Vault-13

TYRA BIOSCIENCES INC TYRA

COM · Common Stock · CUSIP 90240B106

80 institutional holders +2 vs Q1 2024
47,179,53347.2m shares reported held*
89.3% of all shares outstanding*
$754.4mreported value*
16 new 30 added 17 reduced 16 sold out net sold ≈ $2.3m (-141.1k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 52.8m as of 2024-08-05, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $15.99. Options: 1 managers hold calls ($0 notional), 2 hold puts ($1.0k).

Trends to Q2 2024

Institutional holders

Managers reporting a position, each quarter

050100Q3 22: 49Q4 22: 47Q1 23: 52Q2 23: 60Q3 23: 60Q4 23: 63Q1 24: 78Q2 24: 8080Q3 22Q1 23Q3 23Q1 24Q2 24
Numbers
QuarterHolders
Q3 202249
Q4 202247
Q1 202352
Q2 202360
Q3 202360
Q4 202363
Q1 202478
Q2 202480

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
50050Q4 22: 17 bought or addedQ4 22: 15 cut or sold outQ4 22Q1 23: 27 bought or addedQ1 23: 14 cut or sold outQ2 23: 26 bought or addedQ2 23: 14 cut or sold outQ2 23Q3 23: 20 bought or addedQ3 23: 20 cut or sold outQ4 23: 28 bought or addedQ4 23: 18 cut or sold outQ4 23Q1 24: 48 bought or addedQ1 24: 22 cut or sold outQ2 24: 46 bought or addedQ2 24: 33 cut or sold outQ2 24
Numbers
QuarterBought or addedCut or sold out
Q4 20221715
Q1 20232714
Q2 20232614
Q3 20232020
Q4 20232818
Q1 20244822
Q2 20244633

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$500k$1m$1.5m$2mQ3 23 calls: $0Q3 23 puts: $0Q3 23P/C —Q4 23 calls: $1.9mQ4 23 puts: $0Q4 23P/C 0.00Q1 24 calls: $9.8kQ1 24 puts: $66.7kQ1 24P/C 6.78Q2 24 calls: $0Q2 24 puts: $1.0kQ2 24P/C —
Numbers
QuarterCallsPutsP/C
Q3 2023$0$0—
Q4 2023$1.9m$00.00
Q1 2024$9.8k$66.7k6.78
Q2 2024$0$1.0k—

Biggest buyers

BlackRock Inc. Added +374,630+374.6k
Avidity Partners Management LP New +373,000+373.0k
VANGUARD GROUP INC Added +338,701+338.7k
PERCEPTIVE ADVISORS LLC Added +338,208+338.2k
Ally Bridge Group (NY) LLC New +264,660+264.7k
Ensign Peak Advisors, Inc New +190,557+190.6k
JENNISON ASSOCIATES LLC New +149,350+149.3k
AMERICAN CENTURY COMPANIES INC Added +145,346+145.3k
GEODE CAPITAL MANAGEMENT, LLC Added +105,866+105.9k
GOLDMAN SACHS GROUP INC Added +100,797+100.8k

Biggest sellers

Fairmount Funds Management LLC Sold out -1,393,329-1.4m
FMR LLC Reduced -630,545-630.5k
First Turn Management, LLC Sold out -381,210-381.2k
Driehaus Capital Management LLC Sold out -203,709-203.7k
Nicholas Investment Partners, LP Sold out -152,968-153.0k
ExodusPoint Capital Management, LP Reduced -101,433-101.4k
RENAISSANCE TECHNOLOGIES LLC Sold out -54,400-54.4k
MORGAN STANLEY Reduced -41,180-41.2k
JPMORGAN CHASE & CO Reduced -31,692-31.7k
ADAR1 Capital Management, LLC Reduced -28,000-28.0k

Biggest calls

Biggest puts

SIMPLEX TRADING, LLC Reduced $1.0k100 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
RA CAPITAL MANAGEMENT, L.P. 13D · may seek influence -1.3 pts · filed 2026-09-17 19.9% -1.3 pts 14.1m≈ $417.2m 2026-09-17
FMR LLC 13G · institution +11.2 pts · filed 2026-04-07 14.4% +11.2 pts 7.7m≈ $247.5m 2026-04-07
JANUS HENDERSON GROUP PLC 13G · institution +1.8 pts · filed 2026-05-15 7.2% +1.8 pts 3.9m≈ $124.3m 2026-05-15
Farallon Capital Partners, L.P. 13G · passive investor +1.0 pts · filed 2026-05-12 6.6% +1.0 pts 3.6m≈ $114.4m 2026-05-12
BIOTECHNOLOGY VALUE FUND L P 13G · passive investor +2.1 pts · filed 2026-09-21 6.1% +2.1 pts 4.2m≈ $127.9m 2026-09-21
NEXTECH VI ONCOLOGY SCSP 13G · passive investor filed 2026-08-14 6.0% 3.6m≈ $113.5m 2026-08-14
Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-09-17 5.8% new 3.5m≈ $110.9m 2026-09-17
TCG Crossover GP I, LLC 13G · passive investor new · filed 2025-03-06 5.7% new 2.9m≈ $92.6m 2025-03-06

Fell to 5% or below in the last year: BlackRock, Inc. (4.8%, 2026-10-27), FARALLON CAPITAL MANAGEMENT, L.L.C. (0.0%, 2026-08-14; now reported by Farallon Capital Partners, L.P.), Commodore Capital LP (4.2%, 2026-05-15), Harris Todd (4.8%, 2026-05-14), Canaan XI L.P. (1.4%, 2026-04-24), Vestal Point Capital, LP (4.5%, 2025-11-14)

Insider purchases and sales in Q2 2024

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
202Q3 22: 0 buyingQ3 22: 0 sellingQ4 22: 0 buyingQ4 22: 0 sellingQ4 22Q1 23: 0 buyingQ1 23: 2 sellingQ2 23: 0 buyingQ2 23: 2 sellingQ2 23Q3 23: 0 buyingQ3 23: 1 sellingQ4 23: 0 buyingQ4 23: 0 sellingQ4 23Q1 24: 0 buyingQ1 24: 2 sellingQ2 24: 0 buyingQ2 24: 1 sellingQ2 24
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20220—0——
Q4 20220—0——
Q1 20230—2$1.1m$38.4k
Q2 20230—2$3.8m$3.8m
Q3 20230—1$204.6k$204.6k
Q4 20230—0——
Q1 20240—2$3.8m$3.8m
Q2 20240—1$74.0k$74.0k
DateInsiderTradeSharesPrice ValueTheir holding
2024-06-10 Bensen Daniel Chief Operating Officer Sold plan 3,502 $20.00 $70.0k3.5k shares -1%
2024-06-07 Bensen Daniel Chief Operating Officer Sold plan 200 $20.00 $4.0k200 shares -<1%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RA CAPITAL MANAGEMENT, L.P. 2.20% of their portfolio BOSTON, MA 10,416,60910.4m $166.6m $166.6m 2.20% Unchanged
2 Boxer Capital, LLC 5.43% of their portfolio San Diego, CA 6,448,3596.4m $103.1m $103.1m 5.43% Unchanged
3 BVF INC/IL 2.09% of their portfolio San Francisco, CA 4,661,1944.7m $74.5m $74.5m 2.09% Unchanged
4 Canaan Partners XI LLC 85.38% of their portfolio MENLO PARK, CA 4,409,9914.4m $70.5m $70.5m 85.38% Unchanged
5 Nextech Invest Ltd. 10.91% of their portfolio Zurich, V8 4,055,8614.1m $64.9m $64.9m 10.91% Unchanged
6 FMR LLC 0.00% of their portfolio BOSTON, MA 3,346,6633.3m $53.5m $53.5m 0.00% Reduced -630.5k -630,545
7 TCG Crossover Management, LLC 3.31% of their portfolio PALO ALTO, CA 1,989,1032.0m $31.8m $31.8m 3.31% Unchanged
8 BlackRock Inc. 0.00% of their portfolio New York, NY 1,418,8551.4m $22.7m $22.7m 0.00% Added +374.6k +374,630
9 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,238,5011.2m $19.8m $19.8m 0.00% Added +338.7k +338,701
10 PERCEPTIVE ADVISORS LLC 0.39% of their portfolio NEW YORK, NY 1,007,3671.0m $16.1m $16.1m 0.39% Added +338.2k +338,208
11 5AM Venture Management, LLC 3.36% of their portfolio SAN FRANCISCO, CA 939,298939.3k $15.0m $15.0m 3.36% Unchanged
12 Frazier Life Sciences Management, L.P. 0.62% of their portfolio PALO ALTO, CA 832,220832.2k $13.3m $13.3m 0.62% Unchanged
13 ORBIMED ADVISORS LLC 0.24% of their portfolio New York, NY 768,638768.6k $12.3m $12.3m 0.24% Unchanged
14 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 729,502729.5k $11.7m $11.7m 0.00% Reduced -31.7k -31,692
15 Sio Capital Management, LLC 3.62% of their portfolio NEW YORK, NY 600,294600.3k $9.6m $9.6m 3.62% Added +64.6k +64,553
16 Kynam Capital Management, LP 0.95% of their portfolio PRINCETON, NJ 566,715566.7k $9.1m $9.1m 0.95% Added +51.5k +51,525
17 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 522,674522.7k $8.4m $8.4m 0.00% Added +105.9k +105,866
18 Avidity Partners Management LP 0.25% of their portfolio DALLAS, TX 373,000373.0k $6.0m $6.0m 0.25% New
19 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 368,484368.5k $5.9m $5.9m 0.00% Added +76.2k +76,250
20 Ally Bridge Group (NY) LLC 2.52% of their portfolio NEW YORK, NY 264,660264.7k $4.2m $4.2m 2.52% New
21 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 190,557190.6k $3.0m $3.0m 0.01% New
22 ExodusPoint Capital Management, LP 0.03% of their portfolio NEW YORK, NY 170,717170.7k $2.7m $2.7m 0.03% Reduced -101.4k -101,433
23 AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio KANSAS CITY, MO 170,283170.3k $2.7m $2.7m 0.00% Added +145.3k +145,346
24 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 169,945169.9k $2.7m $2.7m 0.00% Added +17.7k +17,733
25 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 155,451155.5k $2.5m $2.5m 0.00% Reduced -1.0k -1,021
26 JENNISON ASSOCIATES LLC 0.00% of their portfolio NEW YORK, NY 149,350149.3k $2.4m $2.4m 0.00% New
27 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 117,032117.0k $1.9m $1.9m 0.00% Added +15.2k +15,244
28 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 114,874114.9k $1.8m $1.8m 0.00% Added +100.8k +100,797
29 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 92,65892.7k $1.5m $1.5m 0.00% Added +66.9k +66,945
30 Woodline Partners LP 0.01% of their portfolio San Francisco, CA 88,65688.7k $1.4m $1.4m 0.01% New
31 Auour Investments LLC 0.51% of their portfolio WOBURN, MA 85,02085.0k $1.4m $1.4m 0.51% Unchanged
32 OPPENHEIMER & CO INC 0.02% of their portfolio NEW YORK, NY 70,48870.5k $1.1m $1.1m 0.02% Added +10.9k +10,912
33 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 64,53164.5k $1.0m $1.0m 0.00% Reduced -41.2k -41,180
34 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 58,08758.1k $928.8k $928.8k 0.00% Added +14.4k +14,352
35 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 49,51749.5k $791.8k $791.8k 0.00% Added +16.5k +16,485
36 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 47,16047.2k $754.1k $754.1k 0.00% Reduced -930 -930
37 TANG CAPITAL MANAGEMENT LLC 0.07% of their portfolio SAN DIEGO, CA 42,22342.2k $675.1k $675.1k 0.07% New
38 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 40,99841.0k $655.6k $655.6k 0.00% New
39 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 38,06538.1k $608.7k $608.7k 0.00% New
40 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 35,27235.3k $564.0k $564.0k 0.00% Reduced -6.5k -6,470
41 Walleye Capital LLC 0.01% of their portfolio NEW YORK, NY 31,14631.1k $498.0k $498.0k 0.01% Added +14.3k +14,259
42 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 23,57223.6k $376.9k $376.9k 0.00% Added +2.6k +2,574
43 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 17,57017.6k $280.9k $280.9k 0.00% New
44 HighVista Strategies LLC 0.09% of their portfolio BOSTON, MA 16,07816.1k $257.1k $257.1k 0.09% New
45 PDT Partners, LLC 0.02% of their portfolio New York, NY 15,30615.3k $244.7k $244.7k 0.02% Added +3.1k +3,132
46 Parkwood LLC 0.03% of their portfolio CLEVELAND, OH 14,05614.1k $225.0k $225.0k 0.03% New
47 Jump Financial, LLC 0.00% of their portfolio Chicago, IL 12,75412.8k $203.9k $203.9k 0.00% Reduced -2.4k -2,405
48 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 12,51912.5k $200.2k $200.2k 0.00% Added +2.7k +2,669
49 FISHMAN JAY A LTD/MI 0.02% of their portfolio TROY, MI 12,50012.5k $199.9k $199.9k 0.02% Reduced -2.5k -2,500
50 EXCHANGE TRADED CONCEPTS, LLC 0.00% of their portfolio Oklahoma City, OK 12,24512.2k $195.8k $195.8k 0.00% Reduced -3.8k -3,808
51 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 12,20712.2k $195.2k $195.2k 0.00% Added +4.5k +4,505
52 Corebridge Financial, Inc. 0.00% of their portfolio HOUSTON, TX 10,93110.9k $174.8k $174.8k 0.00% First filing
53 Mariner, LLC 0.00% of their portfolio Overland Park, KS 10,78510.8k $172.5k $172.5k 0.00% New
54 BAKER BROS. ADVISORS LP 0.00% of their portfolio NEW YORK, NY 10,60710.6k $169.6k $169.6k 0.00% Unchanged
55 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 9,3279.3k $149.1k $149.1k 0.00% Added +3.3k +3,314
56 UBS Group AG 0.00% of their portfolio ZURICH, V8 7,5757.6k $121.1k $121.1k 0.00% Reduced -6.6k -6,597
57 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 7,4237.4k $118.7k $118.7k 0.00% Reduced -24.7k -24,726
58 MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio CAUSEWAY BAY, K3 6,5086.5k $104.1k $104.1k 0.00% First filing
59 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 6,5066.5k $104.0k $104.0k 0.00% Added +1.8k +1,781
60 VIRTUS ADVISERS, LLC 0.04% of their portfolio HARTFORD, CT 4,5604.6k $72.9k $72.9k 0.04% New
61 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 4,4334.4k $70.9k $70.9k 0.00% Reduced -2.7k -2,673
62 Legal & General Group Plc 0.00% of their portfolio London, X0 2,2492.2k $36.0k $36.0k 0.00% Added +984 +984
63 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 2,1772.2k $34.8k $34.8k 0.00% Added +2.0k +2,033
64 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 1,9912.0k $31.8k $31.8k 0.00% Added +1.1k +1,051
65 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 1,9171.9k $31.0k $31.0k 0.00% Added +1.6k +1,597
66 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 1,4721.5k $23.5k $23.5k 0.00% Added +66 +66
67 STRS OHIO 0.00% of their portfolio COLUMBUS, OH 700700 $11.2k $11.2k 0.00% Unchanged
68 FEDERATED HERMES, INC. 0.00% of their portfolio PITTSBURGH, PA 566566 $9.1k $9.1k 0.00% Reduced -147 -147
69 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 424424 $7.0k $7.0k 0.00% Unchanged
70 ADAR1 Capital Management, LLC 0.00% of their portfolio AUSTIN, TX 300300 $4.8k $4.8k 0.00% Reduced -28.0k -28,000
71 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 5959 $0 $0 0.00% Reduced -41 -41
72 PNC Financial Services Group, Inc. 0.00% of their portfolio Pittsburgh, PA 5858 $927 $927 0.00% Unchanged
73 NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio ST. LOUIS, MO 4040 $640 $640 0.00% Added +6 +6
74 GAMMA Investing LLC 0.00% of their portfolio FOSTER CITY, CA 3535 $560 $560 0.00% Added +19 +19
75 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 3434 $544 $544 0.00% New
76 CWM, LLC 0.00% of their portfolio OMAHA, NE 1010 $0 $0 0.00% Added +9 +9
77 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 88 $128 $128 0.00% Reduced -118 -118
78 Arax Advisory Partners 0.00% of their portfolio NEW YORK, NY 77 $112 $112 0.00% New
79 Covestor Ltd 0.00% of their portfolio LONDON, X0 66 $0 $0 0.00% New
80 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged