RHYTHM PHARMACEUTICALS INC RYTM
COM · Common Stock · CUSIP 76243J105
Company in Boston, United States
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoston, MA
- Founded2008
- Websiterhythmtx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.8m this quarter). Holder counts are more reliable. Shares outstanding: 61.1m as of 2024-08-01, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $41.07. Options: 11 managers hold calls ($20.3m notional), 8 hold puts ($11.0m).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 101 |
| Q4 2022 | 116 |
| Q1 2023 | 127 |
| Q2 2023 | 117 |
| Q3 2023 | 145 |
| Q4 2023 | 170 |
| Q1 2024 | 169 |
| Q2 2024 | 167 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 65 | 39 |
| Q1 2023 | 76 | 41 |
| Q2 2023 | 69 | 61 |
| Q3 2023 | 87 | 51 |
| Q4 2023 | 80 | 82 |
| Q1 2024 | 88 | 79 |
| Q2 2024 | 84 | 79 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $10.9m | $1.3m | 0.12 |
| Q4 2023 | $50.0m | $3.1m | 0.06 |
| Q1 2024 | $42.6m | $15.5m | 0.36 |
| Q2 2024 | $20.3m | $11.0m | 0.54 |
Biggest buyers
| ALKEON CAPITAL MANAGEMENT LLC | New | +1.0m |
| RA CAPITAL MANAGEMENT, L.P. | Added | +754.0k |
| Driehaus Capital Management LLC | Added | +326.9k |
| Candriam S.C.A. | New | +271.4k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | Added | +236.6k |
| NISA INVESTMENT ADVISORS, LLC | Added | +229.1k |
| BlackRock Inc. | Added | +212.3k |
| Invesco Ltd. | Added | +188.5k |
| Frazier Life Sciences Management, L.P. | Added | +181.1k |
| PERCEPTIVE ADVISORS LLC | Added | +178.0k |
Biggest sellers
| STATE STREET CORP | Reduced | -1.0m |
| PRIMECAP MANAGEMENT CO/CA/ | Reduced | -435.2k |
| Pictet Asset Management Holding SA | Reduced | -409.9k |
| LORD, ABBETT & CO. LLC | Reduced | -357.1k |
| Rock Springs Capital Management LP | Reduced | -242.4k |
| CITIGROUP INC | Reduced | -170.5k |
| CANADA PENSION PLAN INVESTMENT BOARD | Reduced | -160.0k |
| Rafferty Asset Management, LLC | Reduced | -146.1k |
| VOYA INVESTMENT MANAGEMENT LLC | Reduced | -134.9k |
| Woodline Partners LP | Reduced | -128.0k |
Biggest calls
| NOMURA HOLDINGS INC | New | $6.5m157.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $3.8m93.5k shares |
| JANE STREET GROUP, LLC | Reduced | $3.4m82.7k shares |
| Caption Management, LLC | Reduced | $2.1m50.0k shares |
| CITADEL ADVISORS LLC | Reduced | $1.8m43.5k shares |
| SIMPLEX TRADING, LLC | Added | $1.3m32.3k shares |
| GROUP ONE TRADING LLC | Added | $574.8k14.0k shares |
| HAP Trading, LLC | New | $312.9k109.8k shares |
| GTS SECURITIES LLC | Reduced | $283.3k6.9k shares |
| BARCLAYS PLC | Unchanged | $229.9k5.6k shares |
Biggest puts
| Caption Management, LLC | New | $6.9m169.0k shares |
| JANE STREET GROUP, LLC | Reduced | $1.2m29.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.1m26.7k shares |
| CITADEL ADVISORS LLC | Reduced | $743.2k18.1k shares |
| GROUP ONE TRADING LLC | Unchanged | $554.3k13.5k shares |
| GTS SECURITIES LLC | Added | $398.3k9.7k shares |
| SIMPLEX TRADING, LLC | Reduced | $90.0k2.2k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor +1.2 pts · filed 2026-02-17 | 9.9% |
| BAKER BROS. ADVISORS LP 13G · institution filed 2025-05-15 | 8.9% |
| BlackRock, Inc. 13G · institution filed 2025-04-24 | 6.9% |
| PRIMECAP MANAGEMENT CO/CA/ 13G · institution -1.2 pts · filed 2026-02-12 | 5.2% |
| JPMORGAN CHASE & CO 13G · institution new · filed 2026-10-13 | 5.1% |
| PERCEPTIVE ADVISORS LLC 13G · passive investor -1.7 pts · filed 2026-05-15 | 5.1% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 2 | $345.6k | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 6 | $289.0k | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Q3 2023 | 0 | — | 2 | $503.1k | $503.1k |
| Q4 2023 | 0 | — | 3 | $4.0m | $2.2m |
| Q1 2024 | 0 | — | 6 | $5.4m | $147.7k |
| Q2 2024 | 0 | — | 2 | $168.6k | $153.3k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-05-09 | Shulman Joseph Chief Technical Officer | Sold plan | $153.3k4.0k shares |
| 2024-04-02 | German Christopher Paul Corporate Controller & CAO | Sold | $15.4k368 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| PRIMECAP MANAGEMENT CO/CA/ 0.22% of their portfolio | 7.3m $300.2m | Reduced -435.2k |
| BlackRock Inc. 0.01% of their portfolio | 6.7m $276.8m | Added +212.3k |
| BAKER BROS. ADVISORS LP 3.36% of their portfolio | 6.4m $262.7m | Unchanged |
| RA CAPITAL MANAGEMENT, L.P. 3.30% of their portfolio | 6.1m $249.8m | Added +754.0k |
| GOLDMAN SACHS GROUP INC 0.04% of their portfolio | 5.3m $217.2m | Added +177.0k |
| PERCEPTIVE ADVISORS LLC 3.42% of their portfolio | 3.4m $141.5m | Added +178.0k |
| VANGUARD GROUP INC 0.00% of their portfolio | 3.4m $138.0m | Added +56.5k |
| NEA Management Company, LLC 8.99% of their portfolio | 2.9m $119.5m | Unchanged |
| Frazier Life Sciences Management, L.P. 4.55% of their portfolio | 2.4m $97.4m | Added +181.1k |
| STATE STREET CORP 0.00% of their portfolio | 2.0m $82.3m | Reduced -1.0m |
| FEDERATED HERMES, INC. 0.16% of their portfolio | 1.7m $68.2m | Reduced -313 |
| Polar Capital Holdings Plc 0.36% of their portfolio | 1.5m $61.6m | Unchanged |
| Rock Springs Capital Management LP 1.59% of their portfolio | 1.3m $52.6m | Reduced -242.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.3m $51.4m | Added +72.0k |
| Commodore Capital LP 3.43% of their portfolio | 1.2m $50.3m | Added +175.0k |
| Driehaus Capital Management LLC 0.47% of their portfolio | 1.2m $48.5m | Added +326.9k |
| ALKEON CAPITAL MANAGEMENT LLC 0.21% of their portfolio | 1.0m $41.1m | New |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.12% of their portfolio | 967.2k $39.7m | Added +236.6k |
| Checkpoint Capital L.P. 22.82% of their portfolio | 922.1k $37.9m | Added +96.6k |
| Pictet Asset Management Holding SA 0.04% of their portfolio | 801.8k $32.9m | Reduced -409.9k |
| ORBIMED ADVISORS LLC 0.58% of their portfolio | 704.8k $28.9m | Unchanged |
| JANUS HENDERSON GROUP PLC 0.01% of their portfolio | 593.6k $24.4m | Reduced -27.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 525.9k $21.6m | Added +44.4k |
| Opaleye Management Inc. 4.83% of their portfolio | 515.0k $21.1m | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 499.4k $20.5m | Reduced -3.4k |
| MORGAN STANLEY 0.00% of their portfolio | 475.7k $19.5m | Reduced -73.0k |
| Cormorant Asset Management, LP 1.13% of their portfolio | 475.0k $19.5m | Reduced -75.0k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.07% of their portfolio | 462.2k $19.0m | Reduced -11.3k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 428.0k $17.6m | Added +21.2k |
| CANADA PENSION PLAN INVESTMENT BOARD 0.02% of their portfolio | 417.0k $17.1m | Reduced -160.0k |
| NATIONAL BANK OF CANADA /FI/ 0.03% of their portfolio | 404.2k $17.2m | Added +36.7k |
| NISA INVESTMENT ADVISORS, LLC 0.10% of their portfolio | 374.3k $15.4m | Added +229.1k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 280.3k $11.5m | Added +171.3k |
| Invesco Ltd. 0.00% of their portfolio | 276.7k $11.4m | Added +188.5k |
| Candriam S.C.A. 0.07% of their portfolio | 271.4k $11.1m | New |
| Artisan Partners Limited Partnership 0.02% of their portfolio | 271.3k $11.1m | Reduced -154 |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 236.4k $9.7m | Added +29.5k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 232.7k $9.6m | Added +11.8k |
| Assenagon Asset Management S.A. 0.02% of their portfolio | 229.5k $9.4m | Reduced -56.2k |
| LORD, ABBETT & CO. LLC 0.01% of their portfolio | 205.2k $8.4m | Reduced -357.1k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 202.3k $8.3m | Added +8.8k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 191.9k $7.9m | Added +24.0k |
| SILVERARC CAPITAL MANAGEMENT, LLC 1.87% of their portfolio | 184.7k $7.6m | Added +886 |
| SAMSARA BIOCAPITAL, LLC 1.48% of their portfolio | 172.6k $7.1m | Unchanged |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 149.1k $6.1m | Added +6.4k |
| JANE STREET GROUP, LLC 0.01% of their portfolio | 146.5k $6.0m | Added +120.2k |
| Ghost Tree Capital, LLC 1.68% of their portfolio | 117.4k $4.8m | Reduced -7.6k |
| Aberdeen Group plc 0.01% of their portfolio | 112.8k $4.6m | New |
| MARSHALL WACE, LLP 0.01% of their portfolio | 106.8k $4.4m | Added +87.1k |
| ALGERT GLOBAL LLC 0.14% of their portfolio | 104.1k $4.3m | Added +35.1k |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 103.8k $4.3m | Added +32.8k |
| Hennion & Walsh Asset Management, Inc. 0.20% of their portfolio | 96.4k $4.0m | Added +9.4k |
| RICE HALL JAMES & ASSOCIATES, LLC 0.23% of their portfolio | 93.1k $3.8m | Added +3.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 92.0k $3.8m | Reduced -19.1k |
| FIRST TRUST ADVISORS LP 0.00% of their portfolio | 91.0k $3.7m | New |
| Swiss National Bank 0.00% of their portfolio | 88.7k $3.6m | Reduced -4.6k |
| Clearbridge Investments, LLC 0.00% of their portfolio | 88.1k $3.6m | Reduced -1.9k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 83.1k $3.4m | Added +6.3k |
| Rafferty Asset Management, LLC 0.01% of their portfolio | 72.6k $3.0m | Reduced -146.1k |
| UBS Group AG 0.00% of their portfolio | 65.9k $2.7m | Reduced -105.6k |
| WEDGE CAPITAL MANAGEMENT L L P/NC 0.05% of their portfolio | 63.2k $2.6m | Reduced -10.7k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 61.1k $2.5m | Added +7.6k |
| BARCLAYS PLC 0.00% of their portfolio | 53.6k $2.2m | Reduced -73.9k |
| Legal & General Group Plc 0.00% of their portfolio | 49.8k $2.0m | Added +2.4k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 49.3k $2.0m | Added +1.7k |
| Nan Fung Group Holdings Ltd 2.15% of their portfolio | 49.1k $2.0m | Unchanged |
| Caption Management, LLC 0.20% of their portfolio | 45.0k $1.8m | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 44.8k $1.8m | Reduced -3.1k |
| Woodline Partners LP 0.02% of their portfolio | 44.2k $1.8m | Reduced -128.0k |
| NATIXIS 0.01% of their portfolio | 44.0k $1.8m | Added +37.9k |
| NORGES BANK 0.00% of their portfolio | 43.2k $1.8m | Reduced -7.6k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 40.4k $1.7m | Added +19.4k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 39.4k $1.6m | Added +6.1k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 37.8k $1.6m | Reduced -134.9k |
| HARBOR CAPITAL ADVISORS, INC. 0.11% of their portfolio | 34.6k $1.4m | Added +11.8k |
| SG Americas Securities, LLC 0.01% of their portfolio | 33.7k $1.4m | Added +26.2k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 32.9k $1.3m | Added +44 |
| MetLife Investment Management, LLC 0.01% of their portfolio | 31.7k $1.3m | Added +4.5k |
| TD Asset Management Inc 0.00% of their portfolio | 31.0k $1.3m | Added +3.4k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 30.4k $1.2m | First filing |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 29.5k $1.2m | Added +2.5k |
| Corebridge Financial, Inc. 0.01% of their portfolio | 29.5k $1.2m | First filing |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 28.1k $1.2m | Added +121 |
| FMR LLC 0.00% of their portfolio | 28.0k $1.1m | Reduced -1.0k |
| Atom Investors LP 0.11% of their portfolio | 26.6k $1.1m | Reduced -14.6k |
| Squarepoint Ops LLC 0.00% of their portfolio | 26.2k $1.1m | Reduced -82.5k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 26.1k $1.1m | Reduced -2.1k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 24.1k $990.6k | Reduced -79.1k |
| GTS SECURITIES LLC 0.02% of their portfolio | 23.1k $950.0k | New |
| COMERICA BANK 0.00% of their portfolio | 20.4k $837.6k | Reduced -12.7k |
| Fiduciary Trust Co 0.01% of their portfolio | 20.0k $821.2k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 20.0k $820.9k | Reduced -170.5k |
| CASTLEARK MANAGEMENT LLC 0.03% of their portfolio | 19.0k $780.6k | Reduced -44.9k |
| Quantinno Capital Management LP 0.01% of their portfolio | 18.1k $744.0k | New |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 17.7k $725.1k | Unchanged |
| Parkwood LLC 0.08% of their portfolio | 16.4k $673.0k | Added +1.4k |
| Handelsbanken Fonder AB 0.00% of their portfolio | 15.9k $654.0k | Unchanged |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 14.7k $602.4k | New |
| HighVista Strategies LLC 0.22% of their portfolio | 14.4k $589.7k | Unchanged |
| PROFUND ADVISORS LLC 0.02% of their portfolio | 14.0k $573.8k | Reduced -20.3k |