Vault-13

APOGEE THERAPEUTICS INC

COM · CUSIP 03770N101 · ISIN US03770N1019

140 institutional holders +54 vs Q4 2023
53,202,35953.2m shares reported held*
$3.5bnreported value*
60 new 52 added 19 reduced 7 sold out net bought ≈ $734.6m (+11.1m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($624.6k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $66.45. Options: 4 managers hold calls ($4.5m notional), 2 hold puts ($338.9k).

Trends to Q1 2024

Institutional holders

Managers reporting a position, each quarter

050100150Q3 23: 74Q4 23: 86Q1 24: 140140Q3 23Q4 23Q1 24
Numbers
QuarterHolders
Q3 202374
Q4 202386
Q1 2024140

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 23: 52 bought or addedQ4 23: 17 cut or sold outQ4 23Q1 24: 112 bought or addedQ1 24: 26 cut or sold outQ1 24
Numbers
QuarterBought or addedCut or sold out
Q4 20235217
Q1 202411226

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$2m$4m$6mQ2 23 calls: $0Q2 23 puts: $0Q2 23P/C —Q3 23 calls: $0Q3 23 puts: $0Q3 23P/C —Q4 23 calls: $0Q4 23 puts: $0Q4 23P/C —Q1 24 calls: $4.5mQ1 24 puts: $338.9kQ1 24P/C 0.08
Numbers
QuarterCallsPutsP/C
Q2 2023$0$0—
Q3 2023$0$0—
Q4 2023$0$0—
Q1 2024$4.5m$338.9k0.08

Biggest buyers

FMR LLC Added +1,725,022+1.7m
BlackRock Inc. Added +1,165,788+1.2m
BRAIDWELL LP Added +1,161,414+1.2m
STATE STREET CORP Added +968,527+968.5k
Darwin Global Management, Ltd. New +832,198+832.2k
Driehaus Capital Management LLC Added +734,699+734.7k
ALLIANCEBERNSTEIN L.P. Added +734,478+734.5k
VANGUARD GROUP INC Added +705,795+705.8k
WELLINGTON MANAGEMENT GROUP LLP Added +678,419+678.4k
PRICE T ROWE ASSOCIATES INC /MD/ Added +399,646+399.6k

Biggest sellers

Fairmount Funds Management LLC Reduced -892,529-892.5k
ORBIMED ADVISORS LLC Reduced -559,000-559.0k
JANUS HENDERSON GROUP PLC Reduced -473,576-473.6k
Frazier Life Sciences Management, L.P. Sold out -400,000-400.0k
Vivo Capital, LLC Sold out -400,000-400.0k
ADAGE CAPITAL PARTNERS GP, L.L.C. Reduced -350,000-350.0k
Point72 Asset Management, L.P. Reduced -221,200-221.2k
Blackstone Inc. Reduced -121,810-121.8k
PLATINUM INVESTMENT MANAGEMENT LTD Reduced -115,805-115.8k
Holocene Advisors, LP Sold out -101,202-101.2k

Biggest calls

Caption Management, LLC New $3.3m50.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP New $1.2m17.7k shares
CITADEL ADVISORS LLC New $13.3k200 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. New $00 shares

Biggest puts

CITADEL ADVISORS LLC New $338.9k5.1k shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. New $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
BlackRock, Inc. 13G · institution filed 2025-07-16 5.5% 2.5m≈ $334.3m 2025-07-16

Fell to 5% or below in the last year: Venrock Healthcare Capital Partners III, L.P. (0.0%, 2026-09-08), Fairmount Funds Management LLC (0.0%, 2026-09-03), FMR LLC (4.0%, 2026-07-08), WELLINGTON MANAGEMENT GROUP LLP (0.9%, 2026-07-08), T. Rowe Price Investment Management, Inc. (1.3%, 2026-07-08), VANGUARD GROUP INC (0.0%, 2026-03-26), RTW INVESTMENTS, LP (4.9%, 2026-02-17), DRIEHAUS CAPITAL MANAGEMENT LLC (4.7%, 2025-11-14)

Holders, Q1 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Venrock Adviser, LLC 26.85% of their portfolio NEW YORK, NY 8,493,3218.5m $564.4m $564.4m 26.85% Unchanged
2 FMR LLC 0.03% of their portfolio BOSTON, MA 6,743,9026.7m $448.1m $448.1m 0.03% Added +1.7m +1,725,022
3 BlackRock Inc. 0.00% of their portfolio New York, NY 2,809,8252.8m $186.7m $186.7m 0.00% Added +1.2m +1,165,788
4 RTW INVESTMENTS, LP 2.42% of their portfolio NEW YORK, NY 2,467,5912.5m $164.0m $164.0m 2.42% Added +325.0k +325,000
5 Deep Track Capital, LP 4.44% of their portfolio GREENWICH, CT 2,323,4562.3m $154.4m $154.4m 4.44% Unchanged
6 WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio Boston, MA 2,269,8972.3m $150.8m $150.8m 0.03% Added +678.4k +678,419
7 Driehaus Capital Management LLC 1.37% of their portfolio Chicago, IL 2,063,7632.1m $137.1m $137.1m 1.37% Added +734.7k +734,699
8 PERCEPTIVE ADVISORS LLC 2.41% of their portfolio NEW YORK, NY 2,060,3952.1m $136.9m $136.9m 2.41% Added +232.5k +232,494
9 Fairmount Funds Management LLC 14.84% of their portfolio WEST CONSHOHOCKEN, PA 2,048,6472.0m $136.1m $136.1m 14.84% Reduced -892.5k -892,529
10 RA CAPITAL MANAGEMENT, L.P. 1.67% of their portfolio BOSTON, MA 1,977,9012.0m $131.4m $131.4m 1.67% Unchanged
11 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 1,868,6661.9m $124.2m $124.2m 0.00% Added +705.8k +705,795
12 BRAIDWELL LP 3.95% of their portfolio STAMFORD, CT 1,842,5151.8m $122.4m $122.4m 3.95% Added +1.2m +1,161,414
13 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 1,347,7971.3m $89.6m $89.6m 0.00% Added +968.5k +968,527
14 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 1,170,3271.2m $77.8m $77.8m 0.01% Added +399.6k +399,646
15 FRANKLIN RESOURCES INC 0.02% of their portfolio San Mateo, CA 1,035,3801.0m $68.8m $68.8m 0.02% Reduced -54.4k -54,400
16 Darwin Global Management, Ltd. 7.36% of their portfolio ST. HELIER, Y9 832,198832.2k $55.3m $55.3m 7.36% New
17 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 761,024761.0k $50.6m $50.6m 0.00% Added +319.6k +319,552
18 ALLIANCEBERNSTEIN L.P. 0.02% of their portfolio NASHVILLE, TN 745,118745.1k $49.5m $49.5m 0.02% Added +734.5k +734,478
19 ORBIMED ADVISORS LLC 0.88% of their portfolio New York, NY 718,901718.9k $47.8m $47.8m 0.88% Reduced -559.0k -559,000
20 Woodline Partners LP 0.43% of their portfolio San Francisco, CA 702,421702.4k $46.7m $46.7m 0.43% Added +376.3k +376,319
21 Affinity Asset Advisors, LLC 6.40% of their portfolio NEW YORK, NY 592,093592.1k $39.3m $39.3m 6.40% Added +55.0k +55,000
22 Point72 Asset Management, L.P. 0.09% of their portfolio STAMFORD, CT 487,200487.2k $32.4m $32.4m 0.09% Reduced -221.2k -221,200
23 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 408,414408.4k $27.1m $27.1m 0.00% Added +273.0k +273,016
24 GREAT POINT PARTNERS LLC 4.14% of their portfolio Greenwich, CT 400,000400.0k $26.6m $26.6m 4.14% Unchanged
25 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 396,778396.8k $26.4m $26.4m 0.00% Reduced -92.4k -92,431
26 Avidity Partners Management LP 0.91% of their portfolio DALLAS, TX 384,893384.9k $25.6m $25.6m 0.91% New
27 First Turn Management, LLC 3.78% of their portfolio DEL MAR, CA 379,803379.8k $25.2m $25.2m 3.78% New
28 Paradigm Biocapital Advisors LP 0.77% of their portfolio NEW YORK, NY 330,000330.0k $21.9m $21.9m 0.77% New
29 DEERFIELD MANAGEMENT COMPANY, L.P. 0.38% of their portfolio New York, NY 329,000329.0k $21.9m $21.9m 0.38% New
30 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 324,224324.2k $21.5m $21.5m 0.00% Added +147.5k +147,451
31 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.12% of their portfolio SAN FRANCISCO, CA 305,000305.0k $20.3m $20.3m 0.12% Not comparable
32 JENNISON ASSOCIATES LLC 0.01% of their portfolio NEW YORK, NY 302,892302.9k $20.1m $20.1m 0.01% Added +199.1k +199,148
33 Commodore Capital LP 1.29% of their portfolio NEW YORK, NY 290,000290.0k $19.3m $19.3m 1.29% Added +40.0k +40,000
34 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 240,766240.8k $16.0m $16.0m 0.00% Added +85.0k +85,001
35 Blackstone Inc. 0.07% of their portfolio NEW YORK, NY 230,000230.0k $15.3m $15.3m 0.07% Reduced -121.8k -121,810
36 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.02% of their portfolio Boston, MA 175,000175.0k $11.6m $11.6m 0.02% Reduced -350.0k -350,000
37 PLATINUM INVESTMENT MANAGEMENT LTD 0.45% of their portfolio SYDNEY AUSTRALIA 2000, C3 167,878167.9k $11.2m $11.2m 0.45% Reduced -115.8k -115,805
38 Artal Group S.A. 0.26% of their portfolio LUXEMBOURG, N4 152,500152.5k $10.1m $10.1m 0.26% New
39 TD Asset Management Inc 0.01% of their portfolio Toronto, A6 148,206148.2k $9.8m $9.8m 0.01% Added +47.4k +47,360
40 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 137,267137.3k $9.1m $9.1m 0.00% Added +71.6k +71,584
41 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 131,522131.5k $8.7m $8.7m 0.00% Added +75.8k +75,799
42 HighVista Strategies LLC 2.83% of their portfolio BOSTON, MA 119,403119.4k $7.9m $7.9m 2.83% New
43 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 118,974119.0k $7.9m $7.9m 0.01% Added +90.2k +90,199
44 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 116,673116.7k $7.8m $7.8m 0.00% Added +105.1k +105,064
45 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 112,992113.0k $7.5m $7.5m 0.00% Added +85.2k +85,241
46 ArrowMark Colorado Holdings LLC 0.08% of their portfolio Denver, CO 109,410109.4k $7.3m $7.3m 0.08% Added +30.0k +30,000
47 TANG CAPITAL MANAGEMENT LLC 0.69% of their portfolio SAN DIEGO, CA 100,000100.0k $6.6m $6.6m 0.69% New
48 VICTORY CAPITAL MANAGEMENT INC 0.01% of their portfolio San Antonio, TX 99,65999.7k $6.6m $6.6m 0.01% Added +83.8k +83,839
49 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 93,10693.1k $6.2m $6.2m 0.01% Added +89.3k +89,337
50 Candriam S.C.A. 0.04% of their portfolio STRASSEN, N4 90,00090.0k $6.0m $6.0m 0.04% New
51 TWO SIGMA INVESTMENTS, LP 0.01% of their portfolio NEW YORK, NY 89,48089.5k $5.9m $5.9m 0.01% Added +64.4k +64,441
52 RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio NEW YORK, NY 88,70088.7k $5.9m $5.9m 0.01% New
53 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio Toronto, A6 85,20185.2k $5.7m $5.7m 0.01% Added +34.1k +34,101
54 Sio Capital Management, LLC 1.81% of their portfolio NEW YORK, NY 78,00078.0k $5.2m $5.2m 1.81% New
55 FRONTIER CAPITAL MANAGEMENT CO LLC 0.05% of their portfolio Boston, MA 76,48176.5k $5.1m $5.1m 0.05% New
56 UBS Group AG 0.00% of their portfolio ZURICH, V8 76,03176.0k $5.1m $5.1m 0.00% New
57 Rafferty Asset Management, LLC 0.02% of their portfolio New York, NY 66,12866.1k $4.4m $4.4m 0.02% New
58 Artia Global Partners LP 1.00% of their portfolio MIAMI, FL 61,59061.6k $4.1m $4.1m 1.00% Added +51.2k +51,209
59 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 56,17956.2k $3.7m $3.7m 0.00% Added +42.8k +42,776
60 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 55,69655.7k $3.7m $3.7m 0.00% Added +28.5k +28,468
61 Informed Momentum Co LLC 0.57% of their portfolio SOLANA BEACH, CA 55,11355.1k $3.7m $3.7m 0.57% New
62 SILVERARC CAPITAL MANAGEMENT, LLC 0.93% of their portfolio BOSTON, MA 50,00050.0k $3.3m $3.3m 0.93% New
63 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 48,66648.7k $3.2m $3.2m 0.00% Added +2.5k +2,538
64 SUPERSTRING CAPITAL MANAGEMENT LP 1.97% of their portfolio NEW YORK, NY 44,86844.9k $3.0m $3.0m 1.97% New
65 Swiss National Bank 0.00% of their portfolio ZURICH, V8 41,30041.3k $2.7m $2.7m 0.00% Added +8.3k +8,300
66 CAPSTONE INVESTMENT ADVISORS, LLC 0.05% of their portfolio NEW YORK, NY 41,00141.0k $2.7m $2.7m 0.05% New
67 Integral Health Asset Management, LLC 0.26% of their portfolio New York, NY 40,00040.0k $2.7m $2.7m 0.26% New
68 Nicholas Investment Partners, LP 0.26% of their portfolio RANCHO SANTA FE, CA 37,74737.7k $2.5m $2.5m 0.26% New
69 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 36,64636.6k $2.4m $2.4m 0.00% Added +2.6k +2,590
70 Cinctive Capital Management LP 0.08% of their portfolio New York, NY 23,22923.2k $1.5m $1.5m 0.08% New
71 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 23,00223.0k $1.5m $1.5m 0.00% Added +4.7k +4,693
72 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 21,77021.8k $1.4m $1.4m 0.00% Added +12.8k +12,801
73 MetLife Investment Management, LLC 0.01% of their portfolio Whippany, NJ 21,22921.2k $1.4m $1.4m 0.01% Added +10.6k +10,591
74 AMERICAN INTERNATIONAL GROUP, INC. 0.00% of their portfolio New York, NY 20,39120.4k $1.4m $1.4m 0.00% Added +10.2k +10,188
75 Legal & General Group Plc 0.00% of their portfolio London, X0 20,25920.3k $1.3m $1.3m 0.00% Added +9.9k +9,922
76 Soleus Capital Management, L.P. 0.12% of their portfolio GREENWICH, CT 20,00020.0k $1.3m $1.3m 0.12% Reduced -15.0k -15,000
77 DEUTSCHE BANK AG\ 0.00% of their portfolio FRANKFURT AM MAIN, 2M 19,20619.2k $1.3m $1.3m 0.00% Added +11.5k +11,535
78 Squarepoint Ops LLC 0.00% of their portfolio NEW YORK, NY 18,19318.2k $1.2m $1.2m 0.00% New
79 CREDIT SUISSE AG/ 0.00% of their portfolio ZURICH, V8 17,68617.7k $1.2m $1.2m 0.00% Added +2.9k +2,949
80 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.00% of their portfolio BALA CYNWYD, PA 16,65816.7k $1.1m $1.1m 0.00% Added +7.2k +7,177
81 FIRST TRUST ADVISORS LP 0.00% of their portfolio Wheaton, IL 14,81814.8k $984.7k $984.7k 0.00% New
82 TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.01% of their portfolio FRANKFORT, KY 14,80714.8k $984.0k $984.0k 0.01% Reduced -7.4k -7,441
83 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 13,42813.4k $892.3k $892.3k 0.00% Added +7.6k +7,570
84 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 13,33313.3k $886.0k $886.0k 0.00% Added +5.2k +5,180
85 TUDOR INVESTMENT CORP ET AL 0.01% of their portfolio STAMFORD, CT 12,52212.5k $832.1k $832.1k 0.01% New
86 NORGES BANK 0.00% of their portfolio OSLO, Q8 12,12112.1k $805.4k $805.4k 0.00% Added +2.9k +2,890
87 Ensign Peak Advisors, Inc 0.00% of their portfolio SALT LAKE CITY, UT 12,00012.0k $797.4k $797.4k 0.00% New
88 PROFUND ADVISORS LLC 0.03% of their portfolio BETHESDA, MD 10,92010.9k $725.6k $725.6k 0.03% New
89 Scientech Research LLC 0.36% of their portfolio JERSEY CITY, NJ 10,12110.1k $672.5k $672.5k 0.36% New
90 STATE OF WISCONSIN INVESTMENT BOARD 0.00% of their portfolio MADISON, WI 10,08610.1k $670.2k $670.2k 0.00% Reduced -3.7k -3,700
91 ProShare Advisors LLC 0.00% of their portfolio BETHESDA, MD 10,03810.0k $667.0k $667.0k 0.00% New
92 SEI INVESTMENTS CO 0.00% of their portfolio OAKS, PA 9,7519.8k $648.0k $648.0k 0.00% New
93 PDT Partners, LLC 0.06% of their portfolio New York, NY 9,6299.6k $639.8k $639.8k 0.06% New
94 DARK FOREST CAPITAL MANAGEMENT LP 0.09% of their portfolio NEW YORK, NY 7,8977.9k $524.8k $524.8k 0.09% New
95 Global Endowment Management, LP 0.05% of their portfolio CHARLOTTE, NC 7,7977.8k $518.1k $518.1k 0.05% New
96 China Universal Asset Management Co., Ltd. 0.06% of their portfolio SHANGHAI, F4 7,1557.2k $475.4k $475.4k 0.06% Added +1.6k +1,600
97 Bayesian Capital Management, LP 0.04% of their portfolio Brooklyn, NY 6,7716.8k $449.9k $449.9k 0.04% New
98 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 6,7656.8k $449.5k $449.5k 0.00% New
99 Family Manage LLC 0.08% of their portfolio NEW YORK, NY 6,7406.7k $447.9k $447.9k 0.08% New
100 COMERICA BANK 0.00% of their portfolio DALLAS, TX 6,5766.6k $437.0k $437.0k 0.00% Added +6.5k +6,470