Vault-13

TYRA BIOSCIENCES INC TYRA

COM · Common Stock · CUSIP 90240B106

60 institutional holders +8 vs Q1 2023
36,210,80936.2m shares reported held*
84.2% of all shares outstanding*
$616.7mreported value*
7 new 19 added 14 reduced 0 sold out net sold ≈ $45.6m (-2.7m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 43.0m as of 2023-08-07, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $17.03. Options: 1 managers hold calls ($0 notional), 1 hold puts ($0).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

0204060Q3 22: 49Q4 22: 47Q1 23: 52Q2 23: 6060Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 202249
Q4 202247
Q1 202352
Q2 202360

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
40040Q4 22: 17 bought or addedQ4 22: 15 cut or sold outQ4 22Q1 23: 27 bought or addedQ1 23: 14 cut or sold outQ1 23Q2 23: 26 bought or addedQ2 23: 14 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 20221715
Q1 20232714
Q2 20232614

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$200k$400k$600k$800kQ3 22 calls: $7.0kQ3 22 puts: $0Q3 22P/C 0.00Q4 22 calls: $37.2kQ4 22 puts: $7.6kQ4 22P/C 0.20Q1 23 calls: $645.8kQ1 23 puts: $0Q1 23P/C 0.00Q2 23 calls: $0Q2 23 puts: $0Q2 23P/C —
Numbers
QuarterCallsPutsP/C
Q3 2022$7.0k$00.00
Q4 2022$37.2k$7.6k0.20
Q1 2023$645.8k$00.00
Q2 2023$0$0—

Biggest buyers

JPMORGAN CHASE & CO Added +230,912+230.9k
BlackRock Inc. Added +223,947+223.9k
NORTHERN TRUST CORP Added +32,626+32.6k
STATE STREET CORP Added +24,288+24.3k
Driehaus Capital Management LLC Added +16,295+16.3k
DIMENSIONAL FUND ADVISORS LP New +10,601+10.6k
BOOTHBAY FUND MANAGEMENT, LLC New +10,174+10.2k
VANGUARD GROUP INC Added +9,551+9.6k
EXCHANGE TRADED CONCEPTS, LLC New +8,867+8.9k
MILLENNIUM MANAGEMENT LLC Added +8,116+8.1k

Biggest sellers

FMR LLC Reduced -2,179,105-2.2m
BVF INC/IL Reduced -500,000-500.0k
Frazier Life Sciences Management, L.P. Reduced -393,297-393.3k
PERCEPTIVE ADVISORS LLC Reduced -134,403-134.4k
Logos Global Management LP Reduced -55,801-55.8k
NEW YORK STATE COMMON RETIREMENT FUND Reduced -6,526-6.5k
WELLINGTON MANAGEMENT GROUP LLP Reduced -4,824-4.8k
BARCLAYS PLC Reduced -3,997-4.0k
DEUTSCHE BANK AG\ Reduced -1,915-1.9k
Tower Research Capital LLC (TRC) Reduced -888-888

Biggest calls

Biggest puts

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
RA CAPITAL MANAGEMENT, L.P. 13D · may seek influence -1.3 pts · filed 2026-09-17 19.9% -1.3 pts 14.1m≈ $417.2m 2026-09-17
FMR LLC 13G · institution +11.2 pts · filed 2026-04-07 14.4% +11.2 pts 7.7m≈ $247.5m 2026-04-07
JANUS HENDERSON GROUP PLC 13G · institution +1.8 pts · filed 2026-05-15 7.2% +1.8 pts 3.9m≈ $124.3m 2026-05-15
Farallon Capital Partners, L.P. 13G · passive investor +1.0 pts · filed 2026-05-12 6.6% +1.0 pts 3.6m≈ $114.4m 2026-05-12
BIOTECHNOLOGY VALUE FUND L P 13G · passive investor +2.1 pts · filed 2026-09-21 6.1% +2.1 pts 4.2m≈ $127.9m 2026-09-21
NEXTECH VI ONCOLOGY SCSP 13G · passive investor filed 2026-08-14 6.0% 3.6m≈ $113.5m 2026-08-14
Paradigm Biocapital Advisors LP 13G · passive investor new · filed 2026-09-17 5.8% new 3.5m≈ $110.9m 2026-09-17
TCG Crossover GP I, LLC 13G · passive investor new · filed 2025-03-06 5.7% new 2.9m≈ $92.6m 2025-03-06

Fell to 5% or below in the last year: BlackRock, Inc. (4.8%, 2026-10-27), FARALLON CAPITAL MANAGEMENT, L.L.C. (0.0%, 2026-08-14; now reported by Farallon Capital Partners, L.P.), Commodore Capital LP (4.2%, 2026-05-15), Harris Todd (4.8%, 2026-05-14), Canaan XI L.P. (1.4%, 2026-04-24)

Insider purchases and sales in Q2 2023

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
202Q3 21: 0 buyingQ3 21: 0 sellingQ4 21: 0 buyingQ4 21: 0 sellingQ4 21Q1 22: 0 buyingQ1 22: 0 sellingQ2 22: 0 buyingQ2 22: 0 sellingQ2 22Q3 22: 0 buyingQ3 22: 0 sellingQ4 22: 0 buyingQ4 22: 0 sellingQ4 22Q1 23: 0 buyingQ1 23: 2 sellingQ2 23: 0 buyingQ2 23: 2 sellingQ2 23
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20210—0——
Q4 20210—0——
Q1 20220—0——
Q2 20220—0——
Q3 20220—0——
Q4 20220—0——
Q1 20230—2$1.1m$38.4k
Q2 20230—2$3.8m$3.8m
DateInsiderTradeSharesPrice ValueTheir holding
2023-06-30 Bensen Daniel Chief Operating Officer Sold plan 18,819 $16.97 $319.4k18.8k shares -3%
2023-06-29 Bensen Daniel Chief Operating Officer Sold plan 17,281 $16.49 $285.0k17.3k shares -3%
2023-06-28 Bensen Daniel Chief Operating Officer Sold plan 13,524 $16.91 $228.7k13.5k shares -2%
2023-06-27 Bensen Daniel Chief Operating Officer Sold plan 16,028 $16.91 $271.1k16.0k shares -3%
2023-06-26 Bensen Daniel Chief Operating Officer Sold plan 17,232 $16.77 $288.9k17.2k shares -3%
2023-06-23 Harris Todd Chief Executive Officer, director Sold plan 20,712 $17.01 $352.3k20.7k shares -1%
2023-06-22 Harris Todd Chief Executive Officer, director Sold plan 3,478 $17.04 $59.3k3.5k shares -<1%
2023-06-21 Harris Todd Chief Executive Officer, director Sold plan 19,756 $17.36 $343.0k19.8k shares -1%
2023-06-20 Harris Todd Chief Executive Officer, director Sold plan 1,300 $16.53 $21.5k1.3k shares -<1%
2023-06-16 Harris Todd Chief Executive Officer, director Sold plan 54,754 $17.04 $933.1k54.8k shares -3%
2023-06-15 Harris Todd Chief Executive Officer, director Sold plan 12,773 $16.13 $206.0k12.8k shares -1%
2023-06-15 Bensen Daniel Chief Operating Officer Sold plan 12,592 $16.15 $203.4k12.6k shares -2%
2023-06-14 Bensen Daniel Chief Operating Officer Sold plan 120 $16.45 $2.0k120 shares -<1%
2023-06-13 Harris Todd Chief Executive Officer, director Sold plan 7,927 $16.00 $126.8k7.9k shares -0%
2023-06-13 Bensen Daniel Chief Operating Officer Sold plan 5,628 $16.01 $90.1k5.6k shares -1%
2023-04-03 Bensen Daniel Chief Operating Officer Sold plan 2,000 $16.16 $32.3k2.0k shares -<1%
2023-04-03 Harris Todd Chief Executive Officer, director Sold plan 2,000 $16.13 $32.3k2.0k shares -<1%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RA CAPITAL MANAGEMENT, L.P. 2.33% of their portfolio BOSTON, MA 7,236,4547.2m $123.2m $123.2m 2.33% Unchanged
2 Boxer Capital, LLC 5.09% of their portfolio San Diego, CA 6,448,3596.4m $109.8m $109.8m 5.09% Unchanged
3 Canaan Partners XI LLC 53.19% of their portfolio MENLO PARK, CA 4,409,9914.4m $75.1m $75.1m 53.19% Unchanged
4 FMR LLC 0.01% of their portfolio BOSTON, MA 4,116,8694.1m $70.1m $70.1m 0.01% Reduced -2.2m -2,179,105
5 BVF INC/IL 1.30% of their portfolio San Francisco, CA 2,739,5952.7m $46.7m $46.7m 1.30% Reduced -500.0k -500,000
6 Nextech Invest Ltd. 14.58% of their portfolio Zurich, V8 2,518,5822.5m $42.9m $42.9m 14.58% Unchanged
7 TCG Crossover Management, LLC 5.56% of their portfolio PALO ALTO, CA 1,989,1032.0m $33.9m $33.9m 5.56% Unchanged
8 Fairmount Funds Management LLC 3.40% of their portfolio WEST CONSHOHOCKEN, PA 1,416,9981.4m $24.1m $24.1m 3.40% Unchanged
9 Frazier Life Sciences Management, L.P. 1.05% of their portfolio PALO ALTO, CA 1,028,0131.0m $17.5m $17.5m 1.05% Reduced -393.3k -393,297
10 BlackRock Inc. 0.00% of their portfolio New York, NY 890,832890.8k $15.2m $15.2m 0.00% Added +223.9k +223,947
11 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 648,875648.9k $11.1m $11.1m 0.00% Added +9.6k +9,551
12 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 423,421423.4k $7.2m $7.2m 0.00% Added +230.9k +230,912
13 Woodline Partners LP 0.08% of their portfolio San Francisco, CA 410,435410.4k $7.0m $7.0m 0.08% Unchanged
14 PERCEPTIVE ADVISORS LLC 0.18% of their portfolio NEW YORK, NY 360,000360.0k $6.1m $6.1m 0.18% Reduced -134.4k -134,403
15 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 289,998290.0k $4.9m $4.9m 0.00% Added +3.9k +3,894
16 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 256,377256.4k $4.4m $4.4m 0.00% Added +24.3k +24,288
17 Driehaus Capital Management LLC 0.03% of their portfolio Chicago, IL 150,468150.5k $2.6m $2.6m 0.03% Added +16.3k +16,295
18 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 140,168140.2k $2.4m $2.4m 0.00% Added +32.6k +32,626
19 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 104,657104.7k $1.8m $1.8m 0.00% Added +2.3k +2,287
20 Auour Investments LLC 0.61% of their portfolio WOBURN, MA 85,02085.0k $1.4m $1.4m 0.61% First filing
21 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 79,43679.4k $1.4m $1.4m 0.00% Reduced -4.8k -4,824
22 Ikarian Capital, LLC 0.28% of their portfolio DALLAS, TX 48,17048.2k $820.3k $820.3k 0.28% Unchanged
23 Artia Global Partners LP 0.27% of their portfolio MIAMI, FL 45,25345.3k $770.7k $770.7k 0.27% Unchanged
24 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 40,79640.8k $694.8k $694.8k 0.00% Reduced -735 -735
25 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 33,09033.1k $563.5k $563.5k 0.00% Reduced -670 -670
26 Logos Global Management LP 0.07% of their portfolio San Francisco, CA 31,87231.9k $542.8k $542.8k 0.07% Reduced -55.8k -55,801
27 FISHMAN JAY A LTD/MI 0.02% of their portfolio TROY, MI 22,00022.0k $374.7k $374.7k 0.02% Unchanged
28 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 21,59121.6k $367.7k $367.7k 0.00% Added +8.1k +8,116
29 Mariner, LLC 0.00% of their portfolio Overland Park, KS 21,57321.6k $367.4k $367.4k 0.00% Added +44 +44
30 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 21,28521.3k $362.5k $362.5k 0.00% Reduced -641 -641
31 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 20,41220.4k $347.6k $347.6k 0.00% Added +2.4k +2,401
32 LPL Financial LLC 0.00% of their portfolio FORT MILL, SC 19,50019.5k $332.1k $332.1k 0.00% Unchanged
33 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 18,77018.8k $319.7k $319.7k 0.00% Added +3.5k +3,461
34 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 18,75618.8k $319.4k $319.4k 0.00% Unchanged
35 Sepio Capital, LP 0.01% of their portfolio Salt Lake City, UT 10,62510.6k $180.9k $180.9k 0.01% Unchanged
36 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 10,60110.6k $180.5k $180.5k 0.00% New
37 BOOTHBAY FUND MANAGEMENT, LLC 0.01% of their portfolio NEW YORK, NY 10,17410.2k $173.3k $173.3k 0.01% New
38 EXCHANGE TRADED CONCEPTS, LLC 0.00% of their portfolio Oklahoma City, OK 8,8678.9k $151.0k $151.0k 0.00% New
39 UBS Group AG 0.00% of their portfolio ZURICH, V8 7,9978.0k $136.2k $136.2k 0.00% Added +3.4k +3,378
40 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 7,7027.7k $131.2k $131.2k 0.00% Unchanged
41 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 6,7316.7k $114.6k $114.6k 0.00% Added +331 +331
42 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 6,2236.2k $106.0k $106.0k 0.00% Reduced -1.9k -1,915
43 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 5,5125.5k $93.9k $93.9k 0.00% Added +3.1k +3,150
44 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 4,6524.7k $79.2k $79.2k 0.00% Reduced -278 -278
45 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 4,1654.2k $70.9k $70.9k 0.00% New
46 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 3,9994.0k $68.1k $68.1k 0.00% Reduced -6.5k -6,526
47 FEDERATED HERMES, INC. 0.00% of their portfolio PITTSBURGH, PA 3,0653.1k $52.2k $52.2k 0.00% Added +3.0k +3,011
48 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 2,7882.8k $47.5k $47.5k 0.00% Reduced -4.0k -3,997
49 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 2,2772.3k $39.0k $39.0k 0.00% Added +1.5k +1,535
50 Allspring Global Investments Holdings, LLC 0.00% of their portfolio CHARLOTTE, NC 2,2732.3k $38.7k $38.7k 0.00% New
51 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 1,5711.6k $27.0k $27.0k 0.00% Added +246 +246
52 Legal & General Group Plc 0.00% of their portfolio London, X0 1,5321.5k $26.1k $26.1k 0.00% Added +127 +127
53 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 940940 $16.0k $16.0k 0.00% Unchanged
54 Metropolitan Life Insurance Co/NY 0.00% of their portfolio New York, NY 814814 $13.9k $13.9k 0.00% Unchanged
55 SIMPLEX TRADING, LLC 0.00% of their portfolio CHICAGO, IL 674674 $11.0k $11.0k 0.00% New
56 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 658658 $11.2k $11.2k 0.00% Reduced -888 -888
57 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 176176 $3.0k $3.0k 0.00% New
58 PNC Financial Services Group, Inc. 0.00% of their portfolio Pittsburgh, PA 5858 $988 $988 0.00% Unchanged
59 NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio ST. LOUIS, MO 1616 $272 $272 0.00% Unchanged
60 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged