MONOPAR THERAPEUTICS INC MNPR
COM NEW · Common Stock · CUSIP 61023L207
Biopharmaceutical company
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWilmette, IL
- Websitemonopartx.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $92.59.
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2024 | 7 |
| Q4 2024 | 19 |
| Q1 2025 | 36 |
| Q2 2025 | 44 |
| Q3 2025 | 56 |
| Q4 2025 | 74 |
| Q1 2026 | 82 |
| Q2 2026 | 96 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2024 | 14 | 1 |
| Q1 2025 | 24 | 6 |
| Q2 2025 | 34 | 15 |
| Q3 2025 | 35 | 17 |
| Q4 2025 | 54 | 15 |
| Q1 2026 | 49 | 29 |
| Q2 2026 | 60 | 38 |
Biggest buyers
| ORBIMED ADVISORS LLC | New | +157.4k |
| Candriam S.C.A. | New | +143.3k |
| TCG Crossover Management, LLC | Added | +71.2k |
| Longaeva Partners L.P. | New | +55.8k |
| Driehaus Capital Management LLC | Added | +50.9k |
| Ikarian Capital, LLC | New | +47.9k |
| BlackRock, Inc. | Added | +32.3k |
| STEMPOINT CAPITAL LP | New | +30.1k |
| BOOTHBAY FUND MANAGEMENT, LLC | New | +14.7k |
| NEUBERGER BERMAN GROUP LLC | Added | +12.8k |
Biggest sellers
| Sio Capital Management, LLC | Sold out | -173.5k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -100.0k |
| Walleye Capital LLC | Sold out | -63.1k |
| BANK OF AMERICA CORP /DE/ | Reduced | -56.4k |
| ADAR1 Capital Management, LLC | Reduced | -46.7k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -44.0k |
| SILVERARC CAPITAL MANAGEMENT, LLC | Sold out | -43.5k |
| Saturn V Capital Management LP | Reduced | -33.6k |
| Jump Financial, LLC | Sold out | -22.8k |
| Squarepoint Ops LLC | Sold out | -21.8k |
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| JANUS HENDERSON GROUP PLC 13G · institution +0.3 pts · filed 2025-11-14 | 19.5% |
| Monopar Therapeutics 13D · may seek influence filed 2025-02-07 | 13.4% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor no change · filed 2026-02-17 | 9.9% |
| ASTRAZENECA PLC 13G · passive investor filed 2026-02-06 | 7.8% |
| BlackRock, Inc. 13G · institution new · filed 2026-10-27 | 5.0% |
Fell to 5% or below in the last year: Adage Capital Management, L.P. (4.8%, 2026-08-12), Saturn V Capital Management LP (4.7%, 2026-08-12), Tactic Pharma LLC (4.5%, 2026-01-30)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 1 | $25.2k | 0 | — | — |
| Q1 2025 | 0 | — | 0 | — | — |
| Q2 2025 | 0 | — | 1 | $1.2m | — |
| Q3 2025 | 0 | — | 4 | $36.0m | — |
| Q4 2025 | 1 | $104.9k | 1 | $343.9k | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 3 | $3.4m | $3.4m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-24 | Robinson Chandler Chief Executive Officer, director | Sold plan | $2.6m29.1k shares |
| 2026-08-26 | Tsuchimoto Kim R Director | Sold plan | $455.6k4.1k shares |
| 2026-08-26 | RIOUX PATRICE Acting Chief Medical Officer | Sold plan | $1111 share |
| 2026-08-25 | Anderson Raymond Director | Sold plan | $351.8k3.1k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| Jupiter Topco LLC 0.05% of their portfolio | 1.3m $121.7m | First filing |
| RA CAPITAL MANAGEMENT, L.P. 0.54% of their portfolio | 667.2k $61.8m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 348.8k $32.3m | Added +32.3k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.31% of their portfolio | 323.7k $30.0m | Unchanged |
| Saturn V Capital Management LP 4.14% of their portfolio | 312.0k $28.9m | Reduced -33.6k |
| Siren, L.L.C. 0.51% of their portfolio | 270.1k $25.0m | Unchanged |
| ADAR1 Capital Management, LLC 0.95% of their portfolio | 217.6k $20.1m | Reduced -46.7k |
| Polar Capital Holdings Plc 0.06% of their portfolio | 214.5k $19.9m | Reduced -12.1k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 209.7k $19.4m | Reduced -8.8k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio | 209.2k $19.4m | Reduced -100.0k |
| TCG Crossover Management, LLC 0.45% of their portfolio | 203.3k $18.8m | Added +71.2k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 158.4k $14.7m | Reduced -15.9k |
| ORBIMED ADVISORS LLC 0.28% of their portfolio | 157.4k $14.6m | New |
| Candriam S.C.A. 0.06% of their portfolio | 143.3k $13.3m | New |
| Balyasny Asset Management L.P. 0.02% of their portfolio | 134.5k $12.5m | Reduced -1.9k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 112.6k $10.4m | Added +12.7k |
| Alyeska Investment Group, L.P. 0.02% of their portfolio | 100.0k $9.3m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 92.6k $8.6m | Added +4.2k |
| Vivo Capital, LLC 0.77% of their portfolio | 90.5k $8.4m | Unchanged |
| Driehaus Capital Management LLC 0.05% of their portfolio | 84.0k $7.8m | Added +50.9k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 76.9k $7.1m | Reduced -1.7k |
| Vestal Point Capital, LP 0.16% of their portfolio | 75.7k $7.0m | Added +10.3k |
| Longaeva Partners L.P. 0.15% of their portfolio | 55.8k $5.2m | New |
| NEUBERGER BERMAN GROUP LLC 0.00% of their portfolio | 55.2k $5.1m | Added +12.8k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 50.3k $4.7m | Reduced -2.6k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 48.8k $4.5m | Added +2.8k |
| Ikarian Capital, LLC 0.73% of their portfolio | 47.9k $4.4m | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 37.0k $3.4m | Reduced -21.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 34.6k $3.2m | Added +2.8k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 31.0k $2.9m | Added +2.2k |
| STEMPOINT CAPITAL LP 0.48% of their portfolio | 30.1k $2.8m | New |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 28.3k $2.6m | Reduced -167 |
| UBS Group AG 0.00% of their portfolio | 27.3k $2.5m | Reduced -12.2k |
| MORGAN STANLEY 0.00% of their portfolio | 17.9k $1.7m | Reduced -4.4k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 17.8k $1.6m | Added +11.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 16.2k $1.5m | Reduced -18.5k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 14.8k $1.4m | Added +601 |
| BOOTHBAY FUND MANAGEMENT, LLC 0.03% of their portfolio | 14.7k $1.4m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 14.0k $1.3m | Added +1.4k |
| Ishara Investments LP 0.84% of their portfolio | 12.3k $1.1m | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 12.3k $1.1m | Added +2.5k |
| Trexquant Investment LP 0.01% of their portfolio | 12.0k $1.1m | New |
| Creative Planning 0.00% of their portfolio | 7.8k $719.2k | Added +1.8k |
| GSA CAPITAL PARTNERS LLP 0.04% of their portfolio | 7.5k $697.0k | New |
| XTX Topco Ltd 0.01% of their portfolio | 6.5k $605.2k | New |
| Nuveen, LLC 0.00% of their portfolio | 6.0k $553.7k | Added +429 |
| BARCLAYS PLC 0.00% of their portfolio | 5.8k $540.1k | Reduced -19.1k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 5.6k $521.3k | Added +684 |
| GERBER, LLC 0.24% of their portfolio | 5.6k $518.6k | Unchanged |
| Virtus Investment Advisers, LLC 0.12% of their portfolio | 5.5k $506.8k | Added +1.8k |
| RAYMOND JAMES FINANCIAL INC 0.00% of their portfolio | 5.5k $506.8k | New |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 5.3k $490.7k | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 4.8k $260.8k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 4.0k $366.5k | Added +2.2k |
| Aquatic Capital Management LLC 0.01% of their portfolio | 3.8k $354.3k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 3.7k $343.0k | Reduced -44.0k |
| Engineers Gate Manager LP 0.00% of their portfolio | 3.5k $322.1k | Reduced -955 |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 3.2k $300.9k | Reduced -56.4k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 2.9k $269.3k | Added +370 |
| EP Wealth Advisors, LLC 0.00% of their portfolio | 2.6k $241.0k | New |
| Entropy Technologies, LP 0.01% of their portfolio | 2.6k $240.7k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 2.5k $237.0k | Added +84 |
| GABELLI FUNDS LLC 0.00% of their portfolio | 2.5k $231.5k | New |
| WINTON GROUP Ltd 0.01% of their portfolio | 2.5k $231.5k | Reduced -4.3k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 2.5k $228.6k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 2.4k $222.2k | Added +1.2k |
| Invesco Ltd. 0.00% of their portfolio | 2.4k $218.1k | New |
| Martin Investment Management, LLC 0.07% of their portfolio | 2.3k $215.5k | New |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 2.3k $213.9k | New |
| CITIGROUP INC 0.00% of their portfolio | 2.1k $193.3k | Added +1.9k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 2.1k $192.2k | Added +20 |
| DIADEMA PARTNERS LP 0.05% of their portfolio | 1.6k $150.9k | Unchanged |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 1.6k $143.8k | Unchanged |
| Quarry LP 0.02% of their portfolio | 1.5k $139.1k | New |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 1.5k $135.9k | Added +504 |
| MEEDER ASSET MANAGEMENT INC 0.01% of their portfolio | 1.4k $128.6k | Added +752 |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 1.4k $125.0k | New |
| Persistent Asset Partners Ltd 0.04% of their portfolio | 1.3k $117.7k | Added +488 |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 741 $68.6k | Reduced -238 |
| NewEdge Advisors, LLC 0.00% of their portfolio | 600 $55.6k | Unchanged |
| FMR LLC 0.00% of their portfolio | 530 $49.1k | Added +121 |
| Legal & General Group Plc 0.00% of their portfolio | 465 $43.1k | Added +57 |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 409 $37.9k | Added +109 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 345 $31.9k | Reduced -416 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 136 $13.0k | Added +87 |
| Allworth Financial LP 0.00% of their portfolio | 111 $10.3k | Unchanged |
| C M BIDWELL & ASSOCIATES LTD 0.00% of their portfolio | 94 $8.7k | New |
| Sterling Capital Management LLC 0.00% of their portfolio | 72 $6.7k | Added +43 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 62 $5.7k | Reduced -185 |
| Global Retirement Partners, LLC 0.00% of their portfolio | 32 $3.0k | First filing |
| GAMMA Investing LLC 0.00% of their portfolio | 25 $2.3k | Reduced -4 |
| Farther Finance Advisors, LLC 0.00% of their portfolio | 24 $2.2k | New |
| US BANCORP \DE\ 0.00% of their portfolio | 6 $556 | Reduced -66 |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 6 $556 | New |
| Arax Advisory Partners 0.00% of their portfolio | 3 $278 | New |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 1 $93 | New |