Paradigm Biocapital Advisors LP

NEW YORK, NY · CIK 1855655 · 13F filing filed 2024-05-15

SEC-registered investment adviser since 2021 · limited partnership

Assets managed$4.5bn
Staff11 · 6 in investment roles
Main clients (by assets)Private funds 90%
Private funds2 (2 hedge) · $4.1bn gross assets
Form ADV · 2026-08-27SEC adviser record

Legal entityPARADIGM BIOCAPITAL ADVISORS LP (US)

$2.8bn reported value +33.1% vs Q4 2023

34positions

58.9%in top 10

10 new 16 added 5 reduced 5 sold out vs Q4 2023

Holdings, Q1 2024

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#	Security	Ticker	Shares	Value	% of portfolio	Change	Shares change
1	NUVALENT INC COM COM		4,177,830	$313.7m11.04%	11.04%	Added +319.8k	+319,822 8.3%
2	ARCELLX INC COMMON STOCK ACLX	ACLX	3,818,095	$265.5m9.35%	9.35%	Added +159.5k	+159,471 4.4%
3	ARGENX SE SPONSORED ADR ARGX	ARGX	552,120	$217.4m7.65%	7.65%	Added +129.5k	+129,543 30.7%
4	DISC MEDICINE INC COM IRON	IRON	2,389,902	$148.8m5.24%	5.24%	Added +4.0k	+4,045 0.2%
5	CRINETICS PHARMACEUTICALS IN COM CRNX	CRNX	3,124,749	$146.3m5.15%	5.15%	Added +811.8k	+811,830 35.1%
6	SAREPTA THERAPEUTICS INC COM SRPT	SRPT	1,078,346	$139.6m4.91%	4.91%	New
7	IMMUNOCORE HLDGS PLC ADS IMCR	IMCR	1,787,176	$116.2m4.09%	4.09%	Added +333.3k	+333,293 22.9%
8	LEGEND BIOTECH CORP SPONSORED ADS LEGN	LEGN	1,982,006	$111.2m3.91%	3.91%	Added +87.4k	+87,362 4.6%
9	ARVINAS INC COM ARVN	ARVN	2,614,935	$107.9m3.80%	3.80%	Added +1.7m	+1,683,632 180.8%
10	XENON PHARMACEUTICALS INC COM XENE	XENE	2,484,874	$107.0m3.77%	3.77%	Added +357.5k	+357,474 16.8%
11	TARSUS PHARMACEUTICALS INC COM TARS	TARS	2,863,406	$104.1m3.66%	3.66%	Added +1.8m	+1,838,406 179.4%
12	CEREVEL THERAPEUTICS HLDNG I COM CERE	CERE	2,330,508	$98.5m3.47%	3.47%	Unchanged
13	REVOLUTION MEDICINES INC COM RVMD	RVMD	2,914,975	$93.9m3.31%	3.31%	New
14	OLEMA PHARMACEUTICALS INC COM OLMA	OLMA	7,903,600	$89.5m3.15%	3.15%	Unchanged
15	VIRIDIAN THERAPEUTICS INC COM VRDN	VRDN	5,031,420	$88.1m3.10%	3.10%	Added +236.9k	+236,932 4.9%
16	VAXCYTE INC COM PCVX	PCVX	1,239,995	$84.7m2.98%	2.98%	New
17	ALPINE IMMUNE SCIENCES INC COM NVLS	NVLS	2,121,163	$84.1m2.96%	2.96%	Reduced -1.1m	-1,055,580 -33.2%
18	BICYCLE THERAPEUTICS PLC SPONSORED ADS BCYC	BCYC	3,246,759	$80.8m2.85%	2.85%	Reduced -460.2k	-460,242 -12.4%
19	ASCENDIS PHARMA A/S SPONSORED ADR SPONSORED ADR		507,952	$76.8m2.70%	2.70%	Added +156.3k	+156,252 44.4%
20	KURA ONCOLOGY INC COM KURA	KURA	3,135,387	$66.9m2.35%	2.35%	Added +1.9m	+1,872,559 148.3%
21	EDGEWISE THERAPEUTICS INC COM EWTX	EWTX	2,446,373	$44.6m1.57%	1.57%	New
22	AUTOLUS THERAPEUTICS PLC SPON ADS AUTL	AUTL	6,425,803	$41.0m1.44%	1.44%	Reduced -6.2m	-6,185,532 -49.0%
23	Y-MABS THERAPEUTICS INC COM YMAB	YMAB	2,233,610	$36.3m1.28%	1.28%	New
24	IMMATICS N.V SHS IMTX	IMTX	2,818,908	$29.6m1.04%	1.04%	Added +682.6k	+682,569 31.9%
25	IMMUNOVANT INC COM IMVT	IMVT	799,054	$25.8m0.91%	0.91%	New
26	CULLINAN THERAPEUTICS INC COM CGEM	CGEM	1,348,015	$23.0m0.81%	0.81%	New
27	APOGEE THERAPEUTICS INC COM COM		330,000	$21.9m0.77%	0.77%	New
28	COMPASS PATHWAYS PLC SPONSORED ADS CMPS	CMPS	2,390,988	$19.9m0.70%	0.70%	Added +125.0k	+125,000 5.5%
29	VOR BIOPHARMA INC COM COM		6,457,293	$15.3m0.54%	0.54%	Unchanged
30	ZENTALIS PHARMACEUTICALS INC COM ZNTL	ZNTL	944,917	$14.9m0.52%	0.52%	Added +544.9k	+544,917 136.2%
31	AGIOS PHARMACEUTICALS INC COM AGIO	AGIO	400,000	$11.7m0.41%	0.41%	New
32	CARIBOU BIOSCIENCES INC COM CRBU	CRBU	2,172,620	$11.2m0.39%	0.39%	Reduced -751.2k	-751,231 -25.7%
33	CARGO THERAPEUTICS INC COM COM		147,959	$3.3m0.12%	0.12%	Reduced -185.4k	-185,374 -55.6%
34	KYVERNA THERAPEUTICS INC COM KYTX	KYTX	50,000	$1.2m0.04%	0.04%	New

Sold out since Q4 2023

Security	Ticker	Shares held before	Value then
MIRATI THERAPEUTICS INC MRTX	MRTX	1,543,116	$90.7m1.5m shares
AMBRX BIOPHARMA INC		4,352,689	$62.0m4.4m shares
TG THERAPEUTICS INC TGTX	TGTX	2,171,419	$37.1m2.2m shares
ZAI LAB LTD ZLAB	ZLAB	1,091,779	$29.8m1.1m shares
AEROVATE THERAPEUTICS INC		143,235	$3.2m143.2k shares

Stakes above 5%

Companies where this manager has reported owning more than 5% of a class of shares, on Schedule 13D (may seek influence) or 13G (passive): its latest filing for each, from 19 Dec 2024 on.

Company	Ticker	Stake	Change	Schedule	Last filed
OLEMA PHARMACEUTICALS INC OLMA · 13G · filed 2025-02-14	OLMA	10.0%≈ $92.9m		13G	2025-02-14
EDGEWISE THERAPEUTICS INC EWTX · 13G · filed 2026-08-14	EWTX	9.5%≈ $415.1m	+3.3 pts	13G	2026-08-14
ACHIEVE LIFE SCIENCES INC ACHV · 13G · filed 2026-04-24	ACHV	9.2%≈ $64.7m	new	13G	2026-04-24
ASSEMBLY BIOSCIENCES INC ASMB · 13G · filed 2026-08-14	ASMB	7.8%≈ $42.7m	+2.4 pts	13G	2026-08-14
VIRIDIAN THERAPEUTICS INC VRDN · 13G · filed 2026-08-14	VRDN	6.1%≈ $123.5m	+1.0 pts	13G	2026-08-14
TYRA BIOSCIENCES INC TYRA · 13G · filed 2026-09-17	TYRA	5.8%≈ $110.9m	new	13G	2026-09-17
LEXEO THERAPEUTICS INC LXEO · 13G · filed 2026-08-14	LXEO	5.3%≈ $19.4m	-3.0 pts	13G	2026-08-14
MBX BIOSCIENCES INC MBX · 13G · filed 2026-06-24	MBX	5.2%≈ $137.6m	new	13G	2026-06-24
SPYRE THERAPEUTICS INC SYRE · 13G · filed 2026-10-01	SYRE	5.1%≈ $395.7m	new	13G	2026-10-01
JADE BIOSCIENCES INC JBIO · 13G · filed 2026-07-17	JBIO	5.1%≈ $69.0m	new	13G	2026-07-17