Vault-13

CRINETICS PHARMACEUTICALS IN CRNX

COM · Common Stock · CUSIP 22663K107 · ISIN US22663K1079

236 institutional holders +32 vs Q1 2024
83,328,06583.3m shares reported held*
$3.7bnreported value*
46 new 102 added 58 reduced 16 sold out net bought ≈ $23.8m (+515.9k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($14.9m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $44.79. Options: 8 managers hold calls ($13.5m notional), 6 hold puts ($8.8m).

Trends to Q2 2024

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 122Q4 22: 122Q1 23: 130Q2 23: 141Q3 23: 173Q4 23: 182Q1 24: 204Q2 24: 236236Q3 22Q1 23Q3 23Q1 24Q2 24
Numbers
QuarterHolders
Q3 2022122
Q4 2022122
Q1 2023130
Q2 2023141
Q3 2023173
Q4 2023182
Q1 2024204
Q2 2024236

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 55 bought or addedQ4 22: 50 cut or sold outQ4 22Q1 23: 80 bought or addedQ1 23: 40 cut or sold outQ2 23: 82 bought or addedQ2 23: 50 cut or sold outQ2 23Q3 23: 132 bought or addedQ3 23: 47 cut or sold outQ4 23: 102 bought or addedQ4 23: 82 cut or sold outQ4 23Q1 24: 128 bought or addedQ1 24: 82 cut or sold outQ2 24: 148 bought or addedQ2 24: 74 cut or sold outQ2 24
Numbers
QuarterBought or addedCut or sold out
Q4 20225550
Q1 20238040
Q2 20238250
Q3 202313247
Q4 202310282
Q1 202412882
Q2 202414874

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$10m$20m$30m$40mQ3 23 calls: $31.7mQ3 23 puts: $33.7mQ3 23P/C 1.06Q4 23 calls: $23.7mQ4 23 puts: $12.6mQ4 23P/C 0.53Q1 24 calls: $34.1mQ1 24 puts: $28.1mQ1 24P/C 0.82Q2 24 calls: $13.5mQ2 24 puts: $8.8mQ2 24P/C 0.65
Numbers
QuarterCallsPutsP/C
Q3 2023$31.7m$33.7m1.06
Q4 2023$23.7m$12.6m0.53
Q1 2024$34.1m$28.1m0.82
Q2 2024$13.5m$8.8m0.65

Biggest buyers

WELLINGTON MANAGEMENT GROUP LLP Added +1,648,831+1.6m
VANGUARD GROUP INC Added +939,402+939.4k
Driehaus Capital Management LLC Added +885,876+885.9k
BlackRock Inc. Added +794,267+794.3k
PRICE T ROWE ASSOCIATES INC /MD/ Added +583,238+583.2k
Schonfeld Strategic Advisors LLC Added +518,264+518.3k
FARALLON CAPITAL MANAGEMENT, L.L.C. Added +492,000+492.0k
JANUS HENDERSON GROUP PLC Added +477,489+477.5k
FRANKLIN RESOURCES INC Added +448,213+448.2k
Hood River Capital Management LLC New +410,342+410.3k

Biggest sellers

Point72 Asset Management, L.P. Reduced -2,168,630-2.2m
T. Rowe Price Investment Management, Inc. Reduced -1,307,519-1.3m
MORGAN STANLEY Reduced -997,975-998.0k
Paradigm Biocapital Advisors LP Reduced -611,447-611.4k
First Light Asset Management, LLC Reduced -489,669-489.7k
STATE STREET CORP Reduced -442,330-442.3k
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -431,085-431.1k
FMR LLC Reduced -366,881-366.9k
Vivo Capital, LLC Sold out -350,000-350.0k
EVENTIDE ASSET MANAGEMENT, LLC Reduced -324,545-324.5k

Biggest calls

Caption Management, LLC Reduced $8.9m199.0k shares
Walleye Capital LLC Added $1.6m34.9k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $1.3m29.0k shares
SIMPLEX TRADING, LLC Reduced $756.0k16.9k shares
JANE STREET GROUP, LLC Added $685.3k15.3k shares
CITADEL ADVISORS LLC Reduced $228.4k5.1k shares
GROUP ONE TRADING LLC Reduced $44.8k1.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

Jefferies Financial Group Inc. New $6.7m150.0k shares
Walleye Capital LLC Added $1.5m34.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $394.2k8.8k shares
CITADEL ADVISORS LLC Reduced $156.8k3.5k shares
SIMPLEX TRADING, LLC Reduced $8.0k200 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-03 8.5% 9.0m≈ $336.4m 2026-08-03
Farallon Capital Partners, L.P. 13G · passive investor +2.5 pts · filed 2026-02-05 8.5% +2.5 pts 8.0m≈ $300.3m 2026-02-05
WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.0 pts · filed 2026-08-13 6.8% -1.0 pts 7.1m≈ $266.8m 2026-08-13
DRIEHAUS CAPITAL MANAGEMENT LLC 13G · institution filed 2026-05-15 6.1% 6.4m≈ $239.3m 2026-05-15
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 5.2% new 5.4m≈ $203.6m 2026-04-29
PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution filed 2026-05-15 5.1% 5.4m≈ $200.4m 2026-05-15

Fell to 5% or below in the last year: FMR LLC (1.4%, 2026-08-07), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)

Holders, Q2 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 BlackRock Inc. 0.01% of their portfolio New York, NY 6,230,3716.2m $279.1m $279.1m 0.01% Added +794.3k +794,267
2 Driehaus Capital Management LLC 2.65% of their portfolio Chicago, IL 6,112,1736.1m $273.8m $273.8m 2.65% Added +885.9k +885,876
3 WELLINGTON MANAGEMENT GROUP LLP 0.04% of their portfolio Boston, MA 4,620,4134.6m $206.9m $206.9m 0.04% Added +1.6m +1,648,831
4 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 4,514,4784.5m $202.2m $202.2m 0.00% Added +939.4k +939,402
5 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 4,406,4564.4m $197.4m $197.4m 0.02% Added +583.2k +583,238
6 EcoR1 Capital, LLC 5.69% of their portfolio San Francisco, CA 4,155,3754.2m $186.1m $186.1m 5.69% Unchanged
7 FMR LLC 0.01% of their portfolio BOSTON, MA 4,096,7954.1m $183.5m $183.5m 0.01% Reduced -366.9k -366,881
8 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 2,812,9232.8m $126.0m $126.0m 0.01% Reduced -442.3k -442,330
9 Point72 Asset Management, L.P. 0.40% of their portfolio STAMFORD, CT 2,780,8562.8m $124.6m $124.6m 0.40% Reduced -2.2m -2,168,630
10 JENNISON ASSOCIATES LLC 0.08% of their portfolio NEW YORK, NY 2,780,1442.8m $124.5m $124.5m 0.08% Reduced -37.7k -37,710
11 Paradigm Biocapital Advisors LP 4.31% of their portfolio NEW YORK, NY 2,513,3022.5m $112.6m $112.6m 4.31% Reduced -611.4k -611,447
12 JANUS HENDERSON GROUP PLC 0.06% of their portfolio LONDON, X0 2,455,6612.5m $110.0m $110.0m 0.06% Added +477.5k +477,489
13 LORD, ABBETT & CO. LLC 0.13% of their portfolio JERSEY CITY, NJ 1,775,8421.8m $79.5m $79.5m 0.13% Reduced -153.3k -153,294
14 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 1,678,3871.7m $75.2m $75.2m 0.01% Added +277.0k +276,984
15 PERCEPTIVE ADVISORS LLC 1.60% of their portfolio NEW YORK, NY 1,476,2031.5m $66.1m $66.1m 1.60% Unchanged
16 Cormorant Asset Management, LP 3.52% of their portfolio BOSTON, MA 1,350,0001.4m $60.5m $60.5m 3.52% Added +200.0k +200,000
17 T. Rowe Price Investment Management, Inc. 0.04% of their portfolio BALTIMORE, MD 1,347,2101.3m $60.3m $60.3m 0.04% Reduced -1.3m -1,307,519
18 ORBIMED ADVISORS LLC 1.14% of their portfolio New York, NY 1,280,8001.3m $57.4m $57.4m 1.14% Reduced -104.2k -104,200
19 First Light Asset Management, LLC 4.71% of their portfolio Edina, MN 1,200,5081.2m $53.8m $53.8m 4.71% Reduced -489.7k -489,669
20 Artal Group S.A. 1.23% of their portfolio LUXEMBOURG, N4 1,066,0641.1m $47.7m $47.7m 1.23% Reduced -324.4k -324,413
21 NOVO HOLDINGS A/S 2.41% of their portfolio HELLERUP, G7 1,000,0001.0m $44.8m $44.8m 2.41% Reduced -98.6k -98,600
22 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 861,422861.4k $38.6m $38.6m 0.01% Added +448.2k +448,213
23 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 838,625838.6k $37.6m $37.6m 0.00% Reduced -998.0k -997,975
24 EVENTIDE ASSET MANAGEMENT, LLC 0.56% of their portfolio Boston, MA 735,088735.1k $32.9m $32.9m 0.56% Reduced -324.5k -324,545
25 Schonfeld Strategic Advisors LLC 0.23% of their portfolio NEW YORK, NY 653,557653.6k $29.3m $29.3m 0.23% Added +518.3k +518,264
26 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 649,190649.2k $29.1m $29.1m 0.01% Reduced -214.9k -214,917
27 Ensign Peak Advisors, Inc 0.05% of their portfolio SALT LAKE CITY, UT 616,227616.2k $27.6m $27.6m 0.05% Reduced -5.3k -5,280
28 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 606,037606.0k $27.1m $27.1m 0.00% Added +4.7k +4,653
29 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 597,049597.0k $26.7m $26.7m 0.01% Added +118.5k +118,517
30 Ikarian Capital, LLC 8.23% of their portfolio DALLAS, TX 588,818588.8k $26.4m $26.4m 8.23% Reduced -54.9k -54,933
31 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 570,124570.1k $25.5m $25.5m 0.00% Reduced -181.8k -181,848
32 MPM BIOIMPACT LLC 3.88% of their portfolio BOSTON, MA 557,184557.2k $25.0m $25.0m 3.88% Added +76.6k +76,596
33 STEMPOINT CAPITAL LP 7.26% of their portfolio NEW YORK, NY 551,095551.1k $24.7m $24.7m 7.26% Reduced -68.7k -68,694
34 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 546,759546.8k $24.5m $24.5m 0.01% Reduced -94.0k -94,043
35 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.06% of their portfolio Paris, I0 546,234546.2k $24.5m $24.5m 0.06% Added +3.5k +3,526
36 Affinity Asset Advisors, LLC 3.63% of their portfolio NEW YORK, NY 515,000515.0k $23.1m $23.1m 3.63% Added +45.0k +45,000
37 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.13% of their portfolio SAN FRANCISCO, CA 497,000497.0k $22.3m $22.3m 0.13% Added +492.0k +492,000
38 Fiera Capital Corp 0.07% of their portfolio MONTREAL, A8 480,409480.4k $21.5m $21.5m 0.07% Added +4.9k +4,899
39 Saturn V Capital Management LP 8.12% of their portfolio AUSTIN, TX 479,681479.7k $21.5m $21.5m 8.12% Reduced -180.5k -180,462
40 Nuveen Asset Management, LLC 0.01% of their portfolio CHICAGO, IL 462,766462.8k $20.7m $20.7m 0.01% Reduced -91.0k -90,973
41 Fisher Asset Management, LLC 0.01% of their portfolio PLANO, TX 444,670444.7k $19.9m $19.9m 0.01% Added +8.6k +8,647
42 Hood River Capital Management LLC 0.38% of their portfolio PALM BEACH GARDENS, FL 410,342410.3k $18.4m $18.4m 0.38% New
43 Integral Health Asset Management, LLC 1.78% of their portfolio New York, NY 400,000400.0k $17.9m $17.9m 1.78% Added +75.0k +75,000
44 Qube Research & Technologies Ltd 0.03% of their portfolio LONDON, X0 390,941390.9k $17.5m $17.5m 0.03% Added +296.1k +296,074
45 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 386,450386.4k $17.3m $17.3m 0.00% Added +90.0k +89,972
46 GW&K Investment Management, LLC 0.15% of their portfolio BOSTON, MA 377,663377.7k $16.9m $16.9m 0.15% Reduced -10.4k -10,403
47 First Turn Management, LLC 2.69% of their portfolio DEL MAR, CA 369,302369.3k $16.5m $16.5m 2.69% New
48 Laurion Capital Management LP 0.51% of their portfolio NEW YORK, NY 350,766350.8k $15.7m $15.7m 0.51% Reduced -279.4k -279,416
49 Walleye Capital LLC 0.15% of their portfolio NEW YORK, NY 315,220315.2k $14.1m $14.1m 0.15% Added +73.9k +73,858
50 Duquesne Family Office LLC 0.49% of their portfolio New York, NY 309,000309.0k $13.8m $13.8m 0.49% Unchanged
51 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 305,169305.2k $13.7m $13.7m 0.00% Reduced -52.0k -51,973
52 Pictet Asset Management Holding SA 0.02% of their portfolio CAROUGE, V8 300,868300.9k $13.5m $13.5m 0.02% Added +291.5k +291,501
53 Rock Springs Capital Management LP 0.39% of their portfolio Baltimore, MD 289,400289.4k $13.0m $13.0m 0.39% Unchanged
54 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 260,980261.0k $11.7m $11.7m 0.00% Added +49.2k +49,160
55 Ghost Tree Capital, LLC 3.74% of their portfolio NEW YORK, NY 240,000240.0k $10.7m $10.7m 3.74% Added +40.0k +40,000
56 VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio ATLANTA, GA 236,773236.8k $10.6m $10.6m 0.01% Added +187.5k +187,515
57 VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio San Antonio, TX 226,687226.7k $10.2m $10.2m 0.01% Reduced -30.5k -30,458
58 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 204,998205.0k $9.2m $9.2m 0.01% Reduced -30.2k -30,200
59 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 203,889203.9k $9.1m $9.1m 0.00% Added +134.3k +134,282
60 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio Boston, MA 201,048201.0k $9.0m $9.0m 0.02% Reduced -431.1k -431,085
61 FIRST TRUST ADVISORS LP 0.01% of their portfolio Wheaton, IL 196,961197.0k $8.8m $8.8m 0.01% Added +95.2k +95,224
62 PRUDENTIAL FINANCIAL INC 0.01% of their portfolio NEWARK, NJ 185,755185.8k $8.3m $8.3m 0.01% Added +41.1k +41,121
63 UBS Group AG 0.00% of their portfolio ZURICH, V8 182,942182.9k $8.2m $8.2m 0.00% Reduced -64.9k -64,861
64 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 181,599181.6k $8.1m $8.1m 0.00% Added +4.7k +4,656
65 NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio ALBANY, NY 166,742166.7k $7.5m $7.5m 0.01% Added +14.2k +14,250
66 MAPLELANE CAPITAL, LLC 0.54% of their portfolio New York, NY 160,000160.0k $7.2m $7.2m 0.54% New
67 Decheng Capital LLC 2.17% of their portfolio MENLO PARK, CA 157,958158.0k $7.1m $7.1m 2.17% Unchanged
68 BOOTHBAY FUND MANAGEMENT, LLC 0.21% of their portfolio NEW YORK, NY 150,924150.9k $6.8m $6.8m 0.21% Reduced -11.6k -11,602
69 Moody Aldrich Partners LLC 1.31% of their portfolio MARBLEHEAD, MA 150,183150.2k $6.7m $6.7m 1.31% Added +93.8k +93,781
70 Parkman Healthcare Partners LLC 0.86% of their portfolio STAMFORD, CT 141,375141.4k $6.3m $6.3m 0.86% Added +40.3k +40,256
71 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 141,204141.2k $6.3m $6.3m 0.01% New
