ALX ONCOLOGY HLDGS INC ALXO
COM · Common Stock · CUSIP 00166B105
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersSouth San Francisco, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 138.3m as of 2026-07-30, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.07. Options: 4 managers hold calls ($181.5k notional), 1 hold puts ($1.0k).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 99 |
| Q4 2022 | 88 |
| Q1 2023 | 87 |
| Q2 2023 | 76 |
| Q3 2023 | 77 |
| Q4 2023 | 94 |
| Q1 2024 | 107 |
| Q2 2024 | 114 |
| Q3 2024 | 93 |
| Q4 2024 | 88 |
| Q1 2025 | 86 |
| Q2 2025 | 62 |
| Q3 2025 | 61 |
| Q4 2025 | 57 |
| Q1 2026 | 69 |
| Q2 2026 | 94 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 56 | 58 |
| Q4 2024 | 48 | 46 |
| Q1 2025 | 33 | 38 |
| Q2 2025 | 19 | 66 |
| Q3 2025 | 18 | 39 |
| Q4 2025 | 25 | 25 |
| Q1 2026 | 37 | 24 |
| Q2 2026 | 66 | 21 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $431.1k | $8.0k | 0.02 |
| Q4 2025 | $240.5k | $96.2k | 0.40 |
| Q1 2026 | $155.7k | $100.5k | 0.65 |
| Q2 2026 | $181.5k | $1.0k | 0.01 |
Biggest buyers
| BlackRock, Inc. | Added | +7.0m |
| SILVERARC CAPITAL MANAGEMENT, LLC | New | +5.7m |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +2.3m |
| Nantahala Capital Management, LLC | New | +1.5m |
| STATE STREET CORP | Added | +1.3m |
| JPMORGAN CHASE & CO | Added | +1.0m |
| NORTHERN TRUST CORP | Added | +798.7k |
| VANGUARD CAPITAL MANAGEMENT LLC | Added | +793.7k |
| Blackstone Inc. | Added | +767.0k |
| VANGUARD PORTFOLIO MANAGEMENT LLC | Added | +651.3k |
Biggest sellers
| TCG Crossover Management, LLC | Reduced | -7.4m |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Sold out | -2.0m |
| Squadron Capital Management LLC | Sold out | -1.5m |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -1.2m |
| MARSHALL WACE, LLP | Reduced | -685.7k |
| Redmile Group, LLC | Reduced | -571.7k |
| BANK OF AMERICA CORP /DE/ | Reduced | -501.8k |
| UBS Group AG | Reduced | -451.8k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -445.0k |
| Almitas Capital LLC | Reduced | -235.4k |
Biggest calls
| CITADEL ADVISORS LLC | Reduced | $74.9k36.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $51.3k24.8k shares |
| GROUP ONE TRADING LLC | Added | $44.1k21.3k shares |
| SIMPLEX TRADING, LLC | Unchanged | $11.2k5.4k shares |
Biggest puts
| SIMPLEX TRADING, LLC | Reduced | $1.0k500 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
venBio Global Strategic Fund, L.P.
13D · may seek influence
no change · filed 2026-10-16
Stated purposeItem 4 of the Schedule 13D is hereby amended and supplemented as follows: The responses to Items 3 and 6 of this Amendment No. 2 are incorporated by reference herein. Mr. Goodman resigned from the Issuer's board of directors effective June 29, 2026. Full filing |
10.0% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-02-09 | 9.9% |
| HBM Healthcare Investments (Cayman) Ltd. 13G · passive investor -1.9 pts · filed 2026-05-15 | 6.5% |
| TANG CAPITAL PARTNERS LP 13G · passive investor filed 2025-02-14 | 6.3% |
| BlackRock, Inc. 13G · institution new · filed 2026-07-27 | 5.4% |
Fell to 5% or below in the last year: TCG Crossover GP II, LLC (4.2%, 2026-08-14), LSV Associates, LLC (2.2%, 2026-05-27), Redmile Group, LLC (6.8%, 2026-05-15), MILLENNIUM MANAGEMENT LLC (1.5%, 2026-04-28), TANG CAPITAL MANAGEMENT LLC (0.0%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 1 | $46.5k | 2 | $19.3k | — |
| Q1 2025 | 0 | — | 3 | $8.6k | — |
| Q2 2025 | 0 | — | 1 | $659 | — |
| Q3 2025 | 2 | $157.9k | 2 | $2.8k | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 1 | $5.0m | 2 | $34.3k | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 2 | $8.3k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-08-17 | Lettmann Jason CHIEF EXECUTIVE OFFICER, director | Sold | $4.3k2.2k shares |
| 2026-08-17 | Wong Shelly SVP, FINANCE AND CAO | Sold | $1.1k573 shares |
| 2026-07-01 | Wong Shelly SVP, FINANCE AND CAO | Sold | $2.9k1.4k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. 0.23% of their portfolio | 13.0m $26.9m | Unchanged |
| venBio Partners LLC 5.14% of their portfolio | 12.9m $26.7m | Unchanged |
| BlackRock, Inc. 0.00% of their portfolio | 7.4m $15.3m | Added +7.0m |
| Redmile Group, LLC 1.03% of their portfolio | 7.4m $15.3m | Reduced -571.7k |
| Blackstone Inc. 0.04% of their portfolio | 6.6m $13.6m | Added +767.0k |
| Driehaus Capital Management LLC 0.07% of their portfolio | 6.0m $12.5m | Added +290.6k |
| SILVERARC CAPITAL MANAGEMENT, LLC 1.32% of their portfolio | 5.7m $11.9m | New |
| TCG Crossover Management, LLC 0.28% of their portfolio | 5.7m $11.7m | Reduced -7.4m |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 5.0m $10.3m | Added +793.7k |
| Vivo Capital, LLC 0.60% of their portfolio | 3.2m $6.6m | Unchanged |
| MARSHALL WACE, LLP 0.01% of their portfolio | 3.1m $6.4m | Reduced -685.7k |
| 5AM Venture Management, LLC 2.20% of their portfolio | 3.1m $6.3m | Unchanged |
| Almitas Capital LLC 1.46% of their portfolio | 2.9m $6.1m | Reduced -235.4k |
| ORBIMED ADVISORS LLC 0.11% of their portfolio | 2.9m $5.9m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.8m $5.8m | Added +2.3m |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 2.2m $4.5m | Added +590.3k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 1.5m $3.2m | Reduced -445.0k |
| Nantahala Capital Management, LLC 0.09% of their portfolio | 1.5m $3.1m | New |
| STATE STREET CORP 0.00% of their portfolio | 1.5m $3.1m | Added +1.3m |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 1.3m $2.7m | Added +212.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 1.0m $2.3m | Added +1.0m |
| NORTHERN TRUST CORP 0.00% of their portfolio | 935.7k $1.9m | Added +798.7k |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 810.3k $1.7m | Reduced -140.3k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 749.2k $1.6m | Added +651.3k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 743.5k $1.5m | Added +449.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 742.3k $1.5m | Added +603.7k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 603.8k $1.2m | Reduced -128.8k |
| ADAR1 Capital Management, LLC 0.05% of their portfolio | 533.7k $1.1m | New |
| UBS Group AG 0.00% of their portfolio | 462.9k $958.3k | Reduced -451.8k |
| GSA CAPITAL PARTNERS LLP 0.05% of their portfolio | 413.5k $856.0k | Added +344.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 241.1k $499.1k | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 238.4k $493.6k | New |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 226.1k $468.0k | Added +150.0k |
| Atom Investors LP 0.04% of their portfolio | 219.4k $454.1k | New |
| IEQ CAPITAL, LLC 0.00% of their portfolio | 175.4k $363.0k | Added +83.1k |
| MORGAN STANLEY 0.00% of their portfolio | 157.9k $326.8k | Added +59.0k |
| Invesco Ltd. 0.00% of their portfolio | 149.9k $310.3k | Added +138.9k |
| Nuveen, LLC 0.00% of their portfolio | 143.6k $297.3k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 123.2k $254.9k | Reduced -1.2m |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 107.9k $223.3k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 107.4k $222.4k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 99.9k $206.8k | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 89.8k $186.0k | New |
| Verdad Advisers, LP 0.16% of their portfolio | 82.2k $170.2k | New |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 76.0k $157.4k | Reduced -501.8k |
| Graham Capital Management, L.P. 0.00% of their portfolio | 74.8k $154.9k | Added +37.1k |
| XTX Topco Ltd 0.00% of their portfolio | 69.7k $144.2k | Added +25.5k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 65.0k $134.5k | New |
| CITIGROUP INC 0.00% of their portfolio | 50.6k $104.8k | Added +50.6k |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 0.00% of their portfolio | 49.7k $102.8k | New |
| Squarepoint Ops LLC 0.00% of their portfolio | 46.9k $97.0k | New |
| Vanguard Global Advisers, LLC 0.00% of their portfolio | 43.0k $89.1k | Added +33.1k |
| AXQ CAPITAL, LP 0.01% of their portfolio | 40.6k $83.9k | New |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 0.00% of their portfolio | 38.0k $80.8k | Added +14 |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 33.1k $68.5k | New |
| BARCLAYS PLC 0.00% of their portfolio | 32.9k $68.1k | Added +22.4k |
| Police & Firemen's Retirement System of New Jersey 0.00% of their portfolio | 31.8k $65.9k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 31.0k $64.2k | New |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 26.3k $52.8k | New |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.00% of their portfolio | 25.5k $52.8k | New |
| HC Advisors, LLC 0.03% of their portfolio | 22.9k $47.4k | Unchanged |
| Callan Family Office, LLC 0.00% of their portfolio | 22.4k $46.4k | Unchanged |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 21.5k $44.4k | New |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 21.4k $44.4k | New |
| CAXTON CORP 2.34% of their portfolio | 20.9k $43.4k | Unchanged |
| INTECH INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 19.4k $40.2k | New |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 18.5k $38.2k | New |
| Bronte Capital Management Pty Ltd. 0.00% of their portfolio | 18.1k $37.5k | New |
| JSF Financial, LLC 0.01% of their portfolio | 17.5k $36.2k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 16.6k $34.4k | Added +16.1k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 16.4k $33.9k | New |
| MONETA GROUP INVESTMENT ADVISORS LLC 0.00% of their portfolio | 15.2k $31.5k | Unchanged |
| ProShare Advisors LLC 0.00% of their portfolio | 14.1k $29.2k | New |
| FMR LLC 0.00% of their portfolio | 13.2k $27.4k | Added +256 |
| Lido Advisors, LLC 0.00% of their portfolio | 13.2k $27.4k | Unchanged |
| Abel Hall, LLC 0.00% of their portfolio | 12.7k $26.4k | Added +133 |
| Beacon Pointe Advisors, LLC 0.00% of their portfolio | 12.5k $25.9k | Unchanged |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 12.5k $25.9k | New |
| Legal & General Group Plc 0.00% of their portfolio | 10.5k $21.7k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 10.4k $21.5k | New |
| XPONANCE LLC 0.00% of their portfolio | 10.2k $21.1k | New |
| HSBC HOLDINGS PLC 0.00% of their portfolio | 10.1k $21.6k | Unchanged |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 9.8k $20.3k | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 8.6k $17.9k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 6.2k $13.0k | Added +4.3k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 1.5k $3.1k | New |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 1.1k $2.3k | Unchanged |
| Bradley & Co. Private Wealth Management, LLC 0.00% of their portfolio | 1.0k $2.1k | Unchanged |
| EverSource Wealth Advisors, LLC 0.00% of their portfolio | 905 $1.9k | Unchanged |
| Sterling Capital Management LLC 0.00% of their portfolio | 379 $785 | New |
| Integrated Wealth Concepts LLC 0.00% of their portfolio | 130 $270 | New |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 100 $207 | Unchanged |
| Caitong International Asset Management Co., Ltd 0.00% of their portfolio | 36 $75 | Added +30 |
| SBI Securities Co., Ltd. 0.00% of their portfolio | 14 $29 | Unchanged |