Vault-13

CENTESSA PHARMACEUTICALS PLC

SPONSORED ADS · ADR · CUSIP 152309100

0 institutional holders -161 vs Q1 2026
—reported value*
0 new 0 added 0 reduced 157 sold out net sold ≈ $5.7bn (-144.6m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable.

Trends to Q2 2026

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 45Q4 22: 45Q1 23: 45Q2 23: 46Q3 23: 50Q4 23: 59Q1 24: 71Q2 24: 81Q3 24: 104Q4 24: 115Q1 25: 131Q2 25: 118Q3 25: 126Q4 25: 147Q1 26: 161Q2 26: 00Q3 22Q3 23Q3 24Q3 25Q2 26
Numbers
QuarterHolders
Q3 202245
Q4 202245
Q1 202345
Q2 202346
Q3 202350
Q4 202359
Q1 202471
Q2 202481
Q3 2024104
Q4 2024115
Q1 2025131
Q2 2025118
Q3 2025126
Q4 2025147
Q1 2026161
Q2 20260

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q3 24: 74 bought or addedQ3 24: 24 cut or sold outQ4 24: 52 bought or addedQ4 24: 52 cut or sold outQ4 24Q1 25: 74 bought or addedQ1 25: 51 cut or sold outQ2 25: 63 bought or addedQ2 25: 67 cut or sold outQ2 25Q3 25: 59 bought or addedQ3 25: 70 cut or sold outQ4 25: 87 bought or addedQ4 25: 65 cut or sold outQ4 25Q1 26: 96 bought or addedQ1 26: 77 cut or sold outQ2 26: 0 bought or addedQ2 26: 157 cut or sold outQ2 26
Numbers
QuarterBought or addedCut or sold out
Q3 20247424
Q4 20245252
Q1 20257451
Q2 20256367
Q3 20255970
Q4 20258765
Q1 20269677
Q2 20260157

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$10m$20m$30m$40mQ3 25 calls: $33.2mQ3 25 puts: $22.6mQ3 25P/C 0.68Q4 25 calls: $10.4mQ4 25 puts: $6.5mQ4 25P/C 0.62Q1 26 calls: $31.9mQ1 26 puts: $23.2mQ1 26P/C 0.73Q2 26 calls: $0Q2 26 puts: $0Q2 26P/C —
Numbers
QuarterCallsPutsP/C
Q3 2025$33.2m$22.6m0.68
Q4 2025$10.4m$6.5m0.62
Q1 2026$31.9m$23.2m0.73
Q2 2026$0$0—

Biggest buyers

None

Biggest sellers

Medicxi Ventures Management (Jersey) Ltd Sold out -19,963,157-20.0m
Avoro Capital Advisors LLC Sold out -11,430,455-11.4m
Index Venture Life Associates VI Ltd Sold out -9,961,789-10.0m
ADAGE CAPITAL PARTNERS GP, L.L.C. Sold out -8,925,010-8.9m
Pentwater Capital Management LP Sold out -8,170,000-8.2m
FMR LLC Sold out -6,852,047-6.9m
EcoR1 Capital, LLC Sold out -6,000,000-6.0m
PERCEPTIVE ADVISORS LLC Sold out -5,258,903-5.3m
Capital World Investors Sold out -4,832,548-4.8m
FARALLON CAPITAL MANAGEMENT, L.L.C. Sold out -4,809,000-4.8m

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Avoro Capital Advisors LLC 13G · institution -2.6 pts · filed 2026-05-15 7.4% -2.6 pts 11.4m 2026-05-15
General Atlantic Cooperatief U.A. 13D · may seek influence -1.6 pts · filed 2025-11-28 5.0% -1.6 pts 7.4m 2025-11-28

Fell to 5% or below in the last year: Pentwater Capital Management LP (0.0%, 2026-08-14), INDEX VENTURES LIFE VI (JERSEY) L.P. (0.0%, 2026-08-14), Adage Capital Management, L.P. (0.0%, 2026-08-12), Medicxi Growth I LP (0.0%, 2026-08-04), FMR LLC (0.0%, 2026-07-08), FARALLON CAPITAL MANAGEMENT, L.L.C. (0.0%, 2026-06-26)

Holders, Q2 2026

#ManagerLocationShares Value% of their portfolioChangeShares change