Vault-13

CRINETICS PHARMACEUTICALS IN CRNX

COM · Common Stock · CUSIP 22663K107 · ISIN US22663K1079

204 institutional holders +22 vs Q4 2023
82,698,78282.7m shares reported held*
$3.9bnreported value*
49 new 79 added 54 reduced 28 sold out net bought ≈ $506.2m (+10.8m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($13.6m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $46.79. Options: 13 managers hold calls ($34.1m notional), 16 hold puts ($28.1m).

Trends to Q1 2024

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 122Q4 22: 122Q1 23: 130Q2 23: 141Q3 23: 173Q4 23: 182Q1 24: 204204Q3 22Q1 23Q3 23Q1 24
Numbers
QuarterHolders
Q3 2022122
Q4 2022122
Q1 2023130
Q2 2023141
Q3 2023173
Q4 2023182
Q1 2024204

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 55 bought or addedQ4 22: 50 cut or sold outQ4 22Q1 23: 80 bought or addedQ1 23: 40 cut or sold outQ1 23Q2 23: 82 bought or addedQ2 23: 50 cut or sold outQ2 23Q3 23: 132 bought or addedQ3 23: 47 cut or sold outQ3 23Q4 23: 102 bought or addedQ4 23: 82 cut or sold outQ4 23Q1 24: 128 bought or addedQ1 24: 82 cut or sold outQ1 24
Numbers
QuarterBought or addedCut or sold out
Q4 20225550
Q1 20238040
Q2 20238250
Q3 202313247
Q4 202310282
Q1 202412882

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$10m$20m$30m$40mQ2 23 calls: $31.8kQ2 23 puts: $446.2kQ2 23P/C 14.02Q3 23 calls: $31.7mQ3 23 puts: $33.7mQ3 23P/C 1.06Q4 23 calls: $23.7mQ4 23 puts: $12.6mQ4 23P/C 0.53Q1 24 calls: $34.1mQ1 24 puts: $28.1mQ1 24P/C 0.82
Numbers
QuarterCallsPutsP/C
Q2 2023$31.8k$446.2k14.02
Q3 2023$31.7m$33.7m1.06
Q4 2023$23.7m$12.6m0.53
Q1 2024$34.1m$28.1m0.82

Biggest buyers

EcoR1 Capital, LLC Added +2,142,858+2.1m
Point72 Asset Management, L.P. Added +1,532,586+1.5m
JANUS HENDERSON GROUP PLC Added +1,434,909+1.4m
Artal Group S.A. New +1,390,477+1.4m
PRICE T ROWE ASSOCIATES INC /MD/ Added +814,360+814.4k
Paradigm Biocapital Advisors LP Added +811,830+811.8k
ADAGE CAPITAL PARTNERS GP, L.L.C. New +632,133+632.1k
JPMORGAN CHASE & CO Added +565,764+565.8k
MORGAN STANLEY Added +540,098+540.1k
Fiera Capital Corp New +475,510+475.5k

Biggest sellers

Avidity Partners Management LP Sold out -529,000-529.0k
Vestal Point Capital, LP Sold out -450,000-450.0k
Frazier Life Sciences Management, L.P. Sold out -397,483-397.5k
STATE STREET CORP Reduced -308,483-308.5k
First Light Asset Management, LLC Reduced -297,595-297.6k
ORBIMED ADVISORS LLC Reduced -282,360-282.4k
WELLINGTON MANAGEMENT GROUP LLP Reduced -273,523-273.5k
Candriam S.C.A. Reduced -200,006-200.0k
Propel Bio Management, LLC Sold out -165,000-165.0k
BNP PARIBAS FINANCIAL MARKETS Reduced -134,535-134.5k

Biggest calls

Caption Management, LLC Added $14.9m319.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $8.2m176.2k shares
SIMPLEX TRADING, LLC Added $3.9m83.0k shares
CITADEL ADVISORS LLC Added $2.8m60.0k shares
MILLENNIUM MANAGEMENT LLC New $1.7m35.4k shares
Walleye Capital LLC Added $688.1k14.7k shares
JANE STREET GROUP, LLC Reduced $585.1k12.5k shares
Walleye Trading LLC Added $500.9k10.7k shares
Ikarian Capital, LLC Reduced $407.2k8.7k shares
GTS SECURITIES LLC Reduced $304.3k6.5k shares

Biggest puts

Ikarian Capital, LLC New $14.1m300.4k shares
BOOTHBAY FUND MANAGEMENT, LLC New $4.1m87.7k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $2.7m57.7k shares
Caption Management, LLC Reduced $2.1m43.9k shares
CITADEL ADVISORS LLC Added $1.5m31.6k shares
MILLENNIUM MANAGEMENT LLC Reduced $1.3m27.2k shares
UBS Group AG New $936.2k20.0k shares
SIMPLEX TRADING, LLC Added $528.0k11.3k shares
JANE STREET GROUP, LLC Reduced $327.7k7.0k shares
GROUP ONE TRADING LLC Added $248.1k5.3k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
FARALLON CAPITAL MANAGEMENT, L.L.C. 13G · institution filed 2026-08-03 8.5% 9.0m≈ $336.4m 2026-08-03
Farallon Capital Partners, L.P. 13G · passive investor +2.5 pts · filed 2026-02-05 8.5% +2.5 pts 8.0m≈ $300.3m 2026-02-05
WELLINGTON MANAGEMENT GROUP LLP 13G · institution -1.0 pts · filed 2026-08-13 6.8% -1.0 pts 7.1m≈ $266.8m 2026-08-13
DRIEHAUS CAPITAL MANAGEMENT LLC 13G · institution filed 2026-05-15 6.1% 6.4m≈ $239.3m 2026-05-15
VANGUARD CAPITAL MANAGEMENT LLC 13G · institution new · filed 2026-04-29 5.2% new 5.4m≈ $203.6m 2026-04-29
PRICE T ROWE ASSOCIATES INC /MD/ 13G · institution filed 2026-05-15 5.1% 5.4m≈ $200.4m 2026-05-15

Fell to 5% or below in the last year: FMR LLC (1.4%, 2026-08-07), VANGUARD GROUP INC (0.0%, 2026-03-26; now reported by VANGUARD CAPITAL MANAGEMENT LLC)

Holders, Q1 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 BlackRock Inc. 0.01% of their portfolio New York, NY 5,436,1045.4m $254.5m $254.5m 0.01% Added +91.0k +90,990
2 Driehaus Capital Management LLC 2.44% of their portfolio Chicago, IL 5,226,2975.2m $244.6m $244.6m 2.44% Added +186.3k +186,340
3 Point72 Asset Management, L.P. 0.67% of their portfolio STAMFORD, CT 4,949,4864.9m $231.7m $231.7m 0.67% Added +1.5m +1,532,586
4 FMR LLC 0.01% of their portfolio BOSTON, MA 4,463,6764.5m $208.9m $208.9m 0.01% Added +419.8k +419,811
5 EcoR1 Capital, LLC 4.94% of their portfolio San Francisco, CA 4,155,3754.2m $194.5m $194.5m 4.94% Added +2.1m +2,142,858
6 PRICE T ROWE ASSOCIATES INC /MD/ 0.02% of their portfolio BALTIMORE, MD 3,823,2183.8m $179.0m $179.0m 0.02% Added +814.4k +814,360
7 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 3,575,0763.6m $167.3m $167.3m 0.00% Added +72.6k +72,624
8 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 3,255,2533.3m $152.4m $152.4m 0.01% Reduced -308.5k -308,483
9 Paradigm Biocapital Advisors LP 5.15% of their portfolio NEW YORK, NY 3,124,7493.1m $146.3m $146.3m 5.15% Added +811.8k +811,830
10 WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio Boston, MA 2,971,5823.0m $139.1m $139.1m 0.02% Reduced -273.5k -273,523
11 JENNISON ASSOCIATES LLC 0.09% of their portfolio NEW YORK, NY 2,817,8542.8m $131.9m $131.9m 0.09% Added +270.2k +270,171
12 T. Rowe Price Investment Management, Inc. 0.08% of their portfolio BALTIMORE, MD 2,654,7292.7m $124.3m $124.3m 0.08% Added +237.2k +237,236
13 JANUS HENDERSON GROUP PLC 0.05% of their portfolio LONDON, X0 1,978,1722.0m $92.5m $92.5m 0.05% Added +1.4m +1,434,909
14 LORD, ABBETT & CO. LLC 0.15% of their portfolio JERSEY CITY, NJ 1,929,1361.9m $90.3m $90.3m 0.15% Added +374.6k +374,560
15 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 1,836,6001.8m $86.0m $86.0m 0.00% Added +540.1k +540,098
16 First Light Asset Management, LLC 6.06% of their portfolio Edina, MN 1,690,1771.7m $79.1m $79.1m 6.06% Reduced -297.6k -297,595
17 PERCEPTIVE ADVISORS LLC 1.22% of their portfolio NEW YORK, NY 1,476,2031.5m $69.1m $69.1m 1.22% Added +220.7k +220,691
18 GEODE CAPITAL MANAGEMENT, LLC 0.01% of their portfolio BOSTON, MA 1,401,4031.4m $65.6m $65.6m 0.01% Added +48.7k +48,731
19 Artal Group S.A. 1.68% of their portfolio LUXEMBOURG, N4 1,390,4771.4m $65.1m $65.1m 1.68% New
20 ORBIMED ADVISORS LLC 1.19% of their portfolio New York, NY 1,385,0001.4m $64.8m $64.8m 1.19% Reduced -282.4k -282,360
21 Cormorant Asset Management, LP 2.37% of their portfolio BOSTON, MA 1,150,0001.1m $53.8m $53.8m 2.37% Unchanged
22 NOVO HOLDINGS A/S 3.55% of their portfolio HELLERUP, G7 1,098,6001.1m $51.4m $51.4m 3.55% Reduced -1.4k -1,400
23 EVENTIDE ASSET MANAGEMENT, LLC 0.78% of their portfolio Boston, MA 1,059,6331.1m $49.6m $49.6m 0.78% Unchanged
24 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 864,107864.1k $40.4m $40.4m 0.01% Added +213.9k +213,934
25 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 751,972752.0k $35.2m $35.2m 0.00% Added +565.8k +565,764
26 Saturn V Capital Management LP 12.39% of their portfolio AUSTIN, TX 660,143660.1k $30.9m $30.9m 12.39% Reduced -127.0k -126,989
27 Ikarian Capital, LLC 8.20% of their portfolio DALLAS, TX 643,751643.8k $30.1m $30.1m 8.20% Reduced -36.6k -36,619
28 DIMENSIONAL FUND ADVISORS LP 0.01% of their portfolio AUSTIN, TX 640,802640.8k $30.0m $30.0m 0.01% Reduced -19.1k -19,119
29 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.06% of their portfolio Boston, MA 632,133632.1k $29.6m $29.6m 0.06% New
30 Laurion Capital Management LP 0.82% of their portfolio NEW YORK, NY 630,182630.2k $29.5m $29.5m 0.82% Added +61.2k +61,200
31 Ensign Peak Advisors, Inc 0.05% of their portfolio SALT LAKE CITY, UT 621,507621.5k $29.1m $29.1m 0.05% Added +185.8k +185,822
32 STEMPOINT CAPITAL LP 7.75% of their portfolio NEW YORK, NY 619,789619.8k $29.0m $29.0m 7.75% Added +370.2k +370,214
33 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 601,384601.4k $28.2m $28.2m 0.00% Reduced -1.0k -1,038
34 Nuveen Asset Management, LLC 0.01% of their portfolio CHICAGO, IL 553,739553.7k $25.9m $25.9m 0.01% Reduced -125.4k -125,432
35 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.07% of their portfolio Paris, I0 542,708542.7k $25.4m $25.4m 0.07% Reduced -115.6k -115,581
36 MPM BIOIMPACT LLC 3.64% of their portfolio BOSTON, MA 480,588480.6k $22.5m $22.5m 3.64% Added +2.4k +2,354
37 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 478,532478.5k $22.4m $22.4m 0.01% Added +8.2k +8,159
38 Fiera Capital Corp 0.06% of their portfolio MONTREAL, A8 475,510475.5k $22.3m $22.3m 0.06% New
39 Affinity Asset Advisors, LLC 3.58% of their portfolio NEW YORK, NY 470,000470.0k $22.0m $22.0m 3.58% Added +22.9k +22,905
40 Fisher Asset Management, LLC 0.01% of their portfolio PLANO, TX 436,023436.0k $20.4m $20.4m 0.01% Reduced -5.3k -5,272
41 FRANKLIN RESOURCES INC 0.01% of their portfolio San Mateo, CA 413,209413.2k $19.3m $19.3m 0.01% Unchanged
42 GW&K Investment Management, LLC 0.16% of their portfolio BOSTON, MA 388,066388.1k $18.2m $18.2m 0.16% Reduced -91.0k -90,997
43 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 357,142357.1k $16.7m $16.7m 0.00% Added +12.7k +12,729
44 Vivo Capital, LLC 1.29% of their portfolio Palo Alto, CA 350,000350.0k $16.4m $16.4m 1.29% Unchanged
45 Integral Health Asset Management, LLC 1.49% of their portfolio New York, NY 325,000325.0k $15.2m $15.2m 1.49% Added +125.0k +125,000
46 Duquesne Family Office LLC 0.39% of their portfolio New York, NY 309,000309.0k $14.5m $14.5m 0.39% New
47 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 296,478296.5k $13.9m $13.9m 0.00% Reduced -33.1k -33,101
48 Rock Springs Capital Management LP 0.34% of their portfolio Baltimore, MD 289,400289.4k $13.5m $13.5m 0.34% New
49 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 265,011265.0k $12.4m $12.4m 0.01% Reduced -108.6k -108,618
50 VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio San Antonio, TX 257,145257.1k $12.0m $12.0m 0.01% Added +73.0k +73,038
51 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 248,050248.1k $11.6m $11.6m 0.01% Added +145.7k +145,739
52 UBS Group AG 0.00% of their portfolio ZURICH, V8 247,803247.8k $11.6m $11.6m 0.00% Added +109.3k +109,338
53 Walleye Capital LLC 0.12% of their portfolio NEW YORK, NY 241,362241.4k $11.3m $11.3m 0.12% Reduced -27.7k -27,726
54 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 235,198235.2k $11.0m $11.0m 0.01% Added +58.8k +58,772
55 Rafferty Asset Management, LLC 0.04% of their portfolio New York, NY 216,849216.8k $10.2m $10.2m 0.04% Reduced -27.4k -27,440
56 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 211,820211.8k $9.9m $9.9m 0.00% Added +148.6k +148,645
57 Opaleye Management Inc. 2.14% of their portfolio BOSTON, MA 210,000210.0k $9.8m $9.8m 2.14% Reduced -97.5k -97,500
58 Ghost Tree Capital, LLC 3.01% of their portfolio NEW YORK, NY 200,000200.0k $9.4m $9.4m 3.01% Added +135.0k +135,000
59 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 176,943176.9k $8.3m $8.3m 0.00% Added +5.1k +5,106
60 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 171,424171.4k $8.0m $8.0m 0.01% Added +148.6k +148,632
61 BOOTHBAY FUND MANAGEMENT, LLC 0.21% of their portfolio NEW YORK, NY 162,526162.5k $7.6m $7.6m 0.21% Added +17.6k +17,615
62 Decheng Capital LLC 0.99% of their portfolio MENLO PARK, CA 157,958158.0k $7.4m $7.4m 0.99% New
63 Woodline Partners LP 0.07% of their portfolio San Francisco, CA 153,395153.4k $7.2m $7.2m 0.07% Added +3.4k +3,395
64 NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio ALBANY, NY 152,492152.5k $7.1m $7.1m 0.01% Added +124.8k +124,767
65 PRUDENTIAL FINANCIAL INC 0.01% of their portfolio NEWARK, NJ 144,634144.6k $6.8m $6.8m 0.01% Added +7.7k +7,689
66 New Leaf Venture Partners, L.L.C. 5.78% of their portfolio New York, NY 141,000141.0k $6.6m $6.6m 5.78% Unchanged
67 Schonfeld Strategic Advisors LLC 0.05% of their portfolio NEW YORK, NY 135,293135.3k $6.3m $6.3m 0.05% Added +68.0k +68,000
68 SILVERARC CAPITAL MANAGEMENT, LLC 1.68% of their portfolio BOSTON, MA 127,835127.8k $6.0m $6.0m 1.68% New
69 Swiss National Bank 0.00% of their portfolio ZURICH, V8 126,500126.5k $5.9m $5.9m 0.00% Added +22.3k +22,300
70 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 118,880118.9k $5.6m $5.6m 0.01% Reduced -74.2k -74,221
71 Pier Capital, LLC 0.75% of their portfolio STAMFORD, CT 116,570116.6k $5.5m $5.5m 0.75% Reduced -33 -33
72 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 108,693108.7k $5.1m $5.1m 0.00% Added +1.5k +1,478
73 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 107,665107.7k $5.0m $5.0m 0.00% Added +26.7k +26,699
74 Informed Momentum Co LLC 0.78% of their portfolio SOLANA BEACH, CA 106,614106.6k $5.0m $5.0m 0.78% Added +1.6k +1,609
75 FIRST TRUST ADVISORS LP 0.00% of their portfolio Wheaton, IL 101,737101.7k $4.8m $4.8m 0.00% Added +28.3k +28,280
76 Aberdeen Group plc 0.01% of their portfolio EDINBURGH, X0 101,196101.2k $4.7m $4.7m 0.01% Unchanged
77 Parkman Healthcare Partners LLC 0.58% of their portfolio STAMFORD, CT 101,119101.1k $4.7m $4.7m 0.58% Reduced -19.5k -19,533
78 Qube Research & Technologies Ltd 0.01% of their portfolio LONDON, X0 94,86794.9k $4.4m $4.4m 0.01% Added +37.2k +37,152
79 Candriam S.C.A. 0.03% of their portfolio STRASSEN, N4 88,00588.0k $4.1m $4.1m 0.03% Reduced -200.0k -200,006
80 Artia Global Partners LP 0.98% of their portfolio MIAMI, FL 85,76585.8k $4.0m $4.0m 0.98% New
81 ACUTA CAPITAL PARTNERS, LLC 2.38% of their portfolio REDWOOD CITY, CA 78,40378.4k $3.7m $3.7m 2.38% Reduced -9.1k -9,097
82 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 74,89574.9k $3.5m $3.5m 0.00% Reduced -116.1k -116,089
83 State of New Jersey Common Pension Fund D 0.01% of their portfolio TRENTON, NJ 72,10072.1k $3.4m $3.4m 0.01% New
84 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 69,60769.6k $3.3m $3.3m 0.00% Reduced -10.8k -10,820
85 Lisanti Capital Growth, LLC 0.79% of their portfolio NEW YORK, NY 69,22569.2k $3.2m $3.2m 0.79% Reduced -31.0k -31,020
86 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 68,84068.8k $3.2m $3.2m 0.00% Added +47.9k +47,898
87 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 67,27067.3k $3.1m $3.1m 0.00% Unchanged
88 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 64,29264.3k $3.0m $3.0m 0.00% Added +6.4k +6,421
89 Legal & General Group Plc 0.00% of their portfolio London, X0 63,95264.0k $3.0m $3.0m 0.00% Added +9.8k +9,847
90 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 60,28760.3k $2.8m $2.8m 0.00% Added +11.0k +11,044
91 Moody Aldrich Partners LLC 0.45% of their portfolio MARBLEHEAD, MA 56,40256.4k $2.6m $2.6m 0.45% New
92 AWM Investment Company, Inc. 0.34% of their portfolio NEW YORK, NY 55,00055.0k $2.6m $2.6m 0.34% Added +5.0k +5,000
93 ALPS ADVISORS INC 0.02% of their portfolio Denver, CO 54,96955.0k $2.6m $2.6m 0.02% Added +8.9k +8,944
94 Russell Investments Group, Ltd. 0.00% of their portfolio Seattle, WA 51,33451.3k $2.4m $2.4m 0.00% Added +51.3k +51,320
95 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 50,28250.3k $2.4m $2.4m 0.00% Added +26.6k +26,600
96 STATE OF WISCONSIN INVESTMENT BOARD 0.01% of their portfolio MADISON, WI 50,11150.1k $2.3m $2.3m 0.01% Reduced -7.7k -7,657
97 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 49,25849.3k $2.3m $2.3m 0.00% Reduced -4.3k -4,348
98 BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio PARIS, I0 45,96046.0k $2.2m $2.2m 0.00% Reduced -134.5k -134,535
99 ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio Berwyn, PA 41,93241.9k $2.0m $2.0m 0.00% New
100 NEOS Investment Management LLC 0.12% of their portfolio Westport, CT 40,44940.4k $1.9m $1.9m 0.12% Added +27.0k +26,968