MIRUM PHARMACEUTICALS INC MIRM
COM · Common Stock · CUSIP 604749101 · ISIN US6047491013
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersFoster City, CA
- Founded2018
- Websitemirumpharma.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($47.0k this quarter). Holder counts are more reliable. Shares outstanding: 47.7m as of 2024-08-02, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $34.19. Options: 8 managers hold calls ($3.6m notional), 6 hold puts ($2.4m).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 112 |
| Q4 2022 | 105 |
| Q1 2023 | 119 |
| Q2 2023 | 148 |
| Q3 2023 | 161 |
| Q4 2023 | 189 |
| Q1 2024 | 174 |
| Q2 2024 | 163 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 61 | 49 |
| Q1 2023 | 64 | 40 |
| Q2 2023 | 95 | 37 |
| Q3 2023 | 99 | 48 |
| Q4 2023 | 105 | 67 |
| Q1 2024 | 91 | 89 |
| Q2 2024 | 88 | 83 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $2.0m | $2.3m | 1.15 |
| Q4 2023 | $4.3m | $3.9m | 0.90 |
| Q1 2024 | $1.8m | $1.9m | 1.08 |
| Q2 2024 | $3.6m | $2.4m | 0.67 |
Biggest buyers
| JANUS HENDERSON GROUP PLC | Added | +2.2m |
| BlackRock Inc. | Added | +785.8k |
| Candriam S.C.A. | New | +508.5k |
| MPM BIOIMPACT LLC | New | +492.6k |
| Clearbridge Investments, LLC | Added | +436.3k |
| EVENTIDE ASSET MANAGEMENT, LLC | Added | +314.4k |
| AXA S.A. | Added | +258.2k |
| Invesco Ltd. | Added | +245.0k |
| VANGUARD GROUP INC | Added | +235.0k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +210.0k |
Biggest sellers
| STATE STREET CORP | Reduced | -1.3m |
| CADIAN CAPITAL MANAGEMENT, LP | Reduced | -1.1m |
| MORGAN STANLEY | Reduced | -522.7k |
| Avidity Partners Management LP | Reduced | -411.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -398.3k |
| Checkpoint Capital L.P. | Sold out | -362.2k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -274.2k |
| First Turn Management, LLC | Reduced | -255.3k |
| JPMORGAN CHASE & CO | Reduced | -243.5k |
| Qube Research & Technologies Ltd | Sold out | -241.5k |
Biggest calls
| Caption Management, LLC | Added | $1.2m35.6k shares |
| CITADEL ADVISORS LLC | Added | $844.5k24.7k shares |
| NOMURA HOLDINGS INC | New | $683.8k20.0k shares |
| SIMPLEX TRADING, LLC | Added | $564.0k16.5k shares |
| Jefferies Financial Group Inc. | Reduced | $198.3k5.8k shares |
| GROUP ONE TRADING LLC | Reduced | $119.7k3.5k shares |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | Reduced | $11.2k10.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| Lion Point Capital, LP | Unchanged | $1.5m45.0k shares |
| CITADEL ADVISORS LLC | Reduced | $335.1k9.8k shares |
| JANE STREET GROUP, LLC | Unchanged | $283.8k8.3k shares |
| GROUP ONE TRADING LLC | Added | $232.5k6.8k shares |
| SIMPLEX TRADING, LLC | Reduced | $47.0k1.4k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Janus Henderson Group Ltd. 13G · institution -2.1 pts · filed 2026-08-13 | 9.7% |
Frazier Life Sciences IX, L.P.
