PROTHENA CORP PLC PRTA
SHS · Common Stock · CUSIP G72800108
- SectorHealth care
- IndustryPharmaceutical Preparations
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($3.1m this quarter). Holder counts are more reliable. Shares outstanding: 53.5m as of 2023-07-28, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $68.19. Options: 14 managers hold calls ($19.7m notional), 15 hold puts ($30.9m).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 183 |
| Q4 2022 | 201 |
| Q1 2023 | 192 |
| Q2 2023 | 197 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 116 | 74 |
| Q1 2023 | 97 | 87 |
| Q2 2023 | 99 | 86 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $58.2m | $30.5m | 0.52 |
| Q4 2022 | $25.7m | $9.2m | 0.36 |
| Q1 2023 | $7.7m | $3.6m | 0.46 |
| Q2 2023 | $19.7m | $30.9m | 1.57 |
Biggest buyers
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +351.5k |
| Bank of New York Mellon Corp | Added | +350.1k |
| Man Group plc | New | +170.6k |
| Amundi | Added | +106.1k |
| VOYA INVESTMENT MANAGEMENT LLC | Added | +105.2k |
| Affinity Asset Advisors, LLC | New | +100.0k |
| VANGUARD GROUP INC | Added | +96.1k |
| AXA S.A. | Added | +94.4k |
| JPMORGAN CHASE & CO | Added | +86.3k |
| JANUS HENDERSON GROUP PLC | Added | +76.2k |
Biggest sellers
| FMR LLC | Reduced | -5.6m |
| Avidity Partners Management LP | Reduced | -533.2k |
| BANK OF AMERICA CORP /DE/ | Reduced | -405.6k |
| Prosight Management, LP | Reduced | -327.1k |
| STATE STREET CORP | Reduced | -228.8k |
| TWO SIGMA INVESTMENTS, LP | Reduced | -202.8k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -161.5k |
| MORGAN STANLEY | Reduced | -132.3k |
| Man Group plc | Sold out | -117.9k |
| Point72 Asset Management, L.P. | Reduced | -116.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $8.5m125.1k shares |
| JANE STREET GROUP, LLC | Added | $2.5m36.3k shares |
| BANK OF AMERICA CORP /DE/ | New | $2.0m30.0k shares |
| CITIGROUP INC | New | $1.7m25.0k shares |
| CITADEL ADVISORS LLC | Added | $1.7m24.4k shares |
| Caption Management, LLC | New | $1.0m14.9k shares |
| MILLENNIUM MANAGEMENT LLC | New | $696.5k10.2k shares |
| Nuveen Asset Management, LLC | New | $669.1k9.8k shares |
| GROUP ONE TRADING LLC | Added | $239.0k3.5k shares |
| Walleye Capital LLC | New | $198.0k2.9k shares |
Biggest puts
| Deep Track Capital, LP | New | $17.1m250.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $2.7m39.5k shares |
| JANE STREET GROUP, LLC | Added | $1.8m26.6k shares |
| GROUP ONE TRADING LLC | Added | $1.7m25.1k shares |
| CITIGROUP INC | New | $1.7m25.0k shares |
| Parallax Volatility Advisers, L.P. | New | $1.4m20.0k shares |
| CITADEL ADVISORS LLC | Added | $1.2m17.5k shares |
| Caption Management, LLC | New | $1.0m14.9k shares |
| SIMPLEX TRADING, LLC | Added | $901.0k13.2k shares |
| BANK OF AMERICA CORP /DE/ | New | $614.5k9.0k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution filed 2026-08-06 | 13.8% |
| SCULLY WILLIAM P 13G · passive investor +0.5 pts · filed 2026-05-11 | 10.3% |
| Fennell Todd W. 13G · passive investor +0.4 pts · filed 2026-08-19 | 10.2% |
| Rubric Capital Management LP 13G · institution +2.5 pts · filed 2026-05-15 | 9.3% |
| BlackRock, Inc. 13G · institution +1.2 pts · filed 2026-07-29 | 6.9% |
Fell to 5% or below in the last year: ADAR1 Capital Management, LLC (2.7%, 2025-11-14)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 4 | $4.4m | — |
| Q1 2022 | 0 | — | 1 | $237.2k | — |
| Q2 2022 | 0 | — | 2 | $372.4k | — |
| Q3 2022 | 0 | — | 6 | $10.6m | — |
| Q4 2022 | 0 | — | 7 | $14.4m | — |
| Q1 2023 | 0 | — | 7 | $5.7m | $245.1k |
| Q2 2023 | 0 | — | 9 | $17.2m | $17.2m |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-06-28 | Malecek Michael J Chief Legal Officer | Sold plan | $349.1k5.0k shares |
| 2023-06-20 | Walker Karin L Chief Accounting Officer | Sold plan | $344.5k5.0k shares |
| 2023-06-16 | Garren Hideki Chief Medical Officer | Sold plan | $542.5k7.3k shares |
| 2023-06-14 | Smith Brandon S. Chief Operating Officer | Sold plan | $394.6k5.3k shares |
| 2023-06-14 | Garren Hideki Chief Medical Officer | Sold plan | $346.5k4.7k shares |
| 2023-06-07 | Karp Carol D. Chief Regulatory Officer | Sold plan | $1.4m20.0k shares |
| 2023-06-07 | Zago Wagner M. Chief Scientific Officer | Sold plan | $1.4m19.0k shares |
| 2023-05-31 | Malecek Michael J Chief Legal Officer | Sold plan | $323.2k5.0k shares |
| 2023-05-19 | Walker Karin L Chief Accounting Officer | Sold plan | $370.0k5.0k shares |
| 2023-05-17 | Nguyen Tran Chief Strategy Officer and CFO | Sold plan | $7.0m95.0k shares |
| 2023-05-17 | Kinney Gene G. President and CEO | Sold plan | $3.3m45.0k shares |
| 2023-05-03 | Selkoe Dennis J. Director | Sold plan | $855.0k15.0k shares |
| 2023-04-26 | Malecek Michael J Chief Legal Officer | Sold plan | $267.3k5.0k shares |
| 2023-04-19 | Walker Karin L Chief Accounting Officer | Sold plan | $264.5k5.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| EcoR1 Capital, LLC 20.84% of their portfolio | 11.6m $791.0m | Unchanged |
| FMR LLC 0.05% of their portfolio | 7.9m $540.3m | Reduced -5.6m |
| BlackRock Inc. 0.01% of their portfolio | 3.6m $246.6m | Reduced -13.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.03% of their portfolio | 3.6m $242.7m | Added +351.5k |
| WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio | 2.2m $151.0m | Reduced -54.9k |
| STATE STREET CORP 0.01% of their portfolio | 1.9m $127.9m | Reduced -228.8k |
| JANUS HENDERSON GROUP PLC 0.07% of their portfolio | 1.7m $114.2m | Added +76.2k |
| Palo Alto Investors LP 9.14% of their portfolio | 1.7m $113.2m | Reduced -6.3k |
| First Light Asset Management, LLC 8.03% of their portfolio | 1.5m $102.4m | Reduced -11.0k |
| DIMENSIONAL FUND ADVISORS LP 0.03% of their portfolio | 1.2m $78.5m | Reduced -82.4k |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.0m $71.1m | Added +96.1k |
| T. Rowe Price Investment Management, Inc. 0.04% of their portfolio | 876.2k $59.8m | Reduced -38.5k |
| GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 838.4k $57.2m | Added +58.6k |
| PFM Health Sciences, LP 2.13% of their portfolio | 774.5k $52.9m | Unchanged |
| Rock Springs Capital Management LP 1.22% of their portfolio | 753.5k $51.4m | Unchanged |
| Avidity Partners Management LP 1.28% of their portfolio | 535.0k $36.5m | Reduced -533.2k |
| Bank of New York Mellon Corp 0.01% of their portfolio | 514.2k $35.1m | Added +350.1k |
| EVENTIDE ASSET MANAGEMENT, LLC 0.51% of their portfolio | 445.2k $30.4m | Added +6.4k |
| Nuveen Asset Management, LLC 0.01% of their portfolio | 443.0k $30.2m | Reduced -63.7k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 414.1k $28.3m | Added +86.3k |
| NORTHERN TRUST CORP 0.01% of their portfolio | 412.0k $28.1m | Added +29.3k |
| RENAISSANCE TECHNOLOGIES LLC 0.03% of their portfolio | 323.8k $22.1m | Reduced -83.5k |
| Finepoint Capital LP 7.50% of their portfolio | 317.3k $21.7m | Reduced -14.3k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio | 312.5k $21.3m | Added +13.5k |
| Boxer Capital, LLC 0.95% of their portfolio | 300.0k $20.5m | Unchanged |
| Granahan Investment Management, LLC 0.62% of their portfolio | 295.1k $20.1m | Added +62.4k |
| TWO SIGMA ADVISERS, LP 0.05% of their portfolio | 266.3k $18.2m | Reduced -115.0k |
| Maple Rock Capital Partners Inc. 2.04% of their portfolio | 234.6k $16.0m | Reduced -59.0k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 226.2k $11.0m | Unchanged |
| Point72 Asset Management, L.P. 0.05% of their portfolio | 218.8k $14.9m | Reduced -116.2k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 192.6k $13.2m | Reduced -32.4k |
| PERCEPTIVE ADVISORS LLC 0.37% of their portfolio | 184.6k $12.6m | Reduced -53.0k |
| Man Group plc 0.04% of their portfolio | 170.6k $11.6m | New |
| TWO SIGMA INVESTMENTS, LP 0.03% of their portfolio | 162.7k $11.1m | Reduced -202.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 158.9k $10.8m | Reduced -405.6k |
| Birchview Capital, LP 7.99% of their portfolio | 156.1k $10.7m | Added +27.7k |
| MORGAN STANLEY 0.00% of their portfolio | 152.6k $10.4m | Reduced -132.3k |
| SECTORAL ASSET MANAGEMENT INC 1.73% of their portfolio | 151.8k $10.4m | Added +29.1k |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 143.8k $9.8m | Added +105.2k |
| Mariner, LLC 0.02% of their portfolio | 135.1k $9.2m | Added +28.0k |
| PINNACLE ASSOCIATES LTD 0.15% of their portfolio | 130.5k $8.9m | Reduced -4.8k |
| Frazier Life Sciences Management, L.P. 0.52% of their portfolio | 127.9k $8.7m | Unchanged |
| Ensign Peak Advisors, Inc 0.02% of their portfolio | 126.2k $8.6m | Added +600 |
| Prosight Management, LP 2.40% of their portfolio | 120.0k $8.2m | Reduced -327.1k |
| Rafferty Asset Management, LLC 0.05% of their portfolio | 119.6k $8.2m | Reduced -22.1k |
| AXA S.A. 0.03% of their portfolio | 113.3k $7.7m | Added +94.4k |
| Connor, Clark & Lunn Investment Management Ltd. 0.04% of their portfolio | 110.1k $7.5m | Added +20.7k |
| Amundi 0.00% of their portfolio | 108.9k $7.5m | Added +106.1k |
| NORGES BANK 0.00% of their portfolio | 104.6k $7.1m | Reduced -114.2k |
| Affinity Asset Advisors, LLC 2.69% of their portfolio | 100.0k $6.8m | New |
| Atika Capital Management LLC 0.84% of their portfolio | 97.5k $6.7m | Added +48.9k |
| TD Asset Management Inc 0.01% of their portfolio | 89.4k $6.1m | Added +14.7k |
| Swiss National Bank 0.00% of their portfolio | 85.9k $5.9m | Added +12.8k |
| DCF Advisers, LLC 3.99% of their portfolio | 84.8k $5.8m | Added +500 |
| PRINCIPAL FINANCIAL GROUP INC 0.00% of their portfolio | 74.3k $5.1m | Added +19.5k |
| Global IMC LLC 1.42% of their portfolio | 70.9k $4.8m | Added +7.8k |
| BARCLAYS PLC 0.00% of their portfolio | 67.8k $4.6m | Added +3.2k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 66.8k $4.6m | New |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 65.4k $4.5m | Added +8.4k |
| Invesco Ltd. 0.00% of their portfolio | 63.9k $4.4m | Added +35.6k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 60.8k $4.2m | Added +4.9k |
| Handelsbanken Fonder AB 0.02% of their portfolio | 58.9k $4.0m | Added +6.9k |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 57.4k $3.9m | Added +15.7k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 55.8k $3.8m | Added +8.4k |
| Walleye Capital LLC 0.07% of their portfolio | 55.7k $3.8m | New |
| RBF Capital, LLC 0.23% of their portfolio | 54.4k $3.7m | Unchanged |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 53.5k $3.7m | Added +34.1k |
| PUTNAM INVESTMENTS LLC 0.01% of their portfolio | 52.7k $3.6m | Added +1.8k |
| Integral Health Asset Management, LLC 0.47% of their portfolio | 52.0k $3.6m | New |
| SILVERARC CAPITAL MANAGEMENT, LLC 1.15% of their portfolio | 49.7k $3.4m | New |
| Informed Momentum Co LLC 0.63% of their portfolio | 49.7k $3.4m | Added +13.5k |
| JENNISON ASSOCIATES LLC 0.00% of their portfolio | 49.2k $3.4m | Unchanged |
| ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio | 49.1k $3.4m | Added +4.3k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 48.5k $3.3m | Added +4.2k |
| CITIGROUP INC 0.00% of their portfolio | 47.6k $3.2m | Reduced -67.2k |
| Empowered Funds, LLC 0.11% of their portfolio | 43.9k $3.0m | New |
| EA Series Trust 0.11% of their portfolio | 43.9k $3.0m | First filing |
| STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio | 42.0k $2.9m | Added +10.9k |
| Woodline Partners LP 0.03% of their portfolio | 41.6k $2.8m | New |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.10% of their portfolio | 41.5k $2.8m | Unchanged |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 41.4k $2.8m | Added +33.2k |
| ALPS ADVISORS INC 0.02% of their portfolio | 38.8k $2.6m | Added +4.1k |
| Legal & General Group Plc 0.00% of their portfolio | 37.7k $2.6m | Added +1.4k |
| Moody Aldrich Partners LLC 0.50% of their portfolio | 37.6k $2.6m | Reduced -162 |
| Hillsdale Investment Management Inc. 0.23% of their portfolio | 37.4k $2.6m | Reduced -27.6k |
| State of New Jersey Common Pension Fund D 0.01% of their portfolio | 36.1k $2.5m | Reduced -8.5k |
| MACQUARIE GROUP LTD 0.00% of their portfolio | 34.4k $2.3m | Added +5.8k |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 33.1k $2.3m | Reduced -161.5k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 31.2k $2.1m | Reduced -400 |
| FEDERATED HERMES, INC. 0.01% of their portfolio | 30.9k $2.1m | Added +29.9k |
| THORNBURG INVESTMENT MANAGEMENT INC 0.03% of their portfolio | 29.0k $2.0m | Reduced -632 |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 27.2k $1.9m | Reduced -28.8k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 26.3k $1.8m | Added +6.7k |
| EDGEWOOD MANAGEMENT LLC 0.00% of their portfolio | 24.1k $1.6m | Unchanged |
| Jump Financial, LLC 0.06% of their portfolio | 23.6k $1.6m | Reduced -9.3k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 22.9k $1.6m | Added +5.0k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 22.5k $1.5m | Reduced -38.9k |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 22.4k $1.5m | Reduced -1.4k |
| UBS Group AG 0.00% of their portfolio | 22.4k $1.5m | Reduced -39.3k |
| FRED ALGER MANAGEMENT, LLC 0.01% of their portfolio | 22.1k $1.5m | Added +745 |