SYNDAX PHARMACEUTICALS INC SNDX
COM · Common Stock · CUSIP 87164F105
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew York, NY
- Websitesyndax.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.9m this quarter). Holder counts are more reliable. Shares outstanding: 69.5m as of 2023-07-27, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $20.93. Options: 7 managers hold calls ($2.2m notional), 7 hold puts ($4.7m).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 139 |
| Q4 2022 | 160 |
| Q1 2023 | 164 |
| Q2 2023 | 167 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 95 | 51 |
| Q1 2023 | 106 | 57 |
| Q2 2023 | 104 | 63 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $5.4m | $442.0k | 0.08 |
| Q4 2022 | $2.8m | $2.6m | 0.93 |
| Q1 2023 | $2.0m | $3.5m | 1.77 |
| Q2 2023 | $2.2m | $4.7m | 2.10 |
Biggest buyers
| ORBIMED ADVISORS LLC | Added | +818.6k |
| Point72 Asset Management, L.P. | Added | +710.4k |
| Woodline Partners LP | New | +612.3k |
| Sofinnova Investments, Inc. | Added | +506.9k |
| Hudson Bay Capital Management LP | New | +475.0k |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +440.4k |
| AMERIPRISE FINANCIAL INC | New | +355.9k |
| STATE STREET CORP | Added | +287.8k |
| GOLDMAN SACHS GROUP INC | Added | +255.6k |
| PEREGRINE CAPITAL MANAGEMENT LLC | New | +233.7k |
Biggest sellers
| BVF INC/IL | Sold out | -2.1m |
| CITADEL ADVISORS LLC | Reduced | -1.3m |
| Avidity Partners Management LP | Reduced | -993.3k |
| BRAIDWELL LP | Sold out | -920.0k |
| BARCLAYS PLC | Reduced | -812.7k |
| DIMENSIONAL FUND ADVISORS LP | Reduced | -725.8k |
| MORGAN STANLEY | Reduced | -664.1k |
| Nantahala Capital Management, LLC | Reduced | -652.6k |
| CITIGROUP INC | Reduced | -443.7k |
| 683 Capital Management, LLC | Reduced | -330.0k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $1.5m72.4k shares |
| Caption Management, LLC | Reduced | $627.9k30.0k shares |
| SIMPLEX TRADING, LLC | Added | $33.0k1.6k shares |
| CITADEL ADVISORS LLC | Reduced | $29.3k1.4k shares |
| Walleye Trading LLC | New | $16.7k800 shares |
| GROUP ONE TRADING LLC | New | $10.5k500 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $2.2m103.0k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | New | $1.6m75.5k shares |
| Caption Management, LLC | Reduced | $627.9k30.0k shares |
| GROUP ONE TRADING LLC | Added | $249.1k11.9k shares |
| CITADEL ADVISORS LLC | Reduced | $62.8k3.0k shares |
| Worth Venture Partners, LLC | New | $13.9k10.9k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Kynam Capital Management, LP 13G · institution filed 2025-02-14 | 10.0% |
| BlackRock, Inc. 13G · institution filed 2025-04-17 | 7.8% |
| GOLDMAN SACHS GROUP INC 13G · institution +1.3 pts · filed 2025-08-13 | 6.5% |
| STATE STREET CORP 13G · institution +1.1 pts · filed 2026-08-07 | 6.4% |
| VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-30 | 5.0% |
Fell to 5% or below in the last year: Point72 Asset Management, L.P. (2.3%, 2026-05-15), VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD CAPITAL MANAGEMENT LLC)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 4 | $5.5m | — |
| Q1 2022 | 0 | — | 2 | $39.6k | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 6 | $16.7m | — |
| Q4 2022 | 0 | — | 3 | $1.9m | — |
| Q1 2023 | 0 | — | 4 | $4.5m | — |
| Q2 2023 | 0 | — | 2 | $3.3m | $3.3m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-06-13 | Goldan Keith A. Chief Financial Officer | Sold | $12.9k577 shares |
| 2023-06-09 | Morrison Briggs Director | Sold plan | $1.1m52.9k shares |
| 2023-05-09 | Morrison Briggs Director | Sold plan | $1.1m52.9k shares |
| 2023-04-10 | Morrison Briggs Director | Sold plan | $1.0m52.9k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio | 7.4m $155.8m | Added +440.4k |
| BlackRock Inc. 0.00% of their portfolio | 5.0m $104.5m | Added +90.1k |
| STATE STREET CORP 0.00% of their portfolio | 4.2m $86.9m | Added +287.8k |
| Frazier Life Sciences Management, L.P. 4.64% of their portfolio | 3.7m $77.6m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 3.6m $75.0m | Added +85.6k |
| Kynam Capital Management, LP 10.46% of their portfolio | 3.3m $68.3m | Added +56.0k |
| Avidity Partners Management LP 2.10% of their portfolio | 2.9m $60.1m | Reduced -993.3k |
| Avoro Capital Advisors LLC 0.75% of their portfolio | 2.6m $55.5m | Unchanged |
| ORBIMED ADVISORS LLC 0.97% of their portfolio | 2.5m $53.0m | Added +818.6k |
| JENNISON ASSOCIATES LLC 0.04% of their portfolio | 2.5m $52.8m | Added +105.5k |
| Paradigm Biocapital Advisors LP 4.11% of their portfolio | 2.4m $50.7m | Added +149.6k |
| Eversept Partners, LP 4.84% of their portfolio | 2.2m $45.8m | Reduced -19.3k |
| PFM Health Sciences, LP 1.83% of their portfolio | 2.2m $45.5m | Added +225.8k |
| Sofinnova Investments, Inc. 2.19% of their portfolio | 1.6m $33.1m | Added +506.9k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 1.3m $27.7m | Added +93.5k |
| Point72 Asset Management, L.P. 0.09% of their portfolio | 1.2m $25.8m | Added +710.4k |
| T. Rowe Price Investment Management, Inc. 0.02% of their portfolio | 1.1m $22.3m | Added +65.8k |
| Aisling Capital Management LP 10.51% of their portfolio | 1.0m $21.5m | Unchanged |
| Commodore Capital LP 2.35% of their portfolio | 997.6k $20.9m | Added +143.7k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.04% of their portfolio | 925.0k $19.4m | Added +135.0k |
| Foresite Capital Management IV, LLC 9.00% of their portfolio | 875.0k $18.3m | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 770.7k $16.1m | Added +221.6k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 746.4k $15.6m | Added +255.6k |
| LORD, ABBETT & CO. LLC 0.03% of their portfolio | 730.3k $15.3m | Reduced -239.0k |
| SPHERA FUNDS MANAGEMENT LTD. 3.24% of their portfolio | 723.1k $15.1m | Added +40.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 664.5k $13.9m | Added +69.5k |
| Palo Alto Investors LP 1.04% of their portfolio | 612.6k $12.8m | Unchanged |
| Woodline Partners LP 0.15% of their portfolio | 612.3k $12.8m | New |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 594.5k $12.4m | Reduced -725.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 491.3k $10.3m | Added +21.1k |
| Hudson Bay Capital Management LP 0.10% of their portfolio | 475.0k $9.9m | New |
| DAFNA Capital Management LLC 2.58% of their portfolio | 450.9k $9.4m | Added +3.8k |
| MORGAN STANLEY 0.00% of their portfolio | 429.7k $9.0m | Reduced -664.1k |
| Ensign Peak Advisors, Inc 0.02% of their portfolio | 388.4k $8.1m | Added +153.0k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 355.9k $7.4m | New |
| Ghost Tree Capital, LLC 2.64% of their portfolio | 350.0k $7.3m | Added +25.0k |
| Rafferty Asset Management, LLC 0.04% of their portfolio | 335.3k $7.0m | Added +52.5k |
| Nantahala Capital Management, LLC 0.82% of their portfolio | 323.1k $6.8m | Reduced -652.6k |
| ACUTA CAPITAL PARTNERS, LLC 4.25% of their portfolio | 299.8k $6.3m | Reduced -30.2k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 283.9k $5.9m | Reduced -111.3k |
| PANAGORA ASSET MANAGEMENT INC 0.03% of their portfolio | 267.1k $5.6m | Added +84.7k |
| Assenagon Asset Management S.A. 0.02% of their portfolio | 264.6k $5.5m | Reduced -74.9k |
| Walleye Capital LLC 0.10% of their portfolio | 264.5k $5.5m | Reduced -280.6k |
| ALGERT GLOBAL LLC 0.23% of their portfolio | 253.6k $5.3m | Added +167.7k |
| Candriam S.C.A. 0.04% of their portfolio | 240.0k $5.0m | Reduced -14.9k |
| Schonfeld Strategic Advisors LLC 0.04% of their portfolio | 238.6k $5.0m | Added +91.0k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 236.9k $5.0m | Reduced -1.3m |
| Bank of New York Mellon Corp 0.00% of their portfolio | 235.0k $4.9m | Added +23.3k |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.13% of their portfolio | 233.7k $4.9m | New |
| MACQUARIE GROUP LTD 0.01% of their portfolio | 231.4k $4.8m | Added +51.4k |
| Soleus Capital Management, L.P. 0.49% of their portfolio | 212.6k $4.4m | Reduced -110.0k |
| Parkman Healthcare Partners LLC 0.76% of their portfolio | 208.3k $4.4m | New |
| ExodusPoint Capital Management, LP 0.05% of their portfolio | 205.7k $4.3m | Added +143.8k |
| Saturn V Capital Management LP 2.02% of their portfolio | 173.7k $3.6m | New |
| D. E. Shaw & Co., Inc. 0.01% of their portfolio | 173.0k $3.6m | Added +34.0k |
| BARCLAYS PLC 0.00% of their portfolio | 169.2k $3.5m | Reduced -812.7k |
| PRUDENTIAL FINANCIAL INC 0.01% of their portfolio | 168.8k $3.5m | Reduced -16.9k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 160.9k $3.4m | Added +9.7k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 151.7k $3.2m | Added +110.0k |
| TWINBEECH CAPITAL LP 0.06% of their portfolio | 150.2k $3.1m | Added +20.7k |
| TWO SIGMA ADVISERS, LP 0.01% of their portfolio | 137.2k $2.9m | Reduced -126.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 131.3k $2.7m | Added +22.5k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 130.8k $2.7m | Added +90.1k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 130.6k $2.7m | Added +21.4k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 120.0k $2.5m | Added +36.5k |
| Swiss National Bank 0.00% of their portfolio | 119.3k $2.5m | Added +3.6k |
| CITIGROUP INC 0.00% of their portfolio | 116.7k $2.4m | Reduced -443.7k |
| UBS Group AG 0.00% of their portfolio | 112.7k $2.4m | Added +4.4k |
| Crestline Management, L.P. 0.26% of their portfolio | 112.5k $2.4m | Added +17.3k |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 99.7k $2.1m | Added +80.6k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 98.3k $2.1m | Added +7.4k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 88.9k $1.9m | Added +26.0k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 82.4k $1.7m | Added +26.7k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.05% of their portfolio | 76.5k $1.6m | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 70.2k $1.5m | Reduced -45.5k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 70.1k $1.5m | Added +648 |
| Ergoteles LLC 0.07% of their portfolio | 68.8k $1.4m | New |
| Trexquant Investment LP 0.04% of their portfolio | 65.7k $1.4m | Added +21.7k |
| PROFUND ADVISORS LLC 0.07% of their portfolio | 60.8k $1.3m | Added +8.2k |
| Engineers Gate Manager LP 0.05% of their portfolio | 60.7k $1.3m | Added +9.3k |
| 683 Capital Management, LLC 0.12% of their portfolio | 60.0k $1.3m | Reduced -330.0k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 53.7k $1.1m | Unchanged |
| Legal & General Group Plc 0.00% of their portfolio | 50.7k $1.1m | Added +21.7k |
| ALPS ADVISORS INC 0.01% of their portfolio | 50.6k $1.1m | Added +5.5k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 47.1k $984.9k | Reduced -5.3k |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 0.00% of their portfolio | 45.0k $941.9k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 43.8k $916.2k | Reduced -13.4k |
| FMR LLC 0.00% of their portfolio | 41.7k $873.7k | Reduced -41.3k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 41.6k $870.4k | Reduced -21.8k |
| Inspire Advisors, LLC 0.17% of their portfolio | 41.3k $864.0k | Added +5.7k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 39.5k $821.3k | Added +615 |
| Squarepoint Ops LLC 0.00% of their portfolio | 39.3k $822.2k | New |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio | 37.4k $783.0k | Unchanged |
| BIT Capital GmbH 0.09% of their portfolio | 37.3k $780.7k | Added +11.9k |
| OCCUDO QUANTITATIVE STRATEGIES LP 0.08% of their portfolio | 37.0k $774.5k | Reduced -4.1k |
| Jump Financial, LLC 0.03% of their portfolio | 36.3k $759.5k | New |
| MetLife Investment Management, LLC 0.01% of their portfolio | 34.8k $727.4k | Added +3.1k |
| Lion Point Capital, LP 0.54% of their portfolio | 34.5k $722.1k | New |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 33.7k $706.4k | Added +6.0k |
| HighVista Strategies LLC 0.32% of their portfolio | 33.6k $702.7k | Added +8.0k |