SILVERARC CAPITAL MANAGEMENT, LLC

BOSTON, MA · CIK 1816307 · 13F filing filed 2026-08-13

SEC-registered investment adviser since 2019 · limited liability company

Assets managed$1.6bn
Staff9 · 5 in investment roles
Main clients (by assets)Private funds 58%, Companies 42%
Private funds3 (2 hedge) · $935.3m gross assets
Websitesilverarccapital.com
Form ADV · 2026-03-30SEC adviser record

Legal entitySILVERARC CAPITAL MANAGEMENT, LLC (US)

$898.5m reported value +5.9% vs Q1 2026

65positions

45.3%in top 10

20 new 16 added 27 reduced 22 sold out vs Q1 2026

Options: 5 call positions ($37.9m notional), 3 put positions ($25.7m notional) – listed below, not included above.

This report includes the holdings of 1 other manager that shares the investment decisions:

SILVERARC CAPITAL, LLC – reports through this filing

Shares in two reports are counted once in each security's totals.

Holdings, Q2 2026

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	ASCENDIS PHARMA A/S ORD SHS ASND	ASND	206,234	$55.0m6.12%	6.12%	New
2	CELCUITY INC COM CELC	CELC	500,996	$52.4m5.83%	5.83%	Added +143.1k	+143,093 40.0%
3	COGENT BIOSCIENCES INC COM COGT	COGT	1,280,707	$49.6m5.52%	5.52%	Reduced -33.5k	-33,482 -2.5%
4	UROGEN PHARMA LTD COM URGN	URGN	1,301,979	$47.9m5.33%	5.33%	Reduced -201.1k	-201,066 -13.4%
5	IMMUNOME INC COM IMNM	IMNM	2,017,009	$42.7m4.76%	4.76%	Added +166.7k	+166,731 9.0%
6	DIANTHUS THERAPEUTICS INC COM DNTH	DNTH	390,000	$38.0m4.23%	4.23%	Reduced -264.7k	-264,746 -40.4%
7	RHYTHM PHARMACEUTICALS INC COM RYTM	RYTM	311,461	$34.6m3.85%	3.85%	Added +5.5k	+5,461 1.8%
8	ORUKA THERAPEUTICS INC COM ORKA	ORKA	352,802	$33.6m3.74%	3.74%	Added +201.9k	+201,894 133.8%
9	MONTE ROSA THERAPEUTICS INC COM GLUE	GLUE	1,108,295	$26.8m2.98%	2.98%	Reduced -893.7k	-893,745 -44.6%
10	SYNDAX PHARMACEUTICALS INC COM SNDX	SNDX	1,214,390	$26.5m2.95%	2.95%	Added +325.4k	+325,403 36.6%
11	ENLIVEN THERAPEUTICS INC COM ELVN	ELVN	489,382	$24.8m2.76%	2.76%	New
12	IMMUNOVANT INC COM IMVT	IMVT	619,096	$23.9m2.65%	2.65%	Added +204.9k	+204,860 49.5%
13	ERASCA INC COM ERAS	ERAS	1,263,026	$23.1m2.58%	2.58%	Reduced -588.8k	-588,786 -31.8%
14	SAGIMET BIOSCIENCES INC COM SER A SGMT	SGMT	2,927,698	$22.6m2.52%	2.52%	New
15	ABIVAX SA SPONSORED ADS ABVX	ABVX	169,593	$22.6m2.52%	2.52%	Reduced -132.9k	-132,937 -43.9%
16	PRAXIS PRECISION MEDICINES I COM NEW PRAX	PRAX	65,679	$22.0m2.45%	2.45%	Reduced -5.9k	-5,873 -8.2%
17	KODIAK SCIENCES INC COM KOD	KOD	546,256	$21.3m2.37%	2.37%	Reduced -445.7k	-445,674 -44.9%
18	DEFINIUM THERAPEUTICS INC COM SHS DFTX	DFTX	400,000	$18.8m2.09%	2.09%	New
19	VERACYTE INC COM VCYT	VCYT	318,001	$18.7m2.08%	2.08%	Added +138.3k	+138,301 77.0%
20	GUARDANT HEALTH INC COM GH	GH	99,826	$15.0m1.67%	1.67%	Added +1.3k	+1,312 1.3%
21	C4 THERAPEUTICS INC COM STK CCCC	CCCC	3,032,060	$14.2m1.58%	1.58%	Added +1.1m	+1,120,275 58.6%
22	ZENAS BIOPHARMA INC COM ZBIO	ZBIO	509,789	$12.9m1.44%	1.44%	Reduced -626.1k	-626,146 -55.1%
23	TREVI THERAPEUTICS INC COM TRVI	TRVI	678,095	$12.6m1.41%	1.41%	Added +167.0k	+166,968 32.7%
24	HELIX ACQUISITION CORP III USD CL A ORD SHS HLXC	HLXC	1,177,821	$12.5m1.39%	1.39%	Reduced -31.2k	-31,165 -2.6%
25	ALX ONCOLOGY HLDGS INC COM ALXO	ALXO	5,744,757	$11.9m1.32%	1.32%	New
26	VERADERMICS INC COMMON STOCK MANE	MANE	95,000	$11.7m1.30%	1.30%	New
27	XENON PHARMACEUTICALS INC COM XENE	XENE	186,821	$11.3m1.26%	1.26%	Reduced -10.9k	-10,938 -5.5%
28	AVALYN PHARMACEUTICALS INC COM SHS AVLN	AVLN	330,487	$10.9m1.21%	1.21%	New
29	BIOGEN INC COM BIIB	BIIB	48,101	$10.4m1.16%	1.16%	Reduced -2.9k	-2,866 -5.6%
30	ACLARIS THERAPEUTICS INC COM ACRS	ACRS	1,946,482	$10.3m1.15%	1.15%	New
31	CERUS CORP COM CERS	CERS	3,472,737	$10.1m1.13%	1.13%	Added +296.2k	+296,190 9.3%
32	AVALO THERAPEUTICS INC COM NEW AVTX	AVTX	500,402	$9.2m1.03%	1.03%	New
33	BENITEC BIOPHARMA INC COM NEW BNTC	BNTC	679,826	$9.1m1.01%	1.01%	Reduced -37.9k	-37,899 -5.3%
34	VAXCYTE INC COM PCVX	PCVX	145,000	$8.4m0.94%	0.94%	Added +19	+19 0.0%
35	GENEDX HOLDINGS CORP COM CL A WGS	WGS	122,269	$8.4m0.93%	0.93%	New
36	SAVARA INC COM SVRA	SVRA	1,355,459	$8.3m0.93%	0.93%	Reduced -75.5k	-75,523 -5.3%
37	OVID THERAPEUTICS INC COM OVID	OVID	3,101,129	$8.3m0.93%	0.93%	Added +2.1m	+2,101,129 210.1%
38	ORIC PHARMACEUTICALS INC COM ORIC	ORIC	738,873	$8.0m0.89%	0.89%	Reduced -361.1k	-361,137 -32.8%
39	COMPASS PATHWAYS PLC SPONSORED ADS CMPS	CMPS	503,382	$7.1m0.79%	0.79%	Added +203.4k	+203,382 67.8%
40	COMPUGEN LTD ORD CGEN	CGEN	3,184,257	$6.8m0.76%	0.76%	Reduced -131.6k	-131,588 -4.0%
41	SOLID BIOSCIENCES INC COM NEW SLDB	SLDB	668,450	$6.7m0.74%	0.74%	New
42	IBIO INC COM NEW IBIO	IBIO	3,520,490	$6.2m0.69%	0.69%	Added +3.3m	+3,294,490 1457.7%
43	DISC MEDICINE INC COM IRON	IRON	82,800	$6.1m0.67%	0.67%	Reduced -113.2k	-113,228 -57.8%
44	ALKERMES PLC SHS ALKS	ALKS	113,494	$5.9m0.66%	0.66%	Reduced -346.8k	-346,820 -75.3%
45	SPYRE THERAPEUTICS INC COM NEW SYRE	SYRE	59,959	$5.3m0.59%	0.59%	Reduced -126.7k	-126,659 -67.9%
46	ARTIVA BIOTHERAPEUTICS INC COM ARTV	ARTV	525,000	$5.1m0.57%	0.57%	New
47	CONTINEUM THERAPEUTICS INC CL A CTNM	CTNM	296,135	$4.9m0.54%	0.54%	Reduced -5.6k	-5,594 -1.9%
48	UNIQURE NV SHS QURE	QURE	105,000	$4.8m0.54%	0.54%	New
49	RESEARCH ALLIANCE CORP III ORD SHS CL A RACC	RACC	360,000	$3.9m0.43%	0.43%	New
50	ABEONA THERAPEUTICS INC COM NEW ABEO	ABEO	610,407	$3.8m0.42%	0.42%	Reduced -38.5k	-38,535 -5.9%
51	INSMED INC COM PAR $.01 INSM	INSM	34,438	$3.7m0.41%	0.41%	Reduced -1.4k	-1,412 -3.9%
52	KARYOPHARM THERAPEUTICS INC COM NEW KPTI	KPTI	297,460	$2.9m0.32%	0.32%	New
53	CAMP4 THERAPEUTICS CORP COM CAMP	CAMP	653,594	$2.9m0.32%	0.32%	Unchanged
54	ELUTIA INC CL A COM ELUT	ELUT	2,192,980	$2.1m0.24%	0.24%	Reduced -305.0k	-305,040 -12.2%
55	REVOLUTION MEDICINES INC COM RVMD	RVMD	10,000	$1.9m0.21%	0.21%	New
56	SIONNA THERAPEUTICS INC COM SION	SION	42,478	$1.9m0.21%	0.21%	Added +3.1k	+3,061 7.8%
57	TELA BIO INC COM TELA	TELA	2,137,201	$1.6m0.18%	0.18%	Reduced -122.1k	-122,111 -5.4%
58	ACHIEVE LIFE SCIENCES INC COM ACHV	ACHV	227,178	$1.5m0.17%	0.17%	New
59	FRACTYL HEALTH INC COM COM		1,637,976	$1.3m0.14%	0.14%	Reduced -63.6k	-63,649 -3.7%
60	CONNECT BIOPHARMA HLDGS LTD SHS CNTB	CNTB	545,000	$1.3m0.14%	0.14%	New
61	CRESCENT BIOPHARMA INC. COM CBIO	CBIO	59,104	$1.1m0.12%	0.12%	Reduced -71.4k	-71,396 -54.7%
62	CELLECTAR BIOSCIENCES INC COM NEW CLRB	CLRB	321,728	$894.4k0.10%	0.10%	New
63	FOGHORN THERAPEUTICS INC COM FHTX	FHTX	45,975	$224.4k0.02%	0.02%	New
64	ADAGIO MED HLDGS INC COM ADGM	ADGM	224,360	$146.2k0.02%	0.02%	Reduced -27.6k	-27,612 -11.0%
65	ROCKET PHARMACEUTICALS INC W EXP 09/02/202 W EXP 09/02/202		104,828	$3560.00%	0.00%	Unchanged

Sold out since Q1 2026

Security	Ticker	Shares held before	Value then
KALVISTA PHARMACEUTICALS INC KALV	KALV	2,876,407	$57.9m2.9m shares
NUVALENT INC		354,914	$36.4m354.9k shares
ASCENDIS PHARMA A/S		124,658	$28.5m124.7k shares
CENTESSA PHARMACEUTICALS PLC		466,345	$18.5m466.3k shares
SCHOLAR ROCK HLDG CORP SRRK	SRRK	339,613	$16.7m339.6k shares
CG ONCOLOGY INC CGON	CGON	166,349	$11.3m166.3k shares
CELLDEX THERAPEUTICS INC NEW CLDX	CLDX	178,378	$5.7m178.4k shares
CYTOKINETICS INC CYTK	CYTK	71,203	$4.7m71.2k shares
CLIMB BIO INC CLYM	CLYM	684,908	$4.7m684.9k shares
COMPASS THERAPEUTICS INC CMPX	CMPX	859,049	$4.5m859.0k shares
SURROZEN INC SRZN	SRZN	144,255	$4.2m144.3k shares
ZURA BIO LTD ZURA	ZURA	560,651	$3.3m560.7k shares
FULCRUM THERAPEUTICS INC FULC	FULC	419,949	$3.2m419.9k shares
ANNEXON INC ANNX	ANNX	496,461	$2.8m496.5k shares
MONOPAR THERAPEUTICS INC MNPR	MNPR	43,488	$2.4m43.5k shares
NEXTCURE INC NXTC	NXTC	176,057	$1.9m176.1k shares
NEUMORA THERAPEUTICS INC. NMRA	NMRA	818,156	$1.6m818.2k shares
EDGEWISE THERAPEUTICS INC EWTX	EWTX	42,615	$1.3m42.6k shares
REPLIMUNE GROUP INC REPL	REPL	171,936	$1.3m171.9k shares
GENERATE BIOMEDICINES INC GENB	GENB	100,000	$1.2m100.0k shares
RADIOPHARM THERANOSTICS LTD RADX	RADX	187,406	$805.8k187.4k shares
AARDVARK THERAPEUTICS INC AARD	AARD	33,684	$127.0k33.7k shares

Options (notional value)

Underlying	Ticker	Type	Shares controlled	Notional	Change
ARK ETF TR Put		Put	500,000	$21.0m500.0k shares	New
SYNDAX PHARMACEUTICALS INC SNDX · Call	SNDX	Call	693,600	$15.2m693.6k shares	Added
ORIC PHARMACEUTICALS INC ORIC · Call	ORIC	Call	682,600	$7.4m682.6k shares	New
MONTE ROSA THERAPEUTICS INC GLUE · Call	GLUE	Call	300,000	$7.3m300.0k shares	New
ABIVAX SA ABVX · Call	ABVX	Call	50,000	$6.7m50.0k shares	New
KYMERA THERAPEUTICS INC KYMR · Put	KYMR	Put	25,000	$2.9m25.0k shares	New
ABSCI CORPORATION ABSI · Put	ABSI	Put	157,600	$1.8m157.6k shares	New
FULCRUM THERAPEUTICS INC FULC · Call	FULC	Call	391,900	$1.4m391.9k shares	Unchanged

Stakes above 5%

Companies where this manager has reported owning more than 5% of a class of shares, on Schedule 13D (may seek influence) or 13G (passive): its latest filing for each, from 19 Dec 2024 on.

Company	Ticker	Stake	Change	Schedule	Last filed
CELLECTAR BIOSCIENCES INC CLRB · 13G · filed 2026-08-14	CLRB	10.0%≈ $2.4m	new	13G	2026-08-14
IBIO INC IBIO · 13G · filed 2025-11-14	IBIO	10.0%≈ $3.8m	new	13G	2025-11-14
HELIX ACQUISITION CORP III HLXC · 13G · filed 2026-05-13	HLXC	6.8%≈ $12.9m	new	13G	2026-05-13
KALVISTA PHARMACEUTICALS INC KALV · 13G · filed 2026-05-13	KALV	5.6%	new	13G	2026-05-13