EDGEWISE THERAPEUTICS INC EWTX
COM · Common Stock · CUSIP 28036F105
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersBoulder, CO
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 63.5m as of 2023-07-31, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $7.75. Options: 3 managers hold calls ($124.0k notional), 3 hold puts ($46.5k).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 94 |
| Q4 2022 | 91 |
| Q1 2023 | 86 |
| Q2 2023 | 96 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 53 | 30 |
| Q1 2023 | 40 | 38 |
| Q2 2023 | 53 | 26 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $0 | $0 | — |
| Q4 2022 | $25.0k | $50.1k | 2.00 |
| Q1 2023 | $10.7k | $64.0k | 6.00 |
| Q2 2023 | $124.0k | $46.5k | 0.38 |
Biggest buyers
| VIKING GLOBAL INVESTORS LP | Added | +1.0m |
| GOLDMAN SACHS GROUP INC | Added | +999.7k |
| MPM BIOIMPACT LLC | New | +712.8k |
| Parkman Healthcare Partners LLC | Added | +392.0k |
| BANK OF MONTREAL /CAN/ | New | +316.9k |
| BlackRock Inc. | Added | +263.2k |
| Point72 Asset Management, L.P. | New | +107.1k |
| Schonfeld Strategic Advisors LLC | Added | +100.8k |
| STATE STREET CORP | Added | +89.7k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +80.7k |
Biggest sellers
| FMR LLC | Reduced | -8.5m |
| Deep Track Capital, LP | Reduced | -318.3k |
| DAFNA Capital Management LLC | Reduced | -213.9k |
| JANUS HENDERSON GROUP PLC | Reduced | -189.1k |
| CITADEL ADVISORS LLC | Reduced | -93.4k |
| Granahan Investment Management, LLC | Reduced | -89.0k |
| Tekla Capital Management LLC | Reduced | -44.6k |
| D. E. Shaw & Co., Inc. | Sold out | -24.7k |
| JANE STREET GROUP, LLC | Reduced | -16.2k |
| Tower Research Capital LLC (TRC) | Reduced | -15.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $116.2k15.0k shares |
| CITADEL ADVISORS LLC | Reduced | $7.8k1.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SIMPLEX TRADING, LLC | Added | $31.0k4.0k shares |
| CITADEL ADVISORS LLC | Reduced | $15.5k2.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
ORBIMED ADVISORS LLC
13D · may seek influence
filed 2025-05-12
Stated purposeThe Reporting Persons from time to time intend to review their investment in the Issuer on the basis of various factors, including the Issuer's business, financial condition, results of operations and prospects, general economic and industry conditions, the securities markets in general and those for the Issuer's Shares in particular, as well as other developments and other investment opportunities. Based upon such review, the Reporting Persons will take such actions in the future as the Reporting Persons may deem appropriate in light of the circumstances existing from time to time. If the Reporting Persons believe that further investment in the Issuer is attractive, whether because of the market price of Shares or otherwise, they may acquire Shares or other securities of the Issuer either… Full filing |
14.5% |
| Paradigm Biocapital Advisors LP 13G · passive investor +3.3 pts · filed 2026-08-14 | 9.5% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor -2.1 pts · filed 2026-08-14 | 7.8% |
| JANUS HENDERSON GROUP PLC 13G · institution +0.8 pts · filed 2026-05-15 | 5.5% |
| BlackRock, Inc. 13G · institution filed 2025-07-17 | 5.5% |
| FMR LLC 13G · institution new · filed 2026-08-06 | 5.1% |
Fell to 5% or below in the last year: BAKER BROS. ADVISORS LP (3.4%, 2026-08-14), Novo Holdings A/S (4.9%, 2026-04-27)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 1 | $3.4m | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 2 | $995.0k | 1 | $1.2m | — |
| Q3 2022 | 2 | $5.0m | 1 | $214.8k | — |
| Q4 2022 | 0 | — | 1 | $46.2k | — |
| Q1 2023 | 0 | — | 0 | — | — |
| Q2 2023 | 0 | — | 6 | $116.0k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-05-02 | Donovan Joanne M. CMO | Sold | $29.0k3.3k shares |
| 2023-05-02 | KOCH KEVIN President and CEO, director | Sold | $28.5k3.2k shares |
| 2023-05-02 | MOORE JOHN R General Counsel | Sold | $16.9k1.9k shares |
| 2023-05-02 | Derakhshan Behrad Chief Business Officer | Sold | $15.5k1.7k shares |
| 2023-05-02 | Russell Alan J Chief Scientific Officer, director | Sold | $14.3k1.6k shares |
| 2023-05-02 | Carruthers R Michael Chief Financial Officer | Sold | $11.9k1.3k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| ORBIMED ADVISORS LLC 2.06% of their portfolio | 14.6m $112.9m | Unchanged |
| FMR LLC 0.00% of their portfolio | 7.4m $57.0m | Reduced -8.5m |
| NOVO HOLDINGS A/S 3.64% of their portfolio | 6.1m $47.1m | Unchanged |
| VIKING GLOBAL INVESTORS LP 0.19% of their portfolio | 5.9m $46.1m | Added +1.0m |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.65% of their portfolio | 3.9m $30.5m | Unchanged |
| EcoR1 Capital, LLC 0.71% of their portfolio | 3.5m $27.1m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 3.1m $24.3m | Added +263.2k |
| Cormorant Asset Management, LP 1.30% of their portfolio | 2.9m $22.8m | Unchanged |
| Deep Track Capital, LP 1.00% of their portfolio | 2.8m $21.3m | Reduced -318.3k |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 2.7m $20.7m | Reduced -93.4k |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.0m $15.7m | Added +26.1k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 1.8m $13.6m | Added +999.7k |
| New Leaf Venture Partners, L.L.C. 10.34% of their portfolio | 1.6m $12.0m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 856.2k $6.6m | Added +80.7k |
| Opaleye Management Inc. 1.51% of their portfolio | 815.0k $6.3m | Added +65.0k |
| Frazier Life Sciences Management, L.P. 0.35% of their portfolio | 749.0k $5.8m | Added +66.6k |
| STATE STREET CORP 0.00% of their portfolio | 748.4k $5.8m | Added +89.7k |
| MPM BIOIMPACT LLC 1.11% of their portfolio | 712.8k $5.5m | New |
| Granahan Investment Management, LLC 0.15% of their portfolio | 644.7k $5.0m | Reduced -89.0k |
| JANUS HENDERSON GROUP PLC 0.00% of their portfolio | 580.7k $4.5m | Reduced -189.1k |
| AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio | 520.5k $4.0m | Added +11.4k |
| DAFNA Capital Management LLC 1.10% of their portfolio | 519.4k $4.0m | Reduced -213.9k |
| BAKER BROS. ADVISORS LP 0.02% of their portfolio | 500.0k $3.9m | Unchanged |
| Parkman Healthcare Partners LLC 0.61% of their portfolio | 454.2k $3.5m | Added +392.0k |
| Woodline Partners LP 0.03% of their portfolio | 360.1k $2.8m | Unchanged |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 340.9k $2.6m | Unchanged |
| NORTHERN TRUST CORP 0.00% of their portfolio | 339.5k $2.6m | Added +33.4k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 316.9k $2.7m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 310.9k $2.4m | Added +16.6k |
| Candriam S.C.A. 0.02% of their portfolio | 298.0k $2.3m | Unchanged |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 153.5k $1.2m | Added +55.7k |
| Tekla Capital Management LLC 0.05% of their portfolio | 150.4k $1.2m | Reduced -44.6k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 148.9k $1.2m | Added +25.0k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.02% of their portfolio | 139.9k $1.1m | Added +6.9k |
| ExodusPoint Capital Management, LP 0.01% of their portfolio | 138.2k $1.1m | Reduced -3.6k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 124.7k $968.0k | Added +2.1k |
| Schonfeld Strategic Advisors LLC 0.01% of their portfolio | 113.0k $875.8k | Added +100.8k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 107.5k $833.0k | Added +10.7k |
| Point72 Asset Management, L.P. 0.00% of their portfolio | 107.1k $830.0k | New |
| MORGAN STANLEY 0.00% of their portfolio | 100.4k $778.0k | Added +36.1k |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 80.0k $602.0k | Added +50.0k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 73.1k $565.7k | Added +45.8k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 63.3k $490.4k | Added +4.9k |
| MARTINGALE ASSET MANAGEMENT L P 0.01% of their portfolio | 61.4k $475.9k | Added +4.6k |
| Quantum Private Wealth, LLC 0.22% of their portfolio | 61.2k $474.4k | Added +12.5k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 52.3k $405.3k | Reduced -2.3k |
| ALPS ADVISORS INC 0.00% of their portfolio | 46.5k $360.5k | Added +4.8k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 35.6k $275.7k | Added +4.2k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 33.7k $261.4k | Added +7.9k |
| CORNERCAP INVESTMENT COUNSEL INC 0.03% of their portfolio | 25.1k $194.6k | Reduced -6.8k |
| PDT Partners, LLC 0.03% of their portfolio | 24.9k $193.2k | Added +5.6k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 23.4k $181.0k | Unchanged |
| Balyasny Asset Management L.P. 0.00% of their portfolio | 20.7k $160.1k | Added +5.4k |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 20.6k $159.6k | Added +2.3k |
| BIT Capital GmbH 0.02% of their portfolio | 18.7k $144.6k | New |
| Mariner, LLC 0.00% of their portfolio | 18.2k $141.1k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 17.9k $138.9k | Reduced -5.7k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 17.7k $137.4k | Added +3.3k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 17.5k $135.3k | Added +3.8k |
| BARCLAYS PLC 0.00% of their portfolio | 17.3k $133.9k | Reduced -10.7k |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio | 16.6k $129.0k | Unchanged |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 16.3k $126.2k | Added +9.5k |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 16.1k $124.6k | Added +3.9k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 16.0k $123.9k | Reduced -129 |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 15.4k $119.6k | Reduced -16.2k |
| CITIGROUP INC 0.00% of their portfolio | 14.3k $110.7k | Added +13.6k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 14.2k $110.3k | Added +141 |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 13.3k $103.5k | Reduced -35 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 11.7k $90.9k | Reduced -5.2k |
| Invesco Ltd. 0.00% of their portfolio | 11.7k $90.9k | Reduced -140 |
| VIRTUS ADVISERS, LLC 0.05% of their portfolio | 11.4k $88.5k | Reduced -1.1k |
| Virtu Financial LLC 0.01% of their portfolio | 11.0k $85.0k | New |
| SFMG, LLC 0.01% of their portfolio | 10.0k $77.5k | Unchanged |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 5.2k $40.0k | Added +2.3k |
| Legal & General Group Plc 0.00% of their portfolio | 4.1k $31.5k | Added +436 |
| AMALGAMATED BANK 0.00% of their portfolio | 3.9k $31.0k | Unchanged |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 3.0k $23.2k | Unchanged |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 2.5k $19.0k | Reduced -446 |
| Metropolitan Life Insurance Co/NY 0.00% of their portfolio | 2.1k $16.2k | Unchanged |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.2k $9.5k | Reduced -15.2k |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 829 $6.4k | Reduced -28 |
| US BANCORP \DE\ 0.00% of their portfolio | 484 $3.8k | New |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 357 $2.8k | Reduced -8.7k |
| SIGNATUREFD, LLC 0.00% of their portfolio | 357 $2.8k | Added +234 |
| Parallel Advisors, LLC 0.00% of their portfolio | 296 $2.3k | Added +219 |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 254 $2.0k | Unchanged |
| Allworth Financial LP 0.00% of their portfolio | 221 $1.7k | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 169 $1.3k | Unchanged |
| Lindbrook Capital, LLC 0.00% of their portfolio | 154 $1.2k | Reduced -369 |
| MassMutual Private Wealth & Trust, FSB 0.00% of their portfolio | 102 $791 | Unchanged |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 100 $775 | New |
| Financial Synergies Wealth Advisors, Inc. 0.00% of their portfolio | 83 $644 | New |
| CWM, LLC 0.00% of their portfolio | 45 $0 | New |
| QUADRANT CAPITAL GROUP LLC 0.00% of their portfolio | 41 $318 | New |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 25 $194 | New |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |