DISC MEDICINE INC IRON
COM · Common Stock · CUSIP 254604101
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersWatertown, MA
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.4m this quarter). Holder counts are more reliable. Shares outstanding: 24.7m as of 2024-02-29, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $62.11. Options: 15 managers hold calls ($22.1m notional), 15 hold puts ($68.3m).
Trends to Q1 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q4 2022 | 35 |
| Q1 2023 | 46 |
| Q2 2023 | 91 |
| Q3 2023 | 92 |
| Q4 2023 | 113 |
| Q1 2024 | 132 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q1 2023 | 28 | 8 |
| Q2 2023 | 71 | 20 |
| Q3 2023 | 58 | 36 |
| Q4 2023 | 67 | 39 |
| Q1 2024 | 90 | 40 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2023 | $1.9bn | $93.0k | 0.00 |
| Q3 2023 | $4.4m | $9.9m | 2.25 |
| Q4 2023 | $14.8m | $9.6m | 0.65 |
| Q1 2024 | $22.1m | $68.3m | 3.08 |
Biggest buyers
| STATE STREET CORP | Added | +532.0k |
| WELLINGTON MANAGEMENT GROUP LLP | Added | +492.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +353.4k |
| LORD, ABBETT & CO. LLC | New | +238.6k |
| DEERFIELD MANAGEMENT COMPANY, L.P. | Added | +201.2k |
| Saturn V Capital Management LP | Added | +190.0k |
| FMR LLC | Added | +186.1k |
| MORGAN STANLEY | Added | +185.1k |
| BANK OF AMERICA CORP /DE/ | Added | +181.7k |
| JENNISON ASSOCIATES LLC | Added | +150.2k |
Biggest sellers
| Polar Capital Holdings Plc | Reduced | -302.0k |
| 5AM Venture Management, LLC | Sold out | -294.2k |
| Atlas Venture Life Science Advisors, LLC | Reduced | -267.9k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | Reduced | -175.5k |
| Ikarian Capital, LLC | Reduced | -169.6k |
| FRANKLIN RESOURCES INC | Reduced | -119.4k |
| PERCEPTIVE ADVISORS LLC | Reduced | -83.2k |
| STEMPOINT CAPITAL LP | Reduced | -65.3k |
| Hudson Bay Capital Management LP | Sold out | -62.0k |
| Caption Management, LLC | Sold out | -43.0k |
Biggest calls
| JANE STREET GROUP, LLC | Added | $4.5m72.2k shares |
| Ikarian Capital, LLC | New | $3.1m49.6k shares |
| CITADEL ADVISORS LLC | Added | $2.9m47.2k shares |
| Caption Management, LLC | Reduced | $2.3m37.5k shares |
| MILLENNIUM MANAGEMENT LLC | New | $2.2m35.0k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $1.7m27.1k shares |
| SPHERA FUNDS MANAGEMENT LTD. | New | $1.6m25.0k shares |
| Belvedere Trading LLC | New | $1.5m23.4k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | New | $803.2k12.9k shares |
| HAP Trading, LLC | New | $795.6k95.7k shares |
Biggest puts
| Ikarian Capital, LLC | New | $24.7m396.6k shares |
| PERCEPTIVE ADVISORS LLC | New | $18.7m300.0k shares |
| BOOTHBAY FUND MANAGEMENT, LLC | New | $7.0m112.5k shares |
| Caption Management, LLC | Reduced | $4.3m69.8k shares |
| MILLENNIUM MANAGEMENT LLC | New | $4.1m66.2k shares |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | New | $3.7m59.6k shares |
| SIMPLEX TRADING, LLC | Added | $2.8m44.4k shares |
| JANE STREET GROUP, LLC | New | $1.6m25.5k shares |
| CITADEL ADVISORS LLC | Added | $884.1k14.2k shares |
| Belvedere Trading LLC | New | $236.6k3.8k shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| FMR LLC 13G · institution -1.3 pts · filed 2026-08-06 | 12.8% |
| AI DMI LLC 13D · may seek influence -1.4 pts · filed 2026-10-26 | 6.6% |
| RA CAPITAL MANAGEMENT, L.P. 13G · passive investor new · filed 2026-01-07 | 5.9% |
Fell to 5% or below in the last year: Atlas Venture Fund X, L.P. (2.2%, 2025-12-17)
Insider purchases and sales in Q1 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 2 | $2.5m | 0 | — | — |
| Q2 2023 | 0 | — | 3 | $1.4m | $1.4m |
| Q3 2023 | 0 | — | 3 | $4.9m | $1.1m |
| Q4 2023 | 0 | — | 6 | $40.5m | $1.1m |
| Q1 2024 | 0 | — | 1 | $10.1m | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-03-05 | Bitterman Kevin Director · See footnote | Sold | $1.9m26.2k shares |
| 2024-01-23 | Bitterman Kevin Director · See footnote | Sold | $6.9m102.5k shares |
| 2024-01-23 | Atlas Venture Fund X, L.P. +8 10% owner · See footnote | Sold | $5.6m82.5k shares |
| 2024-01-23 | Atlas Venture Fund X, L.P. +8 10% owner | Sold | $3.2m47.5k shares |
| 2024-01-23 | Atlas Venture Fund X, L.P. +8 10% owner | Sold | $1.4m20.0k shares |
| 2024-01-10 | Atlas Venture Fund X, L.P. +5 10% owner | Sold | $1.9m30.0k shares |
| 2024-01-10 | Atlas Venture Fund X, L.P. +5 10% owner | Sold | $1.3m20.0k shares |
| 2024-01-10 | Bitterman Kevin Director · See footnote | Sold | $1.3m20.0k shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2024
| Manager | Shares | Change |
|---|---|---|
| Paradigm Biocapital Advisors LP 5.24% of their portfolio | 2.4m $148.8m | Added +4.0k |
| Atlas Venture Life Science Advisors, LLC 13.14% of their portfolio | 2.3m $142.4m | Reduced -267.9k |
| ORBIMED ADVISORS LLC 1.95% of their portfolio | 1.7m $106.0m | Unchanged |
| Bain Capital Life Sciences Investors, LLC 6.59% of their portfolio | 1.3m $82.0m | Reduced -15.3k |
| STATE STREET CORP 0.00% of their portfolio | 1.1m $67.9m | Added +532.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio | 944.2k $58.8m | Added +353.4k |
| PERCEPTIVE ADVISORS LLC 1.03% of their portfolio | 939.9k $58.5m | Reduced -83.2k |
| BlackRock Inc. 0.00% of their portfolio | 901.6k $56.1m | Added +33.2k |
| Frazier Life Sciences Management, L.P. 2.06% of their portfolio | 785.0k $48.9m | Unchanged |
| VANGUARD GROUP INC 0.00% of their portfolio | 782.8k $48.7m | Added +18.2k |
| WELLINGTON MANAGEMENT GROUP LLP 0.01% of their portfolio | 670.5k $41.7m | Added +492.8k |
| DEERFIELD MANAGEMENT COMPANY, L.P. 0.72% of their portfolio | 665.5k $41.4m | Added +201.2k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.07% of their portfolio | 574.5k $35.8m | Reduced -175.5k |
| JANUS HENDERSON GROUP PLC 0.02% of their portfolio | 521.8k $32.5m | Added +78.6k |
| ALLIANCEBERNSTEIN L.P. 0.01% of their portfolio | 496.9k $30.9m | Added +133.8k |
| MORGAN STANLEY 0.00% of their portfolio | 409.9k $25.5m | Added +185.1k |
| FMR LLC 0.00% of their portfolio | 403.5k $25.1m | Added +186.1k |
| Rock Springs Capital Management LP 0.58% of their portfolio | 363.5k $22.6m | Unchanged |
| CITADEL ADVISORS LLC 0.02% of their portfolio | 325.7k $20.3m | Added +137.8k |
| Saturn V Capital Management LP 6.36% of their portfolio | 254.8k $15.9m | Added +190.0k |
| First Turn Management, LLC 2.35% of their portfolio | 252.7k $15.7m | Added +95.4k |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 245.8k $15.3m | Added +16.4k |
| Polar Capital Holdings Plc 0.08% of their portfolio | 244.9k $15.2m | Reduced -302.0k |
| Foresite Capital Management V, LLC 14.23% of their portfolio | 243.5k $15.2m | Unchanged |
| LORD, ABBETT & CO. LLC 0.02% of their portfolio | 238.6k $14.9m | New |
| Pictet Asset Management Holding SA 0.02% of their portfolio | 231.8k $14.4m | Added +36.7k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 213.7k $13.3m | Added +181.7k |
| VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio | 213.1k $13.3m | Added +25.5k |
| JENNISON ASSOCIATES LLC 0.01% of their portfolio | 193.2k $12.0m | Added +150.2k |
| Blue Owl Capital Holdings LP 1.93% of their portfolio | 155.3k $9.7m | Added +15.0k |
| Cormorant Asset Management, LP 0.34% of their portfolio | 125.0k $7.8m | Unchanged |
| EAGLE ASSET MANAGEMENT INC 0.02% of their portfolio | 115.7k $4.0m | New |
| MPM BIOIMPACT LLC 1.12% of their portfolio | 110.8k $6.9m | Added +60.8k |
| Artisan Partners Limited Partnership 0.01% of their portfolio | 109.3k $6.8m | New |
| Parkman Healthcare Partners LLC 0.82% of their portfolio | 107.6k $6.7m | Added +14.7k |
| Rafferty Asset Management, LLC 0.02% of their portfolio | 102.9k $6.4m | Added +63.0k |
| FRANKLIN RESOURCES INC 0.00% of their portfolio | 102.0k $6.4m | Reduced -119.4k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 97.4k $6.1m | Added +2.1k |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio | 92.1k $5.7m | Added +2.4k |
| CITIGROUP INC 0.01% of their portfolio | 89.3k $5.6m | Added +72.6k |
| Artia Global Partners LP 1.33% of their portfolio | 87.0k $5.4m | New |
| Candriam S.C.A. 0.03% of their portfolio | 80.0k $5.0m | Unchanged |
| ACUTA CAPITAL PARTNERS, LLC 3.11% of their portfolio | 76.8k $4.8m | Reduced -38.7k |
| Qube Research & Technologies Ltd 0.01% of their portfolio | 74.8k $4.7m | Added +24.1k |
| Invesco Ltd. 0.00% of their portfolio | 71.4k $4.4m | Reduced -42.6k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 68.4k $4.3m | Added +6.2k |
| UBS Group AG 0.00% of their portfolio | 63.0k $3.9m | Added +49.4k |
| Nicholas Investment Partners, LP 0.39% of their portfolio | 61.5k $3.8m | Added +21.0k |
| STEMPOINT CAPITAL LP 1.00% of their portfolio | 60.1k $3.7m | Reduced -65.3k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.00% of their portfolio | 56.5k $3.5m | Reduced -1.8k |
| SPHERA FUNDS MANAGEMENT LTD. 0.49% of their portfolio | 48.9k $3.0m | New |
| Schonfeld Strategic Advisors LLC 0.02% of their portfolio | 48.6k $3.0m | Added +26.2k |
| Informed Momentum Co LLC 0.43% of their portfolio | 43.8k $2.7m | Reduced -9.1k |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 40.8k $2.5m | Added +20.0k |
| Ensign Peak Advisors, Inc 0.00% of their portfolio | 40.0k $2.5m | Unchanged |
| Nuveen Asset Management, LLC 0.00% of their portfolio | 39.6k $2.5m | Added +5.7k |
| TD Asset Management Inc 0.00% of their portfolio | 39.3k $2.4m | Added +19.1k |
| ExodusPoint Capital Management, LP 0.02% of their portfolio | 32.1k $2.0m | New |
| Bank of New York Mellon Corp 0.00% of their portfolio | 27.0k $1.7m | Reduced -3.5k |
| Ikarian Capital, LLC 0.43% of their portfolio | 25.4k $1.6m | Reduced -169.6k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 24.5k $1.5m | Reduced -7.5k |
| Swiss National Bank 0.00% of their portfolio | 23.8k $1.5m | Added +8.0k |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 23.7k $1.5m | Added +13.7k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 22.3k $1.4m | Added +3.4k |
| PRUDENTIAL FINANCIAL INC 0.00% of their portfolio | 19.7k $1.2m | New |
| NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio | 19.3k $1.2m | Added +9.6k |
| Harvest Investment Services, LLC 0.46% of their portfolio | 18.4k $1.1m | New |
| Connor, Clark & Lunn Investment Management Ltd. 0.00% of their portfolio | 18.0k $1.1m | Reduced -7.1k |
| ALPS ADVISORS INC 0.01% of their portfolio | 17.0k $1.1m | Added +880 |
| PROFUND ADVISORS LLC 0.04% of their portfolio | 15.8k $982.7k | Added +9.3k |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 14.7k $915.9k | Reduced -8.4k |
| BARCLAYS PLC 0.00% of their portfolio | 14.4k $898.0k | Reduced -14.0k |
| TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio | 13.5k $839.8k | New |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 13.1k $817.6k | Added +486 |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio | 12.5k $777.8k | Added +5.6k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 12.5k $776.6k | Added +8.9k |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio | 11.8k $734.7k | Added +3.2k |
| MARTINGALE ASSET MANAGEMENT L P 0.01% of their portfolio | 11.4k $709.8k | Added +100 |
| Walleye Capital LLC 0.01% of their portfolio | 11.3k $700.7k | New |
| CREDIT SUISSE AG/ 0.00% of their portfolio | 10.4k $646.7k | Added +2.5k |
| STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio | 8.9k $554.2k | Added +2.1k |
| Legal & General Group Plc 0.00% of their portfolio | 8.8k $545.9k | Reduced -14 |
| RENAISSANCE TECHNOLOGIES LLC 0.00% of their portfolio | 8.5k $530.0k | Reduced -39.8k |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 8.2k $510.1k | Added +5.6k |
| STIFEL FINANCIAL CORP 0.00% of their portfolio | 8.2k $508.2k | Added +3 |
| Legato Capital Management LLC 0.06% of their portfolio | 7.9k $490.1k | Added +2.6k |
| BOOTHBAY FUND MANAGEMENT, LLC 0.01% of their portfolio | 6.8k $420.8k | Reduced -36.4k |
| BANK OF MONTREAL /CAN/ 0.00% of their portfolio | 6.5k $404.0k | New |
| RAYMOND JAMES & ASSOCIATES 0.00% of their portfolio | 6.4k $398.5k | New |
| Sofinnova Investments, Inc. 0.02% of their portfolio | 6.2k $384.3k | New |
| E Fund Management Co., Ltd. 0.02% of their portfolio | 4.9k $302.6k | New |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio | 4.8k $302.0k | New |
| MetLife Investment Management, LLC 0.00% of their portfolio | 4.8k $298.4k | Unchanged |
| AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio | 4.6k $289.4k | Added +205 |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 4.6k $289.3k | Added +124 |
| China Universal Asset Management Co., Ltd. 0.04% of their portfolio | 4.6k $288.9k | Added +1.8k |
| Bleakley Financial Group, LLC 0.01% of their portfolio | 4.6k $284.7k | Added +856 |
| Simplicity Wealth,LLC 0.01% of their portfolio | 4.6k $284.3k | New |
| Engineers Gate Manager LP 0.01% of their portfolio | 4.6k $283.9k | Reduced -6.9k |
| Fiduciary Trust Co 0.00% of their portfolio | 4.1k $252.2k | Unchanged |