Vault-13

APPLIED THERAPEUTICS INC APLT

COM · Common Stock · CUSIP 03828A101

95 institutional holders +5 vs Q1 2024
101,096,286101.1m shares reported held*
$471.5mreported value*
29 new 30 added 23 reduced 24 sold out net bought ≈ $15.6m (+3.3m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($13.2m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $4.66. Options: 10 managers hold calls ($5.0m notional), 6 hold puts ($436.3k).

Trends to Q2 2024

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 45Q4 22: 39Q1 23: 37Q2 23: 41Q3 23: 56Q4 23: 84Q1 24: 90Q2 24: 9595Q3 22Q1 23Q3 23Q1 24Q2 24
Numbers
QuarterHolders
Q3 202245
Q4 202239
Q1 202337
Q2 202341
Q3 202356
Q4 202384
Q1 202490
Q2 202495

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 11 bought or addedQ4 22: 29 cut or sold outQ4 22Q1 23: 19 bought or addedQ1 23: 18 cut or sold outQ2 23: 21 bought or addedQ2 23: 12 cut or sold outQ2 23Q3 23: 36 bought or addedQ3 23: 14 cut or sold outQ4 23: 54 bought or addedQ4 23: 15 cut or sold outQ4 23Q1 24: 64 bought or addedQ1 24: 41 cut or sold outQ2 24: 59 bought or addedQ2 24: 47 cut or sold outQ2 24
Numbers
QuarterBought or addedCut or sold out
Q4 20221129
Q1 20231918
Q2 20232112
Q3 20233614
Q4 20235415
Q1 20246441
Q2 20245947

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ3 23 calls: $19.9mQ3 23 puts: $9.5kQ3 23P/C 0.00Q4 23 calls: $26.4mQ4 23 puts: $510.2kQ4 23P/C 0.02Q1 24 calls: $45.8mQ1 24 puts: $1.7mQ1 24P/C 0.04Q2 24 calls: $5.0mQ2 24 puts: $436.3kQ2 24P/C 0.09
Numbers
QuarterCallsPutsP/C
Q3 2023$19.9m$9.5k0.00
Q4 2023$26.4m$510.2k0.02
Q1 2024$45.8m$1.7m0.04
Q2 2024$5.0m$436.3k0.09

Biggest buyers

BlackRock Inc. Added +5,580,510+5.6m
VANGUARD GROUP INC Added +2,312,170+2.3m
DEUTSCHE BANK AG\ Added +1,721,256+1.7m
GEODE CAPITAL MANAGEMENT, LLC Added +1,494,387+1.5m
STATE STREET CORP Added +1,449,214+1.4m
JANUS HENDERSON GROUP PLC Added +1,233,563+1.2m
PEREGRINE CAPITAL MANAGEMENT LLC New +731,048+731.0k
Alyeska Investment Group, L.P. Added +522,720+522.7k
Venrock Adviser, LLC Added +467,871+467.9k
Propel Bio Management, LLC Added +455,952+456.0k

Biggest sellers

MORGAN STANLEY Reduced -6,062,419-6.1m
Laurion Capital Management LP Reduced -1,431,006-1.4m
Schonfeld Strategic Advisors LLC Reduced -1,302,913-1.3m
MILLENNIUM MANAGEMENT LLC Reduced -815,517-815.5k
ACUTA CAPITAL PARTNERS, LLC Sold out -792,000-792.0k
Parkman Healthcare Partners LLC Reduced -706,456-706.5k
GOLDMAN SACHS GROUP INC Reduced -562,759-562.8k
Invesco Ltd. Reduced -494,597-494.6k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced -371,966-372.0k
FRANKLIN RESOURCES INC Reduced -351,400-351.4k

Biggest calls

J. Goldman & Co LP Unchanged $1.6m337.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $1.3m288.3k shares
SIMPLEX TRADING, LLC Reduced $585.0k125.3k shares
CITADEL ADVISORS LLC Reduced $427.8k91.6k shares
GROUP ONE TRADING LLC Reduced $334.8k71.7k shares
JANE STREET GROUP, LLC Reduced $329.2k70.5k shares
Parallax Volatility Advisers, L.P. Reduced $175.1k37.5k shares
WOLVERINE TRADING, LLC New $101.8k21.8k shares
Belvedere Trading LLC Added $92.5k19.8k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

LMR Partners LLP Reduced $233.5k50.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $106.9k22.9k shares
SIMPLEX TRADING, LLC Reduced $52.0k11.3k shares
CITADEL ADVISORS LLC Added $36.9k7.9k shares
GROUP ONE TRADING LLC Reduced $7.0k1.5k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
T. Rowe Price Investment Management, Inc. 13G · institution +1.7 pts · filed 2025-11-14 14.9% +1.7 pts 21.4m 2025-11-14
Alyeska Investment Group, L.P. 13G · institution new · filed 2025-02-14 5.8% new 6.7m 2025-02-14

Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (0.0%, 2026-08-14), Vestal Point Capital, LP (0.0%, 2026-02-17), Propel Bio Management, LLC (4.2%, 2025-12-31), ALEXANDRIA REAL ESTATE EQUITIES, INC. (4.3%, 2025-12-15)

Holders, Q2 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 10,212,94510.2m $47.7m $47.7m 0.01% Reduced -351.4k -351,400
2 Venrock Adviser, LLC 2.84% of their portfolio NEW YORK, NY 9,542,8719.5m $44.6m $44.6m 2.84% Added +467.9k +467,871
3 PERCEPTIVE ADVISORS LLC 0.90% of their portfolio NEW YORK, NY 8,005,0008.0m $37.4m $37.4m 0.90% Unchanged
4 JANUS HENDERSON GROUP PLC 0.02% of their portfolio LONDON, X0 7,648,2057.6m $35.5m $35.5m 0.02% Added +1.2m +1,233,563
5 BlackRock Inc. 0.00% of their portfolio New York, NY 6,569,7876.6m $30.7m $30.7m 0.00% Added +5.6m +5,580,510
6 Propel Bio Management, LLC 19.89% of their portfolio Los Angeles, CA 6,567,8586.6m $30.7m $30.7m 19.89% Added +456.0k +455,952
7 Knoll Capital Management, LLC 17.54% of their portfolio MIAMI, FL 5,574,6875.6m $26.0m $26.0m 17.54% Unchanged
8 Vestal Point Capital, LP 1.89% of their portfolio NEW YORK, NY 5,430,0005.4m $25.4m $25.4m 1.89% Added +320.0k +320,000
9 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 5,322,4605.3m $24.9m $24.9m 0.00% Added +2.3m +2,312,170
10 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 3,519,7373.5m $16.4m $16.4m 0.00% Reduced -6.1m -6,062,419
11 Simplify Asset Management Inc. 1.15% of their portfolio Las Vegas, NV 2,817,5052.8m $13.2m $13.2m 1.15% Unchanged
12 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio Boston, MA 2,774,7842.8m $13.0m $13.0m 0.02% Added +125.0k +125,000
13 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 2,343,4832.3m $10.9m $10.9m 0.00% Added +1.7m +1,721,256
14 TANG CAPITAL MANAGEMENT LLC 1.11% of their portfolio SAN DIEGO, CA 2,330,0002.3m $10.9m $10.9m 1.11% Added +100.0k +100,000
15 Frazier Life Sciences Management, L.P. 0.50% of their portfolio PALO ALTO, CA 2,286,1352.3m $10.7m $10.7m 0.50% Added +333.3k +333,278
16 STEMPOINT CAPITAL LP 3.04% of their portfolio NEW YORK, NY 2,211,3202.2m $10.3m $10.3m 3.04% Added +194.3k +194,304
17 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 2,098,8152.1m $9.8m $9.8m 0.00% Added +1.5m +1,494,387
18 Alyeska Investment Group, L.P. 0.05% of their portfolio CHICAGO, IL 1,965,6462.0m $9.2m $9.2m 0.05% Added +522.7k +522,720
19 Opaleye Management Inc. 1.79% of their portfolio BOSTON, MA 1,680,0001.7m $7.8m $7.8m 1.79% Reduced -90.0k -90,000
20 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 1,655,8831.7m $7.7m $7.7m 0.00% Added +1.4m +1,449,214
21 Rock Springs Capital Management LP 0.22% of their portfolio Baltimore, MD 1,555,0041.6m $7.3m $7.3m 0.22% Added +57.1k +57,086
22 Soleus Capital Management, L.P. 0.52% of their portfolio GREENWICH, CT 1,269,7141.3m $5.9m $5.9m 0.52% Reduced -295.2k -295,202
23 Logos Global Management LP 0.31% of their portfolio San Francisco, CA 1,200,0001.2m $5.3m $5.3m 0.31% Reduced -150.0k -150,000
24 Parkman Healthcare Partners LLC 0.73% of their portfolio STAMFORD, CT 1,148,3071.1m $5.4m $5.4m 0.73% Reduced -706.5k -706,456
25 Artal Group S.A. 0.12% of their portfolio LUXEMBOURG, N4 1,009,5001.0m $4.7m $4.7m 0.12% Unchanged
26 PEREGRINE CAPITAL MANAGEMENT LLC 0.10% of their portfolio MINNEAPOLIS, MN 731,048731.0k $3.4m $3.4m 0.10% New
27 SPHERA FUNDS MANAGEMENT LTD. 0.51% of their portfolio TEL AVIV, L3 674,268674.3k $3.1m $3.1m 0.51% Added +55.2k +55,239
28 Schonfeld Strategic Advisors LLC 0.02% of their portfolio NEW YORK, NY 533,729533.7k $2.5m $2.5m 0.02% Reduced -1.3m -1,302,913
29 Walleye Capital LLC 0.02% of their portfolio NEW YORK, NY 402,365402.4k $1.9m $1.9m 0.02% Added +94.0k +94,049
30 ADAR1 Capital Management, LLC 0.30% of their portfolio AUSTIN, TX 320,727320.7k $1.5m $1.5m 0.30% Reduced -135.9k -135,861
31 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 283,793283.8k $1.3m $1.3m 0.00% New
32 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 277,277277.3k $1.3m $1.3m 0.00% Added +252.8k +252,773
33 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 271,613271.6k $1.3m $1.3m 0.00% New
34 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 233,784233.8k $1.1m $1.1m 0.00% Added +127.3k +127,331
35 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 229,862229.9k $1.1m $1.1m 0.00% Added +194.3k +194,317
36 MACQUARIE GROUP LTD 0.00% of their portfolio Sydney, NSW 2000, C3 229,153229.2k $1.1m $1.1m 0.00% Added +222.4k +222,417
37 Checkpoint Capital L.P. 0.64% of their portfolio SAN FRANCISCO, CA 227,470227.5k $1.1m $1.1m 0.64% Added +7.5k +7,470
38 Hennion & Walsh Asset Management, Inc. 0.05% of their portfolio Parsippany, NJ 197,042197.0k $920.2k $920.2k 0.05% New
39 UBS Group AG 0.00% of their portfolio ZURICH, V8 172,063172.1k $803.5k $803.5k 0.00% Added +19.3k +19,303
40 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 152,449152.4k $711.9k $711.9k 0.00% Reduced -562.8k -562,759
41 Rockefeller Capital Management L.P. 0.00% of their portfolio NEW YORK, NY 150,000150.0k $700.5k $700.5k 0.00% Unchanged
42 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 149,995150.0k $700.5k $700.5k 0.00% Reduced -309.1k -309,146
43 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio HOUSTON, TX 148,800148.8k $694.9k $694.9k 0.02% Reduced -25.0k -25,000
44 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 133,895133.9k $625.3k $625.3k 0.00% Added +133.4k +133,351
45 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 114,619114.6k $535.3k $535.3k 0.00% New
46 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 112,919112.9k $527.3k $527.3k 0.00% Reduced -372.0k -371,966
47 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 110,908110.9k $517.9k $517.9k 0.00% Reduced -815.5k -815,517
48 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 109,826109.8k $512.9k $512.9k 0.00% Reduced -134.8k -134,786
49 ALPS ADVISORS INC 0.00% of their portfolio Denver, CO 89,13189.1k $416.2k $416.2k 0.00% New
50 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 82,27682.3k $384.2k $384.2k 0.00% Reduced -275.6k -275,572
51 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 76,45376.5k $357.0k $357.0k 0.00% Added +73.3k +73,344
52 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 69,91069.9k $326.5k $326.5k 0.00% Added +8.6k +8,638
53 Richmond Brothers, Inc. 0.57% of their portfolio JACKSON, MI 61,82761.8k $288.7k $288.7k 0.57% Unchanged
54 Jump Financial, LLC 0.01% of their portfolio Chicago, IL 53,23553.2k $248.6k $248.6k 0.01% Added +9.7k +9,666
55 Corebridge Financial, Inc. 0.00% of their portfolio HOUSTON, TX 51,72351.7k $242.1k $242.1k 0.00% First filing
56 Laurion Capital Management LP 0.01% of their portfolio NEW YORK, NY 50,00050.0k $233.5k $233.5k 0.01% Reduced -1.4m -1,431,006
57 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 45,26045.3k $211.4k $211.4k 0.00% Reduced -494.6k -494,597
58 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 43,33843.3k $202.4k $202.4k 0.00% Reduced -111.8k -111,820
