Vault-13

DISC MEDICINE INC IRON

COM · Common Stock · CUSIP 254604101

91 institutional holders +45 vs Q1 2023
19,111,47419.1m shares reported held*
83.5% of all shares outstanding*
$848.5mreported value*
53 new 18 added 11 reduced 9 sold out net bought ≈ $189.2m (+4.3m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($175.2k this quarter). Holder counts are more reliable. Shares outstanding: 22.9m as of 2023-08-08, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $44.40. Options: 4 managers hold calls ($1.9bn notional), 3 hold puts ($93.0k).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

050100Q4 22: 35Q1 23: 46Q2 23: 9191Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q4 202235
Q1 202346
Q2 202391

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q1 23: 28 bought or addedQ1 23: 8 cut or sold outQ1 23Q2 23: 71 bought or addedQ2 23: 20 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q1 2023288
Q2 20237120

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$500m$1bn$1.5bn$2bnQ3 22 calls: $0Q3 22 puts: $0Q3 22P/C —Q4 22 calls: $2.1mQ4 22 puts: $0Q4 22P/C 0.00Q1 23 calls: $0Q1 23 puts: $0Q1 23P/C —Q2 23 calls: $1.9bnQ2 23 puts: $93.0kQ2 23P/C 0.00
Numbers
QuarterCallsPutsP/C
Q3 2022$0$0—
Q4 2022$2.1m$00.00
Q1 2023$0$0—
Q2 2023$1.9bn$93.0k0.00

Biggest buyers

PERCEPTIVE ADVISORS LLC New +742,838+742.8k
Frazier Life Sciences Management, L.P. New +655,000+655.0k
BANK OF AMERICA CORP /DE/ Added +555,414+555.4k
CITADEL ADVISORS LLC Added +480,082+480.1k
BlackRock Inc. Added +479,082+479.1k
JANUS HENDERSON GROUP PLC Added +456,681+456.7k
DEERFIELD MANAGEMENT COMPANY, L.P. New +430,000+430.0k
Octagon Capital Advisors LP New +415,000+415.0k
ADAGE CAPITAL PARTNERS GP, L.L.C. Added +335,688+335.7k
Ikarian Capital, LLC New +240,031+240.0k

Biggest sellers

NOVO HOLDINGS A/S Reduced -1,250,000-1.2m
Bain Capital Life Sciences Investors, LLC Reduced -658,366-658.4k
Logos Global Management LP Sold out -525,000-525.0k
BML Capital Management, LLC Sold out -208,161-208.2k
Ghost Tree Capital, LLC Sold out -100,000-100.0k
5AM Venture Management, LLC Reduced -100,000-100.0k
Nantahala Capital Management, LLC Sold out -89,538-89.5k
SPHERA FUNDS MANAGEMENT LTD. Reduced -49,435-49.4k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced -32,456-32.5k
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) Reduced -28,629-28.6k

Biggest calls

Polar Capital Holdings Plc New $1.9bn42.7m shares
SIMPLEX TRADING, LLC New $22.0k500 shares
GROUP ONE TRADING LLC New $4.4k100 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SIMPLEX TRADING, LLC New $53.0k1.2k shares
GROUP ONE TRADING LLC New $40.0k900 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FMR LLC 13G · institution -1.3 pts · filed 2026-08-06 12.8% -1.3 pts 4.9m≈ $356.6m 2026-08-06
AI DMI LLC 13D · may seek influence -1.4 pts · filed 2026-10-26 6.6% -1.4 pts 2.9m≈ $203.9m 2026-10-26
RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-01-07 5.9% new 2.2m≈ $163.0m 2026-01-07

Fell to 5% or below in the last year: Atlas Venture Fund X, L.P. (2.2%, 2025-12-17)

Insider purchases and sales in Q2 2023

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
404Q3 21: 0 buyingQ3 21: 0 sellingQ4 21: 0 buyingQ4 21: 0 sellingQ4 21Q1 22: 0 buyingQ1 22: 0 sellingQ2 22: 0 buyingQ2 22: 0 sellingQ2 22Q3 22: 0 buyingQ3 22: 0 sellingQ4 22: 0 buyingQ4 22: 0 sellingQ4 22Q1 23: 2 buyingQ1 23: 0 sellingQ2 23: 0 buyingQ2 23: 3 sellingQ2 23
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20210—0——
Q4 20210—0——
Q1 20220—0——
Q2 20220—0——
Q3 20220—0——
Q4 20220—0——
Q1 20232$2.5m0——
Q2 20230—3$1.4m$1.4m
DateInsiderTradeSharesPrice ValueTheir holding
2023-06-30 MacDonald Brian Richard Chief Innovation Officer Sold plan 4,324 $45.04 $194.8k4.3k shares -25%
2023-06-29 MacDonald Brian Richard Chief Innovation Officer Sold plan 5,100 $45.78 $233.5k5.1k shares -23%
2023-06-28 Novo Holdings A/S 10% owner Sold 1,250,000 $46.10 $57.6m1.2m shares -53%
2023-06-28 Bryce Joanne Chief Financial Officer Sold plan 10,072 $49.95 $503.1k10.1k shares -89%
2023-06-28 MacDonald Brian Richard Chief Innovation Officer Sold plan 5,100 $49.96 $254.8k5.1k shares -19%
2023-06-28 Savage William Jacob Chief Medical Officer Sold plan 4,384 $49.98 $219.1k4.4k shares -22%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Atlas Venture Life Science Advisors, LLC 19.13% of their portfolio CAMBRIDGE, MA 3,461,7843.5m $153.7m $153.7m 19.13% Unchanged
2 ORBIMED ADVISORS LLC 1.84% of their portfolio New York, NY 2,269,6372.3m $100.8m $100.8m 1.84% Unchanged
3 Bain Capital Life Sciences Investors, LLC 6.09% of their portfolio Boston, MA 1,332,5481.3m $59.2m $59.2m 6.09% Reduced -658.4k -658,366
4 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.11% of their portfolio Boston, MA 1,162,6241.2m $51.6m $51.6m 0.11% Added +335.7k +335,688
5 NOVO HOLDINGS A/S 3.74% of their portfolio HELLERUP, G7 1,090,7721.1m $48.4m $48.4m 3.74% Reduced -1.2m -1,250,000
6 PERCEPTIVE ADVISORS LLC 0.96% of their portfolio NEW YORK, NY 742,838742.8k $33.0m $33.0m 0.96% New
7 Frazier Life Sciences Management, L.P. 1.74% of their portfolio PALO ALTO, CA 655,000655.0k $29.1m $29.1m 1.74% New
8 CITADEL ADVISORS LLC 0.03% of their portfolio MIAMI, FL 651,320651.3k $28.9m $28.9m 0.03% Added +480.1k +480,082
9 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 559,767559.8k $24.9m $24.9m 0.00% Added +236.9k +236,898
10 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 558,096558.1k $24.8m $24.8m 0.00% Added +555.4k +555,414
11 BlackRock Inc. 0.00% of their portfolio New York, NY 502,549502.5k $22.3m $22.3m 0.00% Added +479.1k +479,082
12 JANUS HENDERSON GROUP PLC 0.01% of their portfolio LONDON, X0 500,379500.4k $22.2m $22.2m 0.01% Added +456.7k +456,681
13 5AM Venture Management, LLC 5.40% of their portfolio SAN FRANCISCO, CA 488,442488.4k $21.7m $21.7m 5.40% Reduced -100.0k -100,000
14 DEERFIELD MANAGEMENT COMPANY, L.P. 0.41% of their portfolio New York, NY 430,000430.0k $19.1m $19.1m 0.41% New
15 Octagon Capital Advisors LP 2.57% of their portfolio NEW YORK, NY 415,000415.0k $18.4m $18.4m 2.57% New
16 Rock Springs Capital Management LP 0.38% of their portfolio Baltimore, MD 363,468363.5k $16.1m $16.1m 0.38% Added +50.0k +50,000
17 FMR LLC 0.00% of their portfolio BOSTON, MA 323,054323.1k $14.3m $14.3m 0.00% Added +19.7k +19,656
18 Assenagon Asset Management S.A. 0.04% of their portfolio SENNINGERBERG, N4 247,400247.4k $11.0m $11.0m 0.04% Added +185.6k +185,595
19 Foresite Capital Management V, LLC 7.90% of their portfolio WEST HOLLYWOOD, CA 243,513243.5k $10.8m $10.8m 7.90% Unchanged
20 Ikarian Capital, LLC 3.60% of their portfolio DALLAS, TX 240,031240.0k $10.7m $10.7m 3.60% New
21 Cormorant Asset Management, LP 0.57% of their portfolio BOSTON, MA 225,000225.0k $10.0m $10.0m 0.57% New
22 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 202,670202.7k $9.0m $9.0m 0.00% New
23 SPHERA FUNDS MANAGEMENT LTD. 1.62% of their portfolio TEL AVIV, L3 170,578170.6k $7.6m $7.6m 1.62% Reduced -49.4k -49,435
24 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 157,255157.3k $7.0m $7.0m 0.00% New
25 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 147,055147.1k $6.5m $6.5m 0.00% Added +100.0k +100,017
26 ACUTA CAPITAL PARTNERS, LLC 4.20% of their portfolio REDWOOD CITY, CA 139,500139.5k $6.2m $6.2m 4.20% New
27 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 139,403139.4k $6.2m $6.2m 0.00% Added +124.9k +124,916
28 Boxer Capital, LLC 0.27% of their portfolio San Diego, CA 130,000130.0k $5.8m $5.8m 0.27% Unchanged
29 Point72 Asset Management, L.P. 0.02% of their portfolio STAMFORD, CT 125,200125.2k $5.6m $5.6m 0.02% New
30 CHI Advisors LLC 1.69% of their portfolio NEW YORK, NY 125,139125.1k $5.6m $5.6m 1.69% New
31 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 110,632110.6k $4.9m $4.9m 0.00% New
32 Trustees of Columbia University in the City of New York 7.19% of their portfolio NEW YORK, NY 110,488110.5k $4.9m $4.9m 7.19% Unchanged
33 Davidson Kempner Capital Management LP 0.08% of their portfolio New York, NY 90,00090.0k $4.0m $4.0m 0.08% Not comparable
34 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 69,97570.0k $3.1m $3.1m 0.00% New
35 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 68,89068.9k $3.1m $3.1m 0.00% Added +53.6k +53,620
36 Woodline Partners LP 0.04% of their portfolio San Francisco, CA 68,14668.1k $3.0m $3.0m 0.04% New
37 ExodusPoint Capital Management, LP 0.03% of their portfolio NEW YORK, NY 52,80052.8k $2.3m $2.3m 0.03% Reduced -18.2k -18,166
38 Parkman Healthcare Partners LLC 0.38% of their portfolio STAMFORD, CT 50,00050.0k $2.2m $2.2m 0.38% New
39 BOOTHBAY FUND MANAGEMENT, LLC 0.07% of their portfolio NEW YORK, NY 48,94148.9k $2.2m $2.2m 0.07% New
40 Informed Momentum Co LLC 0.39% of their portfolio SOLANA BEACH, CA 47,20647.2k $2.1m $2.1m 0.39% New
41 Monashee Investment Management LLC 0.48% of their portfolio Boston, MA 45,00045.0k $2.0m $2.0m 0.48% New
42 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 43,53043.5k $1.9m $1.9m 0.00% Added +33.7k +33,715
43 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 43,27043.3k $1.9m $1.9m 0.00% New
44 Blackstone Inc. 0.01% of their portfolio NEW YORK, NY 40,86640.9k $1.8m $1.8m 0.01% New
45 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 40,26140.3k $1.8m $1.8m 0.00% Added +16.1k +16,111
46 Ensign Peak Advisors, Inc 0.00% of their portfolio SALT LAKE CITY, UT 40,00040.0k $1.8m $1.8m 0.00% New
47 Walleye Capital LLC 0.03% of their portfolio NEW YORK, NY 35,80435.8k $1.6m $1.6m 0.03% New
48 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 35,00535.0k $1.6m $1.6m 0.00% New
49 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 32,80032.8k $1.5m $1.5m 0.00% New
50 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 24,98325.0k $1.1m $1.1m 0.00% New
51 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 20,55620.6k $912.7k $912.7k 0.00% New
52 Ghisallo Capital Management LLC 0.11% of their portfolio BOSTON, MA 20,00020.0k $888.0k $888.0k 0.11% New
53 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.02% of their portfolio CHICAGO, IL 17,12117.1k $760.2k $760.2k 0.02% Reduced -28.6k -28,629
54 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 14,55414.6k $646.2k $646.2k 0.01% New
55 TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio STAMFORD, CT 12,33512.3k $547.7k $547.7k 0.01% New
56 UBS Group AG 0.00% of their portfolio ZURICH, V8 11,69411.7k $519.2k $519.2k 0.00% Added +6.5k +6,451
57 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 10,21010.2k $453.3k $453.3k 0.00% New
58 STIFEL FINANCIAL CORP 0.00% of their portfolio ST. LOUIS, MO 8,7608.8k $388.9k $388.9k 0.00% Reduced -5.0k -4,962
59 HARVARD MANAGEMENT CO INC 0.04% of their portfolio BOSTON, MA 8,4528.5k $375.0k $375.0k 0.04% Reduced -16.5k -16,548
60 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 7,2807.3k $323.2k $323.2k 0.00% New
61 Schonfeld Strategic Advisors LLC 0.00% of their portfolio NEW YORK, NY 7,2007.2k $319.7k $319.7k 0.00% New
62 Hilltop Holdings Inc. 0.04% of their portfolio DALLAS, TX 7,1007.1k $315.2k $315.2k 0.04% New
63 THOMPSON DAVIS & CO., INC. 0.34% of their portfolio RICHMOND, VA 6,8006.8k $301.9k $301.9k 0.34% New
64 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 6,7966.8k $301.7k $301.7k 0.00% New
65 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 5,9976.0k $266.3k $266.3k 0.00% New
66 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 5,6075.6k $249.0k $249.0k 0.00% New
67 Ergoteles LLC 0.01% of their portfolio NEW YORK, NY 5,4025.4k $239.8k $239.8k 0.01% New
68 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 4,7574.8k $211.2k $211.2k 0.00% Reduced -32.5k -32,456
69 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 4,1944.2k $186.2k $186.2k 0.00% New
70 PNC Financial Services Group, Inc. 0.00% of their portfolio Pittsburgh, PA 4,0104.0k $178.0k $178.0k 0.00% New
71 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 3,7233.7k $165.3k $165.3k 0.00% New
72 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 3,6223.6k $160.8k $160.8k 0.00% New
73 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 3,2003.2k $142.1k $142.1k 0.00% New
74 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 3,1993.2k $142.0k $142.0k 0.00% Added +3.2k +3,173
75 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 2,5732.6k $114.2k $114.2k 0.00% New
76 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 2,3022.3k $102.2k $102.2k 0.00% Reduced -22.8k -22,778
77 VIRTUS ADVISERS, LLC 0.06% of their portfolio HARTFORD, CT 2,2192.2k $98.5k $98.5k 0.06% New
78 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 1,5531.6k $69.0k $69.0k 0.00% Reduced -4.1k -4,066
79 US BANCORP \DE\ 0.00% of their portfolio MINNEAPOLIS, MN 1,1761.2k $52.2k $52.2k 0.00% Unchanged
80 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 1,1451.1k $51.0k $51.0k 0.00% New
81 Legal & General Group Plc 0.00% of their portfolio London, X0 925925 $41.1k $41.1k 0.00% New
82 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 639639 $28.4k $28.4k 0.00% New
83 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 502502 $22.0k $22.0k 0.00% Added +402 +402
84 Metropolitan Life Insurance Co/NY 0.00% of their portfolio New York, NY 435435 $19.3k $19.3k 0.00% New
85 Steward Partners Investment Advisory, LLC 0.00% of their portfolio STAMFORD, CT 400400 $17.8k $17.8k 0.00% Added +100 +100
86 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 227227 $10.1k $10.1k 0.00% New
87 FEDERATED HERMES, INC. 0.00% of their portfolio PITTSBURGH, PA 7878 $3.5k $3.5k 0.00% New
88 Ulland Investment Advisors, LLC 0.00% of their portfolio MINNEAPOLIS, MN 3434 $2.0k $2.0k 0.00% Unchanged
89 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 2222 $0 $0 0.00% New
90 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 11 $44 $44 0.00% New
91 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged