ALPINE IMMUNE SCIENCES INC NVLS
COM · Common Stock · CUSIP 02083G100
77
institutional holders
+16 vs Q1 2023
37.0m
shares reported held*
$380.3mreported value*
18 new
34 added
12 reduced
2 sold out
net bought ≈ $23.9m (+2.3m shares)
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Implied quarter-end price ≈ $10.28. Options: 3 managers hold calls ($51.6k notional), 1 hold puts ($0).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 70 |
| Q4 2022 | 64 |
| Q1 2023 | 61 |
| Q2 2023 | 77 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Bought or addedCut or sold out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 40 | 24 |
| Q1 2023 | 31 | 20 |
| Q2 2023 | 52 | 14 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
CallsPuts
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $0 | $1.0k | — |
| Q4 2022 | $8.1k | $735 | 0.09 |
| Q1 2023 | $0 | $0 | — |
| Q2 2023 | $51.6k | $0 | 0.00 |
Biggest buyers
| Vivo Capital, LLC | New | +914.9k |
| BlackRock Inc. | Added | +728.8k |
| FMR LLC | Added | +673.1k |
| Tri Locum Partners LP | New | +332.0k |
| Woodline Partners LP | New | +237.6k |
| STATE STREET CORP | Added | +226.2k |
| Ghost Tree Capital, LLC | Added | +147.4k |
| Walleye Capital LLC | Added | +130.6k |
| MILLENNIUM MANAGEMENT LLC | New | +116.2k |
| DEUTSCHE BANK AG\ | Added | +112.6k |
Biggest sellers
| BVF INC/IL | Sold out | -858.3k |
| Lynx1 Capital Management LP | Reduced | -465.7k |
| Octagon Capital Advisors LP | Reduced | -452.0k |
| GREAT POINT PARTNERS LLC | Reduced | -377.1k |
| Affinity Asset Advisors, LLC | Reduced | -129.0k |
| JPMORGAN CHASE & CO | Reduced | -21.8k |
| BNP PARIBAS FINANCIAL MARKETS | Reduced | -12.0k |
| SG Americas Securities, LLC | Sold out | -11.9k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -11.0k |
| Connor, Clark & Lunn Investment Management Ltd. | Reduced | -7.6k |
Biggest calls
| SIMPLEX TRADING, LLC | New | $28.0k2.8k shares |
| CITADEL ADVISORS LLC | New | $23.6k2.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. 0.91% of their portfolio | 4.7m $48.2m | Added +3.1k |
| ORBIMED ADVISORS LLC 0.77% of their portfolio | 4.1m $42.0m | Unchanged |
| GREAT POINT PARTNERS LLC 6.93% of their portfolio | 3.4m $34.6m | Reduced -377.1k |
| Frazier Life Sciences Management, L.P. 1.83% of their portfolio | 3.0m $30.7m | Unchanged |
| Lynx1 Capital Management LP 17.99% of their portfolio | 2.7m $27.5m | Reduced -465.7k |
| Paradigm Biocapital Advisors LP 2.02% of their portfolio | 2.4m $24.9m | Added +106.3k |
| BlackRock Inc. 0.00% of their portfolio | 2.3m $23.5m | Added +728.8k |
| Omega Fund Management, LLC 11.69% of their portfolio | 2.0m $20.9m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.4m $14.4m | Added +34.3k |
| Commodore Capital LP 1.53% of their portfolio | 1.3m $13.6m | Unchanged |
| Artal Group S.A. 0.39% of their portfolio | 1.2m $12.3m | Unchanged |
| Avidity Partners Management LP 0.38% of their portfolio | 1.1m $10.9m | Added +69.0k |
| Vivo Capital, LLC 0.65% of their portfolio | 914.9k $9.4m | New |
| Octagon Capital Advisors LP 1.08% of their portfolio | 750.0k $7.7m | Reduced -452.0k |
| FMR LLC 0.00% of their portfolio | 675.6k $6.9m | Added +673.1k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 618.0k $6.4m | Added +61.8k |
| STATE STREET CORP 0.00% of their portfolio | 572.8k $5.9m | Added +226.2k |
| Ghost Tree Capital, LLC 1.29% of their portfolio | 347.4k $3.6m | Added +147.4k |
| Tri Locum Partners LP 1.27% of their portfolio | 332.0k $3.4m | New |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 319.3k $3.3m | Reduced -11.0k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 257.5k $2.6m | Added +63.5k |
| TCG Crossover Management, LLC 0.43% of their portfolio | 253.1k $2.6m | Unchanged |
| Woodline Partners LP 0.03% of their portfolio | 237.6k $2.4m | New |
| SPHERA FUNDS MANAGEMENT LTD. 0.44% of their portfolio | 200.0k $2.1m | Unchanged |
| Walleye Capital LLC 0.03% of their portfolio | 164.7k $1.7m | Added +130.6k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 141.5k $1.5m | Added +1.8k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 127.3k $1.3m | Added +112.6k |
| Affinity Asset Advisors, LLC 0.48% of their portfolio | 118.9k $1.2m | Reduced -129.0k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 116.2k $1.2m | New |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 93.7k $963.0k | Added +61.9k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 91.5k $940.7k | Added +19.7k |
| HighVista Strategies LLC 0.42% of their portfolio | 90.3k $928.1k | Unchanged |
| Soleus Capital Management, L.P. 0.10% of their portfolio | 88.1k $905.4k | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 86.4k $887.9k | Added +45.4k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 86.3k $887.0k | Added +19.0k |
| ExodusPoint Capital Management, LP 0.01% of their portfolio | 62.8k $646.0k | New |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 58.0k $596.5k | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 55.8k $573.4k | Added +24.9k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 53.7k $552.3k | New |
| MORGAN STANLEY 0.00% of their portfolio | 50.2k $516.1k | Added +22.3k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 46.6k $479.0k | Reduced -7.6k |
| UBS Group AG 0.00% of their portfolio | 45.9k $471.3k | Added +37.9k |
| WESTWOOD HOLDINGS GROUP INC 0.00% of their portfolio | 43.8k $450.0k | New |
| Trexquant Investment LP 0.01% of their portfolio | 42.8k $439.7k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 39.4k $405.3k | Added +6.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 26.3k $270.9k | Reduced -21.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 21.7k $224.0k | Added +2.1k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 17.9k $184.2k | Reduced -5.6k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 17.1k $175.6k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 16.8k $172.9k | Added +4.8k |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 15.8k $162.6k | New |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 15.3k $157.1k | Added +3.9k |
| MOORE CAPITAL MANAGEMENT, LP 0.00% of their portfolio | 13.8k $142.3k | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 13.5k $138.6k | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 13.1k $135.0k | New |
| Schonfeld Strategic Advisors LLC 0.00% of their portfolio | 12.9k $132.6k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 12.7k $130.4k | Added +8.3k |
| Hikari Power Ltd 0.01% of their portfolio | 12.4k $128.0k | Unchanged |
| PANAGORA ASSET MANAGEMENT INC 0.00% of their portfolio | 12.4k $127.4k | New |
| Western Wealth Management, LLC 0.01% of their portfolio | 12.0k $123.4k | Unchanged |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 11.5k $117.7k | Added +817 |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 10.6k $108.5k | Added +1.8k |
| CITIGROUP INC 0.00% of their portfolio | 10.3k $105.6k | Added +9.8k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 8.5k $87.3k | Reduced -12.0k |
| BARCLAYS PLC 0.00% of their portfolio | 6.3k $65.0k | Reduced -5.8k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 5.5k $56.3k | Reduced -26 |
| AMALGAMATED BANK 0.00% of their portfolio | 3.7k $38.0k | Added +823 |
| Legal & General Group Plc 0.00% of their portfolio | 3.5k $35.9k | Added +1.0k |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 2.6k $27.0k | Added +1.3k |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 2.6k $26.9k | Added +721 |
| Dorsey Wright & Associates 0.01% of their portfolio | 2.4k $24.2k | New |
| Metropolitan Life Insurance Co/NY 0.00% of their portfolio | 1.7k $17.9k | Added +1.2k |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.0k $10.6k | Reduced -466 |
| China Universal Asset Management Co., Ltd. 0.00% of their portfolio | 629 $6.5k | Added +6 |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 85 $1.0k | Unchanged |
| NISA INVESTMENT ADVISORS, LLC 0.00% of their portfolio | 12 $123 | Unchanged |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |