DESIGN THERAPEUTICS INC DSGN
COM · Common Stock · CUSIP 25056L103
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCarlsbad, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($83.0k this quarter). Holder counts are more reliable. Shares outstanding: 56.6m as of 2024-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $3.35. Options: 3 managers hold calls ($4.7k notional), 4 hold puts ($74.7k).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 79 |
| Q4 2022 | 83 |
| Q1 2023 | 97 |
| Q2 2023 | 98 |
| Q3 2023 | 88 |
| Q4 2023 | 89 |
| Q1 2024 | 94 |
| Q2 2024 | 97 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 46 | 37 |
| Q1 2023 | 56 | 44 |
| Q2 2023 | 40 | 52 |
| Q3 2023 | 41 | 62 |
| Q4 2023 | 50 | 38 |
| Q1 2024 | 41 | 50 |
| Q2 2024 | 51 | 40 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $263.0k | $299.1k | 1.14 |
| Q4 2023 | $253.1k | $334.5k | 1.32 |
| Q1 2024 | $4.4k | $17.7k | 4.00 |
| Q2 2024 | $4.7k | $74.7k | 15.95 |
Biggest buyers
| Logos Global Management LP | Added | +5.0m |
| Frazier Life Sciences Management, L.P. | New | +1.2m |
| Point72 Asset Management, L.P. | Added | +397.3k |
| Almitas Capital LLC | Added | +227.2k |
| ACADIAN ASSET MANAGEMENT LLC | Added | +179.6k |
| MILLENNIUM MANAGEMENT LLC | Added | +126.3k |
| GOLDMAN SACHS GROUP INC | Added | +97.4k |
| Opaleye Management Inc. | Added | +92.0k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | Added | +89.7k |
| D. E. Shaw & Co., Inc. | Added | +89.6k |
Biggest sellers
| MORGAN STANLEY | Reduced | -1.0m |
| CITADEL ADVISORS LLC | Reduced | -570.1k |
| BML Capital Management, LLC | Reduced | -457.7k |
| Walleye Capital LLC | Reduced | -134.3k |
| Shay Capital LLC | Sold out | -128.3k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -69.3k |
| JPMORGAN CHASE & CO | Reduced | -49.0k |
| JACOBS LEVY EQUITY MANAGEMENT, INC | Reduced | -25.8k |
| OCCUDO QUANTITATIVE STRATEGIES LP | Sold out | -23.4k |
| NORTHERN TRUST CORP | Reduced | -19.9k |
Biggest calls
| CITADEL ADVISORS LLC | Added | $3.7k1.1k shares |
| SIMPLEX TRADING, LLC | Unchanged | $1.0k500 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $47.9k14.3k shares |
| CITADEL ADVISORS LLC | Added | $23.4k7.0k shares |
| GROUP ONE TRADING LLC | Reduced | $3.4k1.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
SR One Capital Fund I Aggregator LP
13D · may seek influence
filed 2026-03-11
Stated purposeNot applicable. Full filing |
10.7% |
| Sirenia Capital Management LP 13G · institution new · filed 2026-08-14 | 9.5% |
| Light Irrevocable Trust #1 dated April 22, 2019 13G · exempt (held before listing) filed 2025-02-07 | 6.9% |
| Star Irrevocable Trust #1 dated April 22, 2019 13G · exempt (held before listing) filed 2025-02-07 | 6.9% |
Fell to 5% or below in the last year: Point72 Asset Management, L.P. (3.8%, 2026-08-14), Logos Global Management LP (4.4%, 2025-11-18)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 3 | $7.8m | 0 | — | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 3 | $5.5m | 0 | — | — |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 2 | $104.6k | 0 | — | — |
| Q2 2024 | 0 | — | 0 | — | — |
None reported in Q2 2024.
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| Logos Global Management LP 1.96% of their portfolio | 10.1m $33.7m | Added +5.0m |
| SR One Capital Management, LP 6.85% of their portfolio | 6.5m $21.9m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 2.3m $7.7m | Added +30.8k |
| BAKER BROS. ADVISORS LP 0.07% of their portfolio | 1.7m $5.7m | Added +33.2k |
| TANG CAPITAL MANAGEMENT LLC 0.51% of their portfolio | 1.5m $5.0m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.3m $4.3m | Added +10.8k |
| Almitas Capital LLC 1.75% of their portfolio | 1.3m $4.2m | Added +227.2k |
| Frazier Life Sciences Management, L.P. 0.19% of their portfolio | 1.2m $4.0m | New |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 990.8k $3.3m | Added +397.3k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 708.0k $2.4m | Added +24.1k |
| STATE STREET CORP 0.00% of their portfolio | 695.4k $2.3m | Reduced -3.6k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 610.8k $2.0m | Added +126.3k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 603.7k $2.0m | Added +97.4k |
| ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio | 583.2k $2.0m | Added +179.6k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 535.8k $1.8m | Added +89.6k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio | 476.3k $1.6m | Reduced -25.8k |
| BML Capital Management, LLC 1.03% of their portfolio | 421.7k $1.4m | Reduced -457.7k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 402.7k $1.3m | Reduced -19.3k |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 400.1k $1.3m | Reduced -3.9k |
| MORGAN STANLEY 0.00% of their portfolio | 389.4k $1.3m | Reduced -1.0m |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 384.1k $1.3m | Reduced -69.3k |
| Assenagon Asset Management S.A. 0.00% of their portfolio | 347.8k $1.2m | Unchanged |
| Prescott Group Capital Management, L.L.C. 0.18% of their portfolio | 343.0k $1.1m | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 337.3k $1.1m | Reduced -19.9k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 304.6k $1.0m | Reduced -570.1k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 256.6k $859.7k | Added +42.3k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.02% of their portfolio | 235.6k $789.3k | Added +89.7k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 212.6k $712.1k | Added +54.5k |
| GSA CAPITAL PARTNERS LLP 0.05% of their portfolio | 210.0k $703.0k | Reduced -6.4k |
| Opaleye Management Inc. 0.16% of their portfolio | 205.0k $686.8k | Added +92.0k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 180.0k $602.9k | Added +790 |
| Bank of New York Mellon Corp 0.00% of their portfolio | 118.1k $395.7k | Added +2.9k |
| Squarepoint Ops LLC 0.00% of their portfolio | 90.0k $301.3k | Added +53.5k |
| FMR LLC 0.00% of their portfolio | 81.0k $271.4k | Added +2.7k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 81.0k $271.2k | Added +44.1k |
| BARCLAYS PLC 0.00% of their portfolio | 72.0k $241.3k | Reduced -16.9k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 63.2k $211.8k | Added +16.4k |
| Walleye Capital LLC 0.00% of their portfolio | 60.2k $201.7k | Reduced -134.3k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 57.9k $194.0k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 53.1k $177.8k | Added +615 |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 50.5k $169.2k | Unchanged |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 44.5k $145.9k | Reduced -4.3k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 42.1k $141.0k | Added +4.6k |
| CAZ INVESTMENTS LP 0.20% of their portfolio | 40.0k $134.0k | New |
| Palumbo Wealth Management LLC 0.05% of their portfolio | 33.1k $110.7k | Added +16.1k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 33.0k $110.4k | Reduced -15.6k |
| STRS OHIO 0.00% of their portfolio | 32.6k $109.2k | Added +3.3k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 32.3k $108.2k | Reduced -13.1k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 28.4k $95.0k | Reduced -49.0k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 28.1k $94.1k | Unchanged |
| PDT Partners, LLC 0.01% of their portfolio | 27.1k $90.9k | New |
| Verition Fund Management LLC 0.00% of their portfolio | 27.0k $90.6k | New |
| Corient Private Wealth LP 0.00% of their portfolio | 27.0k $90.3k | Unchanged |
| MARSHALL WACE, LLP 0.00% of their portfolio | 24.3k $81.3k | New |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 23.5k $78.7k | Added +10.1k |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 0.00% of their portfolio | 22.4k $75.0k | Reduced -1.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 21.7k $72.8k | Added +10.5k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 21.3k $71.5k | New |
| Jump Financial, LLC 0.00% of their portfolio | 20.1k $67.3k | New |
| TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio | 19.9k $66.5k | Reduced -5.5k |
| Mariner, LLC 0.00% of their portfolio | 18.7k $62.6k | Unchanged |
| Corebridge Financial, Inc. 0.00% of their portfolio | 16.9k $56.6k | First filing |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 16.3k $54.5k | First filing |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 13.8k $46.2k | Added +2.3k |
| UBS Group AG 0.00% of their portfolio | 13.4k $44.8k | Reduced -19.7k |
| ALGERT GLOBAL LLC 0.00% of their portfolio | 12.4k $41.6k | Added +1.3k |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 11.9k $39.7k | Added +295 |
| Simplicity Wealth,LLC 0.00% of their portfolio | 11.6k $39.0k | Added +137 |
| Bleakley Financial Group, LLC 0.00% of their portfolio | 11.6k $39.0k | Added +137 |
| AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 11.1k $37.1k | Reduced -665 |
| Virtu Financial LLC 0.00% of their portfolio | 11.1k $37.0k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 10.3k $35.0k | Reduced -863 |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 9.7k $32.5k | Reduced -1.2k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 8.2k $27.6k | Added +3.9k |
| CITIGROUP INC 0.00% of their portfolio | 7.2k $24.2k | Added +905 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 6.0k $20.2k | Added +3.4k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 4.2k $14.1k | Reduced -6.1k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 3.0k $10.0k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 3.0k $10.0k | Added +2.2k |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 2.6k $8.6k | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 2.6k $8.6k | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 2.3k $7.6k | Reduced -1.0k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 2.0k $6.8k | Unchanged |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 1.3k $4.0k | Reduced -3.7k |
| Point72 Asia (Singapore) Pte. Ltd. 0.00% of their portfolio | 1.3k $4.3k | New |
| AMALGAMATED BANK 0.00% of their portfolio | 1.2k $4.0k | Unchanged |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 1.1k $3.7k | Reduced -200 |
| Clearstead Advisors, LLC 0.00% of their portfolio | 610 $2.0k | Unchanged |
| Private Wealth Management Group, LLC 0.00% of their portfolio | 558 $1.9k | Unchanged |
| Arax Advisory Partners 0.00% of their portfolio | 244 $818 | New |
| MassMutual Private Wealth & Trust, FSB 0.00% of their portfolio | 239 $801 | Unchanged |
| CWM, LLC 0.00% of their portfolio | 98 $0 | Added +97 |
| PRINCIPAL SECURITIES, INC. 0.00% of their portfolio | 74 $248 | New |
| Covestor Ltd 0.00% of their portfolio | 22 $0 | Reduced -10 |
| Capital Advisors, Ltd. LLC 0.00% of their portfolio | 12 $0 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |
| MetLife Investment Management, LLC 0.00% of their portfolio | 0 $0 | New |