BICYCLE THERAPEUTICS PLC BCYC
SPONSORED ADS · ADR · CUSIP 088786108 · ISIN US0887861088
Company in Cambridge, United Kingdom
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCambridge, United Kingdom
- Founded2009
- Websitebicycletherapeutics.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.2m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $20.24. Options: 4 managers hold calls ($187.9k notional), 4 hold puts ($255.0k).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 80 |
| Q4 2022 | 87 |
| Q1 2023 | 90 |
| Q2 2023 | 86 |
| Q3 2023 | 102 |
| Q4 2023 | 102 |
| Q1 2024 | 96 |
| Q2 2024 | 108 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 32 | 43 |
| Q1 2023 | 53 | 29 |
| Q2 2023 | 39 | 41 |
| Q3 2023 | 58 | 31 |
| Q4 2023 | 54 | 51 |
| Q1 2024 | 40 | 49 |
| Q2 2024 | 60 | 39 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $2.0m | $3.8m | 1.89 |
| Q4 2023 | $3.0m | $3.2m | 1.06 |
| Q1 2024 | $599.9k | $340.6k | 0.57 |
| Q2 2024 | $187.9k | $255.0k | 1.36 |
Biggest buyers
| BAKER BROS. ADVISORS LP | Added | +4.5m |
| FCPM III SERVICES B.V. | New | +2.1m |
| RA CAPITAL MANAGEMENT, L.P. | Added | +1.5m |
| Fairmount Funds Management LLC | New | +1.1m |
| EcoR1 Capital, LLC | New | +910.0k |
| Avoro Capital Advisors LLC | New | +700.0k |
| Woodline Partners LP | New | +586.6k |
| PERCEPTIVE ADVISORS LLC | New | +572.0k |
| AXA S.A. | Added | +554.5k |
| WESTFIELD CAPITAL MANAGEMENT CO LP | Added | +484.9k |
Biggest sellers
| MORGAN STANLEY | Reduced | -3.3m |
| Paradigm Biocapital Advisors LP | Sold out | -3.2m |
| MONTANOVA CAPITAL, LLC | Sold out | -914.5k |
| Point72 Asset Management, L.P. | Reduced | -284.1k |
| Schonfeld Strategic Advisors LLC | Reduced | -263.4k |
| BlackRock Inc. | Reduced | -172.8k |
| Candriam S.C.A. | Reduced | -130.1k |
| Soleus Capital Management, L.P. | Reduced | -129.5k |
| Trexquant Investment LP | Sold out | -92.6k |
| Verition Fund Management LLC | Reduced | -74.1k |
Biggest calls
| SIMPLEX TRADING, LLC | Added | $109.0k5.4k shares |
| CITADEL ADVISORS LLC | Reduced | $68.8k3.4k shares |
| GROUP ONE TRADING LLC | Added | $10.1k500 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $200.4k9.9k shares |
| CITADEL ADVISORS LLC | Reduced | $50.6k2.5k shares |
| SIMPLEX TRADING, LLC | Added | $4.0k200 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Forbion Growth Opportunities Fund II Cooperatief U.A. 13G · passive investor new · filed 2024-12-19 | 7.3% |
| ARMISTICE CAPITAL, LLC 13G · institution no change · filed 2026-08-14 | 6.7% |
| Long Focus Capital Management, LLC 13G · institution new · filed 2026-05-15 | 6.6% |
Fell to 5% or below in the last year: Invus Global Management, LLC (3.1%, 2026-05-04), WESTFIELD CAPITAL MANAGEMENT CO LP (0.0%, 2026-03-04)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 7 | $332.2k | — |
| Q2 2023 | 0 | — | 6 | $55.5k | — |
| Q3 2023 | 0 | — | 6 | $58.9k | — |
| Q4 2023 | 0 | — | 6 | $44.8k | — |
| Q1 2024 | 0 | — | 6 | $255.3k | — |
| Q2 2024 | 0 | — | 7 | $126.1k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-04-11 | Hannay Michael Charles Ferguson CHIEF PROD & SUPPLY CHAIN OFF | Sold | $5.8k257 shares |
| 2024-04-03 | Lee Kevin CHIEF EXECUTIVE OFFICER, director | Sold | $75.2k3.2k shares |
| 2024-04-03 | Crockett Nigel CHIEF BUSINESS OFFICER | Sold | $22.7k955 shares |
| 2024-04-03 | Milnes Alistair CHIEF OPERATING OFFICER | Sold | $22.7k955 shares |
| 2024-04-03 | Skynner Michael CHIEF TECHNOLOGY OFFICER | Sold | $22.7k955 shares |
| 2024-04-03 | Keen Nicholas CHIEF SCIENTIFIC OFFICER | Sold | $18.8k790 shares |
| 2024-04-03 | Thompson Travis Alvin CHIEF ACCOUNTING OFFICER | Sold | $3.6k152 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| BAKER BROS. ADVISORS LP 2.43% of their portfolio | 9.4m $190.3m | Added +4.5m |
| Deep Track Capital, LP 2.11% of their portfolio | 3.5m $70.6m | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. 0.60% of their portfolio | 2.3m $45.6m | Added +1.5m |
| FCPM III SERVICES B.V. 6.34% of their portfolio | 2.1m $43.0m | New |
| ARMISTICE CAPITAL, LLC 1.04% of their portfolio | 2.0m $39.9m | Added +300.0k |
| WESTFIELD CAPITAL MANAGEMENT CO LP 0.15% of their portfolio | 1.5m $30.8m | Added +484.9k |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD 6.21% of their portfolio | 1.5m $30.6m | Reduced -35.3k |
| First Light Asset Management, LLC 2.46% of their portfolio | 1.4m $28.0m | Added +191.7k |
| MORGAN STANLEY 0.00% of their portfolio | 1.2m $24.9m | Reduced -3.3m |
| AXA S.A. 0.03% of their portfolio | 1.1m $22.4m | Added +554.5k |
| Fairmount Funds Management LLC 2.44% of their portfolio | 1.1m $21.6m | New |
| Polar Capital Holdings Plc 0.12% of their portfolio | 1.0m $20.3m | Unchanged |
| Camber Capital Management LP 0.71% of their portfolio | 915.0k $18.5m | Added +465.0k |
| EcoR1 Capital, LLC 0.56% of their portfolio | 910.0k $18.4m | New |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.05% of their portfolio | 888.1k $18.0m | Added +5.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 798.5k $16.2m | Added +396.9k |
| Candriam S.C.A. 0.09% of their portfolio | 759.2k $15.4m | Reduced -130.1k |
| Avoro Capital Advisors LLC 0.19% of their portfolio | 700.0k $14.2m | New |
| Woodline Partners LP 0.11% of their portfolio | 586.6k $11.9m | New |
| PERCEPTIVE ADVISORS LLC 0.28% of their portfolio | 572.0k $11.6m | New |
| Parkman Healthcare Partners LLC 1.48% of their portfolio | 535.1k $10.8m | Added +10.8k |
| BlackRock Inc. 0.00% of their portfolio | 402.2k $8.1m | Reduced -172.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 383.8k $7.8m | Reduced -13.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 326.8k $6.6m | Added +161.1k |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.24% of their portfolio | 293.4k $5.9m | Reduced -39.6k |
| Verition Fund Management LLC 0.04% of their portfolio | 266.7k $5.4m | Reduced -74.1k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.11% of their portfolio | 264.0k $5.3m | Added +11.9k |
| Legal & General Group Plc 0.00% of their portfolio | 247.8k $5.0m | Added +114.7k |
| PINNACLE ASSOCIATES LTD 0.08% of their portfolio | 242.0k $4.9m | Added +161.9k |
| Handelsbanken Fonder AB 0.02% of their portfolio | 213.5k $4.3m | Added +33.7k |
| Rubric Capital Management LP 0.11% of their portfolio | 205.4k $4.2m | Unchanged |
| Duquesne Family Office LLC 0.14% of their portfolio | 190.2k $3.9m | Unchanged |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 182.3k $3.7m | Added +122.9k |
| Schonfeld Strategic Advisors LLC 0.02% of their portfolio | 157.4k $3.2m | Reduced -263.4k |
| Aquilo Capital Management, LLC 3.06% of their portfolio | 156.7k $3.2m | New |
| HighVista Strategies LLC 0.94% of their portfolio | 127.3k $2.6m | Reduced -31.0k |
| HHLR ADVISORS, LTD. 0.06% of their portfolio | 125.3k $2.5m | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 124.6k $2.5m | Reduced -12.2k |
| DAFNA Capital Management LLC 0.59% of their portfolio | 122.2k $2.5m | Unchanged |
| COMERICA BANK 0.01% of their portfolio | 110.9k $2.2m | Added +32.2k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 97.4k $2.0m | Added +71.4k |
| TD Asset Management Inc 0.00% of their portfolio | 97.2k $2.0m | Added +42.2k |
| Cubist Systematic Strategies, LLC 0.03% of their portfolio | 96.4k $2.0m | Added +87.0k |
| MARSHALL WACE, LLP 0.00% of their portfolio | 89.0k $1.8m | New |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.05% of their portfolio | 87.1k $1.8m | Added +2.1k |
| AlphaCentric Advisors LLC 0.89% of their portfolio | 60.0k $1.2m | Unchanged |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 58.5k $1.2m | Reduced -284.1k |
| L & S Advisors Inc 0.13% of their portfolio | 58.3k $1.2m | Added +8.1k |
| HARBOR CAPITAL ADVISORS, INC. 0.09% of their portfolio | 55.3k $1.1m | Added +11.8k |
| NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio | 48.7k $988.1k | Unchanged |
| WEXFORD CAPITAL LP 0.23% of their portfolio | 44.9k $908.4k | Added +10.0k |
| Skandinaviska Enskilda Banken AB (publ) 0.00% of their portfolio | 42.7k $866.1k | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 37.5k $759.1k | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 30.9k $625.4k | Reduced -15.7k |
| Allianz Asset Management GmbH 0.00% of their portfolio | 30.6k $619.3k | Unchanged |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 30.0k $582.0k | Unchanged |
| Jump Financial, LLC 0.01% of their portfolio | 29.0k $586.4k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 26.6k $538.0k | Reduced -2.0k |
| STATE STREET CORP 0.00% of their portfolio | 25.9k $523.6k | Unchanged |
| WOODSTOCK CORP 0.05% of their portfolio | 25.0k $505.6k | Unchanged |
| Soleus Capital Management, L.P. 0.04% of their portfolio | 23.5k $475.6k | Reduced -129.5k |
| PEAK6 Investments LLC 0.02% of their portfolio | 22.0k $445.3k | Added +13.0k |
| GILDER GAGNON HOWE & CO LLC 0.01% of their portfolio | 21.7k $438.4k | Added +390 |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 21.4k $432.7k | Unchanged |
| TOCQUEVILLE ASSET MANAGEMENT L.P. 0.01% of their portfolio | 17.4k $352.2k | Reduced -50 |
| Nan Fung Group Holdings Ltd 0.37% of their portfolio | 17.3k $350.2k | New |
| Bellevue Group AG 0.01% of their portfolio | 16.0k $323.8k | Added +3.5k |
| UBS Group AG 0.00% of their portfolio | 15.9k $322.5k | Added +6.0k |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. 0.38% of their portfolio | 15.0k $303.6k | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 14.9k $301.0k | Reduced -5.3k |
| HORIZON KINETICS ASSET MANAGEMENT LLC 0.01% of their portfolio | 14.4k $291.4k | Unchanged |
| Erste Asset Management GmbH 0.00% of their portfolio | 14.0k $283.8k | Unchanged |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 13.9k $281.5k | Reduced -41.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 13.3k $268.9k | Reduced -17.9k |
| NATIXIS ADVISORS, LLC 0.00% of their portfolio | 12.9k $261.0k | New |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 11.0k $222.6k | Added +3.3k |
| Walleye Trading LLC 0.00% of their portfolio | 10.5k $211.9k | Reduced -900 |
| XTX Topco Ltd 0.02% of their portfolio | 10.2k $206.0k | New |
| EXCHANGE TRADED CONCEPTS, LLC 0.00% of their portfolio | 9.5k $191.8k | Reduced -2.9k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 8.1k $163.3k | Unchanged |
| Aquatic Capital Management LLC 0.00% of their portfolio | 5.5k $111.3k | New |
| HighMark Wealth Management LLC 0.05% of their portfolio | 4.4k $89.8k | Unchanged |
| China Universal Asset Management Co., Ltd. 0.01% of their portfolio | 4.2k $85.4k | Reduced -2.6k |
| VIRTUS ADVISERS, LLC 0.04% of their portfolio | 3.7k $75.4k | Reduced -2.0k |
| NATIXIS 0.00% of their portfolio | 2.9k $57.9k | Added +314 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 2.3k $47.5k | Added +1.9k |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 1.3k $25.5k | Reduced -130 |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 1.2k $23.8k | Reduced -7.7k |
| Coppell Advisory Solutions LLC 0.00% of their portfolio | 1.1k $15.0k | First filing |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 1.1k $21.7k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 1.0k $20.8k | Added +388 |
| GAMMA Investing LLC 0.00% of their portfolio | 988 $20.0k | Added +117 |
| CITIGROUP INC 0.00% of their portfolio | 762 $15.4k | Added +634 |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 520 $10.0k | Reduced -9.3k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 463 $9.0k | Added +176 |
| Manchester Capital Management LLC 0.00% of their portfolio | 450 $9.1k | New |
| Blue Trust, Inc. 0.00% of their portfolio | 323 $8.0k | New |
| Winch Advisory Services, LLC 0.00% of their portfolio | 172 $3.5k | New |
| MACROVIEW INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 126 $2.6k | Unchanged |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 103 $2.0k | Unchanged |