DISC MEDICINE INC IRON
COM · Common Stock · CUSIP 254604101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWatertown, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($32.7k this quarter). Holder counts are more reliable. Shares outstanding: 29.7m as of 2024-08-05, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $45.07. Options: 6 managers hold calls ($1.6m notional), 4 hold puts ($986.2k).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2022 | 35 |
| Q1 2023 | 46 |
| Q2 2023 | 91 |
| Q3 2023 | 92 |
| Q4 2023 | 113 |
| Q1 2024 | 132 |
| Q2 2024 | 123 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 28 | 8 |
| Q2 2023 | 71 | 20 |
| Q3 2023 | 58 | 36 |
| Q4 2023 | 67 | 39 |
| Q1 2024 | 90 | 40 |
| Q2 2024 | 82 | 67 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $4.4m | $9.9m | 2.25 |
| Q4 2023 | $14.8m | $9.6m | 0.65 |
| Q1 2024 | $22.1m | $68.3m | 3.08 |
| Q2 2024 | $1.6m | $986.2k | 0.62 |
Biggest buyers
| Logos Global Management LP | New | +1.9m |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +1.1m |
| Frazier Life Sciences Management, L.P. | Added | +969.8k |
| Point72 Asset Management, L.P. | New | +761.4k |
| BlackRock Inc. | Added | +535.9k |
| TCG Crossover Management, LLC | New | +487.0k |
| Bain Capital Life Sciences Investors, LLC | Added | +478.5k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Added | +357.7k |
| VANGUARD GROUP INC | Added | +328.7k |
| Paradigm Biocapital Advisors LP | Added | +314.8k |
Biggest sellers
| STATE STREET CORP | Reduced | -498.4k |
| ALLIANCEBERNSTEIN L.P. | Reduced | -475.8k |
| PERCEPTIVE ADVISORS LLC | Reduced | -386.4k |
| Rock Springs Capital Management LP | Sold out | -363.5k |
| MORGAN STANLEY | Reduced | -311.0k |
| LORD, ABBETT & CO. LLC | Sold out | -238.6k |
| JENNISON ASSOCIATES LLC | Sold out | -193.2k |
| BANK OF AMERICA CORP /DE/ | Reduced | -153.1k |
| Cormorant Asset Management, LP | Sold out | -125.0k |
| First Turn Management, LLC | Reduced | -113.8k |
Biggest calls
| Caption Management, LLC | Reduced | $1.0m22.5k shares |
| CITADEL ADVISORS LLC | Reduced | $265.9k5.9k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $211.8k4.7k shares |
| GROUP ONE TRADING LLC | Reduced | $67.6k1.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $27.0k600 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $513.8k11.4k shares |
| GROUP ONE TRADING LLC | Added | $279.4k6.2k shares |
| SIMPLEX TRADING, LLC | Reduced | $193.0k4.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution -1.3 pts · filed 2026-08-06 | 12.8% |
| AI DMI LLC 13D · may seek influence -1.4 pts · filed 2026-10-26 | 6.6% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-01-07 | 5.9% |
Fell to 5% or below in the last year: Atlas Venture Fund X, L.P. (2.2%, 2025-12-17)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 2 | $2.5m | 0 | — | — |
| Q2 2023 | 0 | — | 3 | $1.4m | $1.4m |
| Q3 2023 | 0 | — | 3 | $4.9m | $1.1m |
| Q4 2023 | 0 | — | 6 | $40.5m | $1.1m |
| Q1 2024 | 0 | — | 1 | $10.1m | — |
| Q2 2024 | 3 | $11.0m | 1 | $157.8k | $157.8k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-06-17 | Bitterman Kevin Director · See footnote | Bought | $8.0m222.2k shares |
| 2024-06-17 | ORBIMED ADVISORS LLC +3 Director · See Footnotes | Bought | $3.0m83.3k shares |
| 2024-06-17 | Ashiya Mona Director · See Footnotes | Bought | $3.0m83.3k shares |
| 2024-06-03 | White William Richard Director | Sold plan | $70.6k2.0k shares |
| 2024-05-01 | White William Richard Director | Sold plan | $5.8k201 shares |
| 2024-04-11 | White William Richard Director | Sold plan | $81.4k2.6k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| Paradigm Biocapital Advisors LP 4.67% of their portfolio | 2.7m $121.9m | Added +314.8k |
| Atlas Venture Life Science Advisors, LLC 11.91% of their portfolio | 2.5m $113.1m | Added +222.2k |
| Logos Global Management LP 4.84% of their portfolio | 1.9m $83.4m | New |
| Bain Capital Life Sciences Investors, LLC 8.89% of their portfolio | 1.8m $80.9m | Added +478.5k |
| ORBIMED ADVISORS LLC 1.60% of their portfolio | 1.8m $80.5m | Added +83.3k |
| WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio | 1.8m $79.2m | Added +1.1m |
| Frazier Life Sciences Management, L.P. 3.70% of their portfolio | 1.8m $79.1m | Added +969.8k |
| BlackRock Inc. 0.00% of their portfolio | 1.4m $64.8m | Added +535.9k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 1.1m $50.6m | Added +178.0k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.1m $50.1m | Added +328.7k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.77% of their portfolio | 1.0m $46.1m | Added +357.7k |
| Point72 Asset Management, L.P. 0.11% of their portfolio | 761.4k $34.3m | New |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.05% of their portfolio | 618.5k $27.9m | Added +44.0k |
| STATE STREET CORP 0.00% of their portfolio | 592.8k $26.7m | Reduced -498.4k |
| PERCEPTIVE ADVISORS LLC 0.60% of their portfolio | 553.4k $24.9m | Reduced -386.4k |
| Saturn V Capital Management LP 8.57% of their portfolio | 503.1k $22.7m | Added +248.3k |
| TCG Crossover Management, LLC 2.29% of their portfolio | 487.0k $21.9m | New |
| JANUS HENDERSON GROUP PLC 0.01% of their portfolio | 445.9k $20.1m | Reduced -75.9k |
| FMR LLC 0.00% of their portfolio | 413.1k $18.6m | Added +9.6k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 403.7k $18.2m | Added +158.0k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 321.5k $14.5m | Reduced -4.2k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 312.0k $14.1m | Added +99.0k |
| MPM BIOIMPACT LLC 2.14% of their portfolio | 305.7k $13.8m | Added +194.9k |
| Nantahala Capital Management, LLC 0.68% of their portfolio | 300.0k $13.5m | New |
| Foresite Capital Management V, LLC 8.61% of their portfolio | 299.1k $13.5m | Added +55.6k |
| Woodline Partners LP 0.12% of their portfolio | 267.9k $12.1m | New |
| Polar Capital Holdings Plc 0.07% of their portfolio | 244.9k $11.0m | Unchanged |
| Pictet Asset Management Holding SA 0.01% of their portfolio | 216.7k $9.8m | Reduced -15.1k |
| Blue Owl Capital Holdings LP 2.70% of their portfolio | 215.3k $9.7m | Added +60.0k |
| Sio Capital Management, LLC 3.26% of their portfolio | 192.0k $8.7m | New |
| Ally Bridge Group (NY) LLC 4.47% of their portfolio | 166.5k $7.5m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 141.2k $6.4m | Added +49.1k |
| First Turn Management, LLC 1.02% of their portfolio | 138.9k $6.3m | Reduced -113.8k |
| Walleye Capital LLC 0.06% of their portfolio | 136.1k $6.1m | Added +124.8k |
| Artisan Partners Limited Partnership 0.01% of their portfolio | 109.3k $4.9m | Unchanged |
| SILVERARC CAPITAL MANAGEMENT, LLC 1.13% of their portfolio | 101.2k $4.6m | New |
| MORGAN STANLEY 0.00% of their portfolio | 98.9k $4.5m | Reduced -311.0k |
| EAGLE ASSET MANAGEMENT INC 0.02% of their portfolio | 98.7k $4.6m | Reduced -17.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 98.4k $4.4m | Added +987 |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 92.1k $4.2m | Added +35.7k |
| UBS Group AG 0.00% of their portfolio | 77.7k $3.5m | Added +14.7k |
| Exome Asset Management LLC 2.45% of their portfolio | 61.0k $2.7m | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 60.6k $2.7m | Reduced -153.1k |
| SPHERA FUNDS MANAGEMENT LTD. 0.43% of their portfolio | 58.0k $2.6m | Added +9.2k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 55.9k $2.5m | Added +16.3k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 54.2k $2.4m | Reduced -14.2k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 51.0k $2.3m | Added +24.1k |
| TD Asset Management Inc 0.00% of their portfolio | 40.7k $1.8m | Added +1.5k |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 40.0k $1.8m | Unchanged |
| Zimmer Partners, LP 0.03% of their portfolio | 34.4k $1.6m | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 32.4k $1.5m | Reduced -8.4k |
| Swiss National Bank 0.00% of their portfolio | 32.0k $1.4m | Added +8.2k |
| Sofinnova Investments, Inc. 0.08% of their portfolio | 29.3k $1.3m | Added +23.1k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 28.3k $1.3m | Added +6.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 28.0k $1.3m | Added +3.5k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 24.4k $1.1m | Added +11.3k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 24.0k $1.1m | Reduced -78.9k |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 23.7k $1.1m | Reduced -2 |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 21.1k $949.2k | Reduced -475.8k |
| ALPS ADVISORS INC 0.01% of their portfolio | 19.3k $869.9k | Added +2.3k |
| Trexquant Investment LP 0.01% of their portfolio | 18.6k $838.3k | New |
| BARCLAYS PLC 0.00% of their portfolio | 17.9k $808.7k | Added +3.5k |
| Harvest Investment Services, LLC 0.32% of their portfolio | 17.8k $802.9k | Reduced -602 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 15.9k $718.8k | Added +4.1k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 15.3k $691.2k | Added +10.5k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 15.0k $675.1k | Added +6.1k |
| CITIGROUP INC 0.00% of their portfolio | 14.1k $636.9k | Reduced -75.1k |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio | 14.1k $636.0k | New |
| Legal & General Group Plc 0.00% of their portfolio | 14.0k $630.2k | Added +5.2k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 13.9k $626.8k | Added +1.4k |
| PRELUDE CAPITAL MANAGEMENT, LLC 0.05% of their portfolio | 13.6k $613.0k | Added +10.1k |
| Artia Global Partners LP 0.16% of their portfolio | 13.4k $605.7k | Reduced -73.6k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.02% of their portfolio | 13.3k $600.3k | Added +10.0k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 12.6k $565.9k | Reduced -6.7k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 12.3k $554.4k | New |
| PDT Partners, LLC 0.05% of their portfolio | 12.1k $545.5k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 11.7k $529.4k | Added +3.6k |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 10.3k $463.1k | New |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 9.7k $438.0k | Added +1.6k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 9.6k $434.6k | Added +4.8k |
| Jump Financial, LLC 0.01% of their portfolio | 9.5k $427.0k | New |
| Corebridge Financial, Inc. 0.00% of their portfolio | 8.8k $398.4k | First filing |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 6.9k $312.1k | Reduced -41.7k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 6.8k $307.1k | Added +2.2k |
| Brevan Howard Capital Management LP 0.02% of their portfolio | 6.6k $299.4k | New |
| RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio | 5.8k $262.7k | Reduced -571 |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 5.8k $260.0k | First filing |
| Invesco Ltd. 0.00% of their portfolio | 5.6k $254.1k | Reduced -65.8k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 5.5k $248.6k | Reduced -7.0k |
| ALGERT GLOBAL LLC 0.01% of their portfolio | 5.3k $238.8k | New |
| ExodusPoint Capital Management, LP 0.00% of their portfolio | 5.0k $226.0k | Reduced -27.1k |
| PROFUND ADVISORS LLC 0.01% of their portfolio | 4.6k $206.7k | Reduced -11.2k |
| SG Americas Securities, LLC 0.00% of their portfolio | 4.1k $183.0k | Added +1.2k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 3.9k $177.0k | Added +2.9k |
| EntryPoint Capital, LLC 0.07% of their portfolio | 3.3k $150.1k | Added +3.1k |
| China Universal Asset Management Co., Ltd. 0.02% of their portfolio | 2.9k $130.9k | Reduced -1.7k |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 2.9k $129.2k | New |
| Catalyst Funds Management Pty Ltd 0.03% of their portfolio | 2.4k $108.2k | New |
| VIRTUS ADVISERS, LLC 0.05% of their portfolio | 2.3k $104.2k | Added +824 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 1.8k $83.0k | Added +1.5k |