TYRA BIOSCIENCES INC TYRA
COM · Common Stock · CUSIP 90240B106
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCarlsbad, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 52.8m as of 2024-08-05, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $15.99. Options: 1 managers hold calls ($0 notional), 2 hold puts ($1.0k).
Trends to Q2 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 49 |
| Q4 2022 | 47 |
| Q1 2023 | 52 |
| Q2 2023 | 60 |
| Q3 2023 | 60 |
| Q4 2023 | 63 |
| Q1 2024 | 78 |
| Q2 2024 | 80 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 17 | 15 |
| Q1 2023 | 27 | 14 |
| Q2 2023 | 26 | 14 |
| Q3 2023 | 20 | 20 |
| Q4 2023 | 28 | 18 |
| Q1 2024 | 48 | 22 |
| Q2 2024 | 46 | 33 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2023 | $0 | $0 | — |
| Q4 2023 | $1.9m | $0 | 0.00 |
| Q1 2024 | $9.8k | $66.7k | 6.78 |
| Q2 2024 | $0 | $1.0k | — |
Biggest buyers
| BlackRock Inc. | Added | +374.6k |
| Avidity Partners Management LP | New | +373.0k |
| VANGUARD GROUP INC | Added | +338.7k |
| PERCEPTIVE ADVISORS LLC | Added | +338.2k |
| Ally Bridge Group (NY) LLC | New | +264.7k |
| Ensign Peak Advisors, Inc | New | +190.6k |
| JENNISON ASSOCIATES LLC | New | +149.3k |
| AMERICAN CENTURY COMPANIES INC | Added | +145.3k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +105.9k |
| GOLDMAN SACHS GROUP INC | Added | +100.8k |
Biggest sellers
| Fairmount Funds Management LLC | Sold out | -1.4m |
| FMR LLC | Reduced | -630.5k |
| First Turn Management, LLC | Sold out | -381.2k |
| Driehaus Capital Management LLC | Sold out | -203.7k |
| Nicholas Investment Partners, LP | Sold out | -153.0k |
| ExodusPoint Capital Management, LP | Reduced | -101.4k |
| RENAISSANCE TECHNOLOGIES LLC | Sold out | -54.4k |
| MORGAN STANLEY | Reduced | -41.2k |
| JPMORGAN CHASE & CO | Reduced | -31.7k |
| ADAR1 Capital Management, LLC | Reduced | -28.0k |
Biggest calls
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SIMPLEX TRADING, LLC | Reduced | $1.0k100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| RA CAPITAL MANAGEMENT, L.P. 13D · may seek influence -1.3 pts · filed 2026-09-17 | 19.9% |
| FMR LLC 13G · institution +11.2 pts · filed 2026-04-07 | 14.4% |
| JANUS HENDERSON GROUP PLC 13G · institution +1.8 pts · filed 2026-05-15 | 7.2% |
| Farallon Capital Partners, L.P. 13G · passive investor +1.0 pts · filed 2026-05-12 | 6.6% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor +2.1 pts · filed 2026-09-21 | 6.1% |
| NEXTECH VI ONCOLOGY SCSP 13G · passive investor filed 2026-08-14 | 6.0% |
| Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-09-17 | 5.8% |
| TCG Crossover GP I, LLC 13G · passive investor new · filed 2025-03-06 | 5.7% |
Fell to 5% or below in the last year: BlackRock, Inc. (4.8%, 2026-10-27), FARALLON CAPITAL MANAGEMENT, L.L.C. (0.0%, 2026-08-14; now reported by Farallon Capital Partners, L.P.), Commodore Capital LP (4.2%, 2026-05-15), Harris Todd (4.8%, 2026-05-14), Canaan XI L.P. (1.4%, 2026-04-24), Vestal Point Capital, LP (4.5%, 2025-11-14)
Insider purchases and sales in Q2 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 2 | $1.1m | $38.4k |
| Q2 2023 | 0 | — | 2 | $3.8m | $3.8m |
| Q3 2023 | 0 | — | 1 | $204.6k | $204.6k |
| Q4 2023 | 0 | — | 0 | — | — |
| Q1 2024 | 0 | — | 2 | $3.8m | $3.8m |
| Q2 2024 | 0 | — | 1 | $74.0k | $74.0k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-06-10 | Bensen Daniel Chief Operating Officer | Sold plan | $70.0k3.5k shares |
| 2024-06-07 | Bensen Daniel Chief Operating Officer | Sold plan | $4.0k200 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2024
| Manager | Shares | Change |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. 2.20% of their portfolio | 10.4m $166.6m | Unchanged |
| Boxer Capital, LLC 5.43% of their portfolio | 6.4m $103.1m | Unchanged |
| BVF INC/IL 2.09% of their portfolio | 4.7m $74.5m | Unchanged |
| Canaan Partners XI LLC 85.38% of their portfolio | 4.4m $70.5m | Unchanged |
| Nextech Invest Ltd. 10.91% of their portfolio | 4.1m $64.9m | Unchanged |
| FMR LLC 0.00% of their portfolio | 3.3m $53.5m | Reduced -630.5k |
| TCG Crossover Management, LLC 3.31% of their portfolio | 2.0m $31.8m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 1.4m $22.7m | Added +374.6k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.2m $19.8m | Added +338.7k |
| PERCEPTIVE ADVISORS LLC 0.39% of their portfolio | 1.0m $16.1m | Added +338.2k |
| 5AM Venture Management, LLC 3.36% of their portfolio | 939.3k $15.0m | Unchanged |
| Frazier Life Sciences Management, L.P. 0.62% of their portfolio | 832.2k $13.3m | Unchanged |
| ORBIMED ADVISORS LLC 0.24% of their portfolio | 768.6k $12.3m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 729.5k $11.7m | Reduced -31.7k |
| Sio Capital Management, LLC 3.62% of their portfolio | 600.3k $9.6m | Added +64.6k |
| Kynam Capital Management, LP 0.95% of their portfolio | 566.7k $9.1m | Added +51.5k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 522.7k $8.4m | Added +105.9k |
| Avidity Partners Management LP 0.25% of their portfolio | 373.0k $6.0m | New |
| STATE STREET CORP 0.00% of their portfolio | 368.5k $5.9m | Added +76.2k |
| Ally Bridge Group (NY) LLC 2.52% of their portfolio | 264.7k $4.2m | New |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 190.6k $3.0m | New |
| ExodusPoint Capital Management, LP 0.03% of their portfolio | 170.7k $2.7m | Reduced -101.4k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 170.3k $2.7m | Added +145.3k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 169.9k $2.7m | Added +17.7k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 155.5k $2.5m | Reduced -1.0k |
| JENNISON ASSOCIATES LLC 0.00% of their portfolio | 149.3k $2.4m | New |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 117.0k $1.9m | Added +15.2k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 114.9k $1.8m | Added +100.8k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 92.7k $1.5m | Added +66.9k |
| Woodline Partners LP 0.01% of their portfolio | 88.7k $1.4m | New |
| Auour Investments LLC 0.51% of their portfolio | 85.0k $1.4m | Unchanged |
| OPPENHEIMER & CO INC 0.02% of their portfolio | 70.5k $1.1m | Added +10.9k |
| MORGAN STANLEY 0.00% of their portfolio | 64.5k $1.0m | Reduced -41.2k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 58.1k $928.8k | Added +14.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 49.5k $791.8k | Added +16.5k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 47.2k $754.1k | Reduced -930 |
| TANG CAPITAL MANAGEMENT LLC 0.07% of their portfolio | 42.2k $675.1k | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 41.0k $655.6k | New |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 38.1k $608.7k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 35.3k $564.0k | Reduced -6.5k |
| Walleye Capital LLC 0.01% of their portfolio | 31.1k $498.0k | Added +14.3k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 23.6k $376.9k | Added +2.6k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 17.6k $280.9k | New |
| HighVista Strategies LLC 0.09% of their portfolio | 16.1k $257.1k | New |
| PDT Partners, LLC 0.02% of their portfolio | 15.3k $244.7k | Added +3.1k |
| Parkwood LLC 0.03% of their portfolio | 14.1k $225.0k | New |
| Jump Financial, LLC 0.00% of their portfolio | 12.8k $203.9k | Reduced -2.4k |
| BARCLAYS PLC 0.00% of their portfolio | 12.5k $200.2k | Added +2.7k |
| FISHMAN JAY A LTD/MI 0.02% of their portfolio | 12.5k $199.9k | Reduced -2.5k |
| EXCHANGE TRADED CONCEPTS, LLC 0.00% of their portfolio | 12.2k $195.8k | Reduced -3.8k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 12.2k $195.2k | Added +4.5k |
| Corebridge Financial, Inc. 0.00% of their portfolio | 10.9k $174.8k | First filing |
| Mariner, LLC 0.00% of their portfolio | 10.8k $172.5k | New |
| BAKER BROS. ADVISORS LP 0.00% of their portfolio | 10.6k $169.6k | Unchanged |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 9.3k $149.1k | Added +3.3k |
| UBS Group AG 0.00% of their portfolio | 7.6k $121.1k | Reduced -6.6k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 7.4k $118.7k | Reduced -24.7k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 6.5k $104.1k | First filing |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 6.5k $104.0k | Added +1.8k |
| VIRTUS ADVISERS, LLC 0.04% of their portfolio | 4.6k $72.9k | New |
| CITIGROUP INC 0.00% of their portfolio | 4.4k $70.9k | Reduced -2.7k |
| Legal & General Group Plc 0.00% of their portfolio | 2.2k $36.0k | Added +984 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 2.2k $34.8k | Added +2.0k |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 2.0k $31.8k | Added +1.1k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 1.9k $31.0k | Added +1.6k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 1.5k $23.5k | Added +66 |
| STRS OHIO 0.00% of their portfolio | 700 $11.2k | Unchanged |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 566 $9.1k | Reduced -147 |
| AMALGAMATED BANK 0.00% of their portfolio | 424 $7.0k | Unchanged |
| ADAR1 Capital Management, LLC 0.00% of their portfolio | 300 $4.8k | Reduced -28.0k |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 59 $0 | Reduced -41 |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 58 $927 | Unchanged |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 40 $640 | Added +6 |
| GAMMA Investing LLC 0.00% of their portfolio | 35 $560 | Added +19 |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 34 $544 | New |
| CWM, LLC 0.00% of their portfolio | 10 $0 | Added +9 |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 8 $128 | Reduced -118 |
| Arax Advisory Partners 0.00% of their portfolio | 7 $112 | New |
| Covestor Ltd 0.00% of their portfolio | 6 $0 | New |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |