Frazier Life Sciences Management, L.P.

PALO ALTO, CA · CIK 1892134 · 13F filing filed 2023-08-14

SEC-registered investment adviser since 2021 · limited partnership

Assets managed$7.0bn
Staff64 · 47 in investment roles
Main clients (by assets)Private funds 100%
Private funds8 (1 hedge) · $7.0bn gross assets
Websitefrazierls.com
Form ADV · 2026-03-31SEC adviser record

Legal entityFrazier Life Sciences Management, L.P. (US)

Kindhedge funds, private equity, venture
Others nearbyPalo Alto, CA, San Diego, CA

As an employer

Offices in1 country
Private fundsventure capital 4, hedge 1, private equity 3

Where they work

people there (dot area)number not reportedmain officeHover or tap a dot. Australian and UK companies are placed at their business or registered address, with their staff across the whole country.

Offices

From Form ADV: the main office and the other offices where it does advisory work (at most the 25 largest), with the people doing investment work at each. “About” is worked out: the firm's investment staff less its other offices. Each city links to the other managers there.

City	Country	People
Palo Alto, CA (main office)United States	United States	about 44
San Diego, CAUnited States	United States	3

Map: places from GeoNames (CC BY 4.0), outlines from Natural Earth.

$1.7bn reported value +21.2% vs Q1 2023

48positions

66.8%in top 10

4 new 12 added 8 reduced 5 sold out vs Q1 2023

Holdings, Q2 2023

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	HILLEVAX INC COM COM		9,781,472	$168.1m10.04%	10.04%	Unchanged
2	CHINOOK THERAPEUTICS INC COM ADRO	ADRO	4,345,559	$167.0m9.97%	9.97%	Unchanged
3	PHATHOM PHARMACEUTICALS INC COM PHAT	PHAT	10,109,279	$144.8m8.65%	8.65%	Added +1.7m	+1,702,127 20.2%
4	NEWAMSTERDAM PHARMA COMPANY ORDINARY SHARES NAMS	NAMS	10,871,803	$129.3m7.72%	7.72%	Added +1.5m	+1,530,252 16.4%
5	KRYSTAL BIOTECH INC COM KRYS	KRYS	990,260	$116.3m6.94%	6.94%	Added +44.9k	+44,853 4.7%
6	MIRUM PHARMACEUTICALS INC COM MIRM	MIRM	4,360,107	$112.8m6.74%	6.74%	Added +500.0k	+500,000 12.9%
7	ARCUTIS BIOTHERAPEUTICS INC COM ARQT	ARQT	8,684,232	$82.8m4.94%	4.94%	Unchanged
8	SYNDAX PHARMACEUTICALS INC COM SNDX	SNDX	3,708,838	$77.6m4.64%	4.64%	Unchanged
9	VERONA PHARMA PLC SPONSORED ADS VRNA	VRNA	2,944,349	$62.2m3.72%	3.72%	Unchanged
10	VAXCYTE INC COM PCVX	PCVX	1,164,405	$58.2m3.47%	3.47%	Reduced -233.0k	-233,000 -16.7%
11	RHYTHM PHARMACEUTICALS INC COM RYTM	RYTM	2,167,222	$35.7m2.13%	2.13%	Added +2.5k	+2,483 0.1%
12	BRIDGEBIO PHARMA INC COM BBIO	BBIO	1,988,876	$34.2m2.04%	2.04%	Added +817.2k	+817,226 69.8%
13	TARSUS PHARMACEUTICALS INC COM TARS	TARS	1,787,527	$32.3m1.93%	1.93%	Unchanged
14	ALPINE IMMUNE SCIENCES INC COM NVLS	NVLS	2,985,757	$30.7m1.83%	1.83%	Unchanged
15	KALVISTA PHARMACEUTICALS INC COM KALV	KALV	3,238,859	$29.1m1.74%	1.74%	Unchanged
16	DISC MEDICINE INC COM IRON	IRON	655,000	$29.1m1.74%	1.74%	New
17	CRINETICS PHARMACEUTICALS IN COM CRNX	CRNX	1,414,823	$25.5m1.52%	1.52%	Unchanged
18	REVOLUTION MEDICINES INC COM RVMD	RVMD	854,484	$22.9m1.37%	1.37%	Unchanged
19	THESEUS PHARMACEUTICALS INC COM COM		2,248,194	$21.0m1.25%	1.25%	Unchanged
20	ACADIA PHARMACEUTICALS INC COM ACAD	ACAD	857,338	$20.5m1.23%	1.23%	Unchanged
21	MERUS N V COM MRUS	MRUS	746,479	$19.7m1.17%	1.17%	Unchanged
22	ANAPTYSBIO INC COM ANAB	ANAB	899,700	$18.3m1.09%	1.09%	Unchanged
23	COGENT BIOSCIENCES INC COM COGT	COGT	1,501,383	$17.8m1.06%	1.06%	Reduced -657.8k	-657,771 -30.5%
24	TYRA BIOSCIENCES INC COM TYRA	TYRA	1,028,013	$17.5m1.05%	1.05%	Reduced -393.3k	-393,297 -27.7%
25	AEROVATE THERAPEUTICS INC COM COM		994,858	$17.1m1.02%	1.02%	Added +656.7k	+656,748 194.2%
26	ENLIVEN THERAPEUTICS INC COM ELVN	ELVN	830,983	$17.0m1.01%	1.01%	Unchanged
27	ORIC PHARMACEUTICALS INC COM ORIC	ORIC	2,142,855	$16.6m0.99%	0.99%	New
28	TREVI THERAPEUTICS INC COM TRVI	TRVI	6,881,090	$16.4m0.98%	0.98%	Added +217.5k	+217,500 3.3%
29	MORPHIC HLDG INC COM MORF	MORF	265,511	$15.2m0.91%	0.91%	Added +51.3k	+51,271 23.9%
30	CEREVEL THERAPEUTICS HLDNG I COM CERE	CERE	393,000	$12.5m0.75%	0.75%	Unchanged
31	REATA PHARMACEUTICALS INC CL A RETA	RETA	100,430	$10.2m0.61%	0.61%	New
32	MACROGENICS INC COM MGNX	MGNX	1,803,204	$9.6m0.58%	0.58%	Added +100.0k	+100,000 5.9%
33	REPLIMUNE GROUP INC COM REPL	REPL	386,762	$9.0m0.54%	0.54%	Reduced -300.0k	-300,000 -43.7%
34	AUTOLUS THERAPEUTICS PLC SPON ADS AUTL	AUTL	3,746,857	$8.9m0.53%	0.53%	Unchanged
35	PROTHENA CORP PLC SHS PRTA	PRTA	127,900	$8.7m0.52%	0.52%	Unchanged
36	INTELLIA THERAPEUTICS INC COM NTLA	NTLA	203,684	$8.3m0.50%	0.50%	Unchanged
37	ARVINAS INC COM ARVN	ARVN	285,331	$7.1m0.42%	0.42%	Unchanged
38	EDGEWISE THERAPEUTICS INC COM EWTX	EWTX	749,022	$5.8m0.35%	0.35%	Added +66.6k	+66,561 9.8%
39	IMMUNOVANT INC COM IMVT	IMVT	300,000	$5.7m0.34%	0.34%	Reduced -285.8k	-285,759 -48.8%
40	BLUEBIRD BIO INC COM COM		1,709,907	$5.6m0.34%	0.34%	Added +269.1k	+269,150 18.7%
41	DECIPHERA PHARMACEUTICALS IN COM DCPH	DCPH	370,000	$5.2m0.31%	0.31%	New
42	SILENCE THERAPEUTICS PLC ADS SLN	SLN	881,173	$4.8m0.29%	0.29%	Unchanged
43	GRITSTONE BIO INC COM GRTS	GRTS	2,401,714	$4.7m0.28%	0.28%	Reduced -2.8m	-2,760,634 -53.5%
44	SUTRO BIOPHARMA INC COM COM		780,000	$3.6m0.22%	0.22%	Reduced -996.5k	-996,479 -56.1%
45	ADC THERAPEUTICS SA SHS ADCT	ADCT	1,647,030	$3.5m0.21%	0.21%	Unchanged
46	ACLARIS THERAPEUTICS INC COM ACRS	ACRS	264,377	$2.7m0.16%	0.16%	Unchanged
47	PASSAGE BIO INC COM COM		1,850,000	$1.7m0.10%	0.10%	Reduced -1.9m	-1,906,915 -50.8%
48	NEWAMSTERDAM PHARMA COMPANY *W EXP 11/22/202 NAMSW	NAMSW	500,333	$1.0m0.06%	0.06%	Unchanged

Sold out since Q1 2023

Security	Ticker	Shares held before	Value then
VECTIVBIO HLDG AG		1,352,199	$11.6m1.4m shares
AVIDITY BIOSCIENCES INC RNA	RNA	500,000	$7.7m500.0k shares
ZYMEWORKS INC ZYME	ZYME	610,000	$5.5m610.0k shares
ALLAKOS INC ALLKG	ALLKG	1,112,684	$5.0m1.1m shares
NABRIVA THERAPEUTICS PLC NBRVF	NBRVF	17,025	$29.7k17.0k shares