| 1 |
TCG Crossover Management, LLC
5.01% of their portfolio |
PALO ALTO, CA |
3,395,4953.4m
$30.6m |
$30.6m |
5.01% |
Unchanged |
|
| 2 |
Frazier Life Sciences Management, L.P.
1.74% of their portfolio |
PALO ALTO, CA |
3,238,8593.2m
$29.1m |
$29.1m |
1.74% |
Unchanged |
|
| 3 |
Venrock Adviser, LLC
4.20% of their portfolio |
NEW YORK, NY |
2,916,6672.9m
$26.3m |
$26.3m |
4.20% |
Unchanged |
|
| 4 |
TANG CAPITAL MANAGEMENT LLC
3.51% of their portfolio |
SAN DIEGO, CA |
2,651,3932.7m
$23.9m |
$23.9m |
3.51% |
Unchanged |
|
| 5 |
MONTANOVA CAPITAL, LLC
0.98% of their portfolio |
New York, NY |
2,034,5062.0m
$18.3m |
$18.3m |
0.98% |
Added
+51.3k |
+51,327 |
| 6 |
Boxer Capital, LLC
0.69% of their portfolio |
San Diego, CA |
1,650,0001.6m
$14.8m |
$14.8m |
0.69% |
Unchanged |
|
| 7 |
BlackRock Inc.
0.00% of their portfolio |
New York, NY |
1,599,7381.6m
$14.4m |
$14.4m |
0.00% |
Added
+41.6k |
+41,604 |
| 8 |
VANGUARD GROUP INC
0.00% of their portfolio |
Valley Forge, PA |
1,580,6811.6m
$14.2m |
$14.2m |
0.00% |
Reduced
-1.8k |
-1,845 |
| 9 |
Saturn V Capital Management LP
7.05% of their portfolio |
AUSTIN, TX |
1,412,3361.4m
$12.7m |
$12.7m |
7.05% |
Added
+290.4k |
+290,354 |
| 10 |
ADAGE CAPITAL PARTNERS GP, L.L.C.
0.02% of their portfolio |
Boston, MA |
1,104,3391.1m
$9.9m |
$9.9m |
0.02% |
Added
+40.0k |
+40,000 |
| 11 |
Driehaus Capital Management LLC
0.12% of their portfolio |
Chicago, IL |
1,035,9351.0m
$9.3m |
$9.3m |
0.12% |
Added
+20.8k |
+20,816 |
| 12 |
Jefferies Financial Group Inc.
0.20% of their portfolio |
NEW YORK, NY |
1,030,0001.0m
$9.3m |
$9.3m |
0.20% |
Reduced
-170.0k |
-170,000 |
| 13 |
Vivo Capital, LLC
0.53% of their portfolio |
Palo Alto, CA |
856,008856.0k
$7.7m |
$7.7m |
0.53% |
Unchanged |
|
| 14 |
CITADEL ADVISORS LLC
0.01% of their portfolio |
MIAMI, FL |
846,606846.6k
$7.6m |
$7.6m |
0.01% |
Added
+718.2k |
+718,211 |
| 15 |
MPM BIOIMPACT LLC
1.38% of their portfolio |
BOSTON, MA |
761,538761.5k
$6.9m |
$6.9m |
1.38% |
New |
|
| 16 |
SILVERARC CAPITAL MANAGEMENT, LLC
2.19% of their portfolio |
BOSTON, MA |
720,508720.5k
$6.5m |
$6.5m |
2.19% |
Reduced
-3.0k |
-3,036 |
| 17 |
Opaleye Management Inc.
1.55% of their portfolio |
BOSTON, MA |
720,000720.0k
$6.5m |
$6.5m |
1.55% |
Reduced
-203.2k |
-203,200 |
| 18 |
DAFNA Capital Management LLC
1.50% of their portfolio |
LOS ANGELES, CA |
611,032611.0k
$5.5m |
$5.5m |
1.50% |
Reduced
-5.0k |
-5,000 |
| 19 |
GEODE CAPITAL MANAGEMENT, LLC
0.00% of their portfolio |
BOSTON, MA |
480,425480.4k
$4.3m |
$4.3m |
0.00% |
Added
+12.9k |
+12,941 |
| 20 |
STATE STREET CORP
0.00% of their portfolio |
BOSTON, MA |
446,175446.2k
$4.0m |
$4.0m |
0.00% |
Added
+26.9k |
+26,914 |
| 21 |
DIMENSIONAL FUND ADVISORS LP
0.00% of their portfolio |
AUSTIN, TX |
420,536420.5k
$3.8m |
$3.8m |
0.00% |
Added
+184.3k |
+184,269 |
| 22 |
FIRST MANHATTAN CO. LLC.
0.01% of their portfolio |
NEW YORK, NY |
392,504392.5k
$3.5m |
$3.5m |
0.01% |
Added
+122.9k |
+122,900 |
| 23 |
Commodore Capital LP
0.32% of their portfolio |
NEW YORK, NY |
312,553312.6k
$2.8m |
$2.8m |
0.32% |
Unchanged |
|
| 24 |
CITIGROUP INC
0.00% of their portfolio |
NEW YORK, NY |
299,808299.8k
$2.7m |
$2.7m |
0.00% |
Added
+22.9k |
+22,902 |
| 25 |
GOLDMAN SACHS GROUP INC
0.00% of their portfolio |
NEW YORK, NY |
293,311293.3k
$2.6m |
$2.6m |
0.00% |
Added
+17.8k |
+17,827 |
| 26 |
JPMORGAN CHASE & CO
0.00% of their portfolio |
NEW YORK, NY |
290,275290.3k
$2.6m |
$2.6m |
0.00% |
Reduced
-44.0k |
-44,034 |
| 27 |
NORTHERN TRUST CORP
0.00% of their portfolio |
CHICAGO, IL |
261,616261.6k
$2.4m |
$2.4m |
0.00% |
Added
+25.5k |
+25,503 |
| 28 |
Nan Fung Group Holdings Ltd
1.18% of their portfolio |
KAI TAK, K3 |
204,720204.7k
$1.8m |
$1.8m |
1.18% |
Added
+126.0k |
+126,000 |
| 29 |
MORGAN STANLEY
0.00% of their portfolio |
NEW YORK, NY |
202,623202.6k
$1.8m |
$1.8m |
0.00% |
Added
+10.8k |
+10,847 |
| 30 |
Affinity Asset Advisors, LLC
0.63% of their portfolio |
NEW YORK, NY |
178,292178.3k
$1.6m |
$1.6m |
0.63% |
Reduced
-30.0k |
-30,000 |
| 31 |
RENAISSANCE TECHNOLOGIES LLC
0.00% of their portfolio |
NEW YORK, NY |
142,928142.9k
$1.3m |
$1.3m |
0.00% |
Added
+62.3k |
+62,328 |
| 32 |
HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND
0.01% of their portfolio |
TORONTO, A6 |
140,200140.2k
$1.3m |
$1.3m |
0.01% |
Unchanged |
|
| 33 |
Ikarian Capital, LLC
0.43% of their portfolio |
DALLAS, TX |
140,000140.0k
$1.3m |
$1.3m |
0.43% |
Unchanged |
|
| 34 |
AlphaCentric Advisors LLC
0.67% of their portfolio |
SAN JUAN, PR |
135,000135.0k
$1.2m |
$1.2m |
0.67% |
New |
|
| 35 |
TWO SIGMA ADVISERS, LP
0.00% of their portfolio |
NEW YORK, NY |
133,122133.1k
$1.2m |
$1.2m |
0.00% |
Added
+33.5k |
+33,500 |
| 36 |
SG Americas Securities, LLC
0.01% of their portfolio |
NEW YORK, NY |
121,353121.4k
$1.1m |
$1.1m |
0.01% |
New |
|
| 37 |
D. E. Shaw & Co., Inc.
0.00% of their portfolio |
New York, NY |
116,862116.9k
$1.1m |
$1.1m |
0.00% |
Added
+71.2k |
+71,198 |
| 38 |
Woodline Partners LP
0.01% of their portfolio |
San Francisco, CA |
108,358108.4k
$975.2k |
$975.2k |
0.01% |
New |
|
| 39 |
Connor, Clark & Lunn Investment Management Ltd.
0.00% of their portfolio |
VANCOUVER, A1 |
107,975108.0k
$971.8k |
$971.8k |
0.00% |
Added
+8.1k |
+8,104 |
| 40 |
TWO SIGMA INVESTMENTS, LP
0.00% of their portfolio |
NEW YORK, NY |
99,16299.2k
$892.5k |
$892.5k |
0.00% |
Added
+44.8k |
+44,797 |
| 41 |
STATE OF WISCONSIN INVESTMENT BOARD
0.00% of their portfolio |
MADISON, WI |
88,60088.6k
$797.4k |
$797.4k |
0.00% |
Reduced
-13.9k |
-13,900 |
| 42 |
Bank of New York Mellon Corp
0.00% of their portfolio |
NEW YORK, NY |
82,80182.8k
$745.2k |
$745.2k |
0.00% |
Reduced
-210 |
-210 |
| 43 |
LOS ANGELES CAPITAL MANAGEMENT LLC
0.00% of their portfolio |
LOS ANGELES, CA |
72,54072.5k
$652.9k |
$652.9k |
0.00% |
New |
|
| 44 |
FMR LLC
0.00% of their portfolio |
BOSTON, MA |
70,86570.9k
$637.8k |
$637.8k |
0.00% |
Reduced
-70.9k |
-70,925 |
| 45 |
HighVista Strategies LLC
0.29% of their portfolio |
BOSTON, MA |
69,56769.6k
$626.1k |
$626.1k |
0.29% |
New |
|
| 46 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC
0.00% of their portfolio |
SAN FRANCISCO, CA |
65,15465.2k
$586.4k |
$586.4k |
0.00% |
Added
+1.3k |
+1,287 |
| 47 |
Nuveen Asset Management, LLC
0.00% of their portfolio |
CHICAGO, IL |
61,78361.8k
$556.0k |
$556.0k |
0.00% |
Unchanged |
|
| 48 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP
0.00% of their portfolio |
BALA CYNWYD, PA |
59,97160.0k
$539.7k |
$539.7k |
0.00% |
Added
+25.9k |
+25,906 |
| 49 |
CIBC WORLD MARKETS CORP
0.00% of their portfolio |
NEW YORK, NY |
50,00050.0k
$450.0k |
$450.0k |
0.00% |
New |
|
| 50 |
RHUMBLINE ADVISERS
0.00% of their portfolio |
BOSTON, MA |
41,73141.7k
$375.6k |
$375.6k |
0.00% |
Added
+2.9k |
+2,909 |
| 51 |
Birchview Capital, LP
0.27% of their portfolio |
BURLINGTON, VT |
40,00040.0k
$360.0k |
$360.0k |
0.27% |
Unchanged |
|
| 52 |
PDT Partners, LLC
0.05% of their portfolio |
New York, NY |
37,30637.3k
$335.8k |
$335.8k |
0.05% |
Reduced
-35 |
-35 |
| 53 |
Atom Investors LP
0.11% of their portfolio |
AUSTIN, TX |
33,55933.6k
$302.0k |
$302.0k |
0.11% |
Added
+11.0k |
+10,975 |
| 54 |
PRICE T ROWE ASSOCIATES INC /MD/
0.00% of their portfolio |
BALTIMORE, MD |
32,51632.5k
$293.0k |
$293.0k |
0.00% |
Reduced
-4.5k |
-4,455 |
| 55 |
ALLIANCEBERNSTEIN L.P.
0.00% of their portfolio |
NASHVILLE, TN |
32,41032.4k
$291.7k |
$291.7k |
0.00% |
Added
+6.7k |
+6,710 |
| 56 |
ExodusPoint Capital Management, LP
0.00% of their portfolio |
NEW YORK, NY |
31,18031.2k
$281.0k |
$281.0k |
0.00% |
New |
|
| 57 |
DENALI ADVISORS LLC
0.09% of their portfolio |
SAN DIEGO, CA |
29,20029.2k
$262.8k |
$262.8k |
0.09% |
Added
+23.4k |
+23,400 |
| 58 |
BOOTHBAY FUND MANAGEMENT, LLC
0.01% of their portfolio |
NEW YORK, NY |
28,09828.1k
$252.9k |
$252.9k |
0.01% |
Unchanged |
|
| 59 |
MILLENNIUM MANAGEMENT LLC
0.00% of their portfolio |
NEW YORK, NY |
27,93527.9k
$251.4k |
$251.4k |
0.00% |
Reduced
-52.8k |
-52,768 |
| 60 |
Jump Financial, LLC
0.01% of their portfolio |
Chicago, IL |
27,14227.1k
$244.3k |
$244.3k |
0.01% |
New |
|
| 61 |
ALGERT GLOBAL LLC
0.01% of their portfolio |
SAN FRANCISCO, CA |
26,29026.3k
$236.6k |
$236.6k |
0.01% |
Reduced
-2.2k |
-2,220 |
| 62 |
PANAGORA ASSET MANAGEMENT INC
0.00% of their portfolio |
BOSTON, MA |
26,09026.1k
$234.8k |
$234.8k |
0.00% |
Reduced
-20.2k |
-20,159 |
| 63 |
ALPS ADVISORS INC
0.00% of their portfolio |
Denver, CO |
25,11625.1k
$226.0k |
$226.0k |
0.00% |
New |
|
| 64 |
BANK OF AMERICA CORP /DE/
0.00% of their portfolio |
CHARLOTTE, NC |
21,04721.0k
$189.4k |
$189.4k |
0.00% |
Reduced
-1.8k |
-1,787 |
| 65 |
AMERICAN CENTURY COMPANIES INC
0.00% of their portfolio |
KANSAS CITY, MO |
16,44616.4k
$148.0k |
$148.0k |
0.00% |
New |
|
| 66 |
UBS Group AG
0.00% of their portfolio |
ZURICH, V8 |
15,86915.9k
$142.8k |
$142.8k |
0.00% |
Added
+9.1k |
+9,123 |
| 67 |
BNP PARIBAS FINANCIAL MARKETS
0.00% of their portfolio |
PARIS, I0 |
12,80212.8k
$115.2k |
$115.2k |
0.00% |
Added
+885 |
+885 |
| 68 |
MetLife Investment Management, LLC
0.00% of their portfolio |
Whippany, NJ |
12,49512.5k
$112.5k |
$112.5k |
0.00% |
Unchanged |
|
| 69 |
AMERICAN INTERNATIONAL GROUP, INC.
0.00% of their portfolio |
New York, NY |
11,85311.9k
$106.7k |
$106.7k |
0.00% |
Added
+39 |
+39 |
| 70 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE
0.00% of their portfolio |
Toronto, A6 |
10,62710.6k
$95.6k |
$95.6k |
0.00% |
New |
|
| 71 |
WELLS FARGO & COMPANY/MN
0.00% of their portfolio |
SAN FRANCISCO, CA |
10,58410.6k
$95.3k |
$95.3k |
0.00% |
Added
+5.0k |
+5,027 |
| 72 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC
0.00% of their portfolio |
HOUSTON, TX |
10,50010.5k
$94.5k |
$94.5k |
0.00% |
Reduced
-10.0k |
-10,000 |
| 73 |
VOYA INVESTMENT MANAGEMENT LLC
0.00% of their portfolio |
ATLANTA, GA |
10,36910.4k
$93.3k |
$93.3k |
0.00% |
New |
|
| 74 |
Choate Investment Advisors
0.00% of their portfolio |
BOSTON, MA |
10,00010.0k
$90.0k |
$90.0k |
0.00% |
New |
|
| 75 |
DEUTSCHE BANK AG\
0.00% of their portfolio |
FRANKFURT AM MAIN, 2M |
9,3879.4k
$84.5k |
$84.5k |
0.00% |
Reduced
-5.7k |
-5,736 |
| 76 |
ACADIAN ASSET MANAGEMENT LLC
0.00% of their portfolio |
Boston, MA |
8,7368.7k
$78.0k |
$78.0k |
0.00% |
Reduced
-155.9k |
-155,935 |
| 77 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM
0.00% of their portfolio |
WEST SACRAMENTO, CA |
8,1928.2k
$73.7k |
$73.7k |
0.00% |
Reduced
-908 |
-908 |
| 78 |
BARCLAYS PLC
0.00% of their portfolio |
LONDON, X0 |
4,9064.9k
$44.2k |
$44.2k |
0.00% |
Reduced
-7.5k |
-7,507 |
| 79 |
ROYAL BANK OF CANADA
0.00% of their portfolio |
TORONTO, A6 |
4,4924.5k
$40.0k |
$40.0k |
0.00% |
Added
+3.1k |
+3,113 |
| 80 |
NISA INVESTMENT ADVISORS, LLC
0.00% of their portfolio |
ST. LOUIS, MO |
4,3394.3k
$39.1k |
$39.1k |
0.00% |
Added
+1.2k |
+1,240 |
| 81 |
GROUP ONE TRADING LLC
0.00% of their portfolio |
CHICAGO, IL |
3,0393.0k
$27.4k |
$27.4k |
0.00% |
New |
|
| 82 |
Legal & General Group Plc
0.00% of their portfolio |
London, X0 |
2,3572.4k
$21.2k |
$21.2k |
0.00% |
Unchanged |
|
| 83 |
AMALGAMATED BANK
0.00% of their portfolio |
NEW YORK, NY |
2,3242.3k
$21.0k |
$21.0k |
0.00% |
Reduced
-112 |
-112 |
| 84 |
Tower Research Capital LLC (TRC)
0.00% of their portfolio |
NEW YORK, NY |
1,8401.8k
$16.6k |
$16.6k |
0.00% |
Added
+806 |
+806 |
| 85 |
Ameritas Investment Partners, Inc.
0.00% of their portfolio |
LINCOLN, NE |
1,5501.6k
$13.9k |
$13.9k |
0.00% |
Unchanged |
|
| 86 |
Metropolitan Life Insurance Co/NY
0.00% of their portfolio |
New York, NY |
1,3531.4k
$12.2k |
$12.2k |
0.00% |
Unchanged |
|
| 87 |
SIMPLEX TRADING, LLC
0.00% of their portfolio |
CHICAGO, IL |
1,2901.3k
$11.0k |
$11.0k |
0.00% |
Added
+194 |
+194 |
| 88 |
Russell Investments Group, Ltd.
0.00% of their portfolio |
Seattle, WA |
1,0041.0k
$9.0k |
$9.0k |
0.00% |
Unchanged |
|
| 89 |
NEW YORK STATE COMMON RETIREMENT FUND
0.00% of their portfolio |
ALBANY, NY |
508508
$4.6k |
$4.6k |
0.00% |
Reduced
-10.1k |
-10,100 |
| 90 |
Red Tortoise LLC
0.00% of their portfolio |
ATLANTA, GA |
187187
$1.7k |
$1.7k |
0.00% |
Unchanged |
|
| 91 |
SIGNATUREFD, LLC
0.00% of their portfolio |
ATLANTA, GA |
8888
$792 |
$792 |
0.00% |
New |
|
| 92 |
NFSG Corp
0.00% of their portfolio |
BOCA RATON, FL |
2525
$225 |
$225 |
0.00% |
Unchanged |
|
| 93 |
Crewe Advisors LLC
0.00% of their portfolio |
SALT LAKE CITY, UT |
1414
$126 |
$126 |
0.00% |
New |
|
| 94 |
Financial Gravity Asset Management, Inc.
0.00% of their portfolio |
Lakeway, TX |
99
$10 |
$10 |
0.00% |
New |
|
| 95 |
CONCOURSE FINANCIAL GROUP SECURITIES, INC.
0.00% of their portfolio |
BIRMINGHAM, AL |
00
$0 |
$0 |
0.00% |
Unchanged |
|
| 96 |
Lindbrook Capital, LLC
0.00% of their portfolio |
CALABASAS, CA |
00
$0 |
$0 |
0.00% |
New |
|