BICYCLE THERAPEUTICS PLC BCYC
SPONSORED ADS · ADR · CUSIP 088786108 · ISIN US0887861088
Company in Cambridge, United Kingdom
- SectorHealth care
- IndustryPharmaceutical Preparations
- HeadquartersCambridge, United Kingdom
- Founded2009
- Websitebicycletherapeutics.com
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($234.6k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $24.90. Options: 6 managers hold calls ($599.9k notional), 4 hold puts ($340.6k).
Trends to Q1 2024
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 80 |
| Q4 2022 | 87 |
| Q1 2023 | 90 |
| Q2 2023 | 86 |
| Q3 2023 | 102 |
| Q4 2023 | 102 |
| Q1 2024 | 96 |
Buyers vs sellers
Managers adding to or starting a position, vs cutting or selling out
Numbers
| Quarter | Bought or added | Cut or sold out |
|---|---|---|
| Q4 2022 | 32 | 43 |
| Q1 2023 | 53 | 29 |
| Q2 2023 | 39 | 41 |
| Q3 2023 | 58 | 31 |
| Q4 2023 | 54 | 51 |
| Q1 2024 | 40 | 49 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q2 2023 | $170.8k | $5.3m | 30.96 |
| Q3 2023 | $2.0m | $3.8m | 1.89 |
| Q4 2023 | $3.0m | $3.2m | 1.06 |
| Q1 2024 | $599.9k | $340.6k | 0.57 |
Biggest buyers
| BAKER BROS. ADVISORS LP | Added | +3.2m |
| MORGAN STANLEY | Added | +2.5m |
| Schonfeld Strategic Advisors LLC | Added | +313.8k |
| Parkman Healthcare Partners LLC | Added | +211.4k |
| Duquesne Family Office LLC | New | +190.2k |
| ARMISTICE CAPITAL, LLC | Added | +136.0k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Added | +124.8k |
| WESTFIELD CAPITAL MANAGEMENT CO LP | Added | +121.6k |
| Point72 Asset Management, L.P. | Added | +116.7k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. | Added | +100.1k |
Biggest sellers
| Jefferies Financial Group Inc. | Sold out | -1.9m |
| AXA S.A. | Reduced | -554.0k |
| Paradigm Biocapital Advisors LP | Reduced | -460.2k |
| NOMURA HOLDINGS INC | Sold out | -400.0k |
| Verition Fund Management LLC | Reduced | -399.7k |
| First Light Asset Management, LLC | Reduced | -357.4k |
| FMR LLC | Sold out | -266.3k |
| MILLENNIUM MANAGEMENT LLC | Sold out | -249.1k |
| CITADEL ADVISORS LLC | Reduced | -235.0k |
| Man Group plc | Sold out | -174.1k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Reduced | $226.6k9.1k shares |
| CITADEL ADVISORS LLC | Reduced | $159.4k6.4k shares |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | Reduced | $129.5k70.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $82.0k3.3k shares |
| GROUP ONE TRADING LLC | Reduced | $2.5k100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Biggest puts
| CITADEL ADVISORS LLC | Reduced | $288.8k11.6k shares |
| GROUP ONE TRADING LLC | Reduced | $49.8k2.0k shares |
| SIMPLEX TRADING, LLC | Reduced | $2.0k100 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
| Holder | Stake |
|---|---|
| Forbion Growth Opportunities Fund II Cooperatief U.A. 13G · passive investor new · filed 2024-12-19 | 7.3% |
| ARMISTICE CAPITAL, LLC 13G · institution no change · filed 2026-08-14 | 6.7% |
| Long Focus Capital Management, LLC 13G · institution new · filed 2026-05-15 | 6.6% |
Fell to 5% or below in the last year: Invus Global Management, LLC (3.1%, 2026-05-04), WESTFIELD CAPITAL MANAGEMENT CO LP (0.0%, 2026-03-04)
Insider purchases and sales in Q1 2024
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
Officers and directors buying vs selling
Number of people, by quarter (10% owners not included)
Numbers
| Quarter | Buying | Bought | Selling | Sold | Sold under a plan |
|---|---|---|---|---|---|
| Q2 2022 | 0 | — | 0 | — | — |
| Q3 2022 | 0 | — | 0 | — | — |
| Q4 2022 | 0 | — | 0 | — | — |
| Q1 2023 | 0 | — | 7 | $332.2k | — |
| Q2 2023 | 0 | — | 6 | $55.5k | — |
| Q3 2023 | 0 | — | 6 | $58.9k | — |
| Q4 2023 | 0 | — | 6 | $44.8k | — |
| Q1 2024 | 0 | — | 6 | $255.3k | — |
| Date | Insider | Trade | Value |
|---|---|---|---|
| 2024-01-03 | Lee Kevin Chief Executive Officer, director | Sold | $152.3k8.7k shares |
| 2024-01-03 | Skynner Michael Chief Technology Officer | Sold | $46.3k2.6k shares |
| 2024-01-03 | Milnes Alistair Chief Operating Officer | Sold | $46.3k2.6k shares |
| 2024-01-03 | Crockett Nigel Chief Business Officer | Sold | $46.3k2.6k shares |
| 2024-01-03 | Keen Nicholas Chief Scientific Officer | Sold | $46.2k2.6k shares |
| 2024-01-03 | Thompson Travis Alvin Chief Accounting Officer | Sold | $10.6k604 shares |
Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).
Holders, Q1 2024
| Manager | Shares | Change |
|---|---|---|
| BAKER BROS. ADVISORS LP 1.54% of their portfolio | 4.9m $123.1m | Added +3.2m |
| MORGAN STANLEY 0.00% of their portfolio | 4.6m $113.3m | Added +2.5m |
| Deep Track Capital, LP 2.50% of their portfolio | 3.5m $86.9m | Unchanged |
| Paradigm Biocapital Advisors LP 2.85% of their portfolio | 3.2m $80.8m | Reduced -460.2k |
| ARMISTICE CAPITAL, LLC 1.11% of their portfolio | 1.7m $41.6m | Added +136.0k |
| TYBOURNE CAPITAL MANAGEMENT (HK) LTD 6.58% of their portfolio | 1.5m $38.5m | Reduced -105.3k |
| First Light Asset Management, LLC 2.27% of their portfolio | 1.2m $29.7m | Reduced -357.4k |
| WESTFIELD CAPITAL MANAGEMENT CO LP 0.14% of their portfolio | 1.0m $25.9m | Added +121.6k |
| Polar Capital Holdings Plc 0.13% of their portfolio | 1.0m $25.0m | Unchanged |
| MONTANOVA CAPITAL, LLC 0.96% of their portfolio | 914.5k $22.8m | Unchanged |
| Candriam S.C.A. 0.14% of their portfolio | 889.3k $22.1m | Added +20.0k |
| BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.06% of their portfolio | 883.1k $22.0m | Added +100.1k |
| RA CAPITAL MANAGEMENT, L.P. 0.25% of their portfolio | 800.0k $19.9m | Unchanged |
| BlackRock Inc. 0.00% of their portfolio | 575.0k $14.3m | Added +73.4k |
| AXA S.A. 0.04% of their portfolio | 554.2k $13.8m | Reduced -554.0k |
| Parkman Healthcare Partners LLC 1.60% of their portfolio | 524.3k $13.1m | Added +211.4k |
| Camber Capital Management LP 0.39% of their portfolio | 450.0k $11.2m | Unchanged |
| Schonfeld Strategic Advisors LLC 0.08% of their portfolio | 420.8k $10.5m | Added +313.8k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio | 401.6k $10.0m | Added +124.8k |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 396.8k $9.9m | Reduced -64.5k |
| Point72 Asset Management, L.P. 0.02% of their portfolio | 342.6k $8.5m | Added +116.7k |
| Verition Fund Management LLC 0.08% of their portfolio | 340.9k $8.5m | Reduced -399.7k |
| PLATINUM INVESTMENT MANAGEMENT LTD 0.33% of their portfolio | 333.0k $8.3m | Reduced -29.1k |
| KENNEDY CAPITAL MANAGEMENT LLC 0.13% of their portfolio | 252.2k $6.3m | Reduced -164.3k |
| Rubric Capital Management LP 0.15% of their portfolio | 205.4k $5.1m | Unchanged |
| Duquesne Family Office LLC 0.13% of their portfolio | 190.2k $4.7m | New |
| Handelsbanken Fonder AB 0.02% of their portfolio | 179.8k $4.5m | Added +40.0k |
| RENAISSANCE TECHNOLOGIES LLC 0.01% of their portfolio | 165.7k $4.1m | Added +60.2k |
| HighVista Strategies LLC 1.41% of their portfolio | 158.3k $3.9m | Unchanged |
| Soleus Capital Management, L.P. 0.33% of their portfolio | 153.0k $3.8m | Added +58.0k |
| VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 136.8k $3.4m | Added +23.6k |
| Legal & General Group Plc 0.00% of their portfolio | 133.1k $3.3m | Added +263 |
