Vault-13

TREVI THERAPEUTICS INC TRVI

COM · Common Stock · CUSIP 89532M101

54 institutional holders +17 vs Q1 2023
48,822,08048.8m shares reported held*
76.5% of all shares outstanding*
$116.7mreported value*
22 new 16 added 8 reduced 5 sold out net bought ≈ $12.8m (+5.4m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once. Holder counts are more reliable. Shares outstanding: 63.9m as of 2023-08-10, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $2.39. Options: 3 managers hold calls ($47.1k notional), 1 hold puts ($0).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

0204060Q3 22: 41Q4 22: 38Q1 23: 37Q2 23: 5454Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 202241
Q4 202238
Q1 202337
Q2 202354

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
40040Q4 22: 17 bought or addedQ4 22: 21 cut or sold outQ4 22Q1 23: 14 bought or addedQ1 23: 12 cut or sold outQ1 23Q2 23: 38 bought or addedQ2 23: 13 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 20221721
Q1 20231412
Q2 20233813

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$25k$50k$75k$100kQ3 22 calls: $0Q3 22 puts: $0Q3 22P/C —Q4 22 calls: $2.3kQ4 22 puts: $22.0kQ4 22P/C 9.50Q1 23 calls: $2.0kQ1 23 puts: $87.7kQ1 23P/C 43.09Q2 23 calls: $47.1kQ2 23 puts: $0Q2 23P/C 0.00
Numbers
QuarterCallsPutsP/C
Q3 2022$0$0—
Q4 2022$2.3k$22.0k9.50
Q1 2023$2.0k$87.7k43.09
Q2 2023$47.1k$00.00

Biggest buyers

BlackRock Inc. Added +2,152,616+2.2m
Opaleye Management Inc. Added +865,700+865.7k
STATE STREET CORP Added +581,051+581.1k
GEODE CAPITAL MANAGEMENT, LLC Added +530,528+530.5k
VANGUARD GROUP INC Added +413,511+413.5k
Venrock Adviser, LLC Added +372,375+372.4k
NORTHERN TRUST CORP Added +257,374+257.4k
Frazier Life Sciences Management, L.P. Added +217,500+217.5k
Bank of New York Mellon Corp Added +117,769+117.8k
PFS Partners, LLC New +100,000+100.0k

Biggest sellers

Fairmount Funds Management LLC Reduced -506,155-506.2k
RENAISSANCE TECHNOLOGIES LLC Reduced -148,100-148.1k
MAI Capital Management Reduced -65,763-65.8k
MILLENNIUM MANAGEMENT LLC Sold out -59,628-59.6k
INNOVIS ASSET MANAGEMENT LLC Reduced -44,137-44.1k
BAILARD, INC. Sold out -21,200-21.2k
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced -16,095-16.1k
TWO SIGMA INVESTMENTS, LP Sold out -12,928-12.9k
Squarepoint Ops LLC Sold out -11,474-11.5k
CITADEL ADVISORS LLC Reduced -11,202-11.2k

Biggest calls

SUSQUEHANNA INTERNATIONAL GROUP, LLP New $44.7k18.7k shares
CITADEL ADVISORS LLC Reduced $2.4k1.0k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
New Enterprise Associates 16, L.P. 13D · may seek influence -1.1 pts · filed 2026-05-07
Stated purposeThe Funds acquired the Firm Shares for investment purposes. Depending on market conditions, its continuing evaluation of the business and prospects of the Issuer and other factors, the Funds and other Reporting Persons may dispose of or acquire additional shares of the Issuer, including shares that may be acquired upon exercise of the NEA 16 Warrants prior to expiration. Except as set forth above, none of the Reporting Persons has any present plans which relate to or would result in: (a) The acquisition by any person of additional securities of the Issuer, or the disposition of securities of the Issuer; (b) An extraordinary corporate transaction, such as a merger, reorganization or liquidation, involving the Issuer or any of its subsidiaries; (c) A sale or transfer of a material amount … Full filing
10.5% -1.1 pts 15.1m≈ $281.1m 2026-05-07
FMR LLC 13G · institution +2.5 pts · filed 2026-08-06 8.8% +2.5 pts 12.6m≈ $234.3m 2026-08-06
Frazier Life Sciences Public Fund, L.P. 13G · passive investor -3.6 pts · filed 2025-11-14 7.0% -3.6 pts 8.5m≈ $158.7m 2025-11-14
BlackRock, Inc. 13G · institution +1.3 pts · filed 2026-10-27 6.9% +1.3 pts 9.8m≈ $182.4m 2026-10-27

Fell to 5% or below in the last year: VANGUARD GROUP INC (0.0%, 2026-03-27), Rubric Capital Management LP (2.9%, 2026-02-13), VIKING GLOBAL INVESTORS LP (4.2%, 2025-11-14)

Insider purchases and sales in Q2 2023

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

Officers and directors buying vs selling

Number of people, by quarter (10% owners not included)

BuyingSelling
101Q3 21: 0 buyingQ3 21: 0 sellingQ4 21: 0 buyingQ4 21: 0 sellingQ4 21Q1 22: 0 buyingQ1 22: 0 sellingQ2 22: 0 buyingQ2 22: 0 sellingQ2 22Q3 22: 0 buyingQ3 22: 0 sellingQ4 22: 0 buyingQ4 22: 0 sellingQ4 22Q1 23: 0 buyingQ1 23: 1 sellingQ2 23: 0 buyingQ2 23: 1 sellingQ2 23
Numbers
QuarterBuyingBoughtSellingSoldSold under a plan
Q3 20210—0——
Q4 20210—0——
Q1 20220—0——
Q2 20220—0——
Q3 20220—0——
Q4 20220—0——
Q1 20230—1$22.3k—
Q2 20230—1$4.8k$4.8k
DateInsiderTradeSharesPrice ValueTheir holding
2023-06-12 Delfini Lisa Chief Financial Officer Sold plan 610 $2.64 $1.6k610 shares -2%
2023-05-11 Delfini Lisa Chief Financial Officer Sold plan 562 $2.89 $1.6k562 shares -2%
2023-04-11 Delfini Lisa Chief Financial Officer Sold plan 840 $1.84 $1.5k840 shares -3%

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 NEA Management Company, LLC 2.07% of their portfolio TIMONIUM, MD 11,370,37611.4m $27.2m $27.2m 2.07% Unchanged
2 Frazier Life Sciences Management, L.P. 0.98% of their portfolio PALO ALTO, CA 6,881,0906.9m $16.4m $16.4m 0.98% Added +217.5k +217,500
3 Rubric Capital Management LP 0.58% of their portfolio NEW YORK, NY 5,684,4205.7m $13.6m $13.6m 0.58% Unchanged
4 Fairmount Funds Management LLC 1.75% of their portfolio WEST CONSHOHOCKEN, PA 5,190,3605.2m $12.4m $12.4m 1.75% Reduced -506.2k -506,155
5 VIKING GLOBAL INVESTORS LP 0.04% of their portfolio STAMFORD, CT 4,400,0004.4m $10.5m $10.5m 0.04% Unchanged
6 Venrock Adviser, LLC 1.31% of their portfolio NEW YORK, NY 3,422,3973.4m $8.2m $8.2m 1.31% Added +372.4k +372,375
7 BlackRock Inc. 0.00% of their portfolio New York, NY 2,234,8612.2m $5.3m $5.3m 0.00% Added +2.2m +2,152,616
8 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,913,2621.9m $4.6m $4.6m 0.00% Added +413.5k +413,511
9 Opaleye Management Inc. 0.97% of their portfolio BOSTON, MA 1,701,5001.7m $4.1m $4.1m 0.97% Added +865.7k +865,700
10 MAI Capital Management 0.05% of their portfolio INDEPENDENCE, OH 1,534,6521.5m $3.7m $3.7m 0.05% Reduced -65.8k -65,763
11 SILVERARC CAPITAL MANAGEMENT, LLC 0.71% of their portfolio BOSTON, MA 885,924885.9k $2.1m $2.1m 0.71% Unchanged
12 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 778,821778.8k $1.9m $1.9m 0.00% Added +530.5k +530,528
13 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 680,593680.6k $1.6m $1.6m 0.00% Added +581.1k +581,051
14 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 321,557321.6k $768.5k $768.5k 0.00% Added +257.4k +257,374
15 BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.01% of their portfolio HOUSTON, TX 186,481186.5k $445.7k $445.7k 0.01% Reduced -1.9k -1,919
16 Tejara Capital Ltd 0.21% of their portfolio London, X0 180,227180.2k $430.7k $430.7k 0.21% Reduced -10.0k -9,991
17 J. Goldman & Co LP 0.02% of their portfolio NEW YORK, NY 137,873137.9k $329.5k $329.5k 0.02% Added +48.7k +48,685
18 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 131,867131.9k $315.2k $315.2k 0.00% Added +117.8k +117,769
19 TRUST CO OF TOLEDO NA /OH/ 0.05% of their portfolio HOLLAND, OH 124,857124.9k $298.4k $298.4k 0.05% Added +41.9k +41,857
20 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 107,707107.7k $257.4k $257.4k 0.00% Added +95.2k +95,150
21 PFS Partners, LLC 0.20% of their portfolio MINE HILL, NJ 100,000100.0k $239.0k $239.0k 0.20% New
22 WealthTrust Axiom LLC 0.07% of their portfolio WAYNE, PA 93,50093.5k $223.5k $223.5k 0.07% Unchanged
23 RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio NEW YORK, NY 89,30089.3k $213.0k $213.0k 0.00% Reduced -148.1k -148,100
24 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 66,93566.9k $160.0k $160.0k 0.00% New
25 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 60,45360.5k $144.5k $144.5k 0.00% Reduced -11.2k -11,202
26 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 50,05750.1k $119.6k $119.6k 0.00% New
27 INNOVIS ASSET MANAGEMENT LLC 0.04% of their portfolio Chicago, IL 43,23243.2k $103.3k $103.3k 0.04% Reduced -44.1k -44,137
28 Atom Investors LP 0.03% of their portfolio AUSTIN, TX 38,37738.4k $91.7k $91.7k 0.03% Added +3.9k +3,906
29 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 37,79137.8k $90.3k $90.3k 0.00% Added +37.4k +37,407
30 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 37,59037.6k $89.8k $89.8k 0.00% New
31 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 36,30036.3k $86.8k $86.8k 0.00% New
32 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 35,05135.1k $83.8k $83.8k 0.00% New
33 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 33,17433.2k $79.3k $79.3k 0.00% New
34 UNITED BANK 0.01% of their portfolio VIENNA, VA 28,45028.4k $68.0k $68.0k 0.01% Unchanged
35 UBS Group AG 0.00% of their portfolio ZURICH, V8 24,05524.1k $57.5k $57.5k 0.00% Added +16.5k +16,475
36 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 20,03720.0k $47.9k $47.9k 0.00% New
37 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 17,46017.5k $41.7k $41.7k 0.00% New
38 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 16,04616.0k $38.4k $38.4k 0.00% New
39 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 15,83715.8k $37.9k $37.9k 0.00% Added +15.6k +15,572
40 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 14,05214.1k $33.6k $33.6k 0.00% New
41 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 13,84813.8k $33.1k $33.1k 0.00% New
42 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 12,39812.4k $29.6k $29.6k 0.00% New
43 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 11,57111.6k $27.7k $27.7k 0.00% Reduced -16.1k -16,095
44 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 10,84910.8k $25.9k $25.9k 0.00% New
45 ZACKS INVESTMENT MANAGEMENT 0.00% of their portfolio Chicago, IL 10,00010.0k $23.9k $23.9k 0.00% New
46 LPL Financial LLC 0.00% of their portfolio FORT MILL, SC 10,00010.0k $23.9k $23.9k 0.00% Unchanged
47 STRS OHIO 0.00% of their portfolio COLUMBUS, OH 8,7008.7k $20.0k $20.0k 0.00% New
48 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 4,3434.3k $10.0k $10.0k 0.00% New
49 AMALGAMATED BANK 0.00% of their portfolio NEW YORK, NY 4,0494.0k $10.0k $10.0k 0.00% New
50 Legal & General Group Plc 0.00% of their portfolio London, X0 3,9744.0k $9.5k $9.5k 0.00% New
51 Ameritas Investment Partners, Inc. 0.00% of their portfolio LINCOLN, NE 3,4383.4k $8.2k $8.2k 0.00% New
52 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 1,5021.5k $3.6k $3.6k 0.00% New
53 FMR LLC 0.00% of their portfolio BOSTON, MA 886886 $2.1k $2.1k 0.00% New
54 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% Unchanged