59 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 38,90038.9k $181.7k $181.7k 0.00% New
60 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 38,04338.0k $177.0k $177.0k 0.00% New
61 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 36,82436.8k $172.0k $172.0k 0.00% New
62 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 35,29635.3k $164.8k $164.8k 0.00% Added +34.9k +34,861
63 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 32,56832.6k $152.1k $152.1k 0.00% New
64 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 30,67530.7k $0 $0 0.00% New
65 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 30,27030.3k $141.4k $141.4k 0.00% New
66 COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio WALTHAM, MA 24,99625.0k $117.0k $117.0k 0.00% Added +11.4k +11,446
67 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 24,57824.6k $114.8k $114.8k 0.00% New
68 ALGERT GLOBAL LLC 0.00% of their portfolio SAN FRANCISCO, CA 23,47623.5k $109.6k $109.6k 0.00% New
69 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 21,17921.2k $98.9k $98.9k 0.00% Reduced -97.6k -97,625
70 WealthTrust Axiom LLC 0.03% of their portfolio WAYNE, PA 21,00021.0k $98.1k $98.1k 0.03% Unchanged
71 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 20,47820.5k $95.6k $95.6k 0.00% Reduced -173.3k -173,280
72 SG Americas Securities, LLC 0.00% of their portfolio NEW YORK, NY 18,56718.6k $87.0k $87.0k 0.00% New
73 VIRTUS ADVISERS, LLC 0.04% of their portfolio HARTFORD, CT 17,21017.2k $80.4k $80.4k 0.04% New
74 Legal & General Group Plc 0.00% of their portfolio London, X0 17,13717.1k $79.7k $79.7k 0.00% New
75 Marathon Trading Investment Management LLC 0.02% of their portfolio RADNOR, PA 15,90715.9k $74.3k $74.3k 0.02% Reduced -43.1k -43,093
76 Marex Group Ltd 0.00% of their portfolio London, X0 15,00015.0k $70.0k $70.0k 0.00% New
77 Susquehanna Portfolio Strategies, LLC 0.00% of their portfolio Bala Cynwyd, PA 14,09914.1k $65.8k $65.8k 0.00% Unchanged
78 BANK OF MONTREAL /CAN/ 0.00% of their portfolio TORONTO, A6 12,20012.2k $57.2k $57.2k 0.00% New
79 Perennial Investment Advisors, LLC 0.01% of their portfolio Los Angeles, CA 11,60011.6k $54.2k $54.2k 0.01% Unchanged
80 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 11,58311.6k $54.1k $54.1k 0.00% New
81 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 11,49411.5k $53.7k $53.7k 0.00% New
82 WOLVERINE TRADING, LLC 0.00% of their portfolio CHICAGO, IL 11,35511.4k $53.0k $53.0k 0.00% New
83 GSA CAPITAL PARTNERS LLP 0.00% of their portfolio LONDON, X0 10,91710.9k $51.0k $51.0k 0.00% Reduced -10.5k -10,514
84 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 9,4199.4k $44.0k $44.0k 0.00% New
85 Caption Management, LLC 0.00% of their portfolio OKLAHOMA CITY, OK 7,8147.8k $36.5k $36.5k 0.00% Reduced -23.5k -23,486
86 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 6,9667.0k $32.5k $32.5k 0.00% New
87 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 6,9196.9k $32.3k $32.3k 0.00% Added +6.9k +6,918
88 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 3,3263.3k $16.0k $16.0k 0.00% New
89 COMERICA BANK 0.00% of their portfolio DALLAS, TX 2,0002.0k $9.3k $9.3k 0.00% Unchanged
90 FMR LLC 0.00% of their portfolio BOSTON, MA 1,1001.1k $5.1k $5.1k 0.00% New
91 Lindbrook Capital, LLC 0.00% of their portfolio CALABASAS, CA 203203 $948 $948 0.00% New
92 NewEdge Advisors, LLC 0.00% of their portfolio NEW ORLEANS, LA 199199 $929 $929 0.00% New
93 Federation des caisses Desjardins du Quebec 0.00% of their portfolio LEVIS, A8 8484 $392 $392 0.00% Unchanged
94 Planning Capital Management Corp 0.00% of their portfolio PAOLI, PA 55 $24 $24 0.00% New
95 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged