Paradigm Biocapital Advisors LP

NEW YORK, NY · CIK 1855655 · 13F filing filed 2024-08-14

SEC-registered investment adviser since 2021 · limited partnership

Assets managed$4.5bn
Staff11 · 6 in investment roles
Main clients (by assets)Private funds 90%
Private funds2 (2 hedge) · $4.1bn gross assets
Form ADV · 2026-08-27SEC adviser record

Legal entityPARADIGM BIOCAPITAL ADVISORS LP (US)

$2.6bn reported value -8.0% vs Q1 2024

35positions

64.6%in top 10

10 new 10 added 11 reduced 9 sold out vs Q1 2024

Holdings, Q2 2024

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	NUVALENT INC COM COM		4,571,678	$346.8m13.27%	13.27%	Added +393.8k	+393,848 9.4%
2	ARGENX SE SPONSORED ADR ARGX	ARGX	538,139	$231.4m8.86%	8.86%	Reduced -14.0k	-13,981 -2.5%
3	ARCELLX INC COMMON STOCK ACLX	ACLX	3,848,095	$212.4m8.13%	8.13%	Added +30.0k	+30,000 0.8%
4	REVOLUTION MEDICINES INC COM RVMD	RVMD	5,259,089	$204.1m7.81%	7.81%	Added +2.3m	+2,344,114 80.4%
5	SAREPTA THERAPEUTICS INC COM SRPT	SRPT	947,574	$149.7m5.73%	5.73%	Reduced -130.8k	-130,772 -12.1%
6	DISC MEDICINE INC COM IRON	IRON	2,704,718	$121.9m4.67%	4.67%	Added +314.8k	+314,816 13.2%
7	MERUS N V COM MRUS	MRUS	2,019,814	$119.5m4.57%	4.57%	New
8	CRINETICS PHARMACEUTICALS IN COM CRNX	CRNX	2,513,302	$112.6m4.31%	4.31%	Reduced -611.4k	-611,447 -19.6%
9	CEREVEL THERAPEUTICS HLDNG I COM CERE	CERE	2,330,508	$95.3m3.65%	3.65%	Unchanged
10	KURA ONCOLOGY INC COM KURA	KURA	4,539,381	$93.5m3.58%	3.58%	Added +1.4m	+1,403,994 44.8%
11	ASCENDIS PHARMA A/S SPONSORED ADR SPONSORED ADR		664,307	$90.6m3.47%	3.47%	Added +156.4k	+156,355 30.8%
12	OLEMA PHARMACEUTICALS INC COM OLMA	OLMA	7,903,600	$85.5m3.27%	3.27%	Unchanged
13	XENON PHARMACEUTICALS INC COM XENE	XENE	2,043,280	$79.7m3.05%	3.05%	Reduced -441.6k	-441,594 -17.8%
14	TARSUS PHARMACEUTICALS INC COM TARS	TARS	2,435,416	$66.2m2.53%	2.53%	Reduced -428.0k	-427,990 -14.9%
15	JANUX THERAPEUTICS INC COM JANX	JANX	1,564,452	$65.5m2.51%	2.51%	New
16	ARVINAS INC COM ARVN	ARVN	2,438,149	$64.9m2.48%	2.48%	Reduced -176.8k	-176,786 -6.8%
17	LEGEND BIOTECH CORP SPONSORED ADS LEGN	LEGN	1,203,308	$53.3m2.04%	2.04%	Reduced -778.7k	-778,698 -39.3%
18	VAXCYTE INC COM PCVX	PCVX	627,202	$47.4m1.81%	1.81%	Reduced -612.8k	-612,793 -49.4%
19	Y-MABS THERAPEUTICS INC COM YMAB	YMAB	3,870,594	$46.8m1.79%	1.79%	Added +1.6m	+1,636,984 73.3%
20	EDGEWISE THERAPEUTICS INC COM EWTX	EWTX	2,325,449	$41.9m1.60%	1.60%	Reduced -120.9k	-120,924 -4.9%
21	IMMATICS N.V SHS IMTX	IMTX	3,421,965	$39.8m1.52%	1.52%	Added +603.1k	+603,057 21.4%
22	VIRIDIAN THERAPEUTICS INC COM VRDN	VRDN	2,896,349	$37.7m1.44%	1.44%	Reduced -2.1m	-2,135,071 -42.4%
23	IMMUNOVANT INC COM IMVT	IMVT	1,362,827	$36.0m1.38%	1.38%	Added +563.8k	+563,773 70.6%
24	COGENT BIOSCIENCES INC COM COGT	COGT	3,624,342	$30.6m1.17%	1.17%	New
25	BRIDGEBIO PHARMA INC COM BBIO	BBIO	1,089,492	$27.6m1.06%	1.06%	New
26	CULLINAN THERAPEUTICS INC COM CGEM	CGEM	1,542,805	$26.9m1.03%	1.03%	Added +194.8k	+194,790 14.4%
27	ERASCA INC COM ERAS	ERAS	7,250,000	$17.1m0.65%	0.65%	New
28	COMPASS PATHWAYS PLC SPONSORED ADS CMPS	CMPS	2,335,926	$14.1m0.54%	0.54%	Reduced -55.1k	-55,062 -2.3%
29	APOGEE THERAPEUTICS INC COM COM		330,000	$13.0m0.50%	0.50%	Unchanged
30	VERONA PHARMA PLC SPONSORED ADS VRNA	VRNA	721,087	$10.4m0.40%	0.40%	New
31	ALX ONCOLOGY HLDGS INC COM ALXO	ALXO	1,575,605	$9.5m0.36%	0.36%	New
32	PERSPECTIVE THERAPEUTICS INC COM NEW CATX	CATX	919,692	$9.2m0.35%	0.35%	New
33	VOR BIOPHARMA INC COM COM		6,457,293	$6.5m0.25%	0.25%	Unchanged
34	ACRIVON THERAPEUTICS INC COMMON STOCK ACRV	ACRV	659,724	$3.8m0.15%	0.15%	New
35	TSCAN THERAPEUTICS INC COM TCRX	TCRX	353,886	$2.1m0.08%	0.08%	New

Sold out since Q1 2024

Security	Ticker	Shares held before	Value then
IMMUNOCORE HLDGS PLC IMCR	IMCR	1,787,176	$116.2m1.8m shares
ALPINE IMMUNE SCIENCES INC NVLS	NVLS	2,121,163	$84.1m2.1m shares
BICYCLE THERAPEUTICS PLC BCYC	BCYC	3,246,759	$80.8m3.2m shares
AUTOLUS THERAPEUTICS PLC AUTL	AUTL	6,425,803	$41.0m6.4m shares
ZENTALIS PHARMACEUTICALS INC ZNTL	ZNTL	944,917	$14.9m944.9k shares
AGIOS PHARMACEUTICALS INC AGIO	AGIO	400,000	$11.7m400.0k shares
CARIBOU BIOSCIENCES INC CRBU	CRBU	2,172,620	$11.2m2.2m shares
CARGO THERAPEUTICS INC		147,959	$3.3m148.0k shares
KYVERNA THERAPEUTICS INC KYTX	KYTX	50,000	$1.2m50.0k shares

Stakes above 5%

Companies where this manager has reported owning more than 5% of a class of shares, on Schedule 13D (may seek influence) or 13G (passive): its latest filing for each, from 19 Dec 2024 on.

Company	Ticker	Stake	Change	Schedule	Last filed
OLEMA PHARMACEUTICALS INC OLMA · 13G · filed 2025-02-14	OLMA	10.0%≈ $92.9m		13G	2025-02-14
EDGEWISE THERAPEUTICS INC EWTX · 13G · filed 2026-08-14	EWTX	9.5%≈ $415.1m	+3.3 pts	13G	2026-08-14
ACHIEVE LIFE SCIENCES INC ACHV · 13G · filed 2026-04-24	ACHV	9.2%≈ $64.7m	new	13G	2026-04-24
ASSEMBLY BIOSCIENCES INC ASMB · 13G · filed 2026-08-14	ASMB	7.8%≈ $42.7m	+2.4 pts	13G	2026-08-14
VIRIDIAN THERAPEUTICS INC VRDN · 13G · filed 2026-08-14	VRDN	6.1%≈ $123.5m	+1.0 pts	13G	2026-08-14
TYRA BIOSCIENCES INC TYRA · 13G · filed 2026-09-17	TYRA	5.8%≈ $110.9m	new	13G	2026-09-17
LEXEO THERAPEUTICS INC LXEO · 13G · filed 2026-08-14	LXEO	5.3%≈ $19.4m	-3.0 pts	13G	2026-08-14
MBX BIOSCIENCES INC MBX · 13G · filed 2026-06-24	MBX	5.2%≈ $137.6m	new	13G	2026-06-24
SPYRE THERAPEUTICS INC SYRE · 13G · filed 2026-10-01	SYRE	5.1%≈ $395.7m	new	13G	2026-10-01
JADE BIOSCIENCES INC JBIO · 13G · filed 2026-07-17	JBIO	5.1%≈ $69.0m	new	13G	2026-07-17