Vault-13

SUTRO BIOPHARMA INC

COM · CUSIP 869367102

121 institutional holders +4 vs Q1 2023
54,073,65054.1m shares reported held*
$251.4mreported value*
18 new 45 added 37 reduced 13 sold out net bought ≈ $2.0m (+650.9k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($146.9k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $4.65. Options: 3 managers hold calls ($27.4k notional), 2 hold puts ($5.1k).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 113Q4 22: 120Q1 23: 117Q2 23: 121121Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 2022113
Q4 2022120
Q1 2023117
Q2 2023121

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 73 bought or addedQ4 22: 39 cut or sold outQ4 22Q1 23: 69 bought or addedQ1 23: 51 cut or sold outQ1 23Q2 23: 63 bought or addedQ2 23: 50 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 20227339
Q1 20236951
Q2 20236350

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$500k$1m$1.5mQ3 22 calls: $191.0kQ3 22 puts: $0Q3 22P/C 0.00Q4 22 calls: $714.3kQ4 22 puts: $1.1mQ4 22P/C 1.60Q1 23 calls: $2.3kQ1 23 puts: $5.1kQ1 23P/C 2.20Q2 23 calls: $27.4kQ2 23 puts: $5.1kQ2 23P/C 0.19
Numbers
QuarterCallsPutsP/C
Q3 2022$191.0k$00.00
Q4 2022$714.3k$1.1m1.60
Q1 2023$2.3k$5.1k2.20
Q2 2023$27.4k$5.1k0.19

Biggest buyers

BlackRock Inc. Added +984,734+984.7k
Verition Fund Management LLC Added +800,874+800.9k
Eversept Partners, LP New +747,912+747.9k
MILLENNIUM MANAGEMENT LLC Added +611,978+612.0k
Kynam Capital Management, LP Added +598,164+598.2k
Vontobel Holding Ltd. Added +402,646+402.6k
SECTORAL ASSET MANAGEMENT INC New +400,646+400.6k
Opaleye Management Inc. New +307,000+307.0k
Man Group plc New +248,665+248.7k
Balyasny Asset Management L.P. New +214,021+214.0k

Biggest sellers

STATE STREET CORP Reduced -1,828,591-1.8m
Frazier Life Sciences Management, L.P. Reduced -996,479-996.5k
GOLDMAN SACHS GROUP INC Reduced -401,739-401.7k
AQR CAPITAL MANAGEMENT LLC Reduced -311,995-312.0k
Rubric Capital Management LP Reduced -311,743-311.7k
CITADEL ADVISORS LLC Reduced -300,840-300.8k
BANK OF AMERICA CORP /DE/ Reduced -247,112-247.1k
Candriam S.C.A. Reduced -232,541-232.5k
Man Group plc Sold out -225,458-225.5k
MARSHALL WACE, LLP Sold out -217,905-217.9k

Biggest calls

CITADEL ADVISORS LLC Added $14.4k3.1k shares
SIMPLEX TRADING, LLC Added $13.0k2.9k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

CITADEL ADVISORS LLC Unchanged $5.1k1.1k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Affinity Asset Advisors, LLC 13G · passive investor new · filed 2025-10-23 7.8% new 6.6m 2025-10-23
MILLENNIUM MANAGEMENT LLC 13G · passive investor new · filed 2025-06-30 5.6% new 4.7m 2025-06-30
Kynam Capital Management, LP 13G · institution -1.2 pts · filed 2026-05-15 5.3% -1.2 pts 0 2026-05-15

Fell to 5% or below in the last year: SUVRETTA CAPITAL MANAGEMENT, LLC (0.0%, 2026-02-13)

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 BlackRock Inc. 0.00% of their portfolio New York, NY 6,005,5576.0m $27.9m $27.9m 0.00% Added +984.7k +984,734
2 MONTANOVA CAPITAL, LLC 1.46% of their portfolio New York, NY 5,883,6935.9m $27.4m $27.4m 1.46% Added +194.6k +194,607
3 Rubric Capital Management LP 0.81% of their portfolio NEW YORK, NY 4,048,7444.0m $18.8m $18.8m 0.81% Reduced -311.7k -311,743
4 BVF INC/IL 0.43% of their portfolio San Francisco, CA 3,347,9463.3m $15.6m $15.6m 0.43% Unchanged
5 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 2,867,5352.9m $13.3m $13.3m 0.01% Added +29.7k +29,666
6 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,829,9082.8m $13.2m $13.2m 0.00% Added +52.9k +52,946
7 Holocene Advisors, LP 0.04% of their portfolio New York, NY 2,132,8732.1m $9.9m $9.9m 0.04% Unchanged
8 Verition Fund Management LLC 0.14% of their portfolio GREENWICH, CT 1,946,6601.9m $9.1m $9.1m 0.14% Added +800.9k +800,874
9 BAILLIE GIFFORD & CO 0.01% of their portfolio EDINBURGH, X0 1,867,6541.9m $8.7m $8.7m 0.01% Unchanged
10 SAMSARA BIOCAPITAL, LLC 1.37% of their portfolio PALO ALTO, CA 1,675,5791.7m $7.8m $7.8m 1.37% Unchanged
11 Candriam S.C.A. 0.05% of their portfolio STRASSEN, N4 1,628,2341.6m $7.6m $7.6m 0.05% Reduced -232.5k -232,541
12 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 1,503,5941.5m $7.0m $7.0m 0.01% Added +612.0k +611,978
13 Kynam Capital Management, LP 1.07% of their portfolio PRINCETON, NJ 1,500,0001.5m $7.0m $7.0m 1.07% Added +598.2k +598,164
14 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 1,211,7881.2m $5.6m $5.6m 0.00% Added +38.6k +38,589
15 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 1,161,5321.2m $5.4m $5.4m 0.00% Added +105.2k +105,218
16 Parkman Healthcare Partners LLC 0.92% of their portfolio STAMFORD, CT 1,143,8611.1m $5.3m $5.3m 0.92% Added +43.8k +43,823
17 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 1,098,8741.1m $5.1m $5.1m 0.00% Reduced -401.7k -401,739
18 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 1,094,1211.1m $5.1m $5.1m 0.00% Reduced -1.8m -1,828,591
19 Frazier Life Sciences Management, L.P. 0.22% of their portfolio PALO ALTO, CA 780,000780.0k $3.6m $3.6m 0.22% Reduced -996.5k -996,479
20 Eversept Partners, LP 0.37% of their portfolio NEW YORK, NY 747,912747.9k $3.5m $3.5m 0.37% New
21 ACADIAN ASSET MANAGEMENT LLC 0.01% of their portfolio Boston, MA 654,468654.5k $3.0m $3.0m 0.01% Reduced -32.8k -32,767
22 JACOBS LEVY EQUITY MANAGEMENT, INC 0.02% of their portfolio FLORHAM PARK, NJ 571,393571.4k $2.7m $2.7m 0.02% Reduced -93.2k -93,208
23 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 483,072483.1k $2.2m $2.2m 0.00% Added +28.2k +28,165
24 Vontobel Holding Ltd. 0.02% of their portfolio ZURICH, V8 415,646415.6k $1.9m $1.9m 0.02% Added +402.6k +402,646
25 SECTORAL ASSET MANAGEMENT INC 0.31% of their portfolio MONTREAL, A8 400,646400.6k $1.9m $1.9m 0.31% New
26 Pentwater Capital Management LP 0.02% of their portfolio Naples, FL 400,000400.0k $1.9m $1.9m 0.02% Added +145.0k +145,000
27 Schonfeld Strategic Advisors LLC 0.01% of their portfolio NEW YORK, NY 356,300356.3k $1.7m $1.7m 0.01% Added +10.3k +10,304
28 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 349,700349.7k $1.6m $1.6m 0.00% Reduced -71.6k -71,600
29 PANAGORA ASSET MANAGEMENT INC 0.01% of their portfolio BOSTON, MA 340,988341.0k $1.6m $1.6m 0.01% Reduced -91.0k -90,994
30 Opaleye Management Inc. 0.34% of their portfolio BOSTON, MA 307,000307.0k $1.4m $1.4m 0.34% New
31 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 269,497269.5k $1.3m $1.3m 0.00% Added +140.1k +140,100
32 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 252,818252.8k $1.2m $1.2m 0.00% Added +12.6k +12,574
33 Man Group plc 0.00% of their portfolio LONDON, X0 248,665248.7k $1.2m $1.2m 0.00% New
34 DAFNA Capital Management LLC 0.31% of their portfolio LOS ANGELES, CA 242,779242.8k $1.1m $1.1m 0.31% Added +158.1k +158,079
35 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.00% of their portfolio Boston, MA 225,720225.7k $1.0m $1.0m 0.00% Added +170.0k +170,000
36 Balyasny Asset Management L.P. 0.00% of their portfolio Chicago, IL 214,021214.0k $995.2k $995.2k 0.00% New
37 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 213,619213.6k $993.3k $993.3k 0.00% Reduced -24.8k -24,842
38 Point72 Asset Management, L.P. 0.00% of their portfolio STAMFORD, CT 209,004209.0k $971.9k $971.9k 0.00% New
39 Fisher Asset Management, LLC 0.00% of their portfolio PLANO, TX 196,517196.5k $913.8k $913.8k 0.00% New
40 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 189,596189.6k $881.6k $881.6k 0.00% Added +45.2k +45,178
41 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 160,876160.9k $748.1k $748.1k 0.00% Added +14.9k +14,936
42 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 145,962146.0k $678.7k $678.7k 0.00% New
43 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 136,802136.8k $636.1k $636.1k 0.00% Reduced -3.0k -3,027
44 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 135,816135.8k $631.5k $631.5k 0.00% Reduced -204.6k -204,596
45 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 134,983135.0k $627.7k $627.7k 0.00% Reduced -22.9k -22,855
46 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 132,700132.7k $617.1k $617.1k 0.00% Added +13.2k +13,200
47 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 125,596125.6k $584.0k $584.0k 0.00% Reduced -4.0k -4,027
48 Simplify Asset Management Inc. 0.10% of their portfolio Las Vegas, NV 120,000120.0k $558.0k $558.0k 0.10% Unchanged
49 Trexquant Investment LP 0.01% of their portfolio STAMFORD, CT 102,548102.5k $476.8k $476.8k 0.01% Reduced -80.3k -80,316
50 Tekla Capital Management LLC 0.02% of their portfolio Boston, MA 98,35498.4k $457.3k $457.3k 0.02% Unchanged
51 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 95,19095.2k $442.6k $442.6k 0.00% Added +80.8k +80,800
52 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 89,64889.6k $416.9k $416.9k 0.00% Added +5.0k +4,952
53 Tejara Capital Ltd 0.20% of their portfolio London, X0 88,68288.7k $412.4k $412.4k 0.20% Added +44.2k +44,199
54 AQR CAPITAL MANAGEMENT LLC 0.00% of their portfolio Greenwich, CT 81,70181.7k $379.9k $379.9k 0.00% Reduced -312.0k -311,995
55 FMR LLC 0.00% of their portfolio BOSTON, MA 79,51079.5k $369.7k $369.7k 0.00% Reduced -87.6k -87,638
56 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 74,70974.7k $347.4k $347.4k 0.00% Added +3.0k +3,040
57 SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.01% of their portfolio BALA CYNWYD, PA 72,98573.0k $339.4k $339.4k 0.01% Unchanged
58 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 71,81071.8k $333.9k $333.9k 0.00% Added +20.4k +20,410
59 PUTNAM INVESTMENTS LLC 0.00% of their portfolio BOSTON, MA 68,98669.0k $320.8k $320.8k 0.00% Reduced -2.2k -2,156
60 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 68,18568.2k $317.1k $317.1k 0.00% Reduced -247.1k -247,112
61 PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 0.00% of their portfolio COLUMBUS, OH 61,77861.8k $287.0k $287.0k 0.00% Unchanged
62 LOS ANGELES CAPITAL MANAGEMENT LLC 0.00% of their portfolio LOS ANGELES, CA 56,52456.5k $262.8k $262.8k 0.00% Added +10.7k +10,670
63 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 45,38545.4k $211.0k $211.0k 0.00% Reduced -8.2k -8,223
64 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 44,48644.5k $206.9k $206.9k 0.00% Reduced -76.7k -76,658
65 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 40,72340.7k $189.4k $189.4k 0.00% Reduced -114.5k -114,476
66 CORNERCAP INVESTMENT COUNSEL INC 0.03% of their portfolio Atlanta, GA 36,16336.2k $168.2k $168.2k 0.03% Added +154 +154
67 PRELUDE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio NEW YORK, NY 30,17230.2k $140.3k $140.3k 0.01% Reduced -616 -616
68 UBS Group AG 0.00% of their portfolio ZURICH, V8 30,06430.1k $139.8k $139.8k 0.00% Reduced -52.6k -52,636
69 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 28,95028.9k $134.6k $134.6k 0.00% Added +2.9k +2,932
70 AMERICAN CENTURY COMPANIES INC 0.00% of their portfolio KANSAS CITY, MO 28,50728.5k $132.6k $132.6k 0.00% Added +13.9k +13,851
71 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 28,38028.4k $132.0k $132.0k 0.00% Unchanged
72 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 28,32828.3k $131.7k $131.7k 0.00% Reduced -300.8k -300,840
73 Virtus Investment Advisers, LLC 0.09% of their portfolio HARTFORD, CT 28,27428.3k $131.5k $131.5k 0.09% Unchanged
74 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 27,93427.9k $129.9k $129.9k 0.00% Reduced -4.9k -4,943
75 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 27,57527.6k $128.2k $128.2k 0.00% Reduced -22.6k -22,588
76 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 26,61926.6k $123.8k $123.8k 0.00% Reduced -77.7k -77,726
77 Soleus Capital Management, L.P. 0.01% of their portfolio GREENWICH, CT 25,88725.9k $120.4k $120.4k 0.01% New
78 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 25,74825.7k $119.7k $119.7k 0.00% Added +5.1k +5,081
79 EXCHANGE TRADED CONCEPTS, LLC 0.00% of their portfolio Oklahoma City, OK 25,61125.6k $119.1k $119.1k 0.00% New
80 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 24,70124.7k $114.9k $114.9k 0.00% Added +4.7k +4,743
81 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 21,78221.8k $101.3k $101.3k 0.00% Added +2.3k +2,339
82 CAXTON ASSOCIATES LP 0.01% of their portfolio NEW YORK, NY 21,35121.4k $99.3k $99.3k 0.01% Reduced -7.6k -7,619
83 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 20,00820.0k $93.0k $93.0k 0.00% Reduced -35 -35
84 PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio DES MOINES, IA 18,98219.0k $88.3k $88.3k 0.00% Added +3.6k +3,634
85 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 18,97919.0k $88.3k $88.3k 0.00% Reduced -153.2k -153,152
86 Allspring Global Investments Holdings, LLC 0.00% of their portfolio CHARLOTTE, NC 18,22718.2k $84.8k $84.8k 0.00% Reduced -5.7k -5,678
87 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.00% of their portfolio TALLAHASSEE, FL 17,07317.1k $79.4k $79.4k 0.00% Added +4.8k +4,780
88 Cubist Systematic Strategies, LLC 0.00% of their portfolio STAMFORD, CT 16,51716.5k $76.8k $76.8k 0.00% Reduced -116.3k -116,313
89 Point72 Middle East FZE 0.00% of their portfolio DUBAI, C0 15,06915.1k $70.1k $70.1k 0.00% Added +11.8k +11,788
90 Y-Intercept (Hong Kong) Ltd 0.01% of their portfolio HONG KONG, K3 14,19014.2k $66.0k $66.0k 0.01% New
91 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 13,49913.5k $62.8k $62.8k 0.00% Reduced -69 -69
92 ALGERT GLOBAL LLC 0.00% of their portfolio SAN FRANCISCO, CA 12,25012.2k $57.0k $57.0k 0.00% Reduced -33.3k -33,290
93 ProShare Advisors LLC 0.00% of their portfolio BETHESDA, MD 11,73211.7k $54.6k $54.6k 0.00% Added +1.4k +1,402
94 Ergoteles LLC 0.00% of their portfolio NEW YORK, NY 11,69011.7k $54.4k $54.4k 0.00% New
95 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 11,54811.5k $54.0k $54.0k 0.00% New
96 DIVERSIFIED TRUST CO 0.00% of their portfolio MEMPHIS, TN 11,18911.2k $52.0k $52.0k 0.00% New
97 Manchester Capital Management LLC 0.01% of their portfolio MANCHESTER, VT 10,56110.6k $49.1k $49.1k 0.01% Unchanged
98 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 10,00010.0k $46.5k $46.5k 0.00% Unchanged
99 FEDERATED HERMES, INC. 0.00% of their portfolio PITTSBURGH, PA 6,3876.4k $29.7k $29.7k 0.00% Reduced -46 -46
100 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 6,2756.3k $29.0k $29.0k 0.00% Added +2.3k +2,289