Vault-13

DESIGN THERAPEUTICS INC DSGN

COM · Common Stock · CUSIP 25056L103

97 institutional holders +3 vs Q1 2024
37,119,25237.1m shares reported held*
65.6% of all shares outstanding*
$124.3mreported value*
14 new 37 added 27 reduced 13 sold out net bought ≈ $18.1m (+5.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($83.0k this quarter). Holder counts are more reliable. Shares outstanding: 56.6m as of 2024-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.35. Options: 3 managers hold calls ($4.7k notional), 4 hold puts ($74.7k).

Trends to Q2 2024

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 79Q4 22: 83Q1 23: 97Q2 23: 98Q3 23: 88Q4 23: 89Q1 24: 94Q2 24: 9797Q3 22Q1 23Q3 23Q1 24Q2 24
Numbers
QuarterHolders
Q3 202279
Q4 202283
Q1 202397
Q2 202398
Q3 202388
Q4 202389
Q1 202494
Q2 202497

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 46 bought or addedQ4 22: 37 cut or sold outQ4 22Q1 23: 56 bought or addedQ1 23: 44 cut or sold outQ2 23: 40 bought or addedQ2 23: 52 cut or sold outQ2 23Q3 23: 41 bought or addedQ3 23: 62 cut or sold outQ4 23: 50 bought or addedQ4 23: 38 cut or sold outQ4 23Q1 24: 41 bought or addedQ1 24: 50 cut or sold outQ2 24: 51 bought or addedQ2 24: 40 cut or sold outQ2 24
Numbers
QuarterBought or addedCut or sold out
Q4 20224637
Q1 20235644
Q2 20234052
Q3 20234162
Q4 20235038
Q1 20244150
Q2 20245140

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$100k$200k$300k$400kQ3 23 calls: $263.0kQ3 23 puts: $299.1kQ3 23P/C 1.14Q4 23 calls: $253.1kQ4 23 puts: $334.5kQ4 23P/C 1.32Q1 24 calls: $4.4kQ1 24 puts: $17.7kQ1 24P/C 4.00Q2 24 calls: $4.7kQ2 24 puts: $74.7kQ2 24P/C 15.95
Numbers
QuarterCallsPutsP/C
Q3 2023$263.0k$299.1k1.14
Q4 2023$253.1k$334.5k1.32
Q1 2024$4.4k$17.7k4.00
Q2 2024$4.7k$74.7k15.95

Biggest buyers

Logos Global Management LP Added +5,032,501+5.0m
Frazier Life Sciences Management, L.P. New +1,195,179+1.2m
Point72 Asset Management, L.P. Added +397,285+397.3k
Almitas Capital LLC Added +227,180+227.2k
ACADIAN ASSET MANAGEMENT LLC Added +179,614+179.6k
MILLENNIUM MANAGEMENT LLC Added +126,335+126.3k
GOLDMAN SACHS GROUP INC Added +97,449+97.4k
Opaleye Management Inc. Added +91,962+92.0k
BRIDGEWAY CAPITAL MANAGEMENT, LLC Added +89,700+89.7k
D. E. Shaw & Co., Inc. Added +89,594+89.6k

Biggest sellers

MORGAN STANLEY Reduced -1,044,839-1.0m
CITADEL ADVISORS LLC Reduced -570,147-570.1k
BML Capital Management, LLC Reduced -457,729-457.7k
Walleye Capital LLC Reduced -134,339-134.3k
Shay Capital LLC Sold out -128,305-128.3k
RENAISSANCE TECHNOLOGIES LLC Reduced -69,325-69.3k
JPMORGAN CHASE & CO Reduced -49,040-49.0k
JACOBS LEVY EQUITY MANAGEMENT, INC Reduced -25,762-25.8k
OCCUDO QUANTITATIVE STRATEGIES LP Sold out -23,395-23.4k
NORTHERN TRUST CORP Reduced -19,939-19.9k

Biggest calls

CITADEL ADVISORS LLC Added $3.7k1.1k shares
SIMPLEX TRADING, LLC Unchanged $1.0k500 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP New $47.9k14.3k shares
CITADEL ADVISORS LLC Added $23.4k7.0k shares
GROUP ONE TRADING LLC Reduced $3.4k1.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
SR One Capital Fund I Aggregator LP 13D · may seek influence filed 2026-03-11
Stated purposeNot applicable. Full filing
10.7% 6.6m≈ $95.6m 2026-03-11
Sirenia Capital Management LP 13G · institution new · filed 2026-08-14 9.5% new 6.0m≈ $86.3m 2026-08-14
Light Irrevocable Trust #1 dated April 22, 2019 13G · exempt (held before listing) filed 2025-02-07 6.9% 3.8m≈ $55.5m 2025-02-07
Star Irrevocable Trust #1 dated April 22, 2019 13G · exempt (held before listing) filed 2025-02-07 6.9% 3.8m≈ $55.5m 2025-02-07

Fell to 5% or below in the last year: Point72 Asset Management, L.P. (3.8%, 2026-08-14), Logos Global Management LP (4.4%, 2025-11-18)

Insider purchases and sales in Q2 2024

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
404Q3 22: 0 buyingQ3 22: 0 sellingQ4 22: 3 buyingQ4 22: 0 sellingQ4 22Q1 23: 0 buyingQ1 23: 0 sellingQ2 23: 0 buyingQ2 23: 0 sellingQ2 23Q3 23: 3 buyingQ3 23: 0 sellingQ4 23: 0 buyingQ4 23: 0 sellingQ4 23Q1 24: 2 buyingQ1 24: 0 sellingQ2 24: 0 buyingQ2 24: 0 sellingQ2 24
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20220—0——
Q4 20223$7.8m0——
Q1 20230—0——
Q2 20230—0——
Q3 20233$5.5m0——
Q4 20230—0——
Q1 20242$104.6k0——
Q2 20240—0——

None reported in Q2 2024.

Holders, Q2 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Logos Global Management LP 1.96% of their portfolio San Francisco, CA 10,065,00210.1m $33.7m $33.7m 1.96% Added +5.0m +5,032,501
2 SR One Capital Management, LP 6.85% of their portfolio Redwood City, CA 6,526,4766.5m $21.9m $21.9m 6.85% Unchanged
3 BlackRock Inc. 0.00% of their portfolio New York, NY 2,304,9482.3m $7.7m $7.7m 0.00% Added +30.8k +30,757
4 BAKER BROS. ADVISORS LP 0.07% of their portfolio NEW YORK, NY 1,695,2941.7m $5.7m $5.7m 0.07% Added +33.2k +33,174
5 TANG CAPITAL MANAGEMENT LLC 0.51% of their portfolio SAN DIEGO, CA 1,480,9751.5m $5.0m $5.0m 0.51% Unchanged
6 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,296,7881.3m $4.3m $4.3m 0.00% Added +10.8k +10,826
7 Almitas Capital LLC 1.75% of their portfolio SANTA MONICA, CA 1,253,2481.3m $4.2m $4.2m 1.75% Added +227.2k +227,180
8 Frazier Life Sciences Management, L.P. 0.19% of their portfolio PALO ALTO, CA 1,195,1791.2m $4.0m $4.0m 0.19% New
9 Point72 Asset Management, L.P. 0.01% of their portfolio STAMFORD, CT 990,801990.8k $3.3m $3.3m 0.01% Added +397.3k +397,285
10 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 707,971708.0k $2.4m $2.4m 0.00% Added +24.1k +24,073
11 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 695,423695.4k $2.3m $2.3m 0.00% Reduced -3.6k -3,563
12 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 610,803610.8k $2.0m $2.0m 0.00% Added +126.3k +126,335
13 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 603,705603.7k $2.0m $2.0m 0.00% Added +97.4k +97,449
14 ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio Boston, MA 583,160583.2k $2.0m $2.0m 0.01% Added +179.6k +179,614
15 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 535,784535.8k $1.8m $1.8m 0.00% Added +89.6k +89,594
16 JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio FLORHAM PARK, NJ 476,258476.3k $1.6m $1.6m 0.01% Reduced -25.8k -25,762
17 BML Capital Management, LLC 1.03% of their portfolio ZIONSVILLE, IN 421,749421.7k $1.4m $1.4m 1.03% Reduced -457.7k -457,729
18 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 402,715402.7k $1.3m $1.3m 0.00% Reduced -19.3k -19,320
19 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 400,100400.1k $1.3m $1.3m 0.00% Reduced -3.9k -3,900
20 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 389,437389.4k $1.3m $1.3m 0.00% Reduced -1.0m -1,044,839
21 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 384,075384.1k $1.3m $1.3m 0.00% Reduced -69.3k -69,325
22 Assenagon Asset Management S.A. 0.00% of their portfolio SENNINGERBERG, N4 347,794347.8k $1.2m $1.2m 0.00% Unchanged
23 Prescott Group Capital Management, L.L.C. 0.18% of their portfolio Tulsa, OK 343,000343.0k $1.1m $1.1m 0.18% Unchanged
24 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 337,345337.3k $1.1m $1.1m 0.00% Reduced -19.9k -19,939
25 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 304,630304.6k $1.0m $1.0m 0.00% Reduced -570.1k -570,147
26 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 256,627256.6k $859.7k $859.7k 0.00% Added +42.3k +42,317
27 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio HOUSTON, TX 235,600235.6k $789.3k $789.3k 0.02% Added +89.7k +89,700
28 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 212,554212.6k $712.1k $712.1k 0.00% Added +54.5k +54,550
29 GSA CAPITAL PARTNERS LLP 0.05% of their portfolio LONDON, X0 209,953210.0k $703.0k $703.0k 0.05% Reduced -6.4k -6,394
30 Opaleye Management Inc. 0.16% of their portfolio BOSTON, MA 205,000205.0k $686.8k $686.8k 0.16% Added +92.0k +91,962
31 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 179,960180.0k $602.9k $602.9k 0.00% Added +790 +790
32 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 118,110118.1k $395.7k $395.7k 0.00% Added +2.9k +2,868
33 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 89,95590.0k $301.3k $301.3k 0.00% Added +53.5k +53,518
34 FMR LLC 0.00% of their portfolio BOSTON, MA 81,01681.0k $271.4k $271.4k 0.00% Added +2.7k +2,675
35 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 80,95381.0k $271.2k $271.2k 0.00% Added +44.1k +44,098
36 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 72,03372.0k $241.3k $241.3k 0.00% Reduced -16.9k -16,875
37 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 63,21563.2k $211.8k $211.8k 0.00% Added +16.4k +16,400
38 Walleye Capital LLC 0.00% of their portfolio NEW YORK, NY 60,21260.2k $201.7k $201.7k 0.00% Reduced -134.3k -134,339
39 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 57,90557.9k $194.0k $194.0k 0.00% New
40 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 53,06753.1k $177.8k $177.8k 0.00% Added +615 +615
41 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 50,51550.5k $169.2k $169.2k 0.00% Unchanged
42 HSBC HOLDINGS PLC 0.00% of their portfolio LONDON, X0 44,47044.5k $145.9k $145.9k 0.00% Reduced -4.3k -4,319
43 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 42,09042.1k $141.0k $141.0k 0.00% Added +4.6k +4,590
44 CAZ INVESTMENTS LP 0.20% of their portfolio HOUSTON, TX 40,00040.0k $134.0k $134.0k 0.20% New
45 Palumbo Wealth Management LLC 0.05% of their portfolio GREAT NECK, NY 33,05433.1k $110.7k $110.7k 0.05% Added +16.1k +16,082
46 PRELUDE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio NEW YORK, NY 32,95633.0k $110.4k $110.4k 0.01% Reduced -15.6k -15,644
47 STRS OHIO 0.00% of their portfolio COLUMBUS, OH 32,60032.6k $109.2k $109.2k 0.00% Added +3.3k +3,300
48 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 32,28432.3k $108.2k $108.2k 0.00% Reduced -13.1k -13,113
49 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 28,36828.4k $95.0k $95.0k 0.00% Reduced -49.0k -49,040
50 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 28,09428.1k $94.1k $94.1k 0.00% Unchanged
51 PDT Partners, LLC 0.01% of their portfolio New York, NY 27,12727.1k $90.9k $90.9k 0.01% New
52 Verition Fund Management LLC 0.00% of their portfolio GREENWICH, CT 27,04527.0k $90.6k $90.6k 0.00% New
53 Corient Private Wealth LP 0.00% of their portfolio MIAMI, FL 26,96527.0k $90.3k $90.3k 0.00% Unchanged
54 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 24,28024.3k $81.3k $81.3k 0.00% New
55 Cubist Systematic Strategies, LLC 0.00% of their portfolio STAMFORD, CT 23,49723.5k $78.7k $78.7k 0.00% Added +10.1k +10,113
56 PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 0.00% of their portfolio COLUMBUS, OH 22,39322.4k $75.0k $75.0k 0.00% Reduced -1.4k -1,355
57 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 21,72621.7k $72.8k $72.8k 0.00% Added +10.5k +10,494
58 AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio KANSAS CITY, MO 21,33321.3k $71.5k $71.5k 0.00% New
59 Jump Financial, LLC 0.00% of their portfolio Chicago, IL 20,08720.1k $67.3k $67.3k 0.00% New
60 TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio STAMFORD, CT 19,86519.9k $66.5k $66.5k 0.00% Reduced -5.5k -5,462
61 Mariner, LLC 0.00% of their portfolio Overland Park, KS 18,67418.7k $62.6k $62.6k 0.00% Unchanged
62 Corebridge Financial, Inc. 0.00% of their portfolio HOUSTON, TX 16,89216.9k $56.6k $56.6k 0.00% First filing
63 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 16,27016.3k $54.5k $54.5k 0.00% First filing
64 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 13,79713.8k $46.2k $46.2k 0.00% Added +2.3k +2,291
65 UBS Group AG 0.00% of their portfolio ZURICH, V8 13,36013.4k $44.8k $44.8k 0.00% Reduced -19.7k -19,673
66 ALGERT GLOBAL LLC 0.00% of their portfolio SAN FRANCISCO, CA 12,41612.4k $41.6k $41.6k 0.00% Added +1.3k +1,336
67 NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio ST. LOUIS, MO 11,85511.9k $39.7k $39.7k 0.00% Added +295 +295
68 Simplicity Wealth,LLC 0.00% of their portfolio SUMMIT, NJ 11,63211.6k $39.0k $39.0k 0.00% Added +137 +137
69 Bleakley Financial Group, LLC 0.00% of their portfolio PARSIPPANY, NJ 11,63211.6k $39.0k $39.0k 0.00% Added +137 +137
70 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 11,08311.1k $37.1k $37.1k 0.00% Reduced -665 -665
71 Virtu Financial LLC 0.00% of their portfolio New York, NY 11,07011.1k $37.0k $37.0k 0.00% New
72 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 10,28410.3k $35.0k $35.0k 0.00% Reduced -863 -863
73 PNC Financial Services Group, Inc. 0.00% of their portfolio Pittsburgh, PA 9,6929.7k $32.5k $32.5k 0.00% Reduced -1.2k -1,151
74 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 8,2448.2k $27.6k $27.6k 0.00% Added +3.9k +3,933
75 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 7,2347.2k $24.2k $24.2k 0.00% Added +905 +905
76 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 6,0426.0k $20.2k $20.2k 0.00% Added +3.4k +3,365
77 FEDERATED HERMES, INC. 0.00% of their portfolio PITTSBURGH, PA 4,2004.2k $14.1k $14.1k 0.00% Reduced -6.1k -6,118
78 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 2,9863.0k $10.0k $10.0k 0.00% New
79 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 2,9533.0k $10.0k $10.0k 0.00% Added +2.2k +2,219
80 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 2,5702.6k $8.6k $8.6k 0.00% Unchanged
81 Legal & General Group Plc 0.00% of their portfolio London, X0 2,5652.6k $8.6k $8.6k 0.00% Unchanged
82 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 2,2752.3k $7.6k $7.6k 0.00% Reduced -1.0k -1,019
83 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 2,0262.0k $6.8k $6.8k 0.00% Unchanged
84 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 1,2951.3k $4.0k $4.0k 0.00% Reduced -3.7k -3,724
85 Point72 Asia (Singapore) Pte. Ltd. 0.00% of their portfolio SINGAPORE, U0 1,2881.3k $4.3k $4.3k 0.00% New
86 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 1,1761.2k $4.0k $4.0k 0.00% Unchanged
87 GROUP ONE TRADING LLC 0.00% of their portfolio CHICAGO, IL 1,1001.1k $3.7k $3.7k 0.00% Reduced -200 -200
88 Clearstead Advisors, LLC 0.00% of their portfolio CLEVELAND, OH 610610 $2.0k $2.0k 0.00% Unchanged
89 Private Wealth Management Group, LLC 0.00% of their portfolio PRINCETON, NJ 558558 $1.9k $1.9k 0.00% Unchanged
90 Arax Advisory Partners 0.00% of their portfolio NEW YORK, NY 244244 $818 $818 0.00% New
91 MassMutual Private Wealth & Trust, FSB 0.00% of their portfolio Windsor, CT 239239 $801 $801 0.00% Unchanged
92 CWM, LLC 0.00% of their portfolio OMAHA, NE 9898 $0 $0 0.00% Added +97 +97
93 PRINCIPAL SECURITIES, INC. 0.00% of their portfolio DES MOINES, IA 7474 $248 $248 0.00% New
94 Covestor Ltd 0.00% of their portfolio LONDON, X0 2222 $0 $0 0.00% Reduced -10 -10
95 Capital Advisors, Ltd. LLC 0.00% of their portfolio SHAKER HEIGHTS, OH 1212 $0 $0 0.00% Unchanged
96 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged
97 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 00 $0 $0 0.00% New