Vault-13

ALPINE IMMUNE SCIENCES INC NVLS

COM · Common Stock · CUSIP 02083G100

181 institutional holders +47 vs Q4 2023
66,184,76366.2m shares reported held*
$2.6bnreported value*
61 new 67 added 41 reduced 16 sold out net bought ≈ $257.5m (+6.5m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($170.5k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $39.64. Options: 7 managers hold calls ($6.3m notional), 8 hold puts ($11.8m).

Trends to Q1 2024

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 70Q4 22: 64Q1 23: 61Q2 23: 77Q3 23: 89Q4 23: 134Q1 24: 181181Q3 22Q1 23Q3 23Q1 24
Numbers
QuarterHolders
Q3 202270
Q4 202264
Q1 202361
Q2 202377
Q3 202389
Q4 2023134
Q1 2024181

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 40 bought or addedQ4 22: 24 cut or sold outQ4 22Q1 23: 31 bought or addedQ1 23: 20 cut or sold outQ1 23Q2 23: 52 bought or addedQ2 23: 14 cut or sold outQ2 23Q3 23: 51 bought or addedQ3 23: 26 cut or sold outQ3 23Q4 23: 109 bought or addedQ4 23: 19 cut or sold outQ4 23Q1 24: 128 bought or addedQ1 24: 57 cut or sold outQ1 24
Numbers
QuarterBought or addedCut or sold out
Q4 20224024
Q1 20233120
Q2 20235214
Q3 20235126
Q4 202310919
Q1 202412857

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$5m$10m$15mQ2 23 calls: $51.6kQ2 23 puts: $0Q2 23P/C 0.00Q3 23 calls: $20.6kQ3 23 puts: $0Q3 23P/C 0.00Q4 23 calls: $140.1kQ4 23 puts: $24.8kQ4 23P/C 0.18Q1 24 calls: $6.3mQ1 24 puts: $11.8mQ1 24P/C 1.88
Numbers
QuarterCallsPutsP/C
Q2 2023$51.6k$00.00
Q3 2023$20.6k$00.00
Q4 2023$140.1k$24.8k0.18
Q1 2024$6.3m$11.8m1.88

Biggest buyers

Avoro Capital Advisors LLC New +5,775,000+5.8m
Darwin Global Management, Ltd. New +1,982,016+2.0m
STATE STREET CORP Added +1,455,810+1.5m
PRICE T ROWE ASSOCIATES INC /MD/ Added +1,392,942+1.4m
Decheng Capital LLC Added +1,234,636+1.2m
Avidity Partners Management LP New +1,174,700+1.2m
MORGAN STANLEY Added +931,453+931.5k
BlackRock Inc. Added +516,594+516.6k
First Light Asset Management, LLC New +501,243+501.2k
VANGUARD GROUP INC Added +477,518+477.5k

Biggest sellers

RA CAPITAL MANAGEMENT, L.P. Sold out -4,909,763-4.9m
GREAT POINT PARTNERS LLC Reduced -2,574,934-2.6m
Lynx1 Capital Management LP Reduced -1,560,743-1.6m
Paradigm Biocapital Advisors LP Reduced -1,055,580-1.1m
Woodline Partners LP Reduced -745,772-745.8k
CITADEL ADVISORS LLC Reduced -732,378-732.4k
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -404,590-404.6k
Ally Bridge Group (NY) LLC Sold out -357,271-357.3k
Vivo Capital, LLC Reduced -298,770-298.8k
MILLENNIUM MANAGEMENT LLC Reduced -258,628-258.6k

Biggest calls

Ikarian Capital, LLC New $4.1m103.0k shares
BOOTHBAY FUND MANAGEMENT, LLC New $1.2m29.9k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP New $669.9k16.9k shares
CITADEL ADVISORS LLC Added $321.1k8.1k shares
Walleye Capital LLC New $19.8k500 shares
SIMPLEX TRADING, LLC Added $11.0k300 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP New $4.8m121.0k shares
JANE STREET GROUP, LLC New $3.1m78.6k shares
CITADEL ADVISORS LLC Added $2.6m64.5k shares
SIMPLEX TRADING, LLC New $800.0k20.2k shares
GTS SECURITIES LLC New $313.2k7.9k shares
Belvedere Trading LLC New $210.1k5.3k shares
Walleye Capital LLC New $27.7k700 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. Unchanged $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Holders, Q1 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Decheng Capital LLC 44.22% of their portfolio MENLO PARK, CA 8,317,9248.3m $329.7m $329.7m 44.22% Added +1.2m +1,234,636
2 Avoro Capital Advisors LLC 2.67% of their portfolio NEW YORK, NY 5,775,0005.8m $228.9m $228.9m 2.67% New
3 BlackRock Inc. 0.00% of their portfolio New York, NY 3,575,0923.6m $141.7m $141.7m 0.00% Added +516.6k +516,594
4 Frazier Life Sciences Management, L.P. 5.24% of their portfolio PALO ALTO, CA 3,131,0083.1m $124.1m $124.1m 5.24% Unchanged
5 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 3,080,2203.1m $122.1m $122.1m 0.01% Added +1.4m +1,392,942
6 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 2,845,8392.8m $112.8m $112.8m 0.01% Added +1.5m +1,455,810
7 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 2,712,2852.7m $107.5m $107.5m 0.00% Added +477.5k +477,518
8 Cormorant Asset Management, LP 4.72% of their portfolio BOSTON, MA 2,700,0002.7m $107.0m $107.0m 4.72% Added +150.0k +150,000
9 ORBIMED ADVISORS LLC 1.95% of their portfolio New York, NY 2,680,4962.7m $106.3m $106.3m 1.95% Added +145.3k +145,251
10 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 2,368,9352.4m $93.9m $93.9m 0.00% Added +931.5k +931,453
11 Lynx1 Capital Management LP 23.00% of their portfolio DORADO, PR 2,253,1832.3m $89.3m $89.3m 23.00% Reduced -1.6m -1,560,743
12 Paradigm Biocapital Advisors LP 2.96% of their portfolio NEW YORK, NY 2,121,1632.1m $84.1m $84.1m 2.96% Reduced -1.1m -1,055,580
13 Darwin Global Management, Ltd. 10.46% of their portfolio ST. HELIER, Y9 1,982,0162.0m $78.6m $78.6m 10.46% New
14 Commodore Capital LP 3.64% of their portfolio NEW YORK, NY 1,375,0001.4m $54.5m $54.5m 3.64% Reduced -235.0k -235,000
15 Octagon Capital Advisors LP 5.98% of their portfolio NEW YORK, NY 1,241,3001.2m $49.2m $49.2m 5.98% Unchanged
16 Avidity Partners Management LP 1.66% of their portfolio DALLAS, TX 1,174,7001.2m $46.6m $46.6m 1.66% New
17 GREAT POINT PARTNERS LLC 6.97% of their portfolio Greenwich, CT 1,128,4991.1m $44.7m $44.7m 6.97% Reduced -2.6m -2,574,934
18 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 1,093,2031.1m $43.3m $43.3m 0.01% Reduced -127.1k -127,130
19 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 910,599910.6k $36.1m $36.1m 0.00% Added +146.3k +146,252
20 TWO SIGMA ADVISERS, LP 0.06% of their portfolio NEW YORK, NY 668,775668.8k $26.5m $26.5m 0.06% Added +404.7k +404,700
21 Vivo Capital, LLC 1.63% of their portfolio Palo Alto, CA 520,505520.5k $20.8m $20.8m 1.63% Reduced -298.8k -298,770
22 TWO SIGMA INVESTMENTS, LP 0.05% of their portfolio NEW YORK, NY 519,971520.0k $20.6m $20.6m 0.05% Added +141.6k +141,558
23 Nuveen Asset Management, LLC 0.01% of their portfolio CHICAGO, IL 513,175513.2k $20.3m $20.3m 0.01% Added +383.2k +383,209
24 First Light Asset Management, LLC 1.52% of their portfolio Edina, MN 501,243501.2k $19.9m $19.9m 1.52% New
25 JANUS HENDERSON GROUP PLC 0.01% of their portfolio LONDON, X0 450,827450.8k $17.8m $17.8m 0.01% Reduced -132.4k -132,412
26 D. E. Shaw & Co., Inc. 0.02% of their portfolio New York, NY 428,555428.6k $17.0m $17.0m 0.02% Added +133.0k +133,013
27 Candriam S.C.A. 0.11% of their portfolio STRASSEN, N4 415,000415.0k $16.5m $16.5m 0.11% Reduced -55.0k -55,000
28 EVENTIDE ASSET MANAGEMENT, LLC 0.25% of their portfolio Boston, MA 408,542408.5k $16.2m $16.2m 0.25% New
29 Artal Group S.A. 0.41% of their portfolio LUXEMBOURG, N4 405,784405.8k $16.1m $16.1m 0.41% Added +355.0k +355,025
30 Balyasny Asset Management L.P. 0.04% of their portfolio Chicago, IL 372,995373.0k $14.8m $14.8m 0.04% New
31 Vestal Point Capital, LP 1.15% of their portfolio NEW YORK, NY 350,000350.0k $13.9m $13.9m 1.15% New
32 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 341,701341.7k $13.5m $13.5m 0.00% Added +45.0k +45,006
33 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 339,142339.1k $13.4m $13.4m 0.00% Added +41.7k +41,690
34 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 325,943325.9k $12.9m $12.9m 0.00% Added +223.6k +223,591
35 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio Boston, MA 310,000310.0k $12.3m $12.3m 0.02% Reduced -404.6k -404,590
36 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 272,627272.6k $10.8m $10.8m 0.00% Added +30.9k +30,851
37 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.04% of their portfolio JUPITER, FL 267,232267.2k $10.6m $10.6m 0.04% Added +33.5k +33,482
38 Nan Fung Group Holdings Ltd 9.69% of their portfolio KAI TAK, K3 263,940263.9k $10.5m $10.5m 9.69% Unchanged
39 Ikarian Capital, LLC 2.82% of their portfolio DALLAS, TX 261,365261.4k $10.4m $10.4m 2.82% Reduced -225.9k -225,883
40 Atika Capital Management LLC 1.14% of their portfolio NEW YORK, NY 256,000256.0k $10.1m $10.1m 1.14% New
41 Woodline Partners LP 0.09% of their portfolio San Francisco, CA 254,334254.3k $10.1m $10.1m 0.09% Reduced -745.8k -745,772
42 RENAISSANCE TECHNOLOGIES LLC 0.02% of their portfolio NEW YORK, NY 244,981245.0k $9.7m $9.7m 0.02% Added +28.3k +28,296
43 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 240,435240.4k $9.5m $9.5m 0.00% Added +42.5k +42,491
44 FMR LLC 0.00% of their portfolio BOSTON, MA 238,561238.6k $9.5m $9.5m 0.00% Added +15 +15
45 Rafferty Asset Management, LLC 0.03% of their portfolio New York, NY 234,625234.6k $9.3m $9.3m 0.03% Added +154.5k +154,463
46 Integral Health Asset Management, LLC 0.89% of their portfolio New York, NY 230,000230.0k $9.1m $9.1m 0.89% New
47 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 207,496207.5k $8.2m $8.2m 0.01% Added +171.7k +171,719
48 Walleye Capital LLC 0.09% of their portfolio NEW YORK, NY 206,104206.1k $8.2m $8.2m 0.09% Reduced -159.8k -159,836
49 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 204,479204.5k $8.1m $8.1m 0.00% Added +75.0k +75,000
50 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 202,414202.4k $8.0m $8.0m 0.00% Added +110.6k +110,648
51 SILVERARC CAPITAL MANAGEMENT, LLC 2.21% of their portfolio BOSTON, MA 199,020199.0k $7.9m $7.9m 2.21% Reduced -98.8k -98,769
52 JENNISON ASSOCIATES LLC 0.01% of their portfolio NEW YORK, NY 191,974192.0k $7.6m $7.6m 0.01% Added +50.9k +50,879
53 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 191,779191.8k $7.6m $7.6m 0.00% Reduced -42.1k -42,102
54 JANE STREET GROUP, LLC 0.01% of their portfolio NEW YORK, NY 177,434177.4k $7.0m $7.0m 0.01% Added +108.0k +107,981
55 ExodusPoint Capital Management, LP 0.08% of their portfolio NEW YORK, NY 171,251171.3k $6.8m $6.8m 0.08% Reduced -37.7k -37,723
56 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 163,323163.3k $6.5m $6.5m 0.01% Reduced -42.4k -42,443
57 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 161,145161.1k $6.4m $6.4m 0.00% Added +51.3k +51,263
58 UBS Group AG 0.00% of their portfolio ZURICH, V8 153,473153.5k $6.1m $6.1m 0.00% Added +87.7k +87,666
59 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 142,879142.9k $5.7m $5.7m 0.01% Reduced -732.4k -732,378
60 Ensign Peak Advisors, Inc 0.01% of their portfolio SALT LAKE CITY, UT 140,043140.0k $5.6m $5.6m 0.01% Added +10.1k +10,068
61 FEDERATED HERMES, INC. 0.01% of their portfolio PITTSBURGH, PA 138,981139.0k $5.5m $5.5m 0.01% Added +138.6k +138,616
62 Hillsdale Investment Management Inc. 0.42% of their portfolio Toronto, A6 133,960134.0k $5.3m $5.3m 0.42% New
63 Tri Locum Partners LP 1.66% of their portfolio NEW YORK, NY 120,687120.7k $4.8m $4.8m 1.66% New
64 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 118,418118.4k $4.7m $4.7m 0.00% Added +85.2k +85,218
65 Exome Asset Management LLC 3.97% of their portfolio NEW YORK, NY 117,000117.0k $4.6m $4.6m 3.97% Reduced -56.5k -56,500
66 Trexquant Investment LP 0.09% of their portfolio STAMFORD, CT 115,776115.8k $4.6m $4.6m 0.09% Added +62.0k +61,996
67 Point72 Asset Management, L.P. 0.01% of their portfolio STAMFORD, CT 110,700110.7k $4.4m $4.4m 0.01% New
68 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 109,860109.9k $4.4m $4.4m 0.01% Added +87.1k +87,085
69 ALGERT GLOBAL LLC 0.17% of their portfolio SAN FRANCISCO, CA 108,841108.8k $4.3m $4.3m 0.17% Added +80.6k +80,551
70 Handelsbanken Fonder AB 0.02% of their portfolio STOCKHOLM, V7 102,000102.0k $4.0m $4.0m 0.02% New
71 Rhenman & Partners Asset Management AB 0.32% of their portfolio Stockholm, V7 85,50085.5k $3.4m $3.4m 0.32% New
72 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 83,86883.9k $3.3m $3.3m 0.00% Added +57.1k +57,090
73 BAKER BROS. ADVISORS LP 0.04% of their portfolio NEW YORK, NY 81,57881.6k $3.2m $3.2m 0.04% New
74 Altium Capital Management LLC 1.38% of their portfolio NEW YORK, NY 77,84877.8k $3.1m $3.1m 1.38% Reduced -875 -875
75 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 77,78477.8k $3.1m $3.1m 0.00% Reduced -29.2k -29,157
76 Raymond James Financial Services Advisors, Inc. 0.00% of their portfolio ST. PETERSBURG, FL 76,50876.5k $3.0m $3.0m 0.00% New
77 Informed Momentum Co LLC 0.46% of their portfolio SOLANA BEACH, CA 74,89974.9k $3.0m $3.0m 0.46% Reduced -87.8k -87,786
78 BOOTHBAY FUND MANAGEMENT, LLC 0.08% of their portfolio NEW YORK, NY 67,97268.0k $2.7m $2.7m 0.08% Reduced -48.9k -48,851
79 Swiss National Bank 0.00% of their portfolio ZURICH, V8 63,50063.5k $2.5m $2.5m 0.00% Added +6.3k +6,300
80 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 58,91858.9k $2.3m $2.3m 0.00% Reduced -7.2k -7,230
81 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 54,54354.5k $2.2m $2.2m 0.00% Added +10.8k +10,822
82 Cinctive Capital Management LP 0.11% of their portfolio New York, NY 54,07154.1k $2.1m $2.1m 0.11% New
83 Monashee Investment Management LLC 0.25% of their portfolio Boston, MA 52,54652.5k $2.1m $2.1m 0.25% Reduced -22.2k -22,246
84 Artia Global Partners LP 0.50% of their portfolio MIAMI, FL 51,71451.7k $2.0m $2.0m 0.50% New
85 Moody Aldrich Partners LLC 0.34% of their portfolio MARBLEHEAD, MA 50,79850.8k $2.0m $2.0m 0.34% New
86 TUDOR INVESTMENT CORP ET AL 0.02% of their portfolio STAMFORD, CT 50,72950.7k $2.0m $2.0m 0.02% New
87 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 49,17049.2k $1.9m $1.9m 0.00% Reduced -31.1k -31,127
88 ALPS ADVISORS INC 0.01% of their portfolio Denver, CO 46,22246.2k $1.8m $1.8m 0.01% Added +6.6k +6,631
89 VICTORY CAPITAL MANAGEMENT INC 0.00% of their portfolio San Antonio, TX 45,06445.1k $1.8m $1.8m 0.00% New
90 SPHERA FUNDS MANAGEMENT LTD. 0.29% of their portfolio TEL AVIV, L3 44,84144.8k $1.8m $1.8m 0.29% Reduced -190.0k -190,000
91 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 41,29041.3k $1.6m $1.6m 0.00% Added +11.2k +11,250
92 AWM Investment Company, Inc. 0.21% of their portfolio NEW YORK, NY 40,00040.0k $1.6m $1.6m 0.21% Unchanged
93 ClariVest Asset Management LLC 0.16% of their portfolio SAN DIEGO, CA 38,87338.9k $1.5m $1.5m 0.16% Added +73 +73
94 CAPSTONE INVESTMENT ADVISORS, LLC 0.03% of their portfolio NEW YORK, NY 38,21238.2k $1.5m $1.5m 0.03% Added +12.9k +12,923
95 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 37,92537.9k $1.5m $1.5m 0.00% Added +25.9k +25,916
96 PROFUND ADVISORS LLC 0.06% of their portfolio BETHESDA, MD 36,37236.4k $1.4m $1.4m 0.06% Added +22.9k +22,934
97 Jefferies Financial Group Inc. 0.03% of their portfolio NEW YORK, NY 35,00035.0k $1.4m $1.4m 0.03% Reduced -65.2k -65,152
98 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 32,82332.8k $1.3m $1.3m 0.00% Added +1.7k +1,660
99 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 32,21132.2k $1.3m $1.3m 0.00% Added +5.5k +5,467
100 Legal & General Group Plc 0.00% of their portfolio London, X0 30,90130.9k $1.2m $1.2m 0.00% Added +4.6k +4,638