KRYSTAL BIOTECH INC KRYS
COM · Common Stock · CUSIP 501147102
Biotechnology company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersPittsburgh, PA
- Websitekrystalbio.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($8.9m this quarter). Holder counts are more reliable. Shares outstanding: 28.7m as of 2024-07-29, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $183.63. Options: 9 managers hold calls ($54.5m notional), 12 hold puts ($42.9m).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 149 |
| Q4 2022 | 156 |
| Q1 2023 | 162 |
| Q2 2023 | 185 |
| Q3 2023 | 190 |
| Q4 2023 | 196 |
| Q1 2024 | 236 |
| Q2 2024 | 247 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 76 | 61 |
| Q1 2023 | 76 | 66 |
| Q2 2023 | 97 | 80 |
| Q3 2023 | 108 | 66 |
| Q4 2023 | 95 | 85 |
| Q1 2024 | 128 | 107 |
| Q2 2024 | 145 | 111 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $22.5m | $38.5m | 1.71 |
| Q4 2023 | $57.9m | $97.6m | 1.69 |
| Q1 2024 | $112.0m | $140.1m | 1.25 |
| Q2 2024 | $54.5m | $42.9m | 0.79 |
Biggest buyers
| BlackRock Inc. | Added | +2.1m |
| Capital World Investors | Added | +781.0k |
| VANGUARD GROUP INC | Added | +436.4k |
| STATE STREET CORP | Added | +388.3k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | Added | +233.5k |
| Invesco Ltd. | Added | +185.4k |
| PRINCIPAL FINANCIAL GROUP INC | Added | +117.5k |
| Bank of New York Mellon Corp | Added | +103.9k |
| EAGLE ASSET MANAGEMENT INC | New | +76.3k |
| AMERIPRISE FINANCIAL INC | Added | +58.6k |
Biggest sellers
| Redmile Group, LLC | Reduced | -487.2k |
| MORGAN STANLEY | Reduced | -338.2k |
| LORD, ABBETT & CO. LLC | Reduced | -200.0k |
| JENNISON ASSOCIATES LLC | Reduced | -150.3k |
| Avoro Capital Advisors LLC | Reduced | -122.6k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -96.1k |
| D. E. Shaw & Co., Inc. | Reduced | -71.0k |
| BRAIDWELL LP | Reduced | -69.9k |
| Balyasny Asset Management L.P. | Reduced | -64.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -58.5k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $20.8m113.4k shares |
| Caption Management, LLC | Added | $14.5m78.7k shares |
| BARCLAYS PLC | Reduced | $7.3m40.0k shares |
| CITADEL ADVISORS LLC | Reduced | $5.0m27.4k shares |
| JANE STREET GROUP, LLC | Reduced | $4.8m26.2k shares |
| MILLENNIUM MANAGEMENT LLC | Added | $1.6m8.6k shares |
| Walleye Capital LLC | New | $257.1k1.4k shares |
| SIMPLEX TRADING, LLC | Reduced | $165.0k900 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $19.8m107.9k shares |
| JANE STREET GROUP, LLC | Reduced | $9.9m54.1k shares |
| Caption Management, LLC | Added | $3.7m20.0k shares |
| Balyasny Asset Management L.P. | New | $2.8m15.0k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | Reduced | $1.8m9.7k shares |
| CITADEL ADVISORS LLC | Reduced | $1.5m8.4k shares |
| Nantahala Capital Management, LLC | New | $1.4m7.8k shares |
| MILLENNIUM MANAGEMENT LLC | New | $661.1k3.6k shares |
| Walleye Capital LLC | New | $606.0k3.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $514.0k2.8k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2026-10-27 | 11.6% |
| Krishnan Krish S 13G · exempt (held before listing) filed 2026-05-04 | 11.5% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.0% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 2 | $4.1m | — |
| Q4 2022 | 0 | — | 2 | $3.1m | — |
| Q1 2023 | 0 | — | 3 | $8.3m | — |
| Q2 2023 | 0 | — | 5 | $30.7m | $18.4m |
| Q3 2023 | 0 | — | 2 | $6.4m | $6.4m |
| Q4 2023 | 0 | — | 2 | $5.3m | $5.3m |
| Q1 2024 | 0 | — | 3 | $12.0m | $12.0m |
| Q2 2024 | 0 | — | 3 | $12.1m | $8.8m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-06-11 | Krishnan Krish S President and CEO, director | Sold plan | $4.4m25.0k shares |
| 2024-06-11 | Krishnan Suma President, R&D, director | Sold plan | $4.4m25.0k shares |
| 2024-06-11 | Krishnan Krish S President and CEO, director | Sold plan | $4.4m25.0k shares |
| 2024-06-11 | Krishnan Suma President, R&D, director | Sold plan | $4.4m25.0k shares |
| 2024-05-20 | Gangolli Julian S Director | Sold | $3.3m20.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.05% of their portfolio | 4.3m $786.7m | Added +39.9k |
| BlackRock Inc. 0.02% of their portfolio | 3.9m $725.0m | Added +2.1m |
| VANGUARD GROUP INC 0.01% of their portfolio | 2.9m $526.9m | Added +436.4k |
| Avoro Capital Advisors LLC 5.95% of their portfolio | 2.4m $446.8m | Reduced -122.6k |
| STATE STREET CORP 0.01% of their portfolio | 1.3m $244.8m | Added +388.3k |
| Redmile Group, LLC 11.34% of their portfolio | 1.0m $187.5m | Reduced -487.2k |
| Frazier Life Sciences Management, L.P. 8.49% of their portfolio | 988.5k $181.5m | Unchanged |
| Capital World Investors 0.03% of their portfolio | 878.2k $161.3m | Added +781.0k |
| LORD, ABBETT & CO. LLC 0.24% of their portfolio | 784.5k $144.1m | Reduced -200.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 600.1k $110.2m | Reduced -58.5k |
| DIMENSIONAL FUND ADVISORS LP 0.03% of their portfolio | 580.5k $106.6m | Added +7.5k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 580.2k $106.6m | Added +54.5k |
| Hood River Capital Management LLC 1.98% of their portfolio | 521.1k $95.7m | Added +25.5k |
| JENNISON ASSOCIATES LLC 0.06% of their portfolio | 520.4k $95.6m | Reduced -150.3k |
| GOLDMAN SACHS GROUP INC 0.02% of their portfolio | 422.3k $77.6m | Reduced -12.2k |
| Nuveen Asset Management, LLC 0.02% of their portfolio | 336.2k $61.7m | Added +5.7k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 327.6k $60.2m | Reduced -22.6k |
| MORGAN STANLEY 0.00% of their portfolio | 318.3k $58.5m | Reduced -338.2k |
| Woodline Partners LP 0.51% of their portfolio | 291.9k $53.6m | Added +16.5k |
| Invesco Ltd. 0.01% of their portfolio | 275.1k $50.5m | Added +185.4k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 251.8k $46.2m | Added +233.5k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 220.4k $40.5m | Added +31.5k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 218.5k $40.1m | Added +13.4k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 193.8k $35.6m | Added +103.9k |
| Skandinaviska Enskilda Banken AB (publ) 0.17% of their portfolio | 191.5k $35.2m | Reduced -26.2k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 181.6k $33.3m | Added +50.1k |
| Allspring Global Investments Holdings, LLC 0.05% of their portfolio | 176.4k $32.4m | Added +18.0k |
| BAKER BROS. ADVISORS LP 0.40% of their portfolio | 169.9k $31.2m | Unchanged |
| VICTORY CAPITAL MANAGEMENT INC 0.03% of their portfolio | 143.9k $26.4m | Added +9.0k |
| Pictet Asset Management Holding SA 0.03% of their portfolio | 137.4k $25.2m | Reduced -5.5k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.43% of their portfolio | 136.5k $25.1m | Unchanged |
| C WorldWide Group Holding A/S 0.27% of their portfolio | 135.8k $24.9m | Unchanged |
| Soleus Capital Management, L.P. 2.04% of their portfolio | 126.0k $23.1m | Added +41.9k |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 123.5k $22.7m | Added +117.5k |
| Driehaus Capital Management LLC 0.21% of their portfolio | 118.7k $21.8m | Added +8.5k |
| First Turn Management, LLC 3.26% of their portfolio | 109.2k $20.1m | Reduced -21.6k |
| BRAIDWELL LP 0.62% of their portfolio | 107.2k $19.7m | Reduced -69.9k |
| Handelsbanken Fonder AB 0.09% of their portfolio | 106.5k $19.6m | Added +1.3k |
| Rock Springs Capital Management LP 0.59% of their portfolio | 105.6k $19.4m | Added +1.6k |
| AMERIPRISE FINANCIAL INC 0.01% of their portfolio | 102.0k $18.7m | Added +58.6k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 93.6k $17.2m | Added +17.8k |
| S SQUARED TECHNOLOGY, LLC 6.91% of their portfolio | 85.2k $15.6m | Reduced -5.0k |
| Integral Health Asset Management, LLC 1.55% of their portfolio | 85.0k $15.6m | Added +5.0k |
| TimesSquare Capital Management, LLC 0.24% of their portfolio | 83.0k $15.2m | Reduced -14.1k |
| JANE STREET GROUP, LLC 0.02% of their portfolio | 77.8k $14.3m | Reduced -15.9k |
| EAGLE ASSET MANAGEMENT INC 0.07% of their portfolio | 76.3k $13.9m | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 74.8k $13.7m | Added +14.0k |
| RHUMBLINE ADVISERS 0.01% of their portfolio | 71.7k $13.2m | Added +39.6k |
| Man Group plc 0.03% of their portfolio | 69.2k $12.7m | Reduced -26.6k |
| Decheng Capital LLC 3.70% of their portfolio | 65.8k $12.1m | Unchanged |
| Corient Private Wealth LP 0.02% of their portfolio | 65.0k $11.9m | Added +29.0k |
| Legal & General Group Plc 0.00% of their portfolio | 64.6k $11.9m | Added +45.0k |
| Balyasny Asset Management L.P. 0.03% of their portfolio | 59.8k $11.0m | Reduced -64.4k |
| TD Asset Management Inc 0.01% of their portfolio | 58.1k $10.7m | Reduced -11.1k |
| Public Sector Pension Investment Board 0.06% of their portfolio | 54.7k $10.0m | New |
| SCOUT INVESTMENTS, INC. 0.23% of their portfolio | 46.6k $8.5m | Reduced -4.4k |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 46.5k $8.5m | Added +8.7k |
| Aberdeen Group plc 0.02% of their portfolio | 43.4k $8.0m | Added +4.3k |
| OBERWEIS ASSET MANAGEMENT INC/ 0.48% of their portfolio | 42.6k $7.8m | Added +6.9k |
| Rafferty Asset Management, LLC 0.03% of their portfolio | 41.8k $7.7m | Reduced -11.6k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 41.0k $7.5m | Reduced -283 |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 40.4k $7.4m | Added +896 |
| SEI INVESTMENTS CO 0.01% of their portfolio | 40.1k $7.4m | Added +6.4k |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.07% of their portfolio | 37.3k $6.9m | Added +3.1k |
| GW&K Investment Management, LLC 0.06% of their portfolio | 37.1k $6.8m | Reduced -402 |
| Swiss National Bank 0.00% of their portfolio | 36.2k $6.6m | Unchanged |
| SEGALL BRYANT & HAMILL, LLC 0.11% of their portfolio | 34.7k $6.4m | New |
| Palisades Investment Partners, LLC 3.15% of their portfolio | 34.7k $6.4m | First filing |
| Janney Montgomery Scott LLC 0.02% of their portfolio | 31.6k $5.8m | Added +13.8k |
| ORBIMED ADVISORS LLC 0.11% of their portfolio | 30.0k $5.5m | Reduced -7.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 29.7k $5.5m | Added +6.0k |
| Global IMC LLC 1.19% of their portfolio | 28.8k $5.3m | Added +1 |
| UBS Group AG 0.00% of their portfolio | 28.6k $5.2m | Reduced -22.5k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio | 28.4k $5.2m | Added +10.4k |
| CASTLEARK MANAGEMENT LLC 0.21% of their portfolio | 28.3k $5.2m | Reduced -240 |
| CANADA LIFE ASSURANCE Co 0.01% of their portfolio | 27.4k $5.0m | Added +24.2k |
| Informed Momentum Co LLC 0.78% of their portfolio | 26.3k $4.8m | Reduced -151 |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 25.3k $4.6m | Added +9.1k |
| ALPS ADVISORS INC 0.03% of their portfolio | 22.3k $4.1m | New |
| Hennion & Walsh Asset Management, Inc. 0.20% of their portfolio | 21.6k $4.0m | Reduced -11.5k |
| CITIGROUP INC 0.00% of their portfolio | 21.2k $3.9m | Reduced -30.9k |
| Hillsdale Investment Management Inc. 0.30% of their portfolio | 21.0k $3.9m | New |
| Thrivent Financial for Lutherans 0.01% of their portfolio | 20.6k $3.8m | New |
| BARCLAYS PLC 0.00% of their portfolio | 19.1k $3.5m | Reduced -2.5k |
| Rhenman & Partners Asset Management AB 0.33% of their portfolio | 19.0k $3.5m | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 18.4k $3.4m | Reduced -235 |
| Erste Asset Management GmbH 0.04% of their portfolio | 18.2k $3.3m | Unchanged |
| Verition Fund Management LLC 0.03% of their portfolio | 18.0k $3.3m | Reduced -43.8k |
| Nicholas Investment Partners, LP 0.33% of their portfolio | 17.3k $3.2m | New |
| Fiera Capital Corp 0.01% of their portfolio | 16.2k $3.0m | Added +130 |
| CWM, LLC 0.01% of their portfolio | 15.6k $2.9m | Reduced -8.2k |
| DekaBank Deutsche Girozentrale 0.01% of their portfolio | 15.5k $2.8m | Unchanged |
| NEW YORK STATE TEACHERS RETIREMENT SYSTEM 0.01% of their portfolio | 14.9k $2.7m | New |
| ExodusPoint Capital Management, LP 0.03% of their portfolio | 14.9k $2.7m | Reduced -3.4k |
| State of Alaska, Department of Revenue 0.03% of their portfolio | 14.6k $2.7m | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 14.5k $2.7m | Added +5.3k |
| Corebridge Financial, Inc. 0.01% of their portfolio | 14.4k $2.6m | First filing |
| MetLife Investment Management, LLC 0.02% of their portfolio | 14.3k $2.6m | Added +3.2k |
| Redwood Investments, LLC 0.87% of their portfolio | 13.9k $2.5m | Added +5.7k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.01% of their portfolio | 12.6k $2.3m | First filing |