TREVI THERAPEUTICS INC TRVI
COM · Common Stock · CUSIP 89532M101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew Haven, CT
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($165.6k this quarter). Holder counts are more reliable. Shares outstanding: 142.5m as of 2026-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $18.54. Options: 7 managers hold calls ($26.4m notional), 3 hold puts ($1.5m).
Trends to Q2 2026
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 41 |
| Q4 2022 | 38 |
| Q1 2023 | 37 |
| Q2 2023 | 54 |
| Q3 2023 | 56 |
| Q4 2023 | 64 |
| Q1 2024 | 81 |
| Q2 2024 | 78 |
| Q3 2024 | 94 |
| Q4 2024 | 111 |
| Q1 2025 | 138 |
| Q2 2025 | 155 |
| Q3 2025 | 164 |
| Q4 2025 | 185 |
| Q1 2026 | 199 |
| Q2 2026 | 219 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q3 2024 | 48 | 21 |
| Q4 2024 | 67 | 31 |
| Q1 2025 | 95 | 43 |
| Q2 2025 | 103 | 55 |
| Q3 2025 | 100 | 65 |
| Q4 2025 | 103 | 63 |
| Q1 2026 | 99 | 87 |
| Q2 2026 | 127 | 80 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2025 | $8.4m | $16.4m | 1.94 |
| Q4 2025 | $5.3m | $7.5m | 1.41 |
| Q1 2026 | $11.1m | $5.7m | 0.51 |
| Q2 2026 | $26.4m | $1.5m | 0.05 |
Biggest buyers
| FMR LLC | Added | +4.5m |
| Woodline Partners LP | Added | +3.1m |
| Assenagon Asset Management S.A. | New | +3.1m |
| First Light Asset Management, LLC | New | +2.1m |
| BARCLAYS PLC | Added | +1.1m |
| FRONTIER CAPITAL MANAGEMENT CO LLC | Added | +1.1m |
| Saturn V Capital Management LP | New | +1.1m |
| Jones Hill Capital LP | Added | +969.0k |
| Vestal Point Capital, LP | Added | +933.5k |
| BlackRock, Inc. | Added | +914.8k |
Biggest sellers
| VIKING GLOBAL INVESTORS LP | Reduced | -1.7m |
| MARSHALL WACE, LLP | Reduced | -1.3m |
| Rubric Capital Management LP | Reduced | -1.2m |
| CITADEL ADVISORS LLC | Sold out | -1.2m |
| Octagon Capital Advisors LP | Reduced | -1.2m |
| ORBIMED ADVISORS LLC | Reduced | -1.0m |
| MILLENNIUM MANAGEMENT LLC | Sold out | -571.0k |
| Logos Global Management LP | Reduced | -520.0k |
| ALLIANCEBERNSTEIN L.P. | Reduced | -490.0k |
| PANAGORA ASSET MANAGEMENT INC | Reduced | -443.3k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $18.1m972.6k shares |
| JANE STREET GROUP, LLC | Reduced | $3.8m201.7k shares |
| CITADEL ADVISORS LLC | Added | $2.2m116.4k shares |
| SIMPLEX TRADING, LLC | Added | $934.4k50.1k shares |
| GROUP ONE TRADING LLC | Added | $645.3k34.6k shares |
| IMC-Chicago, LLC | New | $417.8k22.4k shares |
| RAYMOND JAMES FINANCIAL INC | Reduced | $350.0k50.0k shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $841.1k45.1k shares |
| GROUP ONE TRADING LLC | Reduced | $568.8k30.5k shares |
| SIMPLEX TRADING, LLC | Reduced | $42.9k2.3k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
New Enterprise Associates 16, L.P.
13D · may seek influence
-1.1 pts · filed 2026-05-07
Stated purposeThe Funds acquired the Firm Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, the Funds and other Reporting Persons may dispose of or acquire additional shares of the Issuer, including shares that may be acquired upon exercise of the NEA 16 Warrants prior to expiration. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount … Full filing |
10.5% |
| FMR LLC 13G · institution +2.5 pts · filed 2026-08-06 | 8.8% |
| Frazier Life Sciences Public Fund, L.P. 13G · passive investor -3.6 pts · filed 2025-11-14 | 7.0% |
| BlackRock, Inc. 13G · institution +1.3 pts · filed 2026-10-27 | 6.9% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27), Rubric Capital Management LP (2.9%, 2026-02-13), VIKING GLOBAL INVESTORS LP (4.2%, 2025-11-14)
Insider purchases and sales since 1 Apr 2026
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q4 2024 | 0 | — | 0 | — | — |
| Q1 2025 | 0 | — | 3 | $601.1k | $549.1k |
| Q2 2025 | 0 | — | 0 | — | — |
| Q3 2025 | 0 | — | 0 | — | — |
| Q4 2025 | 0 | — | 0 | — | — |
| Q1 2026 | 0 | — | 0 | — | — |
| Q2 2026 | 0 | — | 0 | — | — |
| Q3 2026 | 0 | — | 1 | $595.8k | $595.8k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2026-09-15 | Heffernan Michael Thomas Director | Sold plan | $595.8k39.5k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2026
| Manager | Shares | Change |
|---|---|---|
| NEA Management Company, LLC 15.53% of their portfolio | 13.2m $246.6m | Unchanged |
| FMR LLC 0.01% of their portfolio | 12.6m $234.3m | Added +4.5m |
| BlackRock, Inc. 0.00% of their portfolio | 11.2m $208.0m | Added +914.8k |
| Frazier Life Sciences Management, L.P. 4.04% of their portfolio | 9.9m $185.4m | Reduced -100 |
| WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio | 5.7m $106.0m | Added +495.5k |
| VANGUARD CAPITAL MANAGEMENT LLC 0.00% of their portfolio | 5.5m $103.1m | Added +552.1k |
| Vivo Capital, LLC 8.68% of their portfolio | 5.1m $95.0m | Unchanged |
| Woodline Partners LP 0.24% of their portfolio | 4.1m $76.1m | Added +3.1m |
| Vestal Point Capital, LP 1.35% of their portfolio | 3.1m $57.8m | Added +933.5k |
| MPM BIOIMPACT LLC 3.50% of their portfolio | 3.1m $57.3m | Reduced -224.9k |
| FRONTIER CAPITAL MANAGEMENT CO LLC 0.53% of their portfolio | 3.1m $57.3m | Added +1.1m |
| Assenagon Asset Management S.A. 0.04% of their portfolio | 3.1m $56.9m | New |
| STATE STREET CORP 0.00% of their portfolio | 3.0m $56.5m | Added +362.0k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 2.9m $54.6m | Added +149.8k |
| MARSHALL WACE, LLP 0.04% of their portfolio | 2.7m $49.9m | Reduced -1.3m |
| EVENTIDE ASSET MANAGEMENT, LLC 0.66% of their portfolio | 2.7m $49.6m | Added +37.7k |
| Rubric Capital Management LP 0.43% of their portfolio | 2.5m $46.7m | Reduced -1.2m |
| ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio | 2.4m $28.1m | Reduced -490.0k |
| Artia Global Partners LP 7.84% of their portfolio | 2.2m $41.2m | Added +197.2k |
| ACORN CAPITAL ADVISORS, LLC 10.92% of their portfolio | 2.1m $40.0m | Unchanged |
| First Light Asset Management, LLC 2.38% of their portfolio | 2.1m $39.1m | New |
| Pictet Asset Management Holding SA 0.04% of their portfolio | 2.0m $37.6m | Added +307.7k |
| Logos Global Management LP 1.51% of their portfolio | 1.9m $35.1m | Reduced -520.0k |
| Affinity Asset Advisors, LLC 1.64% of their portfolio | 1.8m $33.6m | Reduced -200.0k |
| EMERALD ADVISERS, LLC 0.79% of their portfolio | 1.8m $33.5m | Reduced -42.0k |
| Siren, L.L.C. 0.68% of their portfolio | 1.8m $33.3m | Unchanged |
| Pivotal bioVenture Partners Investment Advisor LLC 10.56% of their portfolio | 1.7m $32.5m | Added +188.9k |
| RAYMOND JAMES FINANCIAL INC 0.01% of their portfolio | 1.6m $30.0m | Reduced -77.3k |
| VIKING GLOBAL INVESTORS LP 0.08% of their portfolio | 1.5m $28.8m | Reduced -1.7m |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 1.5m $28.6m | Added +315.9k |
| ORBIMED ADVISORS LLC 0.51% of their portfolio | 1.4m $26.7m | Reduced -1.0m |
| Jones Hill Capital LP 5.31% of their portfolio | 1.3m $25.0m | Added +969.0k |
| NAN FUNG TRINITY (HK) LTD 2.23% of their portfolio | 1.2m $22.6m | Added +70.7k |
| EMERALD MUTUAL FUND ADVISERS TRUST 0.79% of their portfolio | 1.2m $22.6m | Reduced -51.5k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.2m $22.4m | Reduced -25.3k |
| Jupiter Topco LLC 0.01% of their portfolio | 1.2m $22.2m | First filing |
| Soleus Capital Management, L.P. 0.76% of their portfolio | 1.2m $22.0m | Reduced -440.4k |
| VANGUARD PORTFOLIO MANAGEMENT LLC 0.00% of their portfolio | 1.2m $21.9m | Added +208.3k |
| BARCLAYS PLC 0.01% of their portfolio | 1.1m $21.3m | Added +1.1m |
| Saturn V Capital Management LP 2.81% of their portfolio | 1.1m $19.6m | New |
| FLPUTNAM INVESTMENT MANAGEMENT CO 0.23% of their portfolio | 1.0m $19.4m | Reduced -25.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 1.0m $18.8m | Added +199.4k |
| Candriam S.C.A. 0.08% of their portfolio | 966.2k $18.0m | Added +192.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 965.4k $18.0m | Added +124.8k |
| Balyasny Asset Management L.P. 0.03% of their portfolio | 845.1k $15.8m | Added +371.2k |
| VANGUARD FIDUCIARY TRUST CO 0.00% of their portfolio | 841.1k $15.7m | Added +126.4k |
| MORGAN STANLEY 0.00% of their portfolio | 800.5k $14.9m | Added +69.2k |
| Nuveen, LLC 0.00% of their portfolio | 765.2k $14.3m | Added +577.0k |
| Burkehill Global Management, LP 0.49% of their portfolio | 725.0k $13.5m | Added +200.0k |
| SILVERARC CAPITAL MANAGEMENT, LLC 1.41% of their portfolio | 678.1k $12.6m | Added +167.0k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 622.4k $11.6m | Added +117.5k |
| SUPERSTRING CAPITAL MANAGEMENT LP 6.17% of their portfolio | 524.2k $9.8m | Added +272.7k |
| SPHERA FUNDS MANAGEMENT LTD. 1.33% of their portfolio | 499.0k $9.3m | Reduced -75.0k |
| PEREGRINE CAPITAL MANAGEMENT LLC 0.27% of their portfolio | 444.3k $8.3m | Reduced -86.1k |
| KVP Capital Advisors, LP 5.67% of their portfolio | 414.0k $7.7m | Unchanged |
| Ensign Peak Advisors, Inc 0.01% of their portfolio | 396.2k $7.4m | Reduced -68.6k |
| Octagon Capital Advisors LP 0.54% of their portfolio | 315.0k $5.9m | Reduced -1.2m |
| Invesco Ltd. 0.00% of their portfolio | 311.7k $5.8m | Reduced -41.2k |
| Opaleye Management Inc. 0.52% of their portfolio | 310.0k $5.8m | Reduced -35.1k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 306.7k $5.7m | Added +46.5k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 282.0k $5.3m | Added +100.7k |
| UBS Group AG 0.00% of their portfolio | 270.5k $5.0m | Reduced -175.7k |
| Informed Momentum Co LLC 0.44% of their portfolio | 264.6k $4.9m | New |
| FIFTH THIRD BANCORP 0.01% of their portfolio | 260.6k $4.9m | Added +132.3k |
| Rock Springs Capital Management LP 0.24% of their portfolio | 260.0k $4.8m | New |
| Trexquant Investment LP 0.03% of their portfolio | 242.5k $4.5m | New |
| Walleye Capital LLC 0.02% of their portfolio | 242.0k $4.5m | New |
| F/m Investments LLC 0.22% of their portfolio | 234.2k $4.4m | Added +2.6k |
| Integral Health Asset Management, LLC 0.15% of their portfolio | 200.0k $3.7m | New |
| Swiss National Bank 0.00% of their portfolio | 192.3k $3.6m | Added +24.1k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 183.2k $3.4m | Added +29.1k |
| PANAGORA ASSET MANAGEMENT INC 0.01% of their portfolio | 182.2k $3.4m | Reduced -443.3k |
| SEVEN GRAND MANAGERS, LLC 0.11% of their portfolio | 150.0k $2.8m | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 132.5k $2.5m | Added +23.4k |
| TRUST CO OF TOLEDO NA /OH/ 0.19% of their portfolio | 124.0k $2.3m | Reduced -7.5k |
| Harvest Investment Services, LLC 0.33% of their portfolio | 115.1k $2.1m | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 114.7k $2.1m | Added +76.7k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 114.5k $2.1m | Added +29.7k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 108.0k $2.0m | Added +24.6k |
| WINTON GROUP Ltd 0.06% of their portfolio | 106.9k $2.0m | New |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 102.2k $1.9m | New |
| LMR Partners LLP 0.01% of their portfolio | 100.0k $1.9m | Unchanged |
| OPPENHEIMER & CO INC 0.02% of their portfolio | 99.8k $1.9m | Reduced -256 |
| SIMPLEX TRADING, LLC 0.05% of their portfolio | 97.6k $1.8m | Added +77.3k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 93.6k $1.7m | Added +49.2k |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 90.9k $1.7m | Added +22.8k |
| WEXFORD CAPITAL LP 0.23% of their portfolio | 90.8k $1.7m | Unchanged |
| Erste Asset Management GmbH 0.01% of their portfolio | 90.0k $1.7m | Unchanged |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 88.1k $1.6m | Added +23.4k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 82.8k $1.5m | Reduced -52.0k |
| Campbell & CO Investment Adviser LLC 0.08% of their portfolio | 81.9k $1.5m | Added +41.8k |
| J. Goldman & Co LP 0.05% of their portfolio | 81.0k $1.5m | Reduced -156.0k |
| Legal & General Group Plc 0.00% of their portfolio | 79.2k $1.5m | Added +15.4k |
| PFS Partners, LLC 0.60% of their portfolio | 79.0k $1.5m | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 77.5k $1.4m | Reduced -22.5k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 76.0k $1.4m | New |
| Checkpoint Capital L.P. 0.36% of their portfolio | 75.0k $1.4m | Added +25.0k |
| TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio | 74.0k $1.4m | Added +9.5k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 73.3k $1.4m | Added +2.6k |
| VANGUARD ASSET MANAGEMENT, Ltd 0.00% of their portfolio | 72.3k $1.3m | Added +19.0k |