Vault-13

APOGEE THERAPEUTICS INC

COM · CUSIP 03770N101 · ISIN US03770N1019

140 institutional holders +0 vs Q1 2024
53,987,72154.0m shares reported held*
$2.1bnreported value*
32 new 47 added 41 reduced 32 sold out net bought ≈ $49.1m (+1.2m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($7.6m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $39.35. Options: 2 managers hold calls ($86.6k notional), 4 hold puts ($652.5k).

Trends to Q2 2024

Institutional holders

Managers reporting a position, each quarter

050100150Q3 23: 74Q4 23: 86Q1 24: 140Q2 24: 140140Q3 23Q4 23Q1 24Q2 24
Numbers
QuarterHolders
Q3 202374
Q4 202386
Q1 2024140
Q2 2024140

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 23: 52 bought or addedQ4 23: 17 cut or sold outQ4 23Q1 24: 112 bought or addedQ1 24: 26 cut or sold outQ1 24Q2 24: 79 bought or addedQ2 24: 73 cut or sold outQ2 24
Numbers
QuarterBought or addedCut or sold out
Q4 20235217
Q1 202411226
Q2 20247973

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$2m$4m$6mQ3 23 calls: $0Q3 23 puts: $0Q3 23P/C —Q4 23 calls: $0Q4 23 puts: $0Q4 23P/C —Q1 24 calls: $4.5mQ1 24 puts: $338.9kQ1 24P/C 0.08Q2 24 calls: $86.6kQ2 24 puts: $652.5kQ2 24P/C 7.54
Numbers
QuarterCallsPutsP/C
Q3 2023$0$0—
Q4 2023$0$0—
Q1 2024$4.5m$338.9k0.08
Q2 2024$86.6k$652.5k7.54

Biggest buyers

WELLINGTON MANAGEMENT GROUP LLP Added +1,277,052+1.3m
FMR LLC Added +761,973+762.0k
BRAIDWELL LP Added +549,527+549.5k
ALLIANCEBERNSTEIN L.P. Added +387,152+387.2k
Polar Capital Holdings Plc New +250,000+250.0k
RTW INVESTMENTS, LP Added +244,505+244.5k
Affinity Asset Advisors, LLC Added +244,190+244.2k
GOLDMAN SACHS GROUP INC Added +224,161+224.2k
STATE STREET CORP Added +213,565+213.6k
TWO SIGMA INVESTMENTS, LP Added +212,742+212.7k

Biggest sellers

Deep Track Capital, LP Reduced -1,323,456-1.3m
Darwin Global Management, Ltd. Sold out -832,198-832.2k
PRICE T ROWE ASSOCIATES INC /MD/ Reduced -402,106-402.1k
GREAT POINT PARTNERS LLC Sold out -400,000-400.0k
ORBIMED ADVISORS LLC Reduced -339,771-339.8k
Point72 Asset Management, L.P. Reduced -217,968-218.0k
MORGAN STANLEY Reduced -173,634-173.6k
Artal Group S.A. Sold out -152,500-152.5k
Blackstone Inc. Reduced -150,000-150.0k
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -125,000-125.0k

Biggest calls

CITADEL ADVISORS LLC Added $86.6k2.2k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP New $346.3k8.8k shares
CITADEL ADVISORS LLC Added $291.2k7.4k shares
SIMPLEX TRADING, LLC New $15.0k400 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2025-07-16 5.5% 2.5m≈ $334.3m 2025-07-16

Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (0.0%, 2026-09-08), Fairmount Funds Management LLC (0.0%, 2026-09-03), FMR LLC (4.0%, 2026-07-08), WELLINGTON MANAGEMENT GROUP LLP (0.9%, 2026-07-08), T. Rowe Price Investment Management, Inc. (1.3%, 2026-07-08), VANGUARD GROUP INC (0.0%, 2026-03-26), RTW INVESTMENTS, LP (4.9%, 2026-02-17), DRIEHAUS CAPITAL MANAGEMENT LLC (4.7%, 2025-11-14)

Holders, Q2 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Venrock Adviser, LLC 21.28% of their portfolio NEW YORK, NY 8,493,3218.5m $334.2m $334.2m 21.28% Unchanged
2 FMR LLC 0.02% of their portfolio BOSTON, MA 7,505,8757.5m $295.4m $295.4m 0.02% Added +762.0k +761,973
3 WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio Boston, MA 3,546,9493.5m $139.6m $139.6m 0.02% Added +1.3m +1,277,052
4 BlackRock Inc. 0.00% of their portfolio New York, NY 2,742,5492.7m $107.9m $107.9m 0.00% Reduced -67.3k -67,276
5 RTW INVESTMENTS, LP 1.65% of their portfolio NEW YORK, NY 2,712,0962.7m $106.7m $106.7m 1.65% Added +244.5k +244,505
6 BRAIDWELL LP 2.95% of their portfolio STAMFORD, CT 2,392,0422.4m $94.1m $94.1m 2.95% Added +549.5k +549,527
7 Driehaus Capital Management LLC 0.81% of their portfolio Chicago, IL 2,117,8702.1m $83.3m $83.3m 0.81% Added +54.1k +54,107
8 PERCEPTIVE ADVISORS LLC 2.00% of their portfolio NEW YORK, NY 2,105,6362.1m $82.9m $82.9m 2.00% Added +45.2k +45,241
9 Fairmount Funds Management LLC 9.11% of their portfolio WEST CONSHOHOCKEN, PA 2,048,6472.0m $80.6m $80.6m 9.11% Unchanged
10 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,970,3202.0m $77.5m $77.5m 0.00% Added +101.7k +101,654
11 RA CAPITAL MANAGEMENT, L.P. 1.02% of their portfolio BOSTON, MA 1,961,8632.0m $77.2m $77.2m 1.02% Reduced -16.0k -16,038
12 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 1,561,3621.6m $61.4m $61.4m 0.00% Added +213.6k +213,565
13 ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio NASHVILLE, TN 1,132,2701.1m $44.6m $44.6m 0.02% Added +387.2k +387,152
14 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 1,005,4701.0m $39.6m $39.6m 0.01% Reduced -29.9k -29,910
15 Deep Track Capital, LP 1.18% of their portfolio GREENWICH, CT 1,000,0001.0m $39.4m $39.4m 1.18% Reduced -1.3m -1,323,456
16 Affinity Asset Advisors, LLC 5.18% of their portfolio NEW YORK, NY 836,283836.3k $32.9m $32.9m 5.18% Added +244.2k +244,190
17 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 768,221768.2k $30.2m $30.2m 0.00% Reduced -402.1k -402,106
18 Woodline Partners LP 0.28% of their portfolio San Francisco, CA 746,159746.2k $29.4m $29.4m 0.28% Added +43.7k +43,738
19 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 740,861740.9k $29.2m $29.2m 0.00% Reduced -20.2k -20,163
20 Avidity Partners Management LP 0.81% of their portfolio DALLAS, TX 487,000487.0k $19.2m $19.2m 0.81% Added +102.1k +102,107
21 ORBIMED ADVISORS LLC 0.30% of their portfolio New York, NY 379,130379.1k $14.9m $14.9m 0.30% Reduced -339.8k -339,771
22 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 349,556349.6k $13.8m $13.8m 0.00% Reduced -47.2k -47,222
23 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 337,153337.2k $13.3m $13.3m 0.00% Added +224.2k +224,161
24 Paradigm Biocapital Advisors LP 0.50% of their portfolio NEW YORK, NY 330,000330.0k $13.0m $13.0m 0.50% Unchanged
25 DEERFIELD MANAGEMENT COMPANY, L.P. 0.22% of their portfolio New York, NY 329,000329.0k $12.9m $12.9m 0.22% Unchanged
26 First Turn Management, LLC 2.04% of their portfolio DEL MAR, CA 318,327318.3k $12.5m $12.5m 2.04% Reduced -61.5k -61,476
27 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 311,203311.2k $12.2m $12.2m 0.00% Reduced -13.0k -13,021
28 JENNISON ASSOCIATES LLC 0.01% of their portfolio NEW YORK, NY 306,078306.1k $12.0m $12.0m 0.01% Added +3.2k +3,186
29 TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio NEW YORK, NY 302,222302.2k $11.9m $11.9m 0.03% Added +212.7k +212,742
30 Commodore Capital LP 0.78% of their portfolio NEW YORK, NY 290,000290.0k $11.4m $11.4m 0.78% Unchanged
31 Point72 Asset Management, L.P. 0.03% of their portfolio STAMFORD, CT 269,232269.2k $10.6m $10.6m 0.03% Reduced -218.0k -217,968
32 Polar Capital Holdings Plc 0.06% of their portfolio London, X0 250,000250.0k $9.8m $9.8m 0.06% New
33 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 238,742238.7k $9.4m $9.4m 0.00% Reduced -2.0k -2,024
34 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 234,780234.8k $9.2m $9.2m 0.00% Reduced -173.6k -173,634
35 Jefferies Financial Group Inc. 0.14% of their portfolio NEW YORK, NY 180,077180.1k $7.1m $7.1m 0.14% New
36 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.03% of their portfolio JUPITER, FL 174,814174.8k $6.9m $6.9m 0.03% New
37 VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio San Antonio, TX 156,266156.3k $6.1m $6.1m 0.01% Added +56.6k +56,607
38 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 156,204156.2k $6.1m $6.1m 0.01% Added +67.5k +67,504
39 Cubist Systematic Strategies, LLC 0.10% of their portfolio STAMFORD, CT 150,135150.1k $5.9m $5.9m 0.10% New
40 PLATINUM INVESTMENT MANAGEMENT LTD 0.23% of their portfolio SYDNEY AUSTRALIA 2000, C3 147,472147.5k $5.8m $5.8m 0.23% Reduced -20.4k -20,406
41 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 137,898137.9k $5.4m $5.4m 0.00% Added +6.4k +6,376
42 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 135,747135.7k $5.3m $5.3m 0.00% Reduced -1.5k -1,520
43 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 116,318116.3k $4.6m $4.6m 0.00% New
44 SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio London, X0 112,858112.9k $4.4m $4.4m 0.00% New
45 ArrowMark Colorado Holdings LLC 0.05% of their portfolio Denver, CO 109,410109.4k $4.3m $4.3m 0.05% Unchanged
46 TANG CAPITAL MANAGEMENT LLC 0.40% of their portfolio SAN DIEGO, CA 100,000100.0k $3.9m $3.9m 0.40% Unchanged
47 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 97,06597.1k $3.8m $3.8m 0.00% Reduced -21.9k -21,909
48 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 95,00695.0k $3.7m $3.7m 0.00% Reduced -53.2k -53,200
49 Candriam S.C.A. 0.02% of their portfolio STRASSEN, N4 90,00090.0k $3.5m $3.5m 0.02% Unchanged
50 Trexquant Investment LP 0.05% of their portfolio STAMFORD, CT 87,20187.2k $3.4m $3.4m 0.05% New
51 MARSHALL WACE, LLP 0.00% of their portfolio LONDON, X0 81,94681.9k $3.2m $3.2m 0.00% New
52 Blackstone Inc. 0.01% of their portfolio NEW YORK, NY 80,00080.0k $3.1m $3.1m 0.01% Reduced -150.0k -150,000
53 Integral Health Asset Management, LLC 0.31% of their portfolio New York, NY 80,00080.0k $3.1m $3.1m 0.31% Added +40.0k +40,000
54 HighVista Strategies LLC 1.13% of their portfolio BOSTON, MA 78,94278.9k $3.1m $3.1m 1.13% Reduced -40.5k -40,461
55 Sio Capital Management, LLC 1.16% of their portfolio NEW YORK, NY 78,00078.0k $3.1m $3.1m 1.16% Unchanged
56 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 77,80377.8k $3.1m $3.1m 0.00% Added +41.2k +41,157
57 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 74,83874.8k $2.9m $2.9m 0.01% Added +8.7k +8,710
58 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 73,89373.9k $2.9m $2.9m 0.00% Added +17.7k +17,714
59 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 71,64371.6k $2.8m $2.8m 0.00% Reduced -13.6k -13,558
60 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 69,75069.8k $2.7m $2.7m 0.01% Added +57.8k +57,750
61 Artia Global Partners LP 0.59% of their portfolio MIAMI, FL 58,40058.4k $2.3m $2.3m 0.59% Reduced -3.2k -3,190
62 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 56,68656.7k $2.2m $2.2m 0.00% Added +8.0k +8,020
63 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 52,40052.4k $2.1m $2.1m 0.00% Added +48.3k +48,300
64 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 52,02652.0k $2.0m $2.0m 0.00% New
65 UBS Group AG 0.00% of their portfolio ZURICH, V8 50,49050.5k $2.0m $2.0m 0.00% Reduced -25.5k -25,541
66 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio Boston, MA 50,00050.0k $2.0m $2.0m 0.00% Reduced -125.0k -125,000
67 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 49,43549.4k $1.9m $1.9m 0.00% Reduced -6.3k -6,261
68 Squarepoint Ops LLC 0.01% of their portfolio NEW YORK, NY 44,02244.0k $1.7m $1.7m 0.01% Added +25.8k +25,829
69 Jump Financial, LLC 0.03% of their portfolio Chicago, IL 43,45843.5k $1.7m $1.7m 0.03% New
70 Swiss National Bank 0.00% of their portfolio ZURICH, V8 42,20042.2k $1.7m $1.7m 0.00% Added +900 +900
71 ADAR1 Capital Management, LLC 0.32% of their portfolio AUSTIN, TX 40,87540.9k $1.6m $1.6m 0.32% Added +34.9k +34,875
72 SUPERSTRING CAPITAL MANAGEMENT LP 1.83% of their portfolio NEW YORK, NY 36,92836.9k $1.5m $1.5m 1.83% Reduced -7.9k -7,940
73 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 35,06735.1k $1.4m $1.4m 0.01% New
74 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 34,40334.4k $1.4m $1.4m 0.00% New
75 KENNEDY CAPITAL MANAGEMENT LLC 0.03% of their portfolio ST LOUIS, MO 32,43932.4k $1.3m $1.3m 0.03% Added +29.3k +29,251
76 Walleye Capital LLC 0.01% of their portfolio NEW YORK, NY 30,17830.2k $1.2m $1.2m 0.01% New
77 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 25,56025.6k $1.0m $1.0m 0.00% Added +12.2k +12,227
78 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 24,48024.5k $963.3k $963.3k 0.00% Added +17.7k +17,715
79 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 23,96924.0k $944.9k $944.9k 0.00% First filing
80 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 22,01622.0k $866.3k $866.3k 0.00% Reduced -986 -986
81 Legal & General Group Plc 0.00% of their portfolio London, X0 21,08821.1k $829.8k $829.8k 0.00% Added +829 +829
82 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 21,03521.0k $827.7k $827.7k 0.00% Reduced -194 -194
83 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 20,38320.4k $802.1k $802.1k 0.00% Reduced -96.3k -96,290
84 Corebridge Financial, Inc. 0.00% of their portfolio HOUSTON, TX 19,45819.5k $765.7k $765.7k 0.00% First filing
85 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 18,11118.1k $712.7k $712.7k 0.00% Reduced -75.0k -74,995
86 XTX Topco Ltd 0.06% of their portfolio LONDON, X0 17,93017.9k $705.5k $705.5k 0.06% New
87 Point72 (DIFC) Ltd 0.06% of their portfolio DUBAI, C0 16,77916.8k $660.3k $660.3k 0.06% New
88 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 16,38716.4k $644.8k $644.8k 0.00% Reduced -5.4k -5,383
89 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 16,19416.2k $637.2k $637.2k 0.00% Reduced -3.0k -3,012
90 HRT FINANCIAL LP 0.00% of their portfolio NEW YORK, NY 15,74515.7k $619.0k $619.0k 0.00% New
91 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 15,12315.1k $595.1k $595.1k 0.00% Reduced -1.5k -1,535
92 TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio FRANKFORT, KY 14,80714.8k $583.0k $583.0k 0.01% Unchanged
93 DARK FOREST CAPITAL MANAGEMENT LP 0.10% of their portfolio NEW YORK, NY 14,08314.1k $554.2k $554.2k 0.10% Added +6.2k +6,186
94 PROFUND ADVISORS LLC 0.02% of their portfolio BETHESDA, MD 14,01014.0k $551.3k $551.3k 0.02% Added +3.1k +3,090
95 NORGES BANK 0.00% of their portfolio OSLO, Q8 12,12112.1k $477.0k $477.0k 0.00% Unchanged
96 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 11,58011.6k $455.7k $455.7k 0.00% Reduced -1.8k -1,848
97 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 11,53511.5k $453.9k $453.9k 0.00% New
98 JANUS HENDERSON GROUP PLC 0.00% of their portfolio LONDON, X0 11,40011.4k $449.2k $449.2k 0.00% Added +5.3k +5,290
99 GSA CAPITAL PARTNERS LLP 0.03% of their portfolio LONDON, X0 10,31210.3k $406.0k $406.0k 0.03% New
100 OMERS ADMINISTRATION Corp 0.00% of their portfolio TORONTO, A6 9,5009.5k $373.8k $373.8k 0.00% New