Vault-13

CRINETICS PHARMACEUTICALS IN CRNX

COM · Common Stock · CUSIP 22663K107 · ISIN US22663K1079

141 institutional holders +11 vs Q1 2023
53,986,15554.0m shares reported held*
$972.8mreported value*
27 new 55 added 34 reduced 16 sold out net sold ≈ $34.7m (-1.9m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.3m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $18.02. Options: 3 managers hold calls ($31.8k notional), 4 hold puts ($446.2k).

Trends to Q2 2023

Institutional holders

Managers reporting a position, each quarter

050100150Q3 22: 122Q4 22: 122Q1 23: 130Q2 23: 141141Q3 22Q4 22Q1 23Q2 23
Numbers
QuarterHolders
Q3 2022122
Q4 2022122
Q1 2023130
Q2 2023141

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
1000100Q4 22: 55 bought or addedQ4 22: 50 cut or sold outQ4 22Q1 23: 80 bought or addedQ1 23: 40 cut or sold outQ1 23Q2 23: 82 bought or addedQ2 23: 50 cut or sold outQ2 23
Numbers
QuarterBought or addedCut or sold out
Q4 20225550
Q1 20238040
Q2 20238250

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$1m$2m$3mQ3 22 calls: $2.5mQ3 22 puts: $0Q3 22P/C 0.00Q4 22 calls: $43.1kQ4 22 puts: $20.1kQ4 22P/C 0.47Q1 23 calls: $472.0kQ1 23 puts: $1.6kQ1 23P/C 0.00Q2 23 calls: $31.8kQ2 23 puts: $446.2kQ2 23P/C 14.02
Numbers
QuarterCallsPutsP/C
Q3 2022$2.5m$00.00
Q4 2022$43.1k$20.1k0.47
Q1 2023$472.0k$1.6k0.00
Q2 2023$31.8k$446.2k14.02

Biggest buyers

PRICE T ROWE ASSOCIATES INC /MD/ Added +1,387,127+1.4m
BlackRock Inc. Added +644,128+644.1k
Ikarian Capital, LLC New +475,000+475.0k
JENNISON ASSOCIATES LLC New +461,497+461.5k
Paradigm Biocapital Advisors LP Added +261,220+261.2k
ADAGE CAPITAL PARTNERS GP, L.L.C. New +225,000+225.0k
Nuveen Asset Management, LLC Added +218,870+218.9k
Saturn V Capital Management LP Added +197,634+197.6k
MPM BIOIMPACT LLC Added +118,661+118.7k
BOOTHBAY FUND MANAGEMENT, LLC New +96,805+96.8k

Biggest sellers

BVF INC/IL Sold out -2,736,613-2.7m
PERCEPTIVE ADVISORS LLC Reduced -1,607,950-1.6m
BRAIDWELL LP Reduced -1,369,402-1.4m
FMR LLC Reduced -759,002-759.0k
Point72 Asset Management, L.P. Sold out -226,400-226.4k
Walleye Capital LLC Reduced -120,097-120.1k
SPHERA FUNDS MANAGEMENT LTD. Sold out -82,747-82.7k
Schonfeld Strategic Advisors LLC Sold out -73,890-73.9k
Finepoint Capital LP Reduced -70,900-70.9k
First Light Asset Management, LLC Reduced -61,903-61.9k

Biggest calls

CITADEL ADVISORS LLC Reduced $19.8k1.1k shares
SIMPLEX TRADING, LLC Reduced $12.0k700 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP New $302.7k16.8k shares
CITADEL ADVISORS LLC Added $77.5k4.3k shares
SIMPLEX TRADING, LLC New $66.0k3.7k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-03 8.5% 9.0m≈ $336.4m 2026-08-03
Farallon Capital Partners, L.P. 13G · passive investor +2.5 pts · filed 2026-02-05 8.5% +2.5 pts 8.0m≈ $300.3m 2026-02-05
WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.0 pts · filed 2026-08-13 6.8% -1.0 pts 7.1m≈ $266.8m 2026-08-13
DRIEHAUS CAPITAL MANAGEMENT LLC 13G · institution filed 2026-05-15 6.1% 6.4m≈ $239.3m 2026-05-15
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 5.2% new 5.4m≈ $203.6m 2026-04-29
PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution filed 2026-05-15 5.1% 5.4m≈ $200.4m 2026-05-15

Fell to 5% or below in the last year: FMR LLC (1.4%, 2026-08-07), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)

Holders, Q2 2023

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Driehaus Capital Management LLC 1.21% of their portfolio Chicago, IL 5,298,0885.3m $95.5m $95.5m 1.21% Added +8.6k +8,569
2 BlackRock Inc. 0.00% of their portfolio New York, NY 4,600,4864.6m $82.9m $82.9m 0.00% Added +644.1k +644,128
3 ORBIMED ADVISORS LLC 1.30% of their portfolio New York, NY 3,950,7964.0m $71.2m $71.2m 1.30% Unchanged
4 WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio Boston, MA 3,601,7123.6m $64.9m $64.9m 0.01% Reduced -33.8k -33,814
5 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,732,7342.7m $49.2m $49.2m 0.00% Added +39.7k +39,672
6 Bain Capital Life Sciences Investors, LLC 4.28% of their portfolio Boston, MA 2,305,5582.3m $41.5m $41.5m 4.28% Unchanged
7 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 2,237,7352.2m $40.3m $40.3m 0.00% Added +18.9k +18,941
8 PERCEPTIVE ADVISORS LLC 1.02% of their portfolio NEW YORK, NY 1,946,9371.9m $35.1m $35.1m 1.02% Reduced -1.6m -1,607,950
9 First Light Asset Management, LLC 2.20% of their portfolio Edina, MN 1,557,2221.6m $28.1m $28.1m 2.20% Reduced -61.9k -61,903
10 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 1,428,9101.4m $25.8m $25.8m 0.00% Added +1.4m +1,387,127
11 Frazier Life Sciences Management, L.P. 1.52% of their portfolio PALO ALTO, CA 1,414,8231.4m $25.5m $25.5m 1.52% Unchanged
12 Paradigm Biocapital Advisors LP 2.03% of their portfolio NEW YORK, NY 1,395,0021.4m $25.1m $25.1m 2.03% Added +261.2k +261,220
13 EcoR1 Capital, LLC 0.63% of their portfolio San Francisco, CA 1,330,2631.3m $24.0m $24.0m 0.63% Unchanged
14 NOVO HOLDINGS A/S 1.53% of their portfolio HELLERUP, G7 1,100,0001.1m $19.8m $19.8m 1.53% Unchanged
15 FMR LLC 0.00% of their portfolio BOSTON, MA 1,082,9141.1m $19.5m $19.5m 0.00% Reduced -759.0k -759,002
16 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 987,490987.5k $17.8m $17.8m 0.00% Added +32.6k +32,630
17 T. Rowe Price Investment Management, Inc. 0.01% of their portfolio BALTIMORE, MD 964,005964.0k $17.4m $17.4m 0.01% Added +34.6k +34,636
18 Saturn V Capital Management LP 9.38% of their portfolio AUSTIN, TX 938,677938.7k $16.9m $16.9m 9.38% Added +197.6k +197,634
19 5AM Venture Management, LLC 3.87% of their portfolio SAN FRANCISCO, CA 862,286862.3k $15.5m $15.5m 3.87% Unchanged
20 Opaleye Management Inc. 3.64% of their portfolio BOSTON, MA 845,000845.0k $15.2m $15.2m 3.64% Added +59.2k +59,206
21 Finepoint Capital LP 4.97% of their portfolio BOSTON, MA 797,527797.5k $14.4m $14.4m 4.97% Reduced -70.9k -70,900
22 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 746,159746.2k $13.4m $13.4m 0.00% Added +93.2k +93,243
23 BRAIDWELL LP 0.38% of their portfolio STAMFORD, CT 650,312650.3k $11.7m $11.7m 0.38% Reduced -1.4m -1,369,402
24 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.04% of their portfolio Paris, I0 641,345641.3k $11.6m $11.6m 0.04% Reduced -49.9k -49,856
25 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 614,846614.8k $11.1m $11.1m 0.00% Added +94.6k +94,648
26 GW&K Investment Management, LLC 0.10% of their portfolio BOSTON, MA 585,740585.7k $10.6m $10.6m 0.10% Added +48.9k +48,860
27 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 519,109519.1k $9.4m $9.4m 0.00% Added +69.5k +69,504
28 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 490,730490.7k $8.8m $8.8m 0.00% Added +13.4k +13,442
29 MPM BIOIMPACT LLC 1.74% of their portfolio BOSTON, MA 479,053479.1k $8.6m $8.6m 1.74% Added +118.7k +118,661
30 Ikarian Capital, LLC 2.89% of their portfolio DALLAS, TX 475,000475.0k $8.6m $8.6m 2.89% New
31 JANUS HENDERSON GROUP PLC 0.01% of their portfolio LONDON, X0 470,736470.7k $8.5m $8.5m 0.01% Added +54.5k +54,484
32 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 463,418463.4k $8.4m $8.4m 0.00% Added +40.6k +40,629
33 JENNISON ASSOCIATES LLC 0.01% of their portfolio NEW YORK, NY 461,497461.5k $8.3m $8.3m 0.01% New
34 EVENTIDE ASSET MANAGEMENT, LLC 0.13% of their portfolio Boston, MA 434,768434.8k $7.8m $7.8m 0.13% Unchanged
35 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 350,738350.7k $6.3m $6.3m 0.00% Added +5.2k +5,171
36 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 343,179343.2k $6.2m $6.2m 0.00% Added +218.9k +218,870
37 Walleye Capital LLC 0.10% of their portfolio NEW YORK, NY 313,598313.6k $5.7m $5.7m 0.10% Reduced -120.1k -120,097
38 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 270,269270.3k $4.9m $4.9m 0.01% Unchanged
39 CITADEL ADVISORS LLC 0.00% of their portfolio MIAMI, FL 241,728241.7k $4.4m $4.4m 0.00% Reduced -43.9k -43,867
40 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.01% of their portfolio Boston, MA 225,000225.0k $4.1m $4.1m 0.01% New
41 ExodusPoint Capital Management, LP 0.04% of their portfolio NEW YORK, NY 191,974192.0k $3.5m $3.5m 0.04% Added +44.9k +44,858
42 FIRST MANHATTAN CO. LLC. 0.01% of their portfolio NEW YORK, NY 152,200152.2k $2.7m $2.7m 0.01% Unchanged
43 NORGES BANK 0.00% of their portfolio OSLO, Q8 149,100149.1k $2.7m $2.7m 0.00% Unchanged
44 UBS Group AG 0.00% of their portfolio ZURICH, V8 145,693145.7k $2.6m $2.6m 0.00% Added +86.5k +86,525
45 New Leaf Venture Partners, L.L.C. 2.18% of their portfolio New York, NY 141,000141.0k $2.5m $2.5m 2.18% Unchanged
46 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 138,791138.8k $2.5m $2.5m 0.00% Added +261 +261
47 Rafferty Asset Management, LLC 0.01% of their portfolio New York, NY 138,186138.2k $2.5m $2.5m 0.01% Added +9.5k +9,478
48 Altium Capital Management LLC 1.90% of their portfolio NEW YORK, NY 135,000135.0k $2.4m $2.4m 1.90% Added +35.0k +35,000
49 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 120,374120.4k $2.2m $2.2m 0.00% Reduced -56.1k -56,099
50 BOOTHBAY FUND MANAGEMENT, LLC 0.05% of their portfolio NEW YORK, NY 96,80596.8k $1.7m $1.7m 0.05% New
51 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 92,09392.1k $1.7m $1.7m 0.00% Reduced -17.2k -17,180
52 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 91,53591.5k $1.6m $1.6m 0.00% Added +59.3k +59,335
53 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 90,15490.2k $1.6m $1.6m 0.00% Added +8.2k +8,250
54 Swiss National Bank 0.00% of their portfolio ZURICH, V8 82,20082.2k $1.5m $1.5m 0.00% Added +900 +900
55 Tekla Capital Management LLC 0.06% of their portfolio Boston, MA 78,52978.5k $1.4m $1.4m 0.06% Unchanged
56 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 71,76571.8k $1.3m $1.3m 0.00% New
57 D. E. Shaw & Co., Inc. 0.00% of their portfolio New York, NY 70,59070.6k $1.3m $1.3m 0.00% New
58 Fisher Asset Management, LLC 0.00% of their portfolio PLANO, TX 68,27168.3k $1.2m $1.2m 0.00% Unchanged
59 TWO SIGMA ADVISERS, LP 0.00% of their portfolio NEW YORK, NY 62,40062.4k $1.1m $1.1m 0.00% Added +2.1k +2,100
60 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 59,16059.2k $1.1m $1.1m 0.00% Added +372 +372
61 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 58,90058.9k $1.1m $1.1m 0.00% Added +31.3k +31,300
62 OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.02% of their portfolio CHICAGO, IL 56,15356.2k $1.0m $1.0m 0.02% Added +22.7k +22,732
63 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 55,79855.8k $1.0m $1.0m 0.00% Added +44.8k +44,763
64 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 55,38455.4k $998.0k $998.0k 0.00% Reduced -48.4k -48,433
65 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 51,20051.2k $922.6k $922.6k 0.00% Unchanged
66 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 51,16051.2k $921.9k $921.9k 0.00% Added +30.7k +30,745
