ZYMEWORKS INC ZYME
COM · Common Stock · CUSIP 98985Y108 · ISIN US98985Y1082
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersMiddletown, DE
- Founded2003
- Websitezymeworks.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($4.5m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $8.64. Options: 6 managers hold calls ($1.2m notional), 5 hold puts ($2.3m).
Trends to Q2 2023
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 1 |
| Q4 2022 | 94 |
| Q1 2023 | 117 |
| Q2 2023 | 138 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 90 | 0 |
| Q1 2023 | 78 | 44 |
| Q2 2023 | 87 | 64 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $0 | $0 | — |
| Q4 2022 | $1.8m | $1.8m | 0.99 |
| Q1 2023 | $2.5m | $1.4m | 0.58 |
| Q2 2023 | $1.2m | $2.3m | 1.92 |
Biggest buyers
| EcoR1 Capital, LLC | Added | +3.4m |
| BlackRock Inc. | Added | +2.8m |
| STATE STREET CORP | Added | +753.3k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | New | +565.3k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | New | +542.2k |
| GEODE CAPITAL MANAGEMENT, LLC | Added | +530.4k |
| AQR CAPITAL MANAGEMENT LLC | New | +469.5k |
| NORTHERN TRUST CORP | Added | +390.9k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | New | +376.8k |
| Nuveen Asset Management, LLC | New | +241.8k |
Biggest sellers
| PERCEPTIVE ADVISORS LLC | Reduced | -962.3k |
| Frazier Life Sciences Management, L.P. | Sold out | -610.0k |
| MILLENNIUM MANAGEMENT LLC | Reduced | -593.5k |
| Rubric Capital Management LP | Reduced | -497.2k |
| Redmile Group, LLC | Reduced | -406.7k |
| HRT FINANCIAL LP | Sold out | -327.0k |
| Timelo Investment Management Inc. | Reduced | -294.0k |
| Cubist Systematic Strategies, LLC | Reduced | -292.7k |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | -254.4k |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | Reduced | -162.4k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $413.0k47.8k shares |
| GROUP ONE TRADING LLC | Reduced | $313.6k36.3k shares |
| Caption Management, LLC | Reduced | $216.0k25.0k shares |
| CITADEL ADVISORS LLC | Reduced | $182.3k21.1k shares |
| SIMPLEX TRADING, LLC | Reduced | $73.0k8.5k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| SIMPLEX TRADING, LLC | Added | $859.0k99.5k shares |
| GROUP ONE TRADING LLC | Added | $616.0k71.3k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $591.0k68.4k shares |
| CITADEL ADVISORS LLC | Added | $235.9k27.3k shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
EcoR1 Capital, LLC
13D · may seek influence
no change · filed 2025-11-19
Stated purposeScott Platshon, one of EcoR1's employees, resigned from the Issuer's board of directors as of November 16, 2025. Concurrently with his resignation, Mr. Platshon was appointed as the Issuer's Acting Chief Investment Officer. Oleg Nodelman, the manager of EcoR1, is a member of the Issuer's board of directors. The reporting persons acquired the Stock for investment purposes based on their belief that the Issuer's Common Stock, when purchased, was undervalued and represented an attractive investment opportunity. The reporting persons will routinely monitor the Issuer regarding a wide variety of factors that affect their investment considerations, including, current and anticipated future trading prices of the Common Stock and other securities, the Issuer's operations, assets, prospects, fi… Full filing |
30.7% |
| Rubric Capital Management LP 13G · institution +1.8 pts · filed 2026-05-15 | 9.5% |
| PERCEPTIVE ADVISORS LLC 13G · passive investor new · filed 2026-04-15 | 5.4% |
| BIOTECHNOLOGY VALUE FUND L P 13G · passive investor filed 2025-11-14 | 5.2% |
Fell to 5% or below in the last year: MORGAN STANLEY (3.4%, 2026-02-12)
Insider purchases and sales in Q2 2023
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q3 2021 | 0 | — | 0 | — | — |
| Q4 2021 | 0 | — | 0 | — | — |
| Q1 2022 | 0 | — | 0 | — | — |
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 2 | $25.4k | — |
| Q1 2023 | 0 | — | 1 | $23.3k | — |
| Q2 2023 | 0 | — | 0 | — | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2023-06-16 | EcoR1 Capital, LLC 10% owner · See Note | Bought | $27.2m3.4m shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q2 2023
| Manager | Shares | Change |
|---|---|---|
| EcoR1 Capital, LLC 3.06% of their portfolio | 13.4m $116.1m | Added +3.4m |
| BVF INC/IL 1.41% of their portfolio | 5.9m $50.7m | Unchanged |
| Redmile Group, LLC 1.88% of their portfolio | 5.7m $48.9m | Reduced -406.7k |
| MORGAN STANLEY 0.00% of their portfolio | 5.5m $47.4m | Reduced -77.5k |
| BlackRock Inc. 0.00% of their portfolio | 3.5m $30.6m | Added +2.8m |
| CREDIT SUISSE AG/ 0.02% of their portfolio | 2.5m $21.7m | Added +24.0k |
| PERCEPTIVE ADVISORS LLC 0.61% of their portfolio | 2.4m $20.9m | Reduced -962.3k |
| Rubric Capital Management LP 0.87% of their portfolio | 2.4m $20.4m | Reduced -497.2k |
| VANGUARD GROUP INC 0.00% of their portfolio | 2.3m $19.5m | Added +212.2k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.06% of their portfolio | 2.2m $18.8m | Reduced -131.9k |
| FARALLON CAPITAL MANAGEMENT, L.L.C. 0.10% of their portfolio | 2.0m $17.3m | Unchanged |
| SAMSARA BIOCAPITAL, LLC 2.21% of their portfolio | 1.5m $12.6m | Reduced -161.8k |
| TANG CAPITAL MANAGEMENT LLC 1.40% of their portfolio | 1.1m $9.5m | Unchanged |
| STATE STREET CORP 0.00% of their portfolio | 906.3k $7.8m | Added +753.3k |
| Granahan Investment Management, LLC 0.17% of their portfolio | 642.1k $5.5m | Reduced -8.2k |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 605.1k $5.2m | Added +21.6k |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC 0.12% of their portfolio | 565.3k $4.9m | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 561.9k $4.9m | Added +530.4k |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP 0.01% of their portfolio | 542.2k $4.7m | New |
| AQR CAPITAL MANAGEMENT LLC 0.01% of their portfolio | 469.5k $4.1m | New |
| NORTHERN TRUST CORP 0.00% of their portfolio | 421.0k $3.6m | Added +390.9k |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.12% of their portfolio | 409.8k $3.5m | Added +3.5k |
| Monaco Asset Management SAM 1.90% of their portfolio | 409.5k $3.5m | Added +10.4k |
| SILVERCREST ASSET MANAGEMENT GROUP LLC 0.02% of their portfolio | 376.8k $3.3m | New |
| Point72 Asset Management, L.P. 0.01% of their portfolio | 368.1k $3.2m | Added +170.0k |
| PICTON MAHONEY ASSET MANAGEMENT 0.15% of their portfolio | 350.2k $3.0m | Added +32.6k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.06% of their portfolio | 319.5k $2.8m | Added +15.7k |
| Mariner, LLC 0.01% of their portfolio | 303.9k $2.6m | Reduced -17.9k |
| Tejara Capital Ltd 1.23% of their portfolio | 288.1k $2.5m | Reduced -56.3k |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 262.1k $2.3m | Added +178.7k |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 241.8k $2.1m | New |
| Empowered Funds, LLC 0.07% of their portfolio | 228.4k $2.0m | New |
| EA Series Trust 0.07% of their portfolio | 228.4k $2.0m | First filing |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 206.4k $1.8m | Added +121.5k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 190.9k $1.6m | Reduced -137.2k |
| Timelo Investment Management Inc. 3.48% of their portfolio | 185.1k $1.6m | Reduced -294.0k |
| JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio | 179.9k $1.6m | New |
| VIRGINIA RETIREMENT SYSTEMS ET Al 0.01% of their portfolio | 177.6k $1.5m | Added +96.0k |
| Bank of New York Mellon Corp 0.00% of their portfolio | 137.1k $1.2m | New |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 131.7k $1.1m | Reduced -254.4k |
| VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio | 123.3k $1.1m | Reduced -28.6k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 122.0k $1.1m | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 120.5k $1.0m | Reduced -50.8k |
| North Growth Management Ltd. 0.21% of their portfolio | 120.0k $1.0m | Unchanged |
| O'SHAUGHNESSY ASSET MANAGEMENT, LLC 0.01% of their portfolio | 114.9k $992.5k | New |
| ACADIAN ASSET MANAGEMENT LLC 0.00% of their portfolio | 98.1k $846.0k | New |
| Alpha DNA Investment Management LLC 0.45% of their portfolio | 92.8k $802.0k | New |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.00% of their portfolio | 90.8k $784.5k | Reduced -162.4k |
| DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio | 89.8k $775.8k | Unchanged |
| CITIGROUP INC 0.00% of their portfolio | 86.0k $743.2k | Added +10.6k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.02% of their portfolio | 84.9k $733.8k | Added +6.5k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 76.8k $663.2k | Reduced -31.6k |
| RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio | 72.5k $626.3k | Reduced -20.7k |
| Qube Research & Technologies Ltd 0.00% of their portfolio | 71.7k $619.8k | Reduced -99.6k |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 70.0k $604.9k | New |
| Swiss National Bank 0.00% of their portfolio | 69.8k $603.1k | Reduced -59.4k |
| 683 Capital Management, LLC 0.05% of their portfolio | 64.9k $560.7k | Reduced -125.1k |
| AE Wealth Management LLC 0.00% of their portfolio | 63.7k $550.7k | New |
| Mach-1 Financial Group, LLC 0.22% of their portfolio | 63.7k $550.7k | New |
| Brookfield Corp /ON/ 0.00% of their portfolio | 63.0k $544.6k | New |
| Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio | 62.0k $535.4k | Added +4.1k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 59.2k $511.5k | Added +15.6k |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 56.9k $491.2k | Added +15.5k |
| WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio | 56.4k $487.1k | New |
| MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio | 55.7k $481.4k | Reduced -593.5k |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 53.1k $458.9k | Reduced -1.4k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 52.3k $452.1k | Added +8.5k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 50.2k $433.7k | Reduced -5.0k |
| D. E. Shaw & Co., Inc. 0.00% of their portfolio | 49.4k $426.4k | New |
| JUPITER ASSET MANAGEMENT LTD 0.00% of their portfolio | 46.9k $404.0k | New |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 45.9k $396.8k | Reduced -6.7k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 43.4k $392.3k | Unchanged |
| WINTON GROUP Ltd 0.03% of their portfolio | 43.2k $373.3k | New |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 41.6k $359.1k | Added +41.2k |
| Allspring Global Investments Holdings, LLC 0.00% of their portfolio | 41.2k $356.2k | Added +2.2k |
| Legal & General Group Plc 0.00% of their portfolio | 40.2k $347.4k | Added +20.9k |
| SIMPLEX TRADING, LLC 0.01% of their portfolio | 37.0k $319.0k | Added +36.1k |
| Invesco Ltd. 0.00% of their portfolio | 36.3k $313.5k | New |
| STRS OHIO 0.00% of their portfolio | 33.6k $290.0k | New |
| LAZARD ASSET MANAGEMENT LLC 0.00% of their portfolio | 32.0k $275.0k | Added +9.3k |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 0.01% of their portfolio | 31.9k $275.9k | Unchanged |
| Wela Strategies, Inc. 0.20% of their portfolio | 30.7k $265.5k | Added +14.8k |
| UBS Group AG 0.00% of their portfolio | 30.4k $262.6k | Added +15.3k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 29.0k $250.6k | Added +3.3k |
| MetLife Investment Management, LLC 0.00% of their portfolio | 28.9k $249.7k | New |
| JOURNEY STRATEGIC WEALTH LLC 0.01% of their portfolio | 28.8k $249.2k | Unchanged |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 28.3k $244.4k | New |
| Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio | 26.2k $226.5k | New |
| COMMONWEALTH EQUITY SERVICES, LLC 0.00% of their portfolio | 25.7k $222.0k | Reduced -300 |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 25.7k $222.0k | New |
| MARATHON CAPITAL MANAGEMENT 0.05% of their portfolio | 25.2k $218.2k | Reduced -1.0k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 25.2k $218.3k | Reduced -2.5k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 25.1k $217.1k | New |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 24.8k $214.4k | New |
| FMR LLC 0.00% of their portfolio | 24.7k $213.4k | New |
| Man Group plc 0.00% of their portfolio | 22.5k $194.5k | New |
| RITHOLTZ WEALTH MANAGEMENT 0.01% of their portfolio | 22.3k $192.7k | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 21.4k $184.6k | New |
| Russell Investments Group, Ltd. 0.00% of their portfolio | 21.2k $183.2k | Added +16.3k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 20.8k $179.6k | New |