13D · may seek influence
-0.8 pts · filed 2026-01-27
Stated purposeItem 4 is hereby amended and restated in its entirety to read as follows: Each of FLS IX, FLS X, FLSPF, FLS XI and FLS XII acquired the FLS IX Shares, the FLS X Shares, the FLSPF Shares, the FLS XI Shares and the FLS XII Shares, as the case may be, for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, FLS IX, FLS X, FLSPF, FLS XI and FLS XII and the other Reporting Persons may dispose of or acquire additional shares of the Issuer. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporat… Full filing |
6.8% |
| FMR LLC 13G · institution new · filed 2026-08-06 | 6.2% |
| BlackRock, Inc. 13G · institution filed 2026-04-27 | 5.7% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27), EVENTIDE ASSET MANAGEMENT, LLC (4.1%, 2026-02-13), BIOTECHNOLOGY VALUE FUND L P (3.0%, 2025-11-14)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 1 | $6.0m | — |
| Q1 2023 | 0 | — | 4 | $155.5k | — |
| Q2 2023 | 0 | — | 1 | $832.7k | $832.7k |
| Q3 2023 | 2 | $4.5m | 6 | $785.0k | — |
| Q4 2023 | 1 | $82.4k | 1 | $81.0k | — |
| Q1 2024 | 1 | $101.2k | 5 | $617.5k | — |
| Q2 2024 | 0 | — | 2 | $1.2m | $1.2m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-06-24 | Vig Pamela CHIEF SCIENTIFIC OFFICER | Sold plan | $1.0m30.6k shares |
| 2024-06-05 | Ramasastry Saira Director | Sold plan | $128.4k5.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| Frazier Life Sciences Management, L.P. 10.39% of their portfolio | 6.5m $222.1m | Unchanged |
| JANUS HENDERSON GROUP PLC 0.09% of their portfolio | 5.0m $170.6m | Added +2.2m |
| BVF INC/IL 4.19% of their portfolio | 4.4m $149.4m | Unchanged |
| EVENTIDE ASSET MANAGEMENT, LLC 2.12% of their portfolio | 3.6m $123.6m | Added +314.4k |
| BlackRock Inc. 0.00% of their portfolio | 3.2m $110.7m | Added +785.8k |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.4m $83.7m | Added +235.0k |
| Rock Springs Capital Management LP 1.83% of their portfolio | 1.8m $60.6m | Reduced -84.5k |
| CITADEL ADVISORS LLC 0.05% of their portfolio | 1.6m $54.2m | Added +193.1k |
| NOVO HOLDINGS A/S 2.76% of their portfolio | 1.5m $51.3m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 1.5m $51.2m | Reduced -1.3m |
| TANG CAPITAL MANAGEMENT LLC 4.48% of their portfolio | 1.3m $44.0m | Added +100.0k |
| CADIAN CAPITAL MANAGEMENT, LP 2.10% of their portfolio | 1.2m $42.2m | Reduced -1.1m |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 1.2m $41.0m | Reduced -398.3k |
| FRANKLIN RESOURCES INC 0.01% of their portfolio | 941.6k $32.2m | Added +196 |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 907.2k $31.0m | Added +210.0k |
| Pictet Asset Management Holding SA 0.03% of their portfolio | 875.1k $29.9m | Reduced -80.8k |
| AXA S.A. 0.04% of their portfolio | 852.0k $29.1m | Added +258.2k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 759.0k $26.0m | Added +58.9k |
| Polar Capital Holdings Plc 0.15% of their portfolio | 741.0k $25.3m | Added +116.0k |
| Avidity Partners Management LP 1.06% of their portfolio | 731.1k $25.0m | Reduced -411.7k |
| First Turn Management, LLC 3.91% of their portfolio | 703.4k $24.0m | Reduced -255.3k |
| Clearbridge Investments, LLC 0.02% of their portfolio | 699.9k $23.9m | Added +436.3k |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC 0.06% of their portfolio | 677.9k $23.2m | Added +50.7k |
| MORGAN STANLEY 0.00% of their portfolio | 541.0k $18.5m | Reduced -522.7k |
| BOONE CAPITAL MANAGEMENT LLC 4.67% of their portfolio | 523.7k $17.9m | Added +71.8k |
| Candriam S.C.A. 0.11% of their portfolio | 508.5k $17.4m | New |
| MPM BIOIMPACT LLC 2.62% of their portfolio | 492.6k $16.8m | New |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 407.1k $13.9m | Added +95.9k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 332.1k $11.4m | Added +19.5k |
| Prosight Management, LP 3.22% of their portfolio | 314.8k $10.8m | Reduced -150.2k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 311.0k $10.6m | Added +39.4k |
| Invesco Ltd. 0.00% of their portfolio | 284.0k $9.7m | Added +245.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 277.4k $9.5m | Reduced -3.7k |
| MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio | 265.4k $9.1m | Reduced -274.2k |
| Erste Asset Management GmbH 0.12% of their portfolio | 260.0k $8.9m | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 249.1k $8.5m | Added +4.9k |
| Penn Capital Management Company, LLC 0.78% of their portfolio | 241.2k $8.3m | Reduced -4.5k |
| BARCLAYS PLC 0.00% of their portfolio | 235.1k $8.0m | Reduced -39.8k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.47% of their portfolio | 229.7k $7.9m | Added +14.8k |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 222.6k $7.6m | Unchanged |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.05% of their portfolio | 220.5k $7.5m | Added +57.7k |
| CITIGROUP INC 0.01% of their portfolio | 212.5k $7.3m | Reduced -158.5k |
| Woodline Partners LP 0.07% of their portfolio | 203.7k $7.0m | Reduced -29.5k |
| BAKER BROS. ADVISORS LP 0.08% of their portfolio | 190.5k $6.5m | Unchanged |
| NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio | 190.1k $6.5m | Reduced -6.6k |
| ARDSLEY ADVISORY PARTNERS LP 1.11% of their portfolio | 180.0k $6.2m | Reduced -65.0k |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 179.9k $6.2m | Reduced -17.1k |
| TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio | 163.5k $5.6m | Added +8.2k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.01% of their portfolio | 160.0k $5.5m | Unchanged |
| Affinity Asset Advisors, LLC 0.83% of their portfolio | 155.0k $5.3m | Reduced -5.0k |
| RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio | 144.2k $4.9m | Added +13.7k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 143.0k $4.9m | Added +46.5k |
| Rhenman & Partners Asset Management AB 0.44% of their portfolio | 134.2k $4.6m | Added +42.0k |
| Highlander Partners, L.P. 2.80% of their portfolio | 123.0k $4.2m | Unchanged |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 122.7k $4.2m | Added +8.1k |
| Nan Fung Group Holdings Ltd 3.87% of their portfolio | 106.1k $3.6m | Added +10.0k |
| Knights of Columbus Asset Advisors LLC 0.23% of their portfolio | 104.9k $3.6m | Added +2.6k |
| Hennion & Walsh Asset Management, Inc. 0.18% of their portfolio | 104.8k $3.6m | Added +41.2k |
| Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio | 98.9k $3.4m | Added +992 |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.67% of their portfolio | 79.2k $2.7m | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 75.4k $2.6m | Added +5.0k |
| Atle Fund Management AB 1.57% of their portfolio | 75.2k $2.6m | Reduced -47.8k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 68.9k $2.4m | Reduced -197.4k |
| Squarepoint Ops LLC 0.01% of their portfolio | 67.4k $2.3m | Added +26.2k |
| Swiss National Bank 0.00% of their portfolio | 64.8k $2.2m | Added +5.5k |
| Palo Alto Investors LP 0.26% of their portfolio | 64.7k $2.2m | Unchanged |
| AlphaCentric Advisors LLC 1.61% of their portfolio | 64.0k $2.2m | Reduced -30.0k |
| Phocas Financial Corp. 0.24% of their portfolio | 60.4k $2.1m | Reduced -1.1k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 60.0k $2.1m | Added +18.9k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 56.5k $1.9m | Added +10.6k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 52.9k $1.8m | Added +17.3k |
| UBS Group AG 0.00% of their portfolio | 50.7k $1.7m | Reduced -106.2k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 47.7k $1.6m | Reduced -243.5k |
| Secure Asset Management, LLC 0.30% of their portfolio | 45.9k $1.6m | Added +3.6k |
| Connor, Clark & Lunn Investment Management Ltd. 0.01% of their portfolio | 45.8k $1.6m | New |
| ExodusPoint Capital Management, LP 0.02% of their portfolio | 43.7k $1.5m | Reduced -20.7k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 43.0k $1.5m | Reduced -2.3k |
| NEOS Investment Management LLC 0.06% of their portfolio | 41.2k $1.4m | Added +14.0k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 41.0k $1.4m | Added +16.9k |
| PDT Partners, LLC 0.13% of their portfolio | 39.4k $1.3m | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 38.1k $1.3m | Added +30.2k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.04% of their portfolio | 38.1k $1.3m | Reduced -11.8k |
| ALPS ADVISORS INC 0.01% of their portfolio | 36.8k $1.3m | Added +3.9k |
| Steward Partners Investment Advisory, LLC 0.01% of their portfolio | 35.9k $1.2m | Reduced -20.9k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 35.0k $1.2m | Added +10.6k |
| CenterBook Partners LP 0.07% of their portfolio | 34.9k $1.2m | Reduced -87.6k |
| Legal & General Group Plc 0.00% of their portfolio | 34.2k $1.2m | Added +5.5k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 32.7k $1.1m | Reduced -54.3k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 27.4k $936.4k | Added +16.1k |
| Penserra Capital Management LLC 0.01% of their portfolio | 26.9k $920.0k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 22.7k $777.1k | Added +8.6k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 22.2k $760.5k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 22.1k $756.8k | Reduced -22.1k |
| Corebridge Financial, Inc. 0.00% of their portfolio | 21.1k $721.5k | First filing |
| MARSHALL WACE, LLP 0.00% of their portfolio | 20.5k $701.6k | Added +5.4k |
| Jump Financial, LLC 0.01% of their portfolio | 20.5k $700.1k | New |
| HighVista Strategies LLC 0.25% of their portfolio | 20.2k $690.9k | Unchanged |
| Ascentis Independent Advisors 0.14% of their portfolio | 19.9k $681.4k | First filing |
| Values First Advisors, Inc. 0.40% of their portfolio | 19.8k $675.4k | Reduced -1.7k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 17.5k $598.2k | Added +16 |