67 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 50,93650.9k $917.9k $917.9k 0.00% Reduced -1.7k -1,720
68 MARTINGALE ASSET MANAGEMENT L P 0.02% of their portfolio BOSTON, MA 48,18048.2k $868.2k $868.2k 0.02% Unchanged
69 Cubist Systematic Strategies, LLC 0.01% of their portfolio STAMFORD, CT 47,19247.2k $850.4k $850.4k 0.01% Added +46.1k +46,092
70 AlphaCentric Advisors LLC 0.47% of their portfolio SAN JUAN, PR 47,00047.0k $846.9k $846.9k 0.47% New
71 BIT Capital GmbH 0.10% of their portfolio BERLIN, 2M 45,35945.4k $817.4k $817.4k 0.10% Added +5.3k +5,297
72 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 44,13544.1k $795.3k $795.3k 0.00% Added +13.2k +13,151
73 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 43,67443.7k $787.0k $787.0k 0.00% Added +3.2k +3,161
74 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 42,79642.8k $771.2k $771.2k 0.00% Added +11.1k +11,076
75 MILLENNIUM MANAGEMENT LLC 0.00% of their portfolio NEW YORK, NY 42,52842.5k $766.4k $766.4k 0.00% Reduced -52.3k -52,279
76 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 39,71039.7k $715.6k $715.6k 0.01% Added +4.2k +4,190
77 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 39,39839.4k $710.0k $710.0k 0.00% Added +4.6k +4,631
78 Legal & General Group Plc 0.00% of their portfolio London, X0 37,84837.8k $682.0k $682.0k 0.00% Added +15.3k +15,301
79 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 37,57737.6k $677.1k $677.1k 0.00% Reduced -833 -833
80 TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio FRANKFORT, KY 35,21735.2k $635.0k $635.0k 0.01% Reduced -13.1k -13,138
81 GSA CAPITAL PARTNERS LLP 0.06% of their portfolio LONDON, X0 35,18835.2k $634.0k $634.0k 0.06% Added +5.7k +5,733
82 HighVista Strategies LLC 0.27% of their portfolio BOSTON, MA 32,62332.6k $587.9k $587.9k 0.27% Reduced -15.6k -15,622
83 CANTOR FITZGERALD, L. P. 0.01% of their portfolio NEW YORK, NY 32,56232.6k $586.8k $586.8k 0.01% New
84 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 30,11130.1k $542.6k $542.6k 0.00% New
85 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 29,85429.9k $537.0k $537.0k 0.00% Reduced -256 -256
86 Balyasny Asset Management L.P. 0.00% of their portfolio Chicago, IL 29,08929.1k $524.2k $524.2k 0.00% New
87 MetLife Investment Management, LLC 0.00% of their portfolio Whippany, NJ 28,04728.0k $505.4k $505.4k 0.00% Unchanged
88 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 27,42727.4k $494.2k $494.2k 0.00% Reduced -34.6k -34,560
89 TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio STAMFORD, CT 27,02827.0k $487.0k $487.0k 0.01% New
90 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 25,66525.7k $462.5k $462.5k 0.00% Added +266 +266
91 PROFUND ADVISORS LLC 0.02% of their portfolio BETHESDA, MD 25,59625.6k $461.2k $461.2k 0.02% Added +1.2k +1,193
92 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 23,08523.1k $416.0k $416.0k 0.00% Reduced -15.2k -15,234
93 Ergoteles LLC 0.02% of their portfolio NEW YORK, NY 22,83922.8k $411.6k $411.6k 0.02% Added +6.7k +6,682
94 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 22,73922.7k $409.8k $409.8k 0.00% Reduced -6.0k -6,025
95 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 22,12022.1k $398.6k $398.6k 0.00% New
96 Campbell & CO Investment Adviser LLC 0.07% of their portfolio BALTIMORE, MD 21,59421.6k $389.1k $389.1k 0.07% New
97 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 21,50821.5k $387.6k $387.6k 0.00% Added +902 +902
98 NATIXIS ADVISORS, LLC 0.00% of their portfolio Boston, MA 20,38720.4k $367.0k $367.0k 0.00% Added +165 +165
99 Walleye Trading LLC 0.02% of their portfolio NEW YORK, NY 20,09420.1k $362.1k $362.1k 0.02% Reduced -5.1k -5,060
100 J.P. Morgan Private Wealth Advisors LLC 0.00% of their portfolio SAN FRANCISCO, CA 19,35419.4k $348.8k $348.8k 0.00% Reduced -407 -407