ACHIEVE LIFE SCIENCES INC ACHV
COM · Common Stock · CUSIP 004468500
- SectorHealth care
- IndustryIn Vitro & In Vivo Diagnostic Substances
- HeadquartersSeattle, WA
- Founded2015
- Websiteachievelifesciences.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($9.4m this quarter). Holder counts are more reliable. Shares outstanding: 102.9m as of 2026-08-11, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $6.53. Options: 6 managers hold calls ($18.4m notional), 4 hold puts ($844.3k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 29 |
| Q4 2022 | 29 |
| Q1 2023 | 32 |
| Q2 2023 | 40 |
| Q3 2023 | 36 |
| Q4 2023 | 30 |
| Q1 2024 | 42 |
| Q2 2024 | 57 |
| Q3 2024 | 65 |
| Q4 2024 | 71 |
| Q1 2025 | 73 |
| Q2 2025 | 67 |
| Q3 2025 | 66 |
| Q4 2025 | 77 |
| Q1 2026 | 81 |
| Q2 2026 | 111 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 29 | 15 |
| Q4 2024 | 35 | 16 |
| Q1 2025 | 29 | 26 |
| Q2 2025 | 40 | 40 |
| Q3 2025 | 39 | 41 |
| Q4 2025 | 45 | 23 |
| Q1 2026 | 31 | 34 |
| Q2 2026 | 83 | 31 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $2.4m | $239.3k | 0.10 |
| Q4 2025 | $1.4m | $214.2k | 0.15 |
| Q1 2026 | $2.5m | $144.6k | 0.06 |
| Q2 2026 | $18.4m | $844.3k | 0.05 |
Biggest buyers
| Frazier Life Sciences Management, L.P. | New | +7.6m |
| TPG GP A, LLC | New | +6.9m |
| venBio Partners LLC | New | +5.9m |
| Logos Global Management LP | New | +5.4m |
| Paradigm Biocapital Advisors LP | New | +5.0m |
| BlackRock, Inc. | Added | +4.8m |
| Venrock Adviser, LLC | New | +2.8m |
| Vivo Capital, LLC | New | +2.8m |
| MARSHALL WACE, LLP | Added | +2.8m |
| STATE STREET CORP | Added | +2.7m |
Biggest sellers
| MILLENNIUM MANAGEMENT LLC | Sold out | -1.1m |
| Nantahala Capital Management, LLC | Sold out | -648.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -353.3k |
| 683 Capital Management, LLC | Sold out | -200.0k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -147.4k |
| JANE STREET GROUP, LLC | Reduced | -126.1k |
| Shay Capital LLC | Reduced | -112.3k |
| GOLDMAN SACHS GROUP INC | Reduced | -112.0k |
| Lakeside Advisors, INC. | Sold out | -111.1k |
| RAYMOND JAMES FINANCIAL INC | Reduced | -95.6k |
Biggest calls
| Caption Management, LLC | Added | $7.7m1.2m shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $3.8m577.5k shares |
| GROUP ONE TRADING LLC | Added | $2.5m385.9k shares |
| SIMPLEX TRADING, LLC | Added | $1.8m278.3k shares |
| JANE STREET GROUP, LLC | New | $1.3m203.9k shares |
| CITADEL ADVISORS LLC | Added | $1.3m203.1k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $677.2k103.7k shares |
| SIMPLEX TRADING, LLC | Added | $105.1k16.1k shares |
| GROUP ONE TRADING LLC | New | $61.4k9.4k shares |
| SUMMIT SECURITIES GROUP LLC | New | $653100 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
TPG GP A, LLC
13D · may seek influence
new · filed 2026-04-24
Stated purposeThe information set forth in or incorporated by reference in Items 2, 3, 5 and 6 of this Schedule 13D is incorporated by reference in its entirety into this Item 4. Securities Purchase Agreement TPG Auriga entered into a Securities Purchase Agreement (the "Securities Purchase Agreement") with the Issuer, dated as of April 15, 2026, pursuant to which it agreed to purchase, and the Issuer agreed to sell and issue, 6,877,580 shares of Common Stock and 6,877,580 accompanying Warrants at a collective price of $3.635 per combination of share of Common Stock and accompany Warrant (the "Private Placement"). On April 17, 2026, the Private Placement closed (the "Closing"). The aggregate purchase price of $25,000,003.30 paid by TPG Auriga for the shares of Common Stock and accompanying Warrants w… Full filing |
12.6% |
| Logos Global Management LP 13G · institution new · filed 2026-08-17 | 10.0% |
venBio Global Strategic Fund V, L.P.
13D · may seek influence
new · filed 2026-04-27
Stated purposeThe response to Item 3 of this Schedule 13D is incorporated herein by reference. The Reporting Persons acquired the securities reported herein for investment purposes. Subject to a number of factors, including market conditions and their general investment and trading policies, the Reporting Persons may, in the ordinary course of their business, dispose of the shares of Common Stock that they beneficially own. These dispositions may occur in open market transactions, privately negotiated transactions, or through other methods. Additionally, Fund V may distribute the shares of Common Stock that it directly holds to its limited partners. Dr. Royston, who is a member of General Partner V, is a director of the Issuer. The Reporting Persons, either directly or indirectly through Dr. Roys… Full filing |
10.0% |
| Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-04-24 | 9.2% |
| FRANKLIN RESOURCES INC 13G · institution +2.1 pts · filed 2026-07-28 | 8.3% |
| Frazier Life Sciences Public Fund, L.P. 13G · passive investor new · filed 2026-04-24 | 6.5% |
| Alyeska Investment Group, L.P. 13G · institution -4.3 pts · filed 2025-11-14 | 5.6% |
| Janus Henderson Group Ltd. 13G · institution new · filed 2026-08-13 | 5.4% |
| Venrock Healthcare Capital Partners III, L.P. 13G · passive investor new · filed 2026-04-24 | 5.2% |
| BlackRock, Inc. 13G · institution +4.5 pts · filed 2026-07-27 | 5.1% |
| Vivo Opportunity Fund Holdings, L.P. 13G · passive investor new · filed 2026-07-08 | 5.0% |
Fell to 5% or below in the last year: Contrarian Alpha, LP (4.9%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 2 | $57.5k | 0 | — | — |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 6 | $1.1m | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 1 | $175.1k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-08-19 | Stewart Richard Alistair Director | Sold | $175.1k20.6k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Frazier Life Sciences Management, L.P. 1.08% of their portfolio | 7.6m $49.7m | New |
| TPG GP A, LLC 0.90% of their portfolio | 6.9m $44.9m | New |
| venBio Partners LLC 7.44% of their portfolio | 5.9m $38.6m | New |
| Logos Global Management LP 1.53% of their portfolio | 5.4m $35.4m | New |
| BlackRock, Inc. 0.00% of their portfolio | 5.3m $34.4m | Added +4.8m |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 5.0m $32.3m | Added +584.0k |
| Paradigm Biocapital Advisors LP 0.61% of their portfolio | 5.0m $32.3m | New |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 4.1m $27.0m | Added +1.9m |
| Propel Bio Management, LLC 13.79% of their portfolio | 4.0m $26.3m | Added +247.6k |
| MARSHALL WACE, LLP 0.02% of their portfolio | 3.8m $24.6m | Added +2.8m |
| STATE STREET CORP 0.00% of their portfolio | 2.9m $19.2m | Added +2.7m |
| Venrock Adviser, LLC 0.54% of their portfolio | 2.8m $18.0m | New |
| Vivo Capital, LLC 1.64% of their portfolio | 2.8m $18.0m | New |
| Jupiter Topco LLC 0.01% of their portfolio | 2.8m $18.0m | First filing |
| EVENTIDE ASSET MANAGEMENT, LLC 0.19% of their portfolio | 2.2m $14.5m | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.1m $13.5m | Added +1.4m |
| Alyeska Investment Group, L.P. 0.03% of their portfolio | 1.9m $12.6m | New |
| Simplify Asset Management Inc. 0.13% of their portfolio | 1.4m $9.4m | Added +247.6k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 1.4m $9.3m | New |
| LPL Financial LLC 0.00% of their portfolio | 902.3k $5.9m | Added +173.8k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 743.8k $4.9m | Added +519.0k |
| Spruce Street Capital LP 0.94% of their portfolio | 736.6k $4.8m | New |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 593.8k $3.9m | Added +277.6k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 546.3k $3.6m | Reduced -95.6k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 537.6k $3.5m | New |
| KVP Capital Advisors, LP 2.22% of their portfolio | 462.4k $3.0m | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 441.2k $2.9m | Reduced -147.4k |
| UBS Group AG 0.00% of their portfolio | 313.0k $2.0m | Reduced -13.3k |
| CANTOR FITZGERALD, L. P. 0.02% of their portfolio | 243.3k $1.6m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 232.1k $1.5m | Added +189.1k |
| Caption Management, LLC 0.05% of their portfolio | 227.7k $1.5m | Added +227.6k |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.17% of their portfolio | 227.2k $1.5m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 218.1k $1.4m | New |
| Nuveen, LLC 0.00% of their portfolio | 191.2k $1.2m | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 185.1k $1.2m | Added +114.4k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 178.0k $1.2m | Added +150.1k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 170.6k $1.1m | Added +68.7k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 123.1k $804.0k | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 121.2k $791.5k | Added +121.0k |
| Shay Capital LLC 0.07% of their portfolio | 92.8k $606.0k | Reduced -112.3k |
| XTX Topco Ltd 0.01% of their portfolio | 90.0k $587.9k | Added +71.8k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 87.0k $568.3k | New |
| Blue Trust, Inc. 0.01% of their portfolio | 85.9k $560.8k | Unchanged |
| Diametric Capital, LP 0.06% of their portfolio | 81.2k $530.1k | Added +62.5k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 77.5k $506.0k | New |
| CITIGROUP INC 0.00% of their portfolio | 74.1k $484.0k | Added +68.7k |
| MANCHESTER FINANCIAL INC 0.08% of their portfolio | 67.2k $438.7k | Added +955 |
| MEMBERS WEALTH LLC 0.24% of their portfolio | 66.8k $436.0k | Added +36.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 64.8k $423.0k | New |
| MORGAN STANLEY 0.00% of their portfolio | 59.4k $387.7k | Reduced -11.0k |
| Virtus Investment Advisers, LLC 0.09% of their portfolio | 59.3k $387.1k | New |
| ADAR1 Capital Management, LLC 0.02% of their portfolio | 53.8k $351.3k | Added +6.0k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 50.5k $329.5k | Reduced -126.1k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 48.9k $143.9k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 46.0k $300.3k | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 43.1k $281.5k | Reduced -13.0k |
| WINTON GROUP Ltd 0.01% of their portfolio | 42.5k $277.5k | New |
| Invesco Ltd. 0.00% of their portfolio | 42.3k $276.2k | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 41.0k $267.6k | Reduced -112.0k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 40.0k $260.2k | New |
| Rafferty Asset Management, LLC 0.00% of their portfolio | 37.5k $245.0k | New |
| Next Capital Management LLC 0.06% of their portfolio | 35.0k $228.5k | Unchanged |
| AMERIFLEX GROUP, INC. 0.09% of their portfolio | 33.6k $219.4k | New |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 32.4k $211.6k | Added +9.8k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 32.3k $201.2k | Added +32.3k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 30.4k $198.3k | Reduced -353.3k |
| Rockefeller Capital Management L.P. 0.00% of their portfolio | 30.0k $195.9k | Unchanged |
| Jones Hill Capital LP 0.04% of their portfolio | 26.8k $174.7k | New |
| BCV Asset Management Inc. 0.00% of their portfolio | 26.4k $164.6k | Unchanged |
| AXQ CAPITAL, LP 0.02% of their portfolio | 25.2k $164.4k | Added +10.0k |
| Robertson Stephens Wealth Management, LLC 0.00% of their portfolio | 25.0k $163.2k | Added +5.0k |
| Keating Financial Advisory Services, Inc. 0.02% of their portfolio | 24.9k $162.7k | Unchanged |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 23.0k $149.9k | New |
| Scientech Research LLC 0.12% of their portfolio | 22.0k $143.7k | Added +289 |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 20.6k $134.6k | New |
| SEI INVESTMENTS CO 0.00% of their portfolio | 20.5k $133.9k | New |
| BARCLAYS PLC 0.00% of their portfolio | 20.0k $130.6k | Reduced -28.1k |
| PROFUND ADVISORS LLC 0.00% of their portfolio | 19.9k $129.7k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 19.2k $125.4k | New |
| nVerses Capital, LLC 0.18% of their portfolio | 18.2k $118.9k | Added +4.0k |
| FMR LLC 0.00% of their portfolio | 17.7k $115.6k | Added +11.8k |
| StoneX Group Inc. 0.00% of their portfolio | 16.3k $86.5k | New |
| MAGNOLIA CAPITAL ADVISORS LLC 0.02% of their portfolio | 15.1k $98.6k | Reduced -9.0k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 14.8k $96.9k | New |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 14.8k $96.9k | Added +732 |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 13.7k $89.7k | New |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 13.0k $85.2k | New |
| Alpine Global Management, LLC 0.01% of their portfolio | 12.5k $81.6k | Reduced -37.5k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 12.4k $81.0k | Added +12.2k |
| Windsor Capital Management, LLC 0.02% of their portfolio | 10.8k $70.6k | Unchanged |
| ProShare Advisors LLC 0.00% of their portfolio | 10.2k $66.6k | New |
| Legal & General Group Plc 0.00% of their portfolio | 7.6k $49.3k | New |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 7.1k $46.1k | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 6.4k $41.6k | Added +6.2k |
| Allworth Financial LP 0.00% of their portfolio | 3.0k $19.6k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 3.0k $19.6k | New |
| Persistent Asset Partners Ltd 0.01% of their portfolio | 2.8k $18.2k | New |
| Steward Partners Investment Advisory, LLC 0.00% of their portfolio | 2.4k $15.9k | Added +2.2k |
| FIFTH THIRD BANCORP 0.00% of their portfolio | 2.3k $15.0k | Unchanged |
| Federation des caisses Desjardins du Quebec 0.00% of their portfolio | 2.0k $13.1k | Unchanged |