TREVI THERAPEUTICS INC TRVI
COM · Common Stock · CUSIP 89532M101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersNew Haven, CT
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 63.9m as of 2023-08-10, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.39. Options: 3 managers hold calls ($47.1k notional), 1 hold puts ($0).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 41 |
| Q4 2022 | 38 |
| Q1 2023 | 37 |
| Q2 2023 | 54 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 17 | 21 |
| Q1 2023 | 14 | 12 |
| Q2 2023 | 38 | 13 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $0 | $0 | — |
| Q4 2022 | $2.3k | $22.0k | 9.50 |
| Q1 2023 | $2.0k | $87.7k | 43.09 |
| Q2 2023 | $47.1k | $0 | 0.00 |
Biggest buyers
| BlackRock Inc. | Added | +2.2m |
| Opaleye Management Inc. | Added | +865.7k |
| STATE STREET CORP | Added | +581.1k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +530.5k |
| VANGUARD GROUP INC | Added | +413.5k |
| Venrock Adviser, LLC | Added | +372.4k |
| NORTHERN TRUST CORP | Added | +257.4k |
| Frazier Life Sciences Management, L.P. | Added | +217.5k |
| Bank of New York Mellon Corp | Added | +117.8k |
| PFS Partners, LLC | New | +100.0k |
Biggest sellers
| Fairmount Funds Management LLC | Reduced | -506.2k |
| RENAISSANCE TECHNOLOGIES LLC | Reduced | -148.1k |
| MAI Capital Management | Reduced | -65.8k |
| MILLENNIUM MANAGEMENT LLC | Sold out | -59.6k |
| INNOVIS ASSET MANAGEMENT LLC | Reduced | -44.1k |
| BAILARD, INC. | Sold out | -21.2k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -16.1k |
| TWO SIGMA INVESTMENTS, LP | Sold out | -12.9k |
| Squarepoint Ops LLC | Sold out | -11.5k |
| CITADEL ADVISORS LLC | Reduced | -11.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $44.7k18.7k shares |
| CITADEL ADVISORS LLC | Reduced | $2.4k1.0k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
New Enterprise Associates 16, L.P.
13D · may seek influence
-1.1 pts · filed 2026-05-07
Stated purposeThe Funds acquired the Firm Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, the Funds and other Reporting Persons may dispose of or acquire additional shares of the Issuer, including shares that may be acquired upon exercise of the NEA 16 Warrants prior to expiration. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount … Full filing |
10.5% |
| FMR LLC 13G · institution +2.5 pts · filed 2026-08-06 | 8.8% |
| Frazier Life Sciences Public Fund, L.P. 13G · passive investor -3.6 pts · filed 2025-11-14 | 7.0% |
| BlackRock, Inc. 13G · institution +1.3 pts · filed 2026-10-27 | 6.9% |
Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27), Rubric Capital Management LP (2.9%, 2026-02-13), VIKING GLOBAL INVESTORS LP (4.2%, 2025-11-14)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 1 | $22.3k | — |
| Q2 2023 | 0 | — | 1 | $4.8k | $4.8k |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-06-12 | Delfini Lisa Chief Financial Officer | Sold plan | $1.6k610 shares |
| 2023-05-11 | Delfini Lisa Chief Financial Officer | Sold plan | $1.6k562 shares |
| 2023-04-11 | Delfini Lisa Chief Financial Officer | Sold plan | $1.5k840 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| NEA Management Company, LLC 2.07% of their portfolio | 11.4m $27.2m | Unchanged |
| Frazier Life Sciences Management, L.P. 0.98% of their portfolio | 6.9m $16.4m | Added +217.5k |
| Rubric Capital Management LP 0.58% of their portfolio | 5.7m $13.6m | Unchanged |
| Fairmount Funds Management LLC 1.75% of their portfolio | 5.2m $12.4m | Reduced -506.2k |
| VIKING GLOBAL INVESTORS LP 0.04% of their portfolio | 4.4m $10.5m | Unchanged |
| Venrock Adviser, LLC 1.31% of their portfolio | 3.4m $8.2m | Added +372.4k |
| BlackRock Inc. 0.00% of their portfolio | 2.2m $5.3m | Added +2.2m |
| VANGUARD GROUP INC 0.00% of their portfolio | 1.9m $4.6m | Added +413.5k |
| Opaleye Management Inc. 0.97% of their portfolio | 1.7m $4.1m | Added +865.7k |
| MAI Capital Management 0.05% of their portfolio | 1.5m $3.7m | Reduced -65.8k |
| SILVERARC CAPITAL MANAGEMENT, LLC 0.71% of their portfolio | 885.9k $2.1m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 778.8k $1.9m | Added +530.5k |
| STATE STREET CORP 0.00% of their portfolio | 680.6k $1.6m | Added +581.1k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 321.6k $768.5k | Added +257.4k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio | 186.5k $445.7k | Reduced -1.9k |
| Tejara Capital Ltd 0.21% of their portfolio | 180.2k $430.7k | Reduced -10.0k |
| J. Goldman & Co LP 0.02% of their portfolio | 137.9k $329.5k | Added +48.7k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 131.9k $315.2k | Added +117.8k |
| TRUST CO OF TOLEDO NA /OH/ 0.05% of their portfolio | 124.9k $298.4k | Added +41.9k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 107.7k $257.4k | Added +95.2k |
| PFS Partners, LLC 0.20% of their portfolio | 100.0k $239.0k | New |
| WealthTrust Axiom LLC 0.07% of their portfolio | 93.5k $223.5k | Unchanged |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 89.3k $213.0k | Reduced -148.1k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 66.9k $160.0k | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 60.5k $144.5k | Reduced -11.2k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 50.1k $119.6k | New |
| INNOVIS ASSET MANAGEMENT LLC 0.04% of their portfolio | 43.2k $103.3k | Reduced -44.1k |
| Atom Investors LP 0.03% of their portfolio | 38.4k $91.7k | Added +3.9k |
| MORGAN STANLEY 0.00% of their portfolio | 37.8k $90.3k | Added +37.4k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 37.6k $89.8k | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 36.3k $86.8k | New |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 35.1k $83.8k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 33.2k $79.3k | New |
| UNITED BANK 0.01% of their portfolio | 28.4k $68.0k | Unchanged |
| UBS Group AG 0.00% of their portfolio | 24.1k $57.5k | Added +16.5k |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 20.0k $47.9k | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 17.5k $41.7k | New |
| Invesco Ltd. 0.00% of their portfolio | 16.0k $38.4k | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 15.8k $37.9k | Added +15.6k |
| BARCLAYS PLC 0.00% of their portfolio | 14.1k $33.6k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 13.8k $33.1k | New |
| CITIGROUP INC 0.00% of their portfolio | 12.4k $29.6k | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 11.6k $27.7k | Reduced -16.1k |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 10.8k $25.9k | New |
| ZACKS INVESTMENT MANAGEMENT 0.00% of their portfolio | 10.0k $23.9k | New |
| LPL Financial LLC 0.00% of their portfolio | 10.0k $23.9k | Unchanged |
| STRS OHIO 0.00% of their portfolio | 8.7k $20.0k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 4.3k $10.0k | New |
| AMALGAMATED BANK 0.00% of their portfolio | 4.0k $10.0k | New |
| Legal & General Group Plc 0.00% of their portfolio | 4.0k $9.5k | New |
| Ameritas Investment Partners, Inc. 0.00% of their portfolio | 3.4k $8.2k | New |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 1.5k $3.6k | New |
| FMR LLC 0.00% of their portfolio | 886 $2.1k | New |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |