DISC MEDICINE INC IRON
COM · Common Stock · CUSIP 254604101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWatertown, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($175.2k this quarter). Holder counts are more reliable. Shares outstanding: 22.9m as of 2023-08-08, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $44.40. Options: 4 managers hold calls ($1.9bn notional), 3 hold puts ($93.0k).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2022 | 35 |
| Q1 2023 | 46 |
| Q2 2023 | 91 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 28 | 8 |
| Q2 2023 | 71 | 20 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $0 | $0 | — |
| Q4 2022 | $2.1m | $0 | 0.00 |
| Q1 2023 | $0 | $0 | — |
| Q2 2023 | $1.9bn | $93.0k | 0.00 |
Biggest buyers
| PERCEPTIVE ADVISORS LLC | New | +742.8k |
| Frazier Life Sciences Management, L.P. | New | +655.0k |
| BANK OF AMERICA CORP /DE/ | Added | +555.4k |
| CITADEL ADVISORS LLC | Added | +480.1k |
| BlackRock Inc. | Added | +479.1k |
| JANUS HENDERSON GROUP PLC | Added | +456.7k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | New | +430.0k |
| Octagon Capital Advisors LP | New | +415.0k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Added | +335.7k |
| Ikarian Capital, LLC | New | +240.0k |
Biggest sellers
| NOVO HOLDINGS A/S | Reduced | -1.2m |
| Bain Capital Life Sciences Investors, LLC | Reduced | -658.4k |
| Logos Global Management LP | Sold out | -525.0k |
| BML Capital Management, LLC | Sold out | -208.2k |
| Ghost Tree Capital, LLC | Sold out | -100.0k |
| 5AM Venture Management, LLC | Reduced | -100.0k |
| Nantahala Capital Management, LLC | Sold out | -89.5k |
| SPHERA FUNDS MANAGEMENT LTD. | Reduced | -49.4k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -32.5k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | Reduced | -28.6k |
Biggest calls
| Polar Capital Holdings Plc | New | $1.9bn42.7m shares |
| SIMPLEX TRADING, LLC | New | $22.0k500 shares |
| GROUP ONE TRADING LLC | New | $4.4k100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SIMPLEX TRADING, LLC | New | $53.0k1.2k shares |
| GROUP ONE TRADING LLC | New | $40.0k900 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution -1.3 pts · filed 2026-08-06 | 12.8% |
| AI DMI LLC 13D · may seek influence -1.4 pts · filed 2026-10-26 | 6.6% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-01-07 | 5.9% |
Fell to 5% or below in the last year: Atlas Venture Fund X, L.P. (2.2%, 2025-12-17)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 2 | $2.5m | 0 | — | — |
| Q2 2023 | 0 | — | 3 | $1.4m | $1.4m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-06-30 | MacDonald Brian Richard Chief Innovation Officer | Sold plan | $194.8k4.3k shares |
| 2023-06-29 | MacDonald Brian Richard Chief Innovation Officer | Sold plan | $233.5k5.1k shares |
| 2023-06-28 | Novo Holdings A/S 10% owner | Sold | $57.6m1.2m shares |
| 2023-06-28 | Bryce Joanne Chief Financial Officer | Sold plan | $503.1k10.1k shares |
| 2023-06-28 | MacDonald Brian Richard Chief Innovation Officer | Sold plan | $254.8k5.1k shares |
| 2023-06-28 | Savage William Jacob Chief Medical Officer | Sold plan | $219.1k4.4k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| Atlas Venture Life Science Advisors, LLC 19.13% of their portfolio | 3.5m $153.7m | Unchanged |
| ORBIMED ADVISORS LLC 1.84% of their portfolio | 2.3m $100.8m | Unchanged |
| Bain Capital Life Sciences Investors, LLC 6.09% of their portfolio | 1.3m $59.2m | Reduced -658.4k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.11% of their portfolio | 1.2m $51.6m | Added +335.7k |
| NOVO HOLDINGS A/S 3.74% of their portfolio | 1.1m $48.4m | Reduced -1.2m |
| PERCEPTIVE ADVISORS LLC 0.96% of their portfolio | 742.8k $33.0m | New |
| Frazier Life Sciences Management, L.P. 1.74% of their portfolio | 655.0k $29.1m | New |
| CITADEL ADVISORS LLC 0.03% of their portfolio | 651.3k $28.9m | Added +480.1k |
| VANGUARD GROUP INC 0.00% of their portfolio | 559.8k $24.9m | Added +236.9k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 558.1k $24.8m | Added +555.4k |
| BlackRock Inc. 0.00% of their portfolio | 502.5k $22.3m | Added +479.1k |
| JANUS HENDERSON GROUP PLC 0.01% of their portfolio | 500.4k $22.2m | Added +456.7k |
| 5AM Venture Management, LLC 5.40% of their portfolio | 488.4k $21.7m | Reduced -100.0k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.41% of their portfolio | 430.0k $19.1m | New |
| Octagon Capital Advisors LP 2.57% of their portfolio | 415.0k $18.4m | New |
| Rock Springs Capital Management LP 0.38% of their portfolio | 363.5k $16.1m | Added +50.0k |
| FMR LLC 0.00% of their portfolio | 323.1k $14.3m | Added +19.7k |
| Assenagon Asset Management S.A. 0.04% of their portfolio | 247.4k $11.0m | Added +185.6k |
| Foresite Capital Management V, LLC 7.90% of their portfolio | 243.5k $10.8m | Unchanged |
| Ikarian Capital, LLC 3.60% of their portfolio | 240.0k $10.7m | New |
| Cormorant Asset Management, LP 0.57% of their portfolio | 225.0k $10.0m | New |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 202.7k $9.0m | New |
| SPHERA FUNDS MANAGEMENT LTD. 1.62% of their portfolio | 170.6k $7.6m | Reduced -49.4k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 157.3k $7.0m | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 147.1k $6.5m | Added +100.0k |
| ACUTA CAPITAL PARTNERS, LLC 4.20% of their portfolio | 139.5k $6.2m | New |
| STATE STREET CORP 0.00% of their portfolio | 139.4k $6.2m | Added +124.9k |
| Boxer Capital, LLC 0.27% of their portfolio | 130.0k $5.8m | Unchanged |
| Point72 Asset Management, L.P. 0.02% of their portfolio | 125.2k $5.6m | New |
| CHI Advisors LLC 1.69% of their portfolio | 125.1k $5.6m | New |
| Invesco Ltd. 0.00% of their portfolio | 110.6k $4.9m | New |
| Trustees of Columbia University in the City of New York 7.19% of their portfolio | 110.5k $4.9m | Unchanged |
| Davidson Kempner Capital Management LP 0.08% of their portfolio | 90.0k $4.0m | Not comparable |
| NORTHERN TRUST CORP 0.00% of their portfolio | 70.0k $3.1m | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 68.9k $3.1m | Added +53.6k |
| Woodline Partners LP 0.04% of their portfolio | 68.1k $3.0m | New |
| ExodusPoint Capital Management, LP 0.03% of their portfolio | 52.8k $2.3m | Reduced -18.2k |
| Parkman Healthcare Partners LLC 0.38% of their portfolio | 50.0k $2.2m | New |
| BOOTHBAY FUND MANAGEMENT, LLC 0.07% of their portfolio | 48.9k $2.2m | New |
| Informed Momentum Co LLC 0.39% of their portfolio | 47.2k $2.1m | New |
| Monashee Investment Management LLC 0.48% of their portfolio | 45.0k $2.0m | New |
| MORGAN STANLEY 0.00% of their portfolio | 43.5k $1.9m | Added +33.7k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 43.3k $1.9m | New |
| Blackstone Inc. 0.01% of their portfolio | 40.9k $1.8m | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 40.3k $1.8m | Added +16.1k |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 40.0k $1.8m | New |
| Walleye Capital LLC 0.03% of their portfolio | 35.8k $1.6m | New |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 35.0k $1.6m | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 32.8k $1.5m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 25.0k $1.1m | New |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 20.6k $912.7k | New |
| Ghisallo Capital Management LLC 0.11% of their portfolio | 20.0k $888.0k | New |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.02% of their portfolio | 17.1k $760.2k | Reduced -28.6k |
| ALPS ADVISORS INC 0.01% of their portfolio | 14.6k $646.2k | New |
| TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio | 12.3k $547.7k | New |
| UBS Group AG 0.00% of their portfolio | 11.7k $519.2k | Added +6.5k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 10.2k $453.3k | New |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 8.8k $388.9k | Reduced -5.0k |
| HARVARD MANAGEMENT CO INC 0.04% of their portfolio | 8.5k $375.0k | Reduced -16.5k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 7.3k $323.2k | New |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 7.2k $319.7k | New |
| Hilltop Holdings Inc. 0.04% of their portfolio | 7.1k $315.2k | New |
| THOMPSON DAVIS & CO., INC. 0.34% of their portfolio | 6.8k $301.9k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 6.8k $301.7k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 6.0k $266.3k | New |
| TD Asset Management Inc 0.00% of their portfolio | 5.6k $249.0k | New |
| Ergoteles LLC 0.01% of their portfolio | 5.4k $239.8k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 4.8k $211.2k | Reduced -32.5k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 4.2k $186.2k | New |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 4.0k $178.0k | New |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 3.7k $165.3k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 3.6k $160.8k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 3.2k $142.1k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 3.2k $142.0k | Added +3.2k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 2.6k $114.2k | New |
| CITIGROUP INC 0.00% of their portfolio | 2.3k $102.2k | Reduced -22.8k |
| VIRTUS ADVISERS, LLC 0.06% of their portfolio | 2.2k $98.5k | New |
| BARCLAYS PLC 0.00% of their portfolio | 1.6k $69.0k | Reduced -4.1k |
| US BANCORP \DE\ 0.00% of their portfolio | 1.2k $52.2k | Unchanged |
| AMALGAMATED BANK 0.00% of their portfolio | 1.1k $51.0k | New |
| Legal & General Group Plc 0.00% of their portfolio | 925 $41.1k | New |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 639 $28.4k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 502 $22.0k | Added +402 |
| Metropolitan Life Insurance Co/NY 0.00% of their portfolio | 435 $19.3k | New |
| Steward Partners Investment Advisory, LLC 0.00% of their portfolio | 400 $17.8k | Added +100 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 227 $10.1k | New |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 78 $3.5k | New |
| Ulland Investment Advisors, LLC 0.00% of their portfolio | 34 $2.0k | Unchanged |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 22 $0 | New |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 1 $44 | New |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |