JADE BIOSCIENCES INC JBIO
COM NEW · Common Stock · CUSIP 008064206
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWaltham, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($14.2k this quarter). Holder counts are more reliable. Shares outstanding: 63.6m as of 2026-08-03, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $22.21. Options: 2 managers hold calls ($802.1k notional), 4 hold puts ($1.9m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q2 2025 | 74 |
| Q3 2025 | 78 |
| Q4 2025 | 105 |
| Q1 2026 | 120 |
| Q2 2026 | 155 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2025 | 31 | 25 |
| Q4 2025 | 73 | 21 |
| Q1 2026 | 63 | 46 |
| Q2 2026 | 111 | 42 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $0 | $915.2k | — |
| Q4 2025 | $3.1k | $1.8m | 569.36 |
| Q1 2026 | $163.0k | $1.2m | 7.56 |
| Q2 2026 | $802.1k | $1.9m | 2.42 |
Biggest buyers
| Paradigm Biocapital Advisors LP | New | +2.9m |
| FRANKLIN RESOURCES INC | New | +2.8m |
| FMR LLC | Added | +2.0m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | +1.9m |
| Polar Capital Holdings Plc | New | +1.8m |
| STATE STREET CORP | Added | +1.7m |
| JPMORGAN CHASE & CO | Added | +1.5m |
| CITADEL ADVISORS LLC | Added | +792.2k |
| Soleus Capital Management, L.P. | Added | +753.9k |
| Pictet Asset Management Holding SA | New | +733.8k |
Biggest sellers
| Avidity Partners Management LP | Reduced | -1.1m |
| GREAT POINT PARTNERS LLC | Sold out | -964.5k |
| Driehaus Capital Management LLC | Sold out | -635.5k |
| RTW INVESTMENTS, LP | Sold out | -573.2k |
| Versant Venture Management, LLC | Reduced | -534.0k |
| Bellevue Group AG | Reduced | -443.5k |
| BAKER BROS. ADVISORS LP | Reduced | -410.7k |
| MARSHALL WACE, LLP | Reduced | -359.0k |
| STEMPOINT CAPITAL LP | Sold out | -308.1k |
| Opaleye Management Inc. | Reduced | -282.6k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $797.7k35.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $4.4k200 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $1.5m68.3k shares |
| SIMPLEX TRADING, LLC | Unchanged | $415.5k18.7k shares |
| Persistent Asset Partners Ltd | Unchanged | $8.9k88 shares |
| DIADEMA PARTNERS LP | Unchanged | $3.2k1.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Fairmount Funds Management LLC 13D · may seek influence no change · filed 2026-06-09 | 20.0% |
| FMR LLC 13G · institution new · filed 2025-06-06 | 14.7% |
| Janus Henderson Group Ltd. 13G · institution +4.3 pts · filed 2026-07-08 | 10.6% |
| Venrock Healthcare Capital Partners III, L.P. 13G · passive investor -1.6 pts · filed 2026-08-14 | 8.3% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor +2.9 pts · filed 2025-10-16 | 7.0% |
| FRANKLIN TEMPLETON INC 13G · institution new · filed 2026-10-28 | 6.0% |
| BlackRock, Inc. 13G · institution +0.5 pts · filed 2026-10-27 | 5.2% |
| Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-07-17 | 5.1% |
| Bellevue Group AG 13G · institution -1.8 pts · filed 2026-08-14 | 5.0% |
Fell to 5% or below in the last year: Sofinnova Venture Partners X, L.P. (0.3%, 2026-03-05), Deep Track Capital, LP (0.0%, 2026-02-13), VANGUARD GROUP INC (4.2%, 2026-01-30), Frazier Life Sciences Public Fund, L.P. (4.2%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 1 | $44.4k | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 0 | — | — |
None reported since 1 Apr 2026.
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.01% of their portfolio | 9.1m $202.8m | Added +2.0m |
| Jupiter Topco LLC 0.06% of their portfolio | 6.3m $139.4m | First filing |
| Fairmount Funds Management LLC 6.69% of their portfolio | 4.6m $101.2m | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. 0.71% of their portfolio | 3.7m $81.6m | Unchanged |
| Venrock Adviser, LLC 2.17% of their portfolio | 3.2m $71.6m | Unchanged |
| Bellevue Group AG 1.43% of their portfolio | 3.1m $67.9m | Reduced -443.5k |
| Paradigm Biocapital Advisors LP 1.19% of their portfolio | 2.9m $63.5m | New |
| BlackRock, Inc. 0.00% of their portfolio | 2.8m $62.2m | Added +487.5k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 2.8m $62.0m | New |
| STATE STREET CORP 0.00% of their portfolio | 2.3m $51.9m | Added +1.7m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 2.2m $49.9m | Added +448.1k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.06% of their portfolio | 1.9m $42.5m | New |
| Polar Capital Holdings Plc 0.12% of their portfolio | 1.8m $41.0m | New |
| Avidity Partners Management LP 6.05% of their portfolio | 1.7m $37.8m | Reduced -1.1m |
| Remedium Capital Partners, LLC 7.76% of their portfolio | 1.6m $35.1m | Unchanged |
| Soleus Capital Management, L.P. 1.19% of their portfolio | 1.6m $34.5m | Added +753.9k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.5m $32.6m | Added +1.5m |
| BAKER BROS. ADVISORS LP 0.14% of their portfolio | 1.2m $27.3m | Reduced -410.7k |
| Logos Global Management LP 1.08% of their portfolio | 1.1m $25.0m | Added +725.0k |
| Versant Venture Management, LLC 13.55% of their portfolio | 991.8k $22.0m | Reduced -534.0k |
| ACORN CAPITAL ADVISORS, LLC 5.98% of their portfolio | 986.8k $21.9m | Added +200.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 985.2k $21.9m | Added +162.7k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 929.4k $20.7m | Added +792.2k |
| Foresite Capital Management VI LLC 3.07% of their portfolio | 886.7k $19.7m | Added +566.7k |
| Balyasny Asset Management L.P. 0.04% of their portfolio | 878.7k $19.5m | Added +476.2k |
| Affinity Asset Advisors, LLC 0.91% of their portfolio | 840.4k $18.7m | Added +200.4k |
| SAMSARA BIOCAPITAL, LLC 1.34% of their portfolio | 736.2k $16.4m | Reduced -232.6k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 735.2k $16.3m | Added +582.2k |
| Pictet Asset Management Holding SA 0.02% of their portfolio | 733.8k $16.3m | New |
| Aberdeen Group plc 0.02% of their portfolio | 621.1k $13.8m | Reduced -246.2k |
| MARSHALL WACE, LLP 0.01% of their portfolio | 585.8k $13.0m | Reduced -359.0k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 487.0k $10.8m | Added +448.4k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 461.5k $10.3m | Added +250.2k |
| Blackstone Inc. 0.03% of their portfolio | 435.3k $9.7m | Not comparable |
| Ikarian Capital, LLC 1.55% of their portfolio | 427.3k $9.5m | Reduced -85.0k |
| Walleye Capital LLC 0.04% of their portfolio | 365.3k $8.1m | New |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 314.5k $7.0m | Added +154.5k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 304.9k $6.8m | Added +85.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 295.1k $6.6m | Added +53.2k |
| LORD, ABBETT & CO. LLC 0.01% of their portfolio | 226.6k $5.0m | New |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 217.2k $4.8m | Added +48.1k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 199.4k $4.4m | Added +170.8k |
| Jump Financial, LLC 0.03% of their portfolio | 172.7k $3.8m | Added +160.9k |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 167.2k $3.7m | Reduced -97.1k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 163.1k $3.6m | Added +55.5k |
| Opaleye Management Inc. 0.29% of their portfolio | 145.0k $3.2m | Reduced -282.6k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 140.9k $3.1m | Added +101.6k |
| UBS Group AG 0.00% of their portfolio | 127.6k $2.8m | Added +62.6k |
| MORGAN STANLEY 0.00% of their portfolio | 124.5k $2.8m | Added +73.9k |
| Quantinno Capital Management LP 0.00% of their portfolio | 114.7k $2.5m | Added +84.2k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.05% of their portfolio | 112.7k $2.5m | Reduced -27.3k |
| Sofinnova Investments, Inc. 0.13% of their portfolio | 107.4k $2.4m | Unchanged |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 107.1k $2.4m | New |
| Woodline Partners LP 0.01% of their portfolio | 100.3k $2.2m | New |
| SEVEN GRAND MANAGERS, LLC 0.09% of their portfolio | 100.0k $2.2m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 100.0k $2.2m | Added +8.3k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 90.4k $2.0m | Reduced -38.8k |
| Atle Fund Management AB 0.53% of their portfolio | 88.6k $2.0m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 85.3k $1.9m | Reduced -4.6k |
| Swiss National Bank 0.00% of their portfolio | 83.3k $1.9m | New |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 78.7k $1.7m | New |
| Longaeva Partners L.P. 0.05% of their portfolio | 78.5k $1.7m | New |
| Nuveen, LLC 0.00% of their portfolio | 76.0k $1.7m | Added +29.8k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 73.6k $1.6m | Reduced -61.4k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 69.0k $1.5m | Added +35.6k |
| Trexquant Investment LP 0.01% of their portfolio | 68.3k $1.5m | Added +40.2k |
| Harvest Investment Services, LLC 0.22% of their portfolio | 63.0k $1.4m | New |
| Corient Private Wealth LP 0.00% of their portfolio | 61.5k $1.4m | New |
| XTX Topco Ltd 0.02% of their portfolio | 59.1k $1.3m | Reduced -19.0k |
| Verdad Advisers, LP 1.20% of their portfolio | 56.4k $1.3m | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 54.5k $1.2m | Added +9.8k |
| CITIGROUP INC 0.00% of their portfolio | 54.4k $1.2m | Added +46.8k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 51.5k $1.1m | New |
| Maven Securities LTD 0.11% of their portfolio | 50.0k $1.1m | New |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.00% of their portfolio | 48.4k $1.1m | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 47.3k $665.0k | Added +2.0k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 45.4k $1.0m | Added +27.1k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 45.1k $1.0m | Added +43.4k |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 42.6k $947.2k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 40.9k $909.0k | Added +357 |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 36.6k $813.0k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 34.7k $770.6k | Reduced -4.5k |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 34.1k $757.5k | Added +10.4k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 31.6k $702.4k | Added +16.6k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 29.7k $660.4k | Added +17.7k |
| Voleon Capital Management LP 0.01% of their portfolio | 27.8k $617.2k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 26.5k $590.0k | Added +4.0k |
| Man Group plc 0.00% of their portfolio | 26.1k $580.5k | New |
| Legal & General Group Plc 0.00% of their portfolio | 23.4k $520.4k | Added +20.6k |
| BARCLAYS PLC 0.00% of their portfolio | 22.6k $502.9k | Reduced -2.0k |
| Engineers Gate Manager LP 0.01% of their portfolio | 22.6k $502.6k | New |
| Aquatic Capital Management LLC 0.02% of their portfolio | 22.4k $498.4k | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 21.5k $477.4k | Added +21.0k |
| PROFUND ADVISORS LLC 0.01% of their portfolio | 21.4k $475.8k | New |
| Virtus Investment Advisers, LLC 0.11% of their portfolio | 21.3k $473.9k | Added +3.1k |
| Ghisallo Capital Management LLC 0.01% of their portfolio | 20.0k $444.4k | New |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 19.9k $442.6k | Added +5.0k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 19.7k $438.6k | Added +1.8k |
| Invesco Ltd. 0.00% of their portfolio | 18.1k $402.6k | Reduced -11.4k |
| KLP KAPITALFORVALTNING AS 0.00% of their portfolio | 13.8k $306.6k | New |