72 New Leaf Venture Partners, L.L.C. 7.68% of their portfolio New York, NY 141,000141.0k $6.3m $6.3m 7.68% Unchanged
73 ACUTA CAPITAL PARTNERS, LLC 5.10% of their portfolio REDWOOD CITY, CA 135,141135.1k $6.1m $6.1m 5.10% Added +56.7k +56,738
74 Senator Investment Group LP 0.29% of their portfolio New York, NY 135,000135.0k $6.0m $6.0m 0.29% Not comparable
75 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio Toronto, A6 131,063131.1k $5.9m $5.9m 0.01% Added +23.4k +23,398
76 Swiss National Bank 0.00% of their portfolio ZURICH, V8 130,300130.3k $5.8m $5.8m 0.00% Added +3.8k +3,800
77 Man Group plc 0.01% of their portfolio LONDON, X0 125,714125.7k $5.6m $5.6m 0.01% New
78 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 121,879121.9k $5.5m $5.5m 0.01% Reduced -49.5k -49,545
79 JANE STREET GROUP, LLC 0.01% of their portfolio NEW YORK, NY 119,880119.9k $5.4m $5.4m 0.01% Added +83.0k +82,956
80 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 118,354118.4k $5.3m $5.3m 0.00% Added +43.5k +43,459
81 ExodusPoint Capital Management, LP 0.06% of their portfolio NEW YORK, NY 116,322116.3k $5.2m $5.2m 0.06% Added +87.2k +87,203
82 Balyasny Asset Management L.P. 0.01% of their portfolio Chicago, IL 114,637114.6k $5.1m $5.1m 0.01% New
83 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 112,319112.3k $5.0m $5.0m 0.00% Added +3.6k +3,626
84 Rafferty Asset Management, LLC 0.02% of their portfolio New York, NY 112,169112.2k $5.0m $5.0m 0.02% Reduced -104.7k -104,680
85 Pier Capital, LLC 0.72% of their portfolio STAMFORD, CT 108,545108.5k $4.9m $4.9m 0.72% Reduced -8.0k -8,025
86 BAKER BROS. ADVISORS LP 0.06% of their portfolio NEW YORK, NY 103,927103.9k $4.7m $4.7m 0.06% New
87 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 102,394102.4k $4.6m $4.6m 0.01% Added +51.1k +51,060
88 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 92,53092.5k $4.1m $4.1m 0.00% Added +25.3k +25,260
89 Artia Global Partners LP 0.99% of their portfolio MIAMI, FL 85,76585.8k $3.8m $3.8m 0.99% Unchanged
90 Lisanti Capital Growth, LLC 0.90% of their portfolio NEW YORK, NY 83,38083.4k $3.7m $3.7m 0.90% Added +14.2k +14,155
91 SG Americas Securities, LLC 0.02% of their portfolio NEW YORK, NY 79,05179.1k $3.5m $3.5m 0.02% Added +73.1k +73,084
92 Jefferies Financial Group Inc. 0.07% of their portfolio NEW YORK, NY 77,50077.5k $3.5m $3.5m 0.07% Added +72.5k +72,480
93 ADAR1 Capital Management, LLC 0.68% of their portfolio AUSTIN, TX 74,85074.8k $3.4m $3.4m 0.68% New
94 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 72,92072.9k $3.3m $3.3m 0.00% Added +4.1k +4,080
95 Legal & General Group Plc 0.00% of their portfolio London, X0 68,75868.8k $3.1m $3.1m 0.00% Added +4.8k +4,806
96 Aberdeen Group plc 0.01% of their portfolio EDINBURGH, X0 66,19666.2k $3.0m $3.0m 0.01% Reduced -35.0k -35,000
97 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 65,53665.5k $2.9m $2.9m 0.00% Added +1.2k +1,244
98 ALPS ADVISORS INC 0.02% of their portfolio Denver, CO 61,52561.5k $2.8m $2.8m 0.02% Added +6.6k +6,556
99 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 60,41660.4k $2.7m $2.7m 0.01% Added +10.3k +10,305
100 Informed Momentum Co LLC 0.42% of their portfolio SOLANA BEACH, CA 57,17957.2k $2.6m $2.6m 0.42% Reduced -49.4k -49,435