TYRA BIOSCIENCES INC TYRA
COM · Common Stock · CUSIP 90240B106
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCarlsbad, CA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 43.0m as of 2023-08-07, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $17.03. Options: 1 managers hold calls ($0 notional), 1 hold puts ($0).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 49 |
| Q4 2022 | 47 |
| Q1 2023 | 52 |
| Q2 2023 | 60 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 17 | 15 |
| Q1 2023 | 27 | 14 |
| Q2 2023 | 26 | 14 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $7.0k | $0 | 0.00 |
| Q4 2022 | $37.2k | $7.6k | 0.20 |
| Q1 2023 | $645.8k | $0 | 0.00 |
| Q2 2023 | $0 | $0 | — |
Biggest buyers
| JPMORGAN CHASE & CO | Added | +230.9k |
| BlackRock Inc. | Added | +223.9k |
| NORTHERN TRUST CORP | Added | +32.6k |
| STATE STREET CORP | Added | +24.3k |
| Driehaus Capital Management LLC | Added | +16.3k |
| DIMENSIONAL FUND ADVISORS LP | New | +10.6k |
| BOOTHBAY FUND MANAGEMENT, LLC | New | +10.2k |
| VANGUARD GROUP INC | Added | +9.6k |
| EXCHANGE TRADED CONCEPTS, LLC | New | +8.9k |
| MILLENNIUM MANAGEMENT LLC | Added | +8.1k |
Biggest sellers
| FMR LLC | Reduced | -2.2m |
| BVF INC/IL | Reduced | -500.0k |
| Frazier Life Sciences Management, L.P. | Reduced | -393.3k |
| PERCEPTIVE ADVISORS LLC | Reduced | -134.4k |
| Logos Global Management LP | Reduced | -55.8k |
| NEW YORK STATE COMMON RETIREMENT FUND | Reduced | -6.5k |
| WELLINGTON MANAGEMENT GROUP LLP | Reduced | -4.8k |
| BARCLAYS PLC | Reduced | -4.0k |
| DEUTSCHE BANK AG\ | Reduced | -1.9k |
| Tower Research Capital LLC (TRC) | Reduced | -888 |
Biggest calls
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| RA CAPITAL MANAGEMENT, L.P. 13D · may seek influence -1.3 pts · filed 2026-09-17 | 19.9% |
| FMR LLC 13G · institution +11.2 pts · filed 2026-04-07 | 14.4% |
| JANUS HENDERSON GROUP PLC 13G · institution +1.8 pts · filed 2026-05-15 | 7.2% |
| Farallon Capital Partners, L.P. 13G · passive investor +1.0 pts · filed 2026-05-12 | 6.6% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor +2.1 pts · filed 2026-09-21 | 6.1% |
| NEXTECH VI ONCOLOGY SCSP 13G · passive investor filed 2026-08-14 | 6.0% |
| Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-09-17 | 5.8% |
| TCG Crossover GP I, LLC 13G · passive investor new · filed 2025-03-06 | 5.7% |
Fell to 5% or below in the last year: BlackRock, Inc. (4.8%, 2026-10-27), FARALLON CAPITAL MANAGEMENT, L.L.C. (0.0%, 2026-08-14; now reported by Farallon Capital Partners, L.P.), Commodore Capital LP (4.2%, 2026-05-15), Harris Todd (4.8%, 2026-05-14), Canaan XI L.P. (1.4%, 2026-04-24)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 2 | $1.1m | $38.4k |
| Q2 2023 | 0 | — | 2 | $3.8m | $3.8m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-06-30 | Bensen Daniel Chief Operating Officer | Sold plan | $319.4k18.8k shares |
| 2023-06-29 | Bensen Daniel Chief Operating Officer | Sold plan | $285.0k17.3k shares |
| 2023-06-28 | Bensen Daniel Chief Operating Officer | Sold plan | $228.7k13.5k shares |
| 2023-06-27 | Bensen Daniel Chief Operating Officer | Sold plan | $271.1k16.0k shares |
| 2023-06-26 | Bensen Daniel Chief Operating Officer | Sold plan | $288.9k17.2k shares |
| 2023-06-23 | Harris Todd Chief Executive Officer, director | Sold plan | $352.3k20.7k shares |
| 2023-06-22 | Harris Todd Chief Executive Officer, director | Sold plan | $59.3k3.5k shares |
| 2023-06-21 | Harris Todd Chief Executive Officer, director | Sold plan | $343.0k19.8k shares |
| 2023-06-20 | Harris Todd Chief Executive Officer, director | Sold plan | $21.5k1.3k shares |
| 2023-06-16 | Harris Todd Chief Executive Officer, director | Sold plan | $933.1k54.8k shares |
| 2023-06-15 | Harris Todd Chief Executive Officer, director | Sold plan | $206.0k12.8k shares |
| 2023-06-15 | Bensen Daniel Chief Operating Officer | Sold plan | $203.4k12.6k shares |
| 2023-06-14 | Bensen Daniel Chief Operating Officer | Sold plan | $2.0k120 shares |
| 2023-06-13 | Harris Todd Chief Executive Officer, director | Sold plan | $126.8k7.9k shares |
| 2023-06-13 | Bensen Daniel Chief Operating Officer | Sold plan | $90.1k5.6k shares |
| 2023-04-03 | Bensen Daniel Chief Operating Officer | Sold plan | $32.3k2.0k shares |
| 2023-04-03 | Harris Todd Chief Executive Officer, director | Sold plan | $32.3k2.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. 2.33% of their portfolio | 7.2m $123.2m | Unchanged |
| Boxer Capital, LLC 5.09% of their portfolio | 6.4m $109.8m | Unchanged |
| Canaan Partners XI LLC 53.19% of their portfolio | 4.4m $75.1m | Unchanged |
| FMR LLC 0.01% of their portfolio | 4.1m $70.1m | Reduced -2.2m |
| BVF INC/IL 1.30% of their portfolio | 2.7m $46.7m | Reduced -500.0k |
| Nextech Invest Ltd. 14.58% of their portfolio | 2.5m $42.9m | Unchanged |
| TCG Crossover Management, LLC 5.56% of their portfolio | 2.0m $33.9m | Unchanged |
| Fairmount Funds Management LLC 3.40% of their portfolio | 1.4m $24.1m | Unchanged |
| Frazier Life Sciences Management, L.P. 1.05% of their portfolio | 1.0m $17.5m | Reduced -393.3k |
| BlackRock Inc. 0.00% of their portfolio | 890.8k $15.2m | Added +223.9k |
| VANGUARD GROUP INC 0.00% of their portfolio | 648.9k $11.1m | Added +9.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 423.4k $7.2m | Added +230.9k |
| Woodline Partners LP 0.08% of their portfolio | 410.4k $7.0m | Unchanged |
| PERCEPTIVE ADVISORS LLC 0.18% of their portfolio | 360.0k $6.1m | Reduced -134.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 290.0k $4.9m | Added +3.9k |
| STATE STREET CORP 0.00% of their portfolio | 256.4k $4.4m | Added +24.3k |
| Driehaus Capital Management LLC 0.03% of their portfolio | 150.5k $2.6m | Added +16.3k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 140.2k $2.4m | Added +32.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 104.7k $1.8m | Added +2.3k |
| Auour Investments LLC 0.61% of their portfolio | 85.0k $1.4m | First filing |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 79.4k $1.4m | Reduced -4.8k |
| Ikarian Capital, LLC 0.28% of their portfolio | 48.2k $820.3k | Unchanged |
| Artia Global Partners LP 0.27% of their portfolio | 45.3k $770.7k | Unchanged |
| Bank of New York Mellon Corp 0.00% of their portfolio | 40.8k $694.8k | Reduced -735 |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 33.1k $563.5k | Reduced -670 |
| Logos Global Management LP 0.07% of their portfolio | 31.9k $542.8k | Reduced -55.8k |
| FISHMAN JAY A LTD/MI 0.02% of their portfolio | 22.0k $374.7k | Unchanged |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 21.6k $367.7k | Added +8.1k |
| Mariner, LLC 0.00% of their portfolio | 21.6k $367.4k | Added +44 |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 21.3k $362.5k | Reduced -641 |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 20.4k $347.6k | Added +2.4k |
| LPL Financial LLC 0.00% of their portfolio | 19.5k $332.1k | Unchanged |
| MORGAN STANLEY 0.00% of their portfolio | 18.8k $319.7k | Added +3.5k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 18.8k $319.4k | Unchanged |
| Sepio Capital, LP 0.01% of their portfolio | 10.6k $180.9k | Unchanged |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 10.6k $180.5k | New |
| BOOTHBAY FUND MANAGEMENT, LLC 0.01% of their portfolio | 10.2k $173.3k | New |
| EXCHANGE TRADED CONCEPTS, LLC 0.00% of their portfolio | 8.9k $151.0k | New |
| UBS Group AG 0.00% of their portfolio | 8.0k $136.2k | Added +3.4k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 7.7k $131.2k | Unchanged |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 6.7k $114.6k | Added +331 |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 6.2k $106.0k | Reduced -1.9k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 5.5k $93.9k | Added +3.1k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 4.7k $79.2k | Reduced -278 |
| CITIGROUP INC 0.00% of their portfolio | 4.2k $70.9k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 4.0k $68.1k | Reduced -6.5k |
| FEDERATED HERMES, INC. 0.00% of their portfolio | 3.1k $52.2k | Added +3.0k |
| BARCLAYS PLC 0.00% of their portfolio | 2.8k $47.5k | Reduced -4.0k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 2.3k $39.0k | Added +1.5k |
| Allspring Global Investments Holdings, LLC 0.00% of their portfolio | 2.3k $38.7k | New |
| AMALGAMATED BANK 0.00% of their portfolio | 1.6k $27.0k | Added +246 |
| Legal & General Group Plc 0.00% of their portfolio | 1.5k $26.1k | Added +127 |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 940 $16.0k | Unchanged |
| Metropolitan Life Insurance Co/NY 0.00% of their portfolio | 814 $13.9k | Unchanged |
| SIMPLEX TRADING, LLC 0.00% of their portfolio | 674 $11.0k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 658 $11.2k | Reduced -888 |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 176 $3.0k | New |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 58 $988 | Unchanged |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 16 $272 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |