Vault-13

SPYRE THERAPEUTICS INC SYRE

COM NEW · Common Stock · CUSIP 00773J202

Business enterprise in United States of America

267 institutional holders +68 vs Q1 2026
95,721,31395.7m shares reported held*
108.6% of all shares outstanding*
$8.5bnreported value*
88 new 104 added 57 reduced 20 sold out net bought ≈ $1.1bn (+12.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($8.5m this quarter). Holder counts are more reliable. Shares outstanding: 88.2m as of 2026-07-28, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $88.89. Options: 7 managers hold calls ($25.6m notional), 6 hold puts ($35.1m).

Trends to Q2 2026

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 23: 28Q4 23: 55Q1 24: 103Q2 24: 109Q3 24: 121Q4 24: 133Q1 25: 131Q2 25: 131Q3 25: 138Q4 25: 154Q1 26: 199Q2 26: 267267Q3 23Q2 24Q1 25Q4 25Q2 26
Numbers
QuarterHolders
Q3 202328
Q4 202355
Q1 2024103
Q2 2024109
Q3 2024121
Q4 2024133
Q1 2025131
Q2 2025131
Q3 2025138
Q4 2025154
Q1 2026199
Q2 2026267

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q3 24: 71 bought or addedQ3 24: 40 cut or sold outQ4 24: 87 bought or addedQ4 24: 42 cut or sold outQ4 24Q1 25: 71 bought or addedQ1 25: 54 cut or sold outQ2 25: 81 bought or addedQ2 25: 43 cut or sold outQ2 25Q3 25: 66 bought or addedQ3 25: 56 cut or sold outQ4 25: 102 bought or addedQ4 25: 41 cut or sold outQ4 25Q1 26: 118 bought or addedQ1 26: 59 cut or sold outQ2 26: 192 bought or addedQ2 26: 77 cut or sold outQ2 26
Numbers
QuarterBought or addedCut or sold out
Q3 20247140
Q4 20248742
Q1 20257154
Q2 20258143
Q3 20256656
Q4 202510241
Q1 202611859
Q2 202619277

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$10m$20m$30m$40mQ3 25 calls: $1.6mQ3 25 puts: $838.0kQ3 25P/C 0.52Q4 25 calls: $14.6mQ4 25 puts: $2.2mQ4 25P/C 0.15Q1 26 calls: $16.4mQ1 26 puts: $1.6mQ1 26P/C 0.10Q2 26 calls: $25.6mQ2 26 puts: $35.1mQ2 26P/C 1.37
Numbers
QuarterCallsPutsP/C
Q3 2025$1.6m$838.0k0.52
Q4 2025$14.6m$2.2m0.15
Q1 2026$16.4m$1.6m0.10
Q2 2026$25.6m$35.1m1.37

Biggest buyers

Paradigm Biocapital Advisors LP Added +1,883,512+1.9m
VANGUARD PORTFOLIO MANAGEMENT LLC Added +1,744,968+1.7m
ADAGE CAPITAL PARTNERS GP, L.L.C. New +1,722,300+1.7m
Capital World Investors Added +1,648,989+1.6m
PRICE T ROWE ASSOCIATES INC /MD/ Added +1,362,125+1.4m
FMR LLC Added +1,245,163+1.2m
GOLDMAN SACHS GROUP INC Added +1,208,121+1.2m
Holocene Advisors, LP New +1,015,170+1.0m
BlackRock, Inc. Added +985,384+985.4k
MARSHALL WACE, LLP Added +852,434+852.4k

Biggest sellers

Fairmount Funds Management LLC Sold out -4,018,101-4.0m
RA CAPITAL MANAGEMENT, L.P. Sold out -1,621,620-1.6m
Commodore Capital LP Reduced -1,065,594-1.1m
BAKER BROS. ADVISORS LP Sold out -1,000,000-1.0m
Caligan Partners LP Sold out -878,127-878.1k
Capital International Investors Reduced -790,933-790.9k
Venrock Adviser, LLC Reduced -700,000-700.0k
WELLINGTON MANAGEMENT GROUP LLP Reduced -243,306-243.3k
STEMPOINT CAPITAL LP Reduced -228,286-228.3k
BOOTHBAY FUND MANAGEMENT, LLC Reduced -186,578-186.6k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $13.8m155.2k shares
CITADEL ADVISORS LLC New $3.9m43.8k shares
JANE STREET GROUP, LLC New $3.7m41.3k shares
Caption Management, LLC Reduced $2.2m25.0k shares
GROUP ONE TRADING LLC New $1.0m11.5k shares
HRT FINANCIAL LP New $887.0k10.0k shares
SIMPLEX TRADING, LLC New $97.7k1.1k shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $16.9m190.4k shares
Caption Management, LLC New $15.4m173.7k shares
JANE STREET GROUP, LLC New $1.9m21.3k shares
CITADEL ADVISORS LLC Reduced $701.4k7.9k shares
SIMPLEX TRADING, LLC New $150.9k1.7k shares
GROUP ONE TRADING LLC Reduced $26.6k300 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Fairmount Funds Management LLC 13D · may seek influence no change · filed 2026-10-09 10.0% no change 10.2m≈ $860.2m 2026-10-09
BlackRock, Inc. 13G · institution filed 2025-07-16 6.6% 4.0m≈ $351.8m 2025-07-16
Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-10-01 5.1% new 4.5m≈ $395.7m 2026-10-01

Fell to 5% or below in the last year: PERCEPTIVE ADVISORS LLC (4.9%, 2026-08-14), RTW INVESTMENTS, LP (4.8%, 2026-08-14), VANGUARD GROUP INC (0.0%, 2026-03-27), TANG CAPITAL MANAGEMENT LLC (2.4%, 2026-02-17)

Insider purchases and sales since 1 Apr 2026

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
505Q4 24: 0 buyingQ4 24: 1 sellingQ1 25: 0 buyingQ1 25: 0 sellingQ1 25Q2 25: 0 buyingQ2 25: 0 sellingQ3 25: 0 buyingQ3 25: 1 sellingQ3 25Q4 25: 0 buyingQ4 25: 1 sellingQ1 26: 0 buyingQ1 26: 2 sellingQ1 26Q2 26: 0 buyingQ2 26: 5 sellingQ3 26: 0 buyingQ3 26: 5 sellingQ3 26
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q4 20240—1$257.2k$257.2k
Q1 20250—0——
Q2 20250—0——
Q3 20250—1$299.6k—
Q4 20250—1$1.5m$1.5m
Q1 20260—2$1.7m$1.7m
Q2 20260—5$420.2m$19.2m
Q3 20260—5$13.3m$13.3m
DateInsiderTradeSharesPrice ValueTheir holding
2026-09-02 Burrows Scott L Chief Financial Officer Sold plan 18,232 $89.35 $1.6m18.2k shares -19%
2026-09-02 King-Jones Heidy Officer Sold plan 400 $90.00 $36.0k400 shares -12%
2026-09-01 King-Jones Heidy Officer Sold plan 27,999 $87.31 $2.4m28.0k shares -91%
2026-09-01 Turtle Cameron Chief Executive Officer, director Sold plan 15,000 $87.29 $1.3m15.0k shares -3%
2026-09-01 Burrows Scott L Chief Financial Officer Sold plan 7,500 $87.31 $654.8k7.5k shares -7%
2026-08-07 Albers Jeffrey W. Director Sold plan 18,000 $104.55 $1.9m18.0k shares -66%
2026-08-07 Albers Jeffrey W. Director Sold plan 5,000 $104.47 $522.4k5.0k shares -100%
2026-08-03 Turtle Cameron Chief Executive Officer, director Sold plan 15,000 $95.51 $1.4m15.0k shares -3%
2026-08-03 Burrows Scott L Chief Financial Officer Sold plan 7,500 $95.57 $716.8k7.5k shares -7%
2026-07-01 Turtle Cameron Chief Executive Officer, director Sold plan 15,000 $87.69 $1.3m15.0k shares -2%
2026-07-01 Sloan Sheldon Chief Medical Officer Sold plan 8,334 $87.70 $730.9k8.3k shares -100%
2026-07-01 Burrows Scott L Chief Financial Officer Sold plan 7,500 $87.74 $658.0k7.5k shares -7%
2026-06-25 Burrows Scott L Chief Financial Officer Sold 15,000 $87.13 $1.3m15.0k shares -13%
2026-06-23 Harwin Peter Evan +3 Director · By Fairmount Healthcare Fund II L.P. Sold 4,684,781 $85.31 $399.7m4.7m shares -100%
2026-06-22 HENDERSON MICHAEL THOMAS Director Sold plan 20,000 $100.00 $2.0m20.0k shares -23%
2026-06-03 Sloan Sheldon Chief Medical Officer Sold plan 8,333 $75.00 $625.0k8.3k shares -100%
2026-06-01 Turtle Cameron Chief Executive Officer, director Sold plan 15,000 $70.43 $1.1m15.0k shares -2%
2026-06-01 Burrows Scott L Chief Financial Officer Sold plan 7,500 $71.06 $532.9k7.5k shares -7%
2026-05-08 HENDERSON MICHAEL THOMAS Director Sold plan 80,000 $74.40 $6.0m80.0k shares -47%
2026-05-01 Sloan Sheldon Chief Medical Officer Sold plan 78,333 $71.50 $5.6m78.3k shares -100%
2026-05-01 Turtle Cameron Chief Executive Officer, director Sold plan 15,000 $71.37 $1.1m15.0k shares -2%
2026-05-01 Burrows Scott L Chief Financial Officer Sold plan 12,500 $71.37 $892.1k12.5k shares -11%
2026-04-01 Turtle Cameron Chief Executive Officer, director Sold plan 15,000 $49.33 $739.9k15.0k shares -2%
2026-04-01 Sloan Sheldon Chief Medical Officer Sold plan 7,958 $50.00 $397.9k8.0k shares -100%
2026-04-01 Burrows Scott L Chief Financial Officer Sold plan 7,500 $49.34 $370.1k7.5k shares -7%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2026

#ManagerLocationShares Value% of their portfolioChangeShares change
1 FMR LLC 0.05% of their portfolio BOSTON, MA 13,026,18713.0m $1.2bn $1.2bn 0.05% Added +1.2m +1,245,163
2 BlackRock, Inc. 0.01% of their portfolio New York, NY 6,506,6056.5m $577.7m $577.7m 0.01% Added +985.4k +985,384
3 PERCEPTIVE ADVISORS LLC 5.95% of their portfolio NEW YORK, NY 4,319,4964.3m $383.5m $383.5m 5.95% Added +536.3k +536,271
4 RTW INVESTMENTS, LP 3.22% of their portfolio NEW YORK, NY 4,251,9964.3m $377.5m $377.5m 3.22% Added +80.0k +80,000
5 Paradigm Biocapital Advisors LP 6.38% of their portfolio NEW YORK, NY 3,840,7783.8m $341.0m $341.0m 6.38% Added +1.9m +1,883,512
6 VANGUARD CAPITAL MANAGEMENT LLC 0.01% of their portfolio MALVERN, PA 3,448,6813.4m $306.2m $306.2m 0.01% Added +391.3k +391,280
7 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 3,057,4163.1m $271.4m $271.4m 0.01% Added +450.4k +450,385
8 Venrock Adviser, LLC 8.04% of their portfolio NEW YORK, NY 2,985,4483.0m $265.0m $265.0m 8.04% Reduced -700.0k -700,000
9 PRICE T ROWE ASSOCIATES INC /MD/ 0.03% of their portfolio BALTIMORE, MD 2,960,8553.0m $262.9m $262.9m 0.03% Added +1.4m +1,362,125
10 Driehaus Capital Management LLC 1.44% of their portfolio Chicago, IL 2,799,1662.8m $248.5m $248.5m 1.44% Added +8.4k +8,381
11 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 2,562,2652.6m $239.3m $239.3m 0.01% Added +841.4k +841,353
12 VANGUARD PORTFOLIO MANAGEMENT LLC 0.01% of their portfolio MALVERN, PA 2,330,0982.3m $206.9m $206.9m 0.01% Added +1.7m +1,744,968
13 Capital World Investors 0.02% of their portfolio LOS ANGELES, CA 2,315,5532.3m $205.6m $205.6m 0.02% Added +1.6m +1,648,989
14 Jupiter Topco LLC 0.08% of their portfolio NEW YORK, NY 2,206,9362.2m $195.9m $195.9m 0.08% First filing
15 TCG Crossover Management, LLC 4.06% of their portfolio PALO ALTO, CA 1,900,5821.9m $168.7m $168.7m 4.06% Unchanged
16 TANG CAPITAL MANAGEMENT LLC 7.63% of their portfolio SAN DIEGO, CA 1,892,2001.9m $168.0m $168.0m 7.63% Unchanged
17 BANK OF AMERICA CORP /DE/ 0.01% of their portfolio CHARLOTTE, NC 1,777,8541.8m $157.8m $157.8m 0.01% Added +549.8k +549,761
18 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.21% of their portfolio Boston, MA 1,722,3001.7m $152.9m $152.9m 0.21% New
19 WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio Boston, MA 1,581,5051.6m $140.4m $140.4m 0.02% Reduced -243.3k -243,306
20 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 1,478,0591.5m $131.2m $131.2m 0.01% Added +1.2m +1,208,121
21 FRANKLIN RESOURCES INC 0.03% of their portfolio San Mateo, CA 1,472,9431.5m $130.8m $130.8m 0.03% Added +590.1k +590,110
22 Remedium Capital Partners, LLC 28.78% of their portfolio WEST PALM BEACH, FL 1,464,1691.5m $130.0m $130.0m 28.78% Added +7.9k +7,938
23 Affinity Asset Advisors, LLC 5.55% of their portfolio NEW YORK, NY 1,279,1341.3m $113.6m $113.6m 5.55% Unchanged
24 JPMORGAN CHASE & CO 0.01% of their portfolio NEW YORK, NY 1,093,0261.1m $98.9m $98.9m 0.01% Added +113.7k +113,727
25 Holocene Advisors, LP 0.21% of their portfolio New York, NY 1,015,1701.0m $90.1m $90.1m 0.21% New
26 MARSHALL WACE, LLP 0.07% of their portfolio LONDON, X0 991,693991.7k $88.0m $88.0m 0.07% Added +852.4k +852,434
27 Polar Capital Holdings Plc 0.25% of their portfolio London, X0 988,009988.0k $87.7m $87.7m 0.25% Added +195.2k +195,162
28 Siren, L.L.C. 1.75% of their portfolio New York, NY 968,598968.6k $86.0m $86.0m 1.75% Added +150.0k +150,000
29 Capital International Investors 0.02% of their portfolio Los Angeles, CA 955,196955.2k $84.8m $84.8m 0.02% Reduced -790.9k -790,933
30 BRAIDWELL LP 2.89% of their portfolio STAMFORD, CT 879,467879.5k $78.1m $78.1m 2.89% Reduced -53.4k -53,356
31 Commodore Capital LP 4.48% of their portfolio NEW YORK, NY 846,786846.8k $75.2m $75.2m 4.48% Reduced -1.1m -1,065,594
32 UBS Group AG 0.01% of their portfolio ZURICH, V8 843,071843.1k $74.8m $74.8m 0.01% Added +171.8k +171,836
33 NORTHERN TRUST CORP 0.01% of their portfolio CHICAGO, IL 674,529674.5k $59.9m $59.9m 0.01% Added +95.6k +95,622
34 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 652,958653.0k $58.0m $58.0m 0.01% Added +90.3k +90,305
35 Pictet Asset Management Holding SA 0.05% of their portfolio CAROUGE, V8 628,138628.1k $55.8m $55.8m 0.05% Added +136.5k +136,489
36 EMERALD ADVISERS, LLC 1.19% of their portfolio LEOLA, PA 567,430567.4k $50.4m $50.4m 1.19% Reduced -45.9k -45,935
37 VICTORY CAPITAL MANAGEMENT INC 0.03% of their portfolio San Antonio, TX 553,980554.0k $49.2m $49.2m 0.03% Added +261.9k +261,854
38 VANGUARD FIDUCIARY TRUST CO 0.01% of their portfolio MALVERN, PA 551,389551.4k $49.0m $49.0m 0.01% Added +86.7k +86,738
39 Candriam S.C.A. 0.22% of their portfolio STRASSEN, N4 546,312546.3k $48.5m $48.5m 0.22% Reduced -64.0k -63,970
40 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio NEW YORK, NY 522,071522.1k $46.3m $46.3m 0.01% Added +314.8k +314,757
41 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 499,963500.0k $44.4m $44.4m 0.00% Added +253.2k +253,244
42 VOYA INVESTMENT MANAGEMENT LLC 0.03% of their portfolio ATLANTA, GA 431,694431.7k $38.3m $38.3m 0.03% Added +377.7k +377,724
43 EMERALD MUTUAL FUND ADVISERS TRUST 1.25% of their portfolio LEOLA, PA 401,271401.3k $35.6m $35.6m 1.25% Reduced -6.8k -6,842
44 SAMLYN CAPITAL, LLC 0.59% of their portfolio New York, NY 400,075400.1k $35.5m $35.5m 0.59% Added +3.4k +3,414
45 AMERIPRISE FINANCIAL INC 0.01% of their portfolio MINNEAPOLIS, MN 356,082356.1k $31.6m $31.6m 0.01% Added +196.9k +196,865
46 Integral Health Asset Management, LLC 1.18% of their portfolio New York, NY 325,000325.0k $28.9m $28.9m 1.18% New
47 Woodline Partners LP 0.08% of their portfolio San Francisco, CA 306,049306.0k $27.2m $27.2m 0.08% Added +40.2k +40,157
48 JENNISON ASSOCIATES LLC 0.02% of their portfolio NEW YORK, NY 303,180303.2k $26.9m $26.9m 0.02% New
49 ADAR1 Capital Management, LLC 1.19% of their portfolio AUSTIN, TX 283,982284.0k $25.2m $25.2m 1.19% Reduced -54.3k -54,341
50 BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio PARIS, I0 259,923259.9k $23.1m $23.1m 0.01% Added +241.3k +241,293
51 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 245,193245.2k $21.8m $21.8m 0.00% Added +53.8k +53,798
52 Bellevue Group AG 0.43% of their portfolio ZURICH, V8 229,931229.9k $20.4m $20.4m 0.43% New
53 Cormorant Asset Management, LP 1.02% of their portfolio BOSTON, MA 225,000225.0k $20.0m $20.0m 1.02% New
54 SEVEN GRAND MANAGERS, LLC 0.80% of their portfolio BRONXVILLE, NY 225,000225.0k $20.0m $20.0m 0.80% Added +125.0k +125,000
55 EVENTIDE ASSET MANAGEMENT, LLC 0.24% of their portfolio Boston, MA 201,616201.6k $17.9m $17.9m 0.24% New
56 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 196,712196.7k $17.5m $17.5m 0.01% Added +50.1k +50,073
57 ORBIMED ADVISORS LLC 0.31% of their portfolio New York, NY 186,145186.1k $16.5m $16.5m 0.31% New
58 FRONTIER CAPITAL MANAGEMENT CO LLC 0.15% of their portfolio Boston, MA 182,931182.9k $16.2m $16.2m 0.15% New
59 Nuveen, LLC 0.00% of their portfolio CHARLOTTE, NC 181,105181.1k $16.1m $16.1m 0.00% Added +27.2k +27,206
60 NEUBERGER BERMAN GROUP LLC 0.01% of their portfolio NEW YORK, NY 180,884180.9k $16.1m $16.1m 0.01% New
61 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 174,459174.5k $15.5m $15.5m 0.00% Added +45.2k +45,217
62 Universal- Beteiligungs- und Servicegesellschaft mbH 0.02% of their portfolio FRANKFURT AM MAIN, 2M 172,923172.9k $15.4m $15.4m 0.02% Added +2.5k +2,542
63 Balyasny Asset Management L.P. 0.02% of their portfolio Chicago, IL 147,042147.0k $13.1m $13.1m 0.02% Added +91.6k +91,565
64 Soleus Capital Management, L.P. 0.45% of their portfolio GREENWICH, CT 147,000147.0k $13.1m $13.1m 0.45% New
65 Squarepoint Ops LLC 0.02% of their portfolio NEW YORK, NY 139,605139.6k $12.4m $12.4m 0.02% New
66 ARMISTICE CAPITAL, LLC 0.34% of their portfolio NEW YORK, NY 137,588137.6k $12.2m $12.2m 0.34% Added +16.7k +16,657
67 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 134,757134.8k $12.0m $12.0m 0.01% Added +124.8k +124,826
68 Ensign Peak Advisors, Inc 0.02% of their portfolio SALT LAKE CITY, UT 126,620126.6k $11.2m $11.2m 0.02% Reduced -21.9k -21,917
69 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 120,541120.5k $10.7m $10.7m 0.00% Reduced -11.8k -11,849
70 Blackstone Inc. 0.03% of their portfolio NEW YORK, NY 120,177120.2k $10.7m $10.7m 0.03% Reduced -172.7k -172,670
71 Rhenman & Partners Asset Management AB 1.00% of their portfolio Stockholm, V7 119,300119.3k $10.6m $10.6m 1.00% New
72 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 115,990116.0k $10.3m $10.3m 0.01% Reduced -21.4k -21,400
73 Swiss National Bank 0.01% of their portfolio ZURICH, V8 112,500112.5k $10.0m $10.0m 0.01% Added +16.0k +16,000
74 STEMPOINT CAPITAL LP 1.64% of their portfolio NEW YORK, NY 106,926106.9k $9.5m $9.5m 1.64% Reduced -228.3k -228,286
75 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio Toronto, A6 104,516104.5k $9.3m $9.3m 0.01% Reduced -8.3k -8,325
76 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 103,100103.1k $9.2m $9.2m 0.01% Reduced -5.0k -5,035
77 Boxer Capital Management, LLC 0.67% of their portfolio San Diego, CA 100,000100.0k $8.9m $8.9m 0.67% New
78 RHUMBLINE ADVISERS 0.01% of their portfolio BOSTON, MA 94,76394.8k $8.4m $8.4m 0.01% Added +9.6k +9,642
79 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 94,06994.1k $8.4m $8.4m 0.00% Added +48.3k +48,283
80 F/m Investments LLC 0.42% of their portfolio WASHINGTON, DC 92,61892.6k $8.2m $8.2m 0.42% Reduced -6.8k -6,842
81 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 92,54092.5k $4.7m $4.7m 0.00% Added +21.6k +21,640
82 PRUDENTIAL FINANCIAL INC 0.01% of their portfolio NEWARK, NJ 87,37087.4k $7.8m $7.8m 0.01% Added +27.8k +27,815
83 FEDERATED HERMES, INC. 0.01% of their portfolio PITTSBURGH, PA 85,95086.0k $7.6m $7.6m 0.01% New
84 Granahan Investment Management, LLC 0.26% of their portfolio WALTHAM, MA 82,99183.0k $7.4m $7.4m 0.26% New
85 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 82,59382.6k $7.3m $7.3m 0.00% Added +70.6k +70,587
86 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 82,50682.5k $7.3m $7.3m 0.00% Added +49.3k +49,298
87 HighVista Strategies LLC 1.57% of their portfolio BOSTON, MA 77,80777.8k $6.9m $6.9m 1.57% Reduced -68.5k -68,457
88 MERCER GLOBAL ADVISORS INC /ADV 0.01% of their portfolio DENVER, CO 71,14571.1k $6.3m $6.3m 0.01% Added +54 +54
89 B Group, Inc. 3.53% of their portfolio DALLAS, TX 70,00070.0k $6.2m $6.2m 3.53% Reduced -30.0k -30,000
90 Trexquant Investment LP 0.04% of their portfolio STAMFORD, CT 67,00767.0k $5.9m $5.9m 0.04% New
91 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio WEST SACRAMENTO, CA 64,68764.7k $5.7m $5.7m 0.01% Added +5.4k +5,445
92 Informed Momentum Co LLC 0.48% of their portfolio SOLANA BEACH, CA 60,39360.4k $5.4m $5.4m 0.48% New
93 SILVERARC CAPITAL MANAGEMENT, LLC 0.59% of their portfolio BOSTON, MA 59,95960.0k $5.3m $5.3m 0.59% Reduced -126.7k -126,659
94 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 59,74759.7k $5.3m $5.3m 0.00% Added +55.4k +55,448
95 Hudson Bay Capital Management LP 0.02% of their portfolio STAMFORD, CT 58,38758.4k $5.2m $5.2m 0.02% New
96 Atle Fund Management AB 1.36% of their portfolio STOCKHOLM, V7 57,03057.0k $5.1m $5.1m 1.36% Reduced -5.7k -5,705
97 RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio ST. PETERSBURG, FL 53,62753.6k $4.8m $4.8m 0.00% Added +33.9k +33,872
98 Susquehanna Portfolio Strategies, LLC 0.08% of their portfolio Bala Cynwyd, PA 53,10153.1k $4.7m $4.7m 0.08% Unchanged
99 ROYCE & ASSOCIATES LP 0.04% of their portfolio New York, NY 51,78951.8k $4.6m $4.6m 0.04% New
100 XTX Topco Ltd 0.06% of their portfolio LONDON, X0 50,48350.5k $4.5m $4.5m 0.06% Added +26.0k +26,048