE
SHS · Common Stock · CUSIP N90064101
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($136.5k this quarter). Holder counts are more reliable. Shares outstanding: 69.4m as of 2026-07-24, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $46.08. Options: 36 managers hold calls ($553.2m notional), 18 hold puts ($117.2m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 162 |
| Q4 2022 | 177 |
| Q1 2023 | 175 |
| Q2 2023 | 178 |
| Q3 2023 | 161 |
| Q4 2023 | 144 |
| Q1 2024 | 133 |
| Q2 2024 | 118 |
| Q3 2024 | 132 |
| Q4 2024 | 139 |
| Q1 2025 | 142 |
| Q2 2025 | 144 |
| Q3 2025 | 219 |
| Q4 2025 | 226 |
| Q1 2026 | 213 |
| Q2 2026 | 254 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 66 | 55 |
| Q4 2024 | 62 | 75 |
| Q1 2025 | 77 | 57 |
| Q2 2025 | 74 | 79 |
| Q3 2025 | 145 | 78 |
| Q4 2025 | 135 | 124 |
| Q1 2026 | 112 | 113 |
| Q2 2026 | 175 | 107 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $291.9m | $281.4m | 0.96 |
| Q4 2025 | $232.6m | $63.7m | 0.27 |
| Q1 2026 | $282.9m | $42.8m | 0.15 |
| Q2 2026 | $553.2m | $117.2m | 0.21 |
Biggest buyers
| JPMORGAN CHASE & CO | Added | +2.0m |
| RTW INVESTMENTS, LP | Added | +1.4m |
| JANE STREET GROUP, LLC | Added | +974.5k |
| Assenagon Asset Management S.A. | Added | +880.3k |
| Boxer Capital Management, LLC | Added | +841.3k |
| Longaeva Partners L.P. | New | +804.6k |
| MAK CAPITAL ONE LLC | Added | +790.8k |
| Avoro Capital Advisors LLC | Added | +768.2k |
| MORGAN STANLEY | Added | +700.5k |
| Nantahala Capital Management, LLC | Added | +674.2k |
Biggest sellers
| Aberdeen Group plc | Reduced | -2.5m |
| TWO SIGMA INVESTMENTS, LP | Reduced | -1.2m |
| Siren, L.L.C. | Sold out | -1.0m |
| SG Americas Securities, LLC | Reduced | -735.5k |
| Whitefort Capital Management, LP | Sold out | -657.6k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -505.9k |
| Catalio Capital Management, LP | Sold out | -491.1k |
| FMR LLC | Reduced | -473.7k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -449.6k |
| ExodusPoint Capital Management, LP | Sold out | -436.5k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $118.7m2.6m shares |
| Caption Management, LLC | Reduced | $75.0m1.6m shares |
| Nantahala Capital Management, LLC | Reduced | $73.7m1.6m shares |
| CITADEL ADVISORS LLC | Added | $46.1m1.0m shares |
| GROUP ONE TRADING LLC | Reduced | $38.1m826.1k shares |
| CITIGROUP INC | Reduced | $30.6m665.0k shares |
| TUDOR INVESTMENT CORP ET AL | Added | $25.3m548.3k shares |
| JANE STREET GROUP, LLC | Added | $25.2m547.8k shares |
| IMC-Chicago, LLC | Added | $18.8m409.1k shares |
| 683 Capital Management, LLC | Reduced | $14.6m316.2k shares |
Biggest puts
| CITADEL ADVISORS LLC | Added | $27.5m596.7k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $19.3m420.1k shares |
| Nantahala Capital Management, LLC | New | $14.9m323.0k shares |
| DIADEMA PARTNERS LP | Unchanged | $13.8m299.0k shares |
| TUDOR INVESTMENT CORP ET AL | Added | $9.4m204.0k shares |
| Caption Management, LLC | Reduced | $9.3m201.1k shares |
| GROUP ONE TRADING LLC | Reduced | $5.9m127.8k shares |
| IMC-Chicago, LLC | Added | $5.0m108.8k shares |
| JANE STREET GROUP, LLC | Reduced | $4.2m91.4k shares |
| LMR Partners LLP | Added | $2.2m47.4k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Avoro Capital Advisors LLC 13G · institution +3.3 pts · filed 2026-02-17 | 9.9% |
| JPMORGAN CHASE & CO 13G · institution +1.5 pts · filed 2026-10-16 | 8.5% |
| RTW INVESTMENTS, LP 13G · institution +1.6 pts · filed 2026-08-14 | 5.7% |
Fell to 5% or below in the last year: SUSQUEHANNA SECURITIES, LLC (4.8%, 2026-08-14), Aberdeen Group plc (4.5%, 2026-07-20), STATE STREET CORP (3.6%, 2026-05-12), FMR LLC (2.8%, 2026-05-06), EcoR1 Capital, LLC (0.0%, 2026-02-17), Vestal Point Capital, LP (0.4%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 2 | $1.5m | $1.5m |
| Q1 2025 | 0 | — | 4 | $1.0m | — |
| Q2 2025 | 0 | — | 9 | $169.8k | — |
| Q3 2025 | 0 | — | 2 | $10.3m | $10.3m |
| Q4 2025 | 0 | — | 2 | $2.0m | $2.0m |
| Q1 2026 | 0 | — | 6 | $2.1m | $804.8k |
| Q2 2026 | 0 | — | 11 | $16.7m | $16.0m |
| Q3 2026 | 0 | — | 1 | $952.1k | $952.1k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-07-02 | Kapusta Matthew C CEO, Managing Director, director | Sold plan | $952.1k21.1k shares |
| 2026-06-30 | Abi-Saab Walid Chief Medical Officer | Sold plan | $1.4m30.0k shares |
| 2026-06-30 | Kaye Jack Director | Sold plan | $983.0k21.2k shares |
| 2026-06-26 | Abi-Saab Walid Chief Medical Officer | Sold | $67.2k1.4k shares |
| 2026-06-25 | Kapusta Matthew C CEO, Managing Director, director | Sold plan | $1.4m28.7k shares |
| 2026-06-24 | Kapusta Matthew C CEO, Managing Director, director | Sold plan | $334.8k6.7k shares |
| 2026-06-18 | Kapusta Matthew C CEO, Managing Director, director | Sold plan | $2.1m41.7k shares |
| 2026-06-17 | Kapusta Matthew C CEO, Managing Director, director | Sold plan | $7.3m164.4k shares |
| 2026-06-17 | Balachandran Madhavan Director | Sold plan | $526.5k11.7k shares |
| 2026-06-17 | Kaye Jack Director | Sold plan | $225.4k5.3k shares |
| 2026-06-15 | Balachandran Madhavan Director | Sold plan | $278.5k10.0k shares |
| 2026-06-15 | Potts Jeannette Chief Legal Officer | Sold | $144.9k5.2k shares |
| 2026-06-11 | O'Keefe Kylie Chief Customer & Strat Officer | Sold | $431.2k15.9k shares |
| 2026-06-11 | Gut Robert Director | Sold plan | $73.8k2.7k shares |
| 2026-06-11 | Jacques Rachelle Suzanne Director | Sold | $53.9k2.0k shares |
| 2026-06-11 | Kaye Jack Director | Sold | $53.9k2.0k shares |
| 2026-06-11 | POST LEONARD E Director | Sold | $53.9k2.0k shares |
| 2026-06-11 | Springhorn Jeremy P. Director | Sold | $53.9k2.0k shares |
| 2026-06-11 | Meek David D. Director | Sold | $53.9k2.0k shares |
| 2026-06-11 | Balachandran Madhavan Director | Sold | $53.9k2.0k shares |
| 2026-06-10 | Gut Robert Director | Sold plan | $196.7k7.6k shares |
| 2026-06-03 | Kaye Jack Director | Sold plan | $79.4k2.6k shares |
| 2026-05-08 | Abi-Saab Walid Chief Medical Officer | Sold plan | $1.1m45.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Avoro Capital Advisors LLC 2.78% of their portfolio | 6.7m $309.9m | Added +768.2k |
| JPMORGAN CHASE & CO 0.01% of their portfolio | 4.9m $230.8m | Added +2.0m |
| RTW INVESTMENTS, LP 1.55% of their portfolio | 3.9m $181.5m | Added +1.4m |
| STATE STREET CORP 0.00% of their portfolio | 2.9m $133.8m | Added +643.3k |
| Aberdeen Group plc 0.18% of their portfolio | 2.8m $131.2m | Reduced -2.5m |
| BlackRock, Inc. 0.00% of their portfolio | 1.9m $86.5m | Added +144.0k |
| ORBIMED ADVISORS LLC 1.58% of their portfolio | 1.8m $83.3m | Reduced -328.7k |
| JANE STREET GROUP, LLC 0.05% of their portfolio | 1.6m $74.2m | Added +974.5k |
| JENNISON ASSOCIATES LLC 0.04% of their portfolio | 1.6m $71.9m | Added +327.6k |
| Boxer Capital Management, LLC 5.21% of their portfolio | 1.5m $69.2m | Added +841.3k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 1.5m $68.0m | Added +212.7k |
| TWO SIGMA INVESTMENTS, LP 0.05% of their portfolio | 1.5m $67.3m | Reduced -1.2m |
| Two Seas Capital LP 2.53% of their portfolio | 1.4m $66.4m | Added +141.4k |
| FMR LLC 0.00% of their portfolio | 1.3m $58.5m | Reduced -473.7k |
| MAK CAPITAL ONE LLC 7.95% of their portfolio | 1.2m $56.7m | Added +790.8k |
| MPM BIOIMPACT LLC 3.44% of their portfolio | 1.2m $56.5m | Reduced -143.4k |
| MORGAN STANLEY 0.00% of their portfolio | 1.1m $49.1m | Added +700.5k |
| Assenagon Asset Management S.A. 0.03% of their portfolio | 1.0m $47.3m | Added +880.3k |
| Vestal Point Capital, LP 1.01% of their portfolio | 935.0k $43.1m | Added +576.0k |
| MAVERICK CAPITAL LTD 0.38% of their portfolio | 925.4k $42.6m | Added +227.7k |
| Nantahala Capital Management, LLC 1.27% of their portfolio | 911.3k $42.0m | Added +674.2k |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 910.3k $41.9m | Added +505.8k |
| Fiera Capital Corp 0.15% of their portfolio | 909.1k $41.9m | Added +92.2k |
| Integral Health Asset Management, LLC 1.70% of their portfolio | 900.0k $41.5m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 860.6k $39.7m | Added +56.0k |
| Longaeva Partners L.P. 1.07% of their portfolio | 804.6k $37.1m | New |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 779.8k $35.9m | Added +85.1k |
| Invesco Ltd. 0.00% of their portfolio | 627.8k $28.9m | New |
| First Turn Management, LLC 3.00% of their portfolio | 608.9k $28.0m | Reduced -6.6k |
| Point72 Asset Management, L.P. 0.04% of their portfolio | 606.2k $27.9m | New |
| Balyasny Asset Management L.P. 0.05% of their portfolio | 586.6k $27.0m | Reduced -377.7k |
| Kinetic Partners Management, LP 0.64% of their portfolio | 581.0k $26.8m | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 578.8k $26.7m | Added +331.9k |
| 683 Capital Management, LLC 2.44% of their portfolio | 575.0k $26.5m | Added +75.0k |
| GILDER GAGNON HOWE & CO LLC 0.25% of their portfolio | 531.0k $24.5m | New |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. 1.32% of their portfolio | 521.7k $24.0m | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.02% of their portfolio | 496.9k $22.9m | Reduced -505.9k |
| UBS Group AG 0.00% of their portfolio | 467.6k $21.5m | Reduced -20.3k |
| Voss Capital, LP 1.04% of their portfolio | 450.4k $20.7m | Reduced -154.6k |
| Rubric Capital Management LP 0.17% of their portfolio | 408.6k $18.8m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 403.3k $18.6m | Added +27.5k |
| READYSTATE ASSET MANAGEMENT LP 0.75% of their portfolio | 401.0k $18.5m | Reduced -103.7k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 369.6k $17.0m | Added +37.1k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 343.1k $15.8m | Reduced -449.6k |
| Creek Drive Management Group LLC 9.59% of their portfolio | 337.0k $15.5m | Added +187.0k |
| TUDOR INVESTMENT CORP ET AL 0.06% of their portfolio | 328.9k $15.1m | New |
| Privium Fund Management B.V. 2.78% of their portfolio | 328.3k $15.1m | Reduced -158.2k |
| FLAX POND CAPITAL, LLC 3.69% of their portfolio | 324.8k $10.0m | Added +172.7k |
| ADAR1 Capital Management, LLC 0.70% of their portfolio | 324.7k $15.0m | Added +248.5k |
| MARSHALL WACE, LLP 0.01% of their portfolio | 304.7k $14.0m | Added +182.0k |
| BRAIDWELL LP 0.51% of their portfolio | 301.7k $13.9m | New |
| Squarepoint Ops LLC 0.03% of their portfolio | 280.3k $12.9m | Reduced -65.7k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 245.3k $11.3m | Reduced -235.6k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio | 244.2k $11.2m | Added +96.7k |
| NOMURA ASSET MANAGEMENT INTERNATIONAL INC. 0.02% of their portfolio | 217.5k $10.0m | Reduced -40.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 212.9k $9.8m | Added +43.0k |
| Parkman Healthcare Partners LLC 0.98% of their portfolio | 208.2k $9.6m | Added +1.3k |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 207.6k $9.6m | Added +46.9k |
| Diametric Capital, LP 0.97% of their portfolio | 197.2k $9.1m | Added +178.8k |
| PICTON MAHONEY ASSET MANAGEMENT 0.08% of their portfolio | 181.2k $8.3m | New |
| Affinity Asset Advisors, LLC 0.39% of their portfolio | 175.0k $8.1m | New |
| Trexquant Investment LP 0.05% of their portfolio | 171.1k $7.9m | New |
| PERCEPTIVE ADVISORS LLC 0.12% of their portfolio | 168.0k $7.7m | New |
| Freshford Capital Management, LLC 2.55% of their portfolio | 161.9k $7.5m | New |
| Kalehua Capital Management LLC 2.33% of their portfolio | 158.8k $7.3m | Reduced -344.0k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 152.3k $7.0m | Added +95.2k |
| Casdin Capital, LLC 0.35% of their portfolio | 150.0k $6.9m | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 150.0k $6.9m | Added +46.5k |
| Hennion & Walsh Asset Management, Inc. 0.19% of their portfolio | 142.1k $6.5m | Added +73.6k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 141.1k $6.5m | New |
| HRT FINANCIAL LP 0.01% of their portfolio | 135.6k $6.2m | New |
| CITIGROUP INC 0.00% of their portfolio | 127.9k $5.9m | Reduced -403.9k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 126.6k $5.8m | Added +30.0k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 124.3k $5.7m | Added +16.4k |
| Susquehanna Portfolio Strategies, LLC 0.09% of their portfolio | 121.9k $5.6m | Reduced -17.1k |
| Hudson Bay Capital Management LP 0.03% of their portfolio | 120.0k $5.5m | Reduced -38.5k |
| NAN FUNG TRINITY (HK) LTD 0.53% of their portfolio | 115.5k $5.3m | Unchanged |
| SIMPLEX TRADING, LLC 0.13% of their portfolio | 110.2k $5.1m | Reduced -121.5k |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.54% of their portfolio | 105.0k $4.8m | New |
| Ghisallo Capital Management LLC 0.09% of their portfolio | 100.0k $4.6m | New |
| LORD, ABBETT & CO. LLC 0.01% of their portfolio | 95.3k $4.4m | New |
| Pekin Hardy Strauss, Inc. 0.38% of their portfolio | 94.2k $4.3m | Reduced -18.3k |
| Swiss National Bank 0.00% of their portfolio | 94.1k $4.3m | Added +15.1k |
| STEMPOINT CAPITAL LP 0.70% of their portfolio | 88.1k $4.1m | Reduced -68.0k |
| FourWorld Capital Management LLC 5.11% of their portfolio | 87.0k $4.0m | New |
| Marex Group Ltd 0.03% of their portfolio | 81.5k $3.8m | Added +1.5k |
| Exome Asset Management LLC 2.30% of their portfolio | 81.1k $3.7m | New |
| K2 PRINCIPAL FUND, L.P. 0.33% of their portfolio | 78.6k $3.6m | Reduced -40.0k |
| Alyeska Investment Group, L.P. 0.01% of their portfolio | 75.0k $3.5m | New |
| Burkehill Global Management, LP 0.12% of their portfolio | 75.0k $3.5m | New |
| FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio | 69.6k $3.2m | Added +47.9k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 67.4k $3.1m | Added +24.6k |
| XTX Topco Ltd 0.04% of their portfolio | 66.7k $3.1m | New |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 66.4k $3.1m | Reduced -23.8k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 62.4k $2.9m | Added +51.8k |
| Massar Capital Management, LP 0.97% of their portfolio | 61.3k $2.8m | Reduced -364.7k |
| Holocene Advisors, LP 0.01% of their portfolio | 59.9k $2.8m | New |
| Clearline Capital LP 0.17% of their portfolio | 58.1k $2.7m | Reduced -25.6k |
| Engineers Gate Manager LP 0.03% of their portfolio | 56.1k $2.6m | Reduced -243.7k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 52.6k $2.4m | Added +16.7k |