KRYSTAL BIOTECH INC KRYS
COM · Common Stock · CUSIP 501147102
Biotechnology company
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- HeadquartersPittsburgh, PA
- Websitekrystalbio.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.6m this quarter). Holder counts are more reliable. Shares outstanding: 28.0m as of 2023-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $117.37. Options: 11 managers hold calls ($26.0m notional), 13 hold puts ($20.0m).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 149 |
| Q4 2022 | 156 |
| Q1 2023 | 162 |
| Q2 2023 | 185 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 76 | 61 |
| Q1 2023 | 76 | 66 |
| Q2 2023 | 97 | 80 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $5.1m | $10.9m | 2.14 |
| Q4 2022 | $5.7m | $21.4m | 3.77 |
| Q1 2023 | $10.6m | $11.7m | 1.10 |
| Q2 2023 | $26.0m | $20.0m | 0.77 |
Biggest buyers
| Avoro Capital Advisors LLC | Added | +810.8k |
| Redmile Group, LLC | Added | +653.4k |
| VANGUARD GROUP INC | Added | +504.1k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +314.3k |
| MORGAN STANLEY | Added | +148.0k |
| Driehaus Capital Management LLC | Added | +144.7k |
| Eversept Partners, LP | New | +106.5k |
| Nuveen Asset Management, LLC | Added | +97.9k |
| SILVERARC CAPITAL MANAGEMENT, LLC | Added | +84.9k |
| JENNISON ASSOCIATES LLC | New | +58.3k |
Biggest sellers
| FMR LLC | Reduced | -1.7m |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Sold out | -311.9k |
| LORD, ABBETT & CO. LLC | Reduced | -237.2k |
| PICTET ASSET MANAGEMENT SA | Reduced | -203.0k |
| CREDIT SUISSE AG/ | Reduced | -165.6k |
| BAKER BROS. ADVISORS LP | Reduced | -132.8k |
| STATE STREET CORP | Reduced | -122.7k |
| ExodusPoint Capital Management, LP | Reduced | -112.0k |
| BRAIDWELL LP | Reduced | -106.6k |
| First Light Asset Management, LLC | Reduced | -94.7k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $13.7m116.6k shares |
| JANE STREET GROUP, LLC | Added | $4.3m36.8k shares |
| GROUP ONE TRADING LLC | Reduced | $2.5m21.6k shares |
| Caption Management, LLC | New | $2.3m20.0k shares |
| CITADEL ADVISORS LLC | Reduced | $1.2m9.9k shares |
| MILLENNIUM MANAGEMENT LLC | New | $598.7k5.1k shares |
| Walleye Capital LLC | Added | $457.9k3.9k shares |
| SIMPLEX TRADING, LLC | Reduced | $305.0k2.6k shares |
| Walleye Trading LLC | Reduced | $293.5k2.5k shares |
| WOLVERINE TRADING, LLC | New | $242.9k2.1k shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $8.2m69.9k shares |
| CITADEL ADVISORS LLC | Added | $3.5m29.5k shares |
| JANE STREET GROUP, LLC | New | $3.1m26.1k shares |
| Caption Management, LLC | New | $2.3m20.0k shares |
| Ikarian Capital, LLC | Unchanged | $1.2m10.3k shares |
| SIMPLEX TRADING, LLC | Reduced | $680.0k5.8k shares |
| WOLVERINE TRADING, LLC | New | $347.0k3.0k shares |
| Walleye Capital LLC | Reduced | $246.5k2.1k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | New | $223.1k1.9k shares |
| GROUP ONE TRADING LLC | Reduced | $152.6k1.3k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| BlackRock, Inc. 13G · institution filed 2026-10-27 | 11.6% |
| Krishnan Krish S 13G · exempt (held before listing) filed 2026-05-04 | 11.5% |
| VANGUARD PORTFOLIO MANAGEMENT LLC 13G · institution new · filed 2026-04-29 | 5.0% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27; now reported by VANGUARD PORTFOLIO MANAGEMENT LLC)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 3 | $7.0m | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 2 | $4.1m | — |
| Q4 2022 | 0 | — | 2 | $3.1m | — |
| Q1 2023 | 0 | — | 3 | $8.3m | — |
| Q2 2023 | 0 | — | 5 | $30.7m | $18.4m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-06-09 | JANNEY DANIEL Director · Directly beneficially owned by Alta Bioequities, L.P. | Sold | $2.4m18.9k shares |
| 2023-06-09 | ORTH ANDREW C. Chief Commercial Officer | Sold plan | $1.6m12.5k shares |
| 2023-06-08 | JANNEY DANIEL Director · Directly beneficially owned by Alta Bioequities, L.P. | Sold | $4.0m31.1k shares |
| 2023-05-31 | Krishnan Suma President, R&D, director | Sold | $2.9m25.0k shares |
| 2023-05-31 | Krishnan Krish S President and CEO, director | Sold | $2.9m25.0k shares |
| 2023-05-31 | Krishnan Krish S President and CEO, director | Sold | $2.9m25.0k shares |
| 2023-05-31 | Krishnan Suma President, R&D, director | Sold | $2.9m25.0k shares |
| 2023-05-22 | Romano Kathryn Chief Accounting Officer | Sold plan | $2.7m25.0k shares |
| 2023-05-19 | JANNEY DANIEL Director · Directly beneficially owned by Alta Bioequities, L.P. | Sold plan | $4.8m50.0k shares |
| 2023-05-19 | Romano Kathryn Chief Accounting Officer | Sold plan | $2.7m28.4k shares |
| 2023-05-09 | JANNEY DANIEL Director · Directly beneficially owned by Alta Bioequities, L.P. | Sold plan | $1.6m17.1k shares |
| 2023-04-19 | JANNEY DANIEL Director · Directly beneficially owned by Alta Bioequities, L.P. | Sold plan | $713.5k7.9k shares |
| 2023-04-17 | Krishnan Suma President, R&D, director | Sold plan | $2.2m25.0k shares |
| 2023-04-17 | Krishnan Krish S President and CEO, director | Sold plan | $2.2m25.0k shares |
| 2023-04-17 | Krishnan Krish S President and CEO, director | Sold plan | $2.2m25.0k shares |
| 2023-04-17 | Krishnan Suma President, R&D, director | Sold plan | $2.2m25.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.03% of their portfolio | 2.7m $314.8m | Reduced -1.7m |
| Redmile Group, LLC 11.57% of their portfolio | 2.6m $301.3m | Added +653.4k |
| Avoro Capital Advisors LLC 4.08% of their portfolio | 2.6m $300.6m | Added +810.8k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.7m $200.3m | Added +504.1k |
| LORD, ABBETT & CO. LLC 0.34% of their portfolio | 1.7m $197.9m | Reduced -237.2k |
| BlackRock Inc. 0.01% of their portfolio | 1.6m $191.7m | Reduced -82.8k |
| Frazier Life Sciences Management, L.P. 6.94% of their portfolio | 990.3k $116.3m | Added +44.9k |
| STATE STREET CORP 0.01% of their portfolio | 903.7k $106.1m | Reduced -122.7k |
| Point72 Asset Management, L.P. 0.23% of their portfolio | 559.3k $65.7m | Added +56.9k |
| DIMENSIONAL FUND ADVISORS LP 0.02% of their portfolio | 486.6k $57.1m | Added +24.5k |
| CREDIT SUISSE AG/ 0.05% of their portfolio | 467.2k $54.8m | Reduced -165.6k |
| Hood River Capital Management LLC 1.58% of their portfolio | 452.5k $53.1m | Added +5.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 444.3k $52.2m | Added +13.7k |
| PICTET ASSET MANAGEMENT SA 0.06% of their portfolio | 429.4k $50.4m | Reduced -203.0k |
| Nicholas Investment Partners, LP 3.01% of their portfolio | 375.0k $44.0m | Added +233 |
| Artal Group S.A. 1.31% of their portfolio | 349.7k $41.1m | Reduced -62.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 324.9k $38.1m | Added +314.3k |
| Skandinaviska Enskilda Banken AB (publ) 0.22% of their portfolio | 285.9k $33.6m | Reduced -158 |
| MORGAN STANLEY 0.00% of their portfolio | 274.8k $32.3m | Added +148.0k |
| BRAIDWELL LP 0.93% of their portfolio | 241.4k $28.3m | Reduced -106.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 239.8k $28.2m | Added +1.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 209.1k $24.6m | Added +7.7k |
| Driehaus Capital Management LLC 0.29% of their portfolio | 198.6k $23.3m | Added +144.7k |
| VICTORY CAPITAL MANAGEMENT INC 0.03% of their portfolio | 197.0k $23.1m | Reduced -15.1k |
| GOLDMAN SACHS GROUP INC 0.01% of their portfolio | 194.9k $22.9m | Reduced -62.9k |
| C WorldWide Group Holding A/S 0.28% of their portfolio | 185.8k $21.8m | Reduced -40.0k |
| BAKER BROS. ADVISORS LP 0.12% of their portfolio | 169.9k $20.0m | Reduced -132.8k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 162.2k $19.0m | Added +2.3k |
| Nuveen Asset Management, LLC 0.01% of their portfolio | 150.8k $17.7m | Added +97.9k |
| SILVERARC CAPITAL MANAGEMENT, LLC 4.71% of their portfolio | 118.9k $14.0m | Added +84.9k |
| Soleus Capital Management, L.P. 1.44% of their portfolio | 110.2k $12.9m | Added +25.0k |
| S SQUARED TECHNOLOGY, LLC 6.29% of their portfolio | 108.2k $12.7m | Unchanged |
| Handelsbanken Fonder AB 0.07% of their portfolio | 107.2k $12.6m | Added +2.0k |
| Eversept Partners, LP 1.32% of their portfolio | 106.5k $12.5m | New |
| First Light Asset Management, LLC 0.93% of their portfolio | 101.3k $11.9m | Reduced -94.7k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 96.6k $11.3m | Added +17.1k |
| Verition Fund Management LLC 0.17% of their portfolio | 91.7k $10.8m | Reduced -1.9k |
| Candriam S.C.A. 0.06% of their portfolio | 70.0k $8.2m | Reduced -22.0k |
| Invesco Ltd. 0.00% of their portfolio | 65.2k $7.7m | Added +13.6k |
| Integral Health Asset Management, LLC 0.96% of their portfolio | 62.0k $7.3m | Reduced -23.0k |
| JENNISON ASSOCIATES LLC 0.01% of their portfolio | 58.3k $6.8m | New |
| Rafferty Asset Management, LLC 0.04% of their portfolio | 53.2k $6.2m | Reduced -8.3k |
| Hennion & Walsh Asset Management, Inc. 0.35% of their portfolio | 49.7k $5.8m | Added +4.4k |
| BARCLAYS PLC 0.00% of their portfolio | 46.6k $5.5m | Added +16.7k |
| INTERNATIONAL BIOTECHNOLOGY TRUST PLC 1.64% of their portfolio | 45.9k $5.4m | Reduced -15.1k |
| Woodline Partners LP 0.06% of their portfolio | 44.2k $5.2m | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 42.8k $5.0m | Reduced -50.1k |
| Swiss National Bank 0.00% of their portfolio | 42.1k $4.9m | Added +3.2k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 41.3k $4.9m | Added +8.2k |
| CITADEL ADVISORS LLC 0.01% of their portfolio | 39.3k $4.6m | Reduced -68.0k |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC 0.05% of their portfolio | 38.5k $4.5m | Added +12.9k |
| Balyasny Asset Management L.P. 0.01% of their portfolio | 36.6k $4.3m | Reduced -4.5k |
| Global IMC LLC 1.21% of their portfolio | 35.2k $4.1m | New |
| Rock Springs Capital Management LP 0.10% of their portfolio | 34.9k $4.1m | New |
| CWM, LLC 0.02% of their portfolio | 33.7k $4.0m | Reduced -1.4k |
| Russell Investments Group, Ltd. 0.01% of their portfolio | 33.0k $3.9m | Added +10.3k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 31.0k $3.6m | Reduced -1.5k |
| DekaBank Deutsche Girozentrale 0.01% of their portfolio | 30.3k $3.5m | Unchanged |
| Apis Capital Advisors, LLC 3.18% of their portfolio | 26.8k $3.1m | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 26.1k $3.1m | Unchanged |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 24.2k $2.8m | Added +439 |
| Empowered Funds, LLC 0.10% of their portfolio | 24.1k $2.8m | New |
| EA Series Trust 0.10% of their portfolio | 24.1k $2.8m | First filing |
| ExodusPoint Capital Management, LP 0.03% of their portfolio | 24.1k $2.8m | Reduced -112.0k |
| CITIGROUP INC 0.00% of their portfolio | 22.4k $2.6m | Reduced -28.2k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 22.0k $2.6m | Reduced -2.4k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 21.7k $2.5m | Added +3.5k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 21.6k $2.5m | Added +13.1k |
| Calamos Advisors LLC 0.01% of their portfolio | 20.6k $2.4m | Added +9.1k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 20.3k $2.4m | Reduced -9.6k |
| ALPS ADVISORS INC 0.02% of their portfolio | 20.2k $2.4m | Added +3.3k |
| Ghost Tree Capital, LLC 0.85% of their portfolio | 20.0k $2.3m | New |
| Legal & General Group Plc 0.00% of their portfolio | 18.7k $2.2m | Added +9.5k |
| Schonfeld Strategic Advisors LLC 0.02% of their portfolio | 18.3k $2.1m | New |
| NORGES BANK 0.00% of their portfolio | 18.1k $2.1m | Reduced -30.0k |
| Bellevue Group AG 0.03% of their portfolio | 18.0k $2.1m | Reduced -300 |
| EFG Asset Management (North America) Corp. 0.45% of their portfolio | 17.8k $2.1m | Reduced -3.1k |
| HighMark Wealth Management LLC 1.52% of their portfolio | 17.2k $2.0m | Unchanged |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 17.1k $2.0m | Reduced -7.1k |
| Lisanti Capital Growth, LLC 0.27% of their portfolio | 16.8k $2.0m | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 16.8k $1.3m | Unchanged |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 16.7k $2.0m | Added +156 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.01% of their portfolio | 16.1k $1.9m | New |
| LOS ANGELES CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 16.0k $1.9m | New |
| TD Asset Management Inc 0.00% of their portfolio | 15.8k $1.9m | New |
| Informed Momentum Co LLC 0.34% of their portfolio | 15.7k $1.8m | Reduced -9.0k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 15.2k $1.8m | Added +10.6k |
| PUTNAM INVESTMENTS LLC 0.00% of their portfolio | 15.2k $1.8m | New |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 15.0k $1.8m | Reduced -10.4k |
| SEI INVESTMENTS CO 0.00% of their portfolio | 13.2k $1.6m | Added +279 |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 13.1k $1.5m | Reduced -4.2k |
| Legato Capital Management LLC 0.20% of their portfolio | 12.7k $1.5m | Added +1.8k |
| MARTINGALE ASSET MANAGEMENT L P 0.03% of their portfolio | 12.1k $1.4m | Reduced -1.5k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 11.9k $1.4m | Reduced -563 |
| ADVISORY RESEARCH INC 0.18% of their portfolio | 11.7k $1.4m | New |
| MetLife Investment Management, LLC 0.01% of their portfolio | 11.4k $1.3m | Added +190 |
| UBS Group AG 0.00% of their portfolio | 11.2k $1.3m | Reduced -16.9k |
| AMERICAN INTERNATIONAL GROUP, INC. 0.01% of their portfolio | 10.4k $1.2m | Added +108 |
| PROFUND ADVISORS LLC 0.06% of their portfolio | 9.9k $1.2m | Reduced -1.7k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 9.8k $1.2m | New |