Vault-13

ASCENDIS PHARMA A/S

SPONSORED ADR · CUSIP 04351P101 · ISIN US04351P1012

204 institutional holders +14 vs Q1 2024
60,754,69160.8m shares reported held*
$8.3bnreported value*
37 new 74 added 68 reduced 21 sold out net sold ≈ $35.3m (-260.9k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($79.1k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $136.38. Options: 10 managers hold calls ($21.1m notional), 11 hold puts ($43.9m).

Trends to Q2 2024

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 183Q4 22: 187Q1 23: 165Q2 23: 159Q3 23: 161Q4 23: 186Q1 24: 190Q2 24: 204204Q3 22Q1 23Q3 23Q1 24Q2 24
Numbers
QuarterHolders
Q3 2022183
Q4 2022187
Q1 2023165
Q2 2023159
Q3 2023161
Q4 2023186
Q1 2024190
Q2 2024204

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 94 bought or addedQ4 22: 91 cut or sold outQ4 22Q1 23: 75 bought or addedQ1 23: 100 cut or sold outQ2 23: 87 bought or addedQ2 23: 88 cut or sold outQ2 23Q3 23: 71 bought or addedQ3 23: 78 cut or sold outQ4 23: 90 bought or addedQ4 23: 86 cut or sold outQ4 23Q1 24: 111 bought or addedQ1 24: 83 cut or sold outQ2 24: 111 bought or addedQ2 24: 89 cut or sold outQ2 24
Numbers
QuarterBought or addedCut or sold out
Q4 20229491
Q1 202375100
Q2 20238788
Q3 20237178
Q4 20239086
Q1 202411183
Q2 202411189

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ3 23 calls: $17.4mQ3 23 puts: $23.0mQ3 23P/C 1.32Q4 23 calls: $26.8mQ4 23 puts: $20.7mQ4 23P/C 0.77Q1 24 calls: $48.3mQ1 24 puts: $51.8mQ1 24P/C 1.07Q2 24 calls: $21.1mQ2 24 puts: $43.9mQ2 24P/C 2.08
Numbers
QuarterCallsPutsP/C
Q3 2023$17.4m$23.0m1.32
Q4 2023$26.8m$20.7m0.77
Q1 2024$48.3m$51.8m1.07
Q2 2024$21.1m$43.9m2.08

Biggest buyers

WESTFIELD CAPITAL MANAGEMENT CO LP Added +887,610+887.6k
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +611,000+611.0k
AMERIPRISE FINANCIAL INC Added +605,496+605.5k
FIL Ltd Added +431,781+431.8k
Avoro Capital Advisors LLC Added +229,995+230.0k
Vestal Point Capital, LP Added +225,000+225.0k
Paradigm Biocapital Advisors LP Added +156,355+156.4k
JANUS HENDERSON GROUP PLC Added +151,610+151.6k
Invesco Ltd. Added +141,786+141.8k
LOOMIS SAYLES & CO L P New +121,594+121.6k

Biggest sellers

T. Rowe Price Investment Management, Inc. Reduced -2,538,339-2.5m
Artisan Partners Limited Partnership Reduced -1,376,905-1.4m
MORGAN STANLEY Reduced -289,187-289.2k
BROWN ADVISORY INC Reduced -205,396-205.4k
TD Asset Management Inc Reduced -136,924-136.9k
WELLINGTON MANAGEMENT GROUP LLP Reduced -133,016-133.0k
Pictet Asset Management Holding SA Reduced -124,443-124.4k
ACADIAN ASSET MANAGEMENT LLC Reduced -108,327-108.3k
Capital International Investors Reduced -87,014-87.0k
SEI INVESTMENTS CO Reduced -81,615-81.6k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $10.8m79.5k shares
CITADEL ADVISORS LLC Added $4.4m32.6k shares
CITIGROUP INC Reduced $1.7m12.5k shares
SIMPLEX TRADING, LLC Added $1.3m9.2k shares
GOLDMAN SACHS GROUP INC New $1.2m9.1k shares
JANE STREET GROUP, LLC Reduced $613.7k4.5k shares
LMR Partners LLP New $545.5k4.0k shares
Walleye Capital LLC Reduced $272.8k2.0k shares
GROUP ONE TRADING LLC Reduced $177.3k1.3k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC Added $17.8m130.7k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $11.8m86.6k shares
JANE STREET GROUP, LLC Added $5.5m40.1k shares
GROUP ONE TRADING LLC New $2.5m18.0k shares
CITIGROUP INC Reduced $1.7m12.5k shares
LMR Partners LLP New $1.4m10.0k shares
CITADEL ADVISORS LLC Reduced $1.1m7.7k shares
SIMPLEX TRADING, LLC Added $1.0m7.4k shares
Caption Management, LLC Reduced $968.3k7.1k shares
Walleye Capital LLC Reduced $231.8k1.7k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
T. Rowe Price Investment Management, Inc. 13G · institution +0.6 pts · filed 2026-05-07 10.5% +0.6 pts 6.5m 2026-05-07
WESTFIELD CAPITAL MANAGEMENT CO LP 13G · institution -0.7 pts · filed 2026-02-11 8.5% -0.7 pts 5.2m 2026-02-11
FMR LLC 13G · institution filed 2025-05-12 8.0% 4.6m 2025-05-12
JANUS HENDERSON GROUP PLC 13G · institution -1.8 pts · filed 2026-05-15 6.0% -1.8 pts 3.7m 2026-05-15
Artisan Partners Limited Partnership 13G · institution filed 2026-02-03 5.2% 3.2m 2026-02-03

Fell to 5% or below in the last year: Capital International Investors (3.2%, 2026-05-14)

Holders, Q2 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RA CAPITAL MANAGEMENT, L.P. 18.23% of their portfolio BOSTON, MA 10,108,40010.1m $1.4bn $1.4bn 18.23% Unchanged
2 WESTFIELD CAPITAL MANAGEMENT CO LP 3.33% of their portfolio BOSTON, MA 4,962,8245.0m $676.8m $676.8m 3.33% Added +887.6k +887,610
3 FMR LLC 0.04% of their portfolio BOSTON, MA 4,922,5554.9m $671.3m $671.3m 0.04% Reduced -15.9k -15,906
4 Artisan Partners Limited Partnership 0.89% of their portfolio Milwaukee, WI 4,295,0294.3m $585.8m $585.8m 0.89% Reduced -1.4m -1,376,905
5 Avoro Capital Advisors LLC 7.62% of their portfolio NEW YORK, NY 4,196,6614.2m $572.3m $572.3m 7.62% Added +230.0k +229,995
6 JANUS HENDERSON GROUP PLC 0.29% of their portfolio LONDON, X0 3,918,8133.9m $534.5m $534.5m 0.29% Added +151.6k +151,610
7 WELLINGTON MANAGEMENT GROUP LLP 0.06% of their portfolio Boston, MA 2,612,8562.6m $356.3m $356.3m 0.06% Reduced -133.0k -133,016
8 Capital International Investors 0.06% of their portfolio Los Angeles, CA 2,104,2982.1m $287.0m $287.0m 0.06% Reduced -87.0k -87,014
9 FRANKLIN RESOURCES INC 0.09% of their portfolio San Mateo, CA 2,084,8512.1m $284.3m $284.3m 0.09% Added +103.0k +102,982
10 PRICE T ROWE ASSOCIATES INC /MD/ 0.03% of their portfolio BALTIMORE, MD 1,784,1481.8m $243.3m $243.3m 0.03% Added +2.2k +2,222
11 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.07% of their portfolio Boston, MA 1,711,0151.7m $233.3m $233.3m 0.07% Added +93.2k +93,185
12 Invesco Ltd. 0.03% of their portfolio ATLANTA, GA 1,106,4491.1m $150.9m $150.9m 0.03% Added +141.8k +141,786
13 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.21% of their portfolio Boston, MA 820,512820.5k $111.9m $111.9m 0.21% Added +611.0k +611,000
14 Vestal Point Capital, LP 7.63% of their portfolio NEW YORK, NY 750,000750.0k $102.3m $102.3m 7.63% Added +225.0k +225,000
15 Sofinnova Investments, Inc. 6.31% of their portfolio Menlo Park, CA 734,284734.3k $100.1m $100.1m 6.31% Reduced -19.7k -19,748
16 Paradigm Biocapital Advisors LP 3.47% of their portfolio NEW YORK, NY 664,307664.3k $90.6m $90.6m 3.47% Added +156.4k +156,355
17 Spyglass Capital Management LLC 6.62% of their portfolio Greenbrae, CA 662,888662.9k $90.4m $90.4m 6.62% Added +48.8k +48,781
18 AMERIPRISE FINANCIAL INC 0.02% of their portfolio MINNEAPOLIS, MN 660,662660.7k $90.1m $90.1m 0.02% Added +605.5k +605,496
19 TimesSquare Capital Management, LLC 1.28% of their portfolio NEW YORK, NY 596,314596.3k $81.3m $81.3m 1.28% Added +20.6k +20,616
20 CITADEL ADVISORS LLC 0.07% of their portfolio MIAMI, FL 537,762537.8k $73.3m $73.3m 0.07% Added +80.3k +80,258
21 BROWN ADVISORY INC 0.09% of their portfolio BALTIMORE, MD 478,676478.7k $65.3m $65.3m 0.09% Reduced -205.4k -205,396
22 ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio NASHVILLE, TN 475,001475.0k $64.8m $64.8m 0.02% Added +1.2k +1,248
23 MILLENNIUM MANAGEMENT LLC 0.05% of their portfolio NEW YORK, NY 473,449473.4k $64.6m $64.6m 0.05% Added +111.4k +111,389
24 FIL Ltd 0.06% of their portfolio HAMILTON, D0 442,508442.5k $60.3m $60.3m 0.06% Added +431.8k +431,781
25 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 421,551421.6k $57.5m $57.5m 0.01% Reduced -15.5k -15,541
26 BlackRock Inc. 0.00% of their portfolio New York, NY 405,989406.0k $55.4m $55.4m 0.00% Added +820 +820
27 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.18% of their portfolio JUPITER, FL 346,218346.2k $47.2m $47.2m 0.18% Added +38.7k +38,719
28 FRED ALGER MANAGEMENT, LLC 0.20% of their portfolio NEW YORK, NY 307,073307.1k $41.9m $41.9m 0.20% Added +121.0k +120,952
29 AMERICAN CENTURY COMPANIES INC 0.03% of their portfolio KANSAS CITY, MO 305,974306.0k $41.7m $41.7m 0.03% Reduced -167 -167
30 Rock Springs Capital Management LP 1.19% of their portfolio Baltimore, MD 290,000290.0k $39.6m $39.6m 1.19% Unchanged
31 D. E. Shaw & Co., Inc. 0.05% of their portfolio New York, NY 281,537281.5k $38.4m $38.4m 0.05% Reduced -58.6k -58,581
32 SEI INVESTMENTS CO 0.05% of their portfolio OAKS, PA 264,571264.6k $36.1m $36.1m 0.05% Reduced -81.6k -81,615
33 TWO SIGMA INVESTMENTS, LP 0.08% of their portfolio NEW YORK, NY 255,320255.3k $34.8m $34.8m 0.08% Added +45.0k +44,995
34 ARS Investment Partners, LLC 3.30% of their portfolio New York, NY 253,139253.1k $34.5m $34.5m 3.30% Reduced -1.8k -1,828
35 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 246,961247.0k $33.7m $33.7m 0.00% Reduced -17.5k -17,484
36 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 1.47% of their portfolio Boston, MA 233,673233.7k $31.9m $31.9m 1.47% Added +8.6k +8,562
37 Tri Locum Partners LP 7.85% of their portfolio NEW YORK, NY 227,762227.8k $31.1m $31.1m 7.85% Added +115.1k +115,092
38 Q Global Advisors, LLC 21.23% of their portfolio FORT WORTH, TX 219,459219.5k $29.9m $29.9m 21.23% Reduced -65.5k -65,541
39 TWO SIGMA ADVISERS, LP 0.06% of their portfolio NEW YORK, NY 202,000202.0k $27.5m $27.5m 0.06% Added +38.6k +38,600
40 NEW YORK STATE COMMON RETIREMENT FUND 0.04% of their portfolio ALBANY, NY 199,401199.4k $27.2m $27.2m 0.04% Added +3.3k +3,322
41 Woodline Partners LP 0.26% of their portfolio San Francisco, CA 198,766198.8k $27.1m $27.1m 0.26% Added +2.7k +2,736
42 Candriam S.C.A. 0.16% of their portfolio STRASSEN, N4 195,347195.3k $26.6m $26.6m 0.16% Added +96.0k +95,972
43 Finepoint Capital LP 7.33% of their portfolio BOSTON, MA 189,272189.3k $25.8m $25.8m 7.33% Added +13.6k +13,600
44 First Turn Management, LLC 4.14% of their portfolio DEL MAR, CA 186,581186.6k $25.4m $25.4m 4.14% Added +35.0k +34,994
45 DEUTSCHE BANK AG\ 0.01% of their portfolio FRANKFURT AM MAIN, 2M 181,029181.0k $24.7m $24.7m 0.01% Reduced -80.0k -80,000
46 Allspring Global Investments Holdings, LLC 0.04% of their portfolio CHARLOTTE, NC 179,252179.3k $24.4m $24.4m 0.04% Reduced -10.0k -9,956
47 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 166,969167.0k $22.8m $22.8m 0.00% Reduced -289.2k -289,187
48 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.06% of their portfolio Paris, I0 163,110163.1k $22.2m $22.2m 0.06% Added +76.9k +76,908
49 Aberdeen Group plc 0.04% of their portfolio EDINBURGH, X0 160,602160.6k $21.9m $21.9m 0.04% Added +21.8k +21,811
50 RICE HALL JAMES & ASSOCIATES, LLC 1.24% of their portfolio San Diego, CA 151,656151.7k $20.7m $20.7m 1.24% Reduced -10.8k -10,756
51 Pictet Asset Management Holding SA 0.02% of their portfolio CAROUGE, V8 146,327146.3k $20.0m $20.0m 0.02% Reduced -124.4k -124,443
52 ACADIAN ASSET MANAGEMENT LLC 0.06% of their portfolio Boston, MA 142,165142.2k $19.4m $19.4m 0.06% Reduced -108.3k -108,327
53 VICTORY CAPITAL MANAGEMENT INC 0.02% of their portfolio San Antonio, TX 134,409134.4k $18.3m $18.3m 0.02% Reduced -155 -155
54 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 130,524130.5k $17.8m $17.8m 0.00% Added +74.5k +74,512
55 BNP PARIBAS FINANCIAL MARKETS 0.02% of their portfolio PARIS, I0 128,074128.1k $17.5m $17.5m 0.02% Added +52.5k +52,534
56 LOOMIS SAYLES & CO L P 0.02% of their portfolio BOSTON, MA 121,594121.6k $16.6m $16.6m 0.02% New
57 Saturn V Capital Management LP 5.83% of their portfolio AUSTIN, TX 113,224113.2k $15.4m $15.4m 5.83% Added +9.8k +9,796
58 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 110,641110.6k $15.1m $15.1m 0.00% Reduced -40.3k -40,303
59 BIT Capital GmbH 1.29% of their portfolio BERLIN, 2M 104,638104.6k $14.3m $14.3m 1.29% Reduced -5.0k -5,000
60 Artal Group S.A. 0.35% of their portfolio LUXEMBOURG, N4 101,100101.1k $13.8m $13.8m 0.35% New
61 SOROS FUND MANAGEMENT LLC 0.31% of their portfolio NEW YORK, NY 100,000100.0k $13.6m $13.6m 0.31% Added +96.6k +96,568
62 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 99,94699.9k $13.6m $13.6m 0.01% Reduced -136.9k -136,924
63 Schonfeld Strategic Advisors LLC 0.10% of their portfolio NEW YORK, NY 98,14198.1k $13.4m $13.4m 0.10% Reduced -3.9k -3,859
64 Ghost Tree Capital, LLC 4.12% of their portfolio NEW YORK, NY 86,72186.7k $11.8m $11.8m 4.12% New
65 Driehaus Capital Management LLC 0.11% of their portfolio Chicago, IL 81,39681.4k $11.1m $11.1m 0.11% Reduced -18.9k -18,924
66 DAFNA Capital Management LLC 2.64% of their portfolio LOS ANGELES, CA 80,97281.0k $11.0m $11.0m 2.64% Reduced -11.5k -11,500
67 Thrivent Financial for Lutherans 0.02% of their portfolio Minneapolis, MN 78,24578.2k $10.7m $10.7m 0.02% Reduced -36.2k -36,156
68 BAILLIE GIFFORD & CO 0.01% of their portfolio EDINBURGH, X0 71,07171.1k $9.7m $9.7m 0.01% Reduced -10.1k -10,135
69 Alyeska Investment Group, L.P. 0.05% of their portfolio CHICAGO, IL 60,00060.0k $8.2m $8.2m 0.05% New
70 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 57,78657.8k $7.9m $7.9m 0.00% Added +1.7k +1,684
71 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 54,74854.7k $7.5m $7.5m 0.01% New
72 HARBOR CAPITAL ADVISORS, INC. 0.54% of their portfolio CHICAGO, IL 52,20052.2k $7.1m $7.1m 0.54% Added +30.2k +30,194
73 Gray Foundation 2.16% of their portfolio Cohoes, NY 51,70051.7k $7.1m $7.1m 2.16% Unchanged
74 ADAR1 Capital Management, LLC 1.41% of their portfolio AUSTIN, TX 51,26351.3k $7.0m $7.0m 1.41% Added +2.7k +2,679
75 Altium Capital Management LLC 2.82% of their portfolio NEW YORK, NY 50,00050.0k $6.8m $6.8m 2.82% Added +25.0k +25,000
76 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio Toronto, A6 47,71247.7k $6.5m $6.5m 0.01% Reduced -6.8k -6,814
77 Resolute Capital Asset Partners LLC 3.69% of their portfolio DENVER, CO 47,00047.0k $6.4m $6.4m 3.69% Unchanged
78 SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio London, X0 44,91844.9k $6.1m $6.1m 0.01% New
79 First Light Asset Management, LLC 0.43% of their portfolio Edina, MN 36,15736.2k $4.9m $4.9m 0.43% New
80 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 35,05735.1k $4.8m $4.8m 0.00% Added +705 +705
81 Matisse Capital 2.34% of their portfolio PORTLAND, OR 34,72934.7k $4.7m $4.7m 2.34% Reduced -811 -811
82 TUDOR INVESTMENT CORP ET AL 0.05% of their portfolio STAMFORD, CT 33,37533.4k $4.6m $4.6m 0.05% New
83 T. Rowe Price Investment Management, Inc. 0.00% of their portfolio BALTIMORE, MD 30,56430.6k $4.2m $4.2m 0.00% Reduced -2.5m -2,538,339
84 NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio NEW YORK, NY 30,29630.3k $4.1m $4.1m 0.00% New
85 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 30,28930.3k $4.1m $4.1m 0.01% Added +5.2k +5,205
86 DekaBank Deutsche Girozentrale 0.01% of their portfolio FRANKFURT, 2M 30,00030.0k $4.1m $4.1m 0.01% Unchanged
87 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 25,28125.3k $3.4m $3.4m 0.00% Added +5.3k +5,305
88 Evolutionary Tree Capital Management, LLC 3.49% of their portfolio ALEXANDRIA, VA 24,86224.9k $3.4m $3.4m 3.49% Added +11.2k +11,223
89 Henry James International Management Inc. 1.18% of their portfolio NEW YORK, NY 24,49724.5k $3.3m $3.3m 1.18% Reduced -24 -24
90 Trexquant Investment LP 0.05% of their portfolio STAMFORD, CT 23,69723.7k $3.2m $3.2m 0.05% Added +3.4k +3,408
91 Nicholas Investment Partners, LP 0.33% of their portfolio RANCHO SANTA FE, CA 23,21623.2k $3.2m $3.2m 0.33% Added +5.2k +5,232
92 Lighthouse Investment Partners, LLC 0.15% of their portfolio Palm Beach Gardens, FL 20,25020.2k $2.8m $2.8m 0.15% New
93 Exome Asset Management LLC 2.43% of their portfolio NEW YORK, NY 20,00020.0k $2.7m $2.7m 2.43% New
94 Cinctive Capital Management LP 0.14% of their portfolio New York, NY 19,35019.4k $2.6m $2.6m 0.14% Reduced -29.0k -29,033
95 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 19,00419.0k $2.6m $2.6m 0.00% Reduced -2.1k -2,068
96 Erste Asset Management GmbH 0.03% of their portfolio VIENNA, C4 18,50018.5k $2.5m $2.5m 0.03% Unchanged
97 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 17,65517.7k $2.4m $2.4m 0.00% Reduced -1.9k -1,925
98 Campbell & CO Investment Adviser LLC 0.20% of their portfolio BALTIMORE, MD 17,26017.3k $2.4m $2.4m 0.20% New
99 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 16,26116.3k $2.2m $2.2m 0.00% Reduced -4.1k -4,133
100 UBS Group AG 0.00% of their portfolio ZURICH, V8 15,92115.9k $2.2m $2.2m 0.00% Reduced -11.8k -11,834