| DAFNA Capital Management LLC 0.69% of their portfolio | 122.2k $3.0m | Unchanged |
| Trexquant Investment LP 0.05% of their portfolio | 92.6k $2.3m | Reduced -103.8k |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) 0.06% of their portfolio | 85.0k $2.1m | Added +11.4k |
| PINNACLE ASSOCIATES LTD 0.03% of their portfolio | 80.1k $2.0m | New |
| COMERICA BANK 0.01% of their portfolio | 78.8k $2.0m | Reduced -3.1k |
| AlphaCentric Advisors LLC 0.90% of their portfolio | 60.0k $1.5m | New |
| CITADEL ADVISORS LLC 0.00% of their portfolio | 59.4k $1.5m | Reduced -235.0k |
| GOLDMAN SACHS GROUP INC 0.00% of their portfolio | 55.5k $1.4m | New |
| TD Asset Management Inc 0.00% of their portfolio | 55.0k $1.4m | Added +19.8k |
| L & S Advisors Inc 0.14% of their portfolio | 50.3k $1.3m | Added +40.1k |
| NATIONAL BANK OF CANADA /FI/ 0.00% of their portfolio | 48.7k $1.1m | New |
| TWO SIGMA ADVISERS, LP 0.00% of their portfolio | 46.6k $1.2m | Reduced -15.6k |
| HARBOR CAPITAL ADVISORS, INC. 0.14% of their portfolio | 43.5k $1.1m | Added +16.8k |
| Skandinaviska Enskilda Banken AB (publ) 0.01% of their portfolio | 42.7k $1.1m | New |
| WEXFORD CAPITAL LP 0.18% of their portfolio | 34.9k $868.5k | Unchanged |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 31.2k $776.3k | Added +11.0k |
| Allianz Asset Management GmbH 0.00% of their portfolio | 30.6k $761.9k | Unchanged |
| DekaBank Deutsche Girozentrale 0.00% of their portfolio | 30.0k $700.0k | Unchanged |
| TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio | 28.6k $711.8k | Reduced -75.0k |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio | 26.0k $646.4k | Added +12.8k |
| STATE STREET CORP 0.00% of their portfolio | 25.9k $644.2k | Reduced -3.7k |
| WOODSTOCK CORP 0.06% of their portfolio | 25.0k $622.0k | Added +3.5k |
| Concurrent Investment Advisors, LLC 0.02% of their portfolio | 21.8k $542.8k | New |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 21.4k $532.3k | Added +2.5k |
| GILDER GAGNON HOWE & CO LLC 0.01% of their portfolio | 21.3k $529.6k | New |
| JANE STREET GROUP, LLC 0.00% of their portfolio | 20.2k $502.9k | Reduced -62.8k |
| TOCQUEVILLE ASSET MANAGEMENT L.P. 0.01% of their portfolio | 17.4k $434.5k | Reduced -5.9k |
| ADAR1 Capital Management, LLC 0.10% of their portfolio | 14.4k $359.3k | Reduced -60.4k |
| HORIZON KINETICS ASSET MANAGEMENT LLC 0.01% of their portfolio | 14.4k $358.5k | Unchanged |
| Erste Asset Management GmbH 0.00% of their portfolio | 14.0k $343.7k | Unchanged |
| DANSKE BANK A/S 0.00% of their portfolio | 13.3k $331.9k | First filing |
| Bellevue Group AG 0.00% of their portfolio | 12.5k $311.2k | Reduced -7.5k |
| EXCHANGE TRADED CONCEPTS, LLC 0.01% of their portfolio | 12.4k $309.3k | Added +5.7k |
| Walleye Trading LLC 0.00% of their portfolio | 11.4k $283.1k | Reduced -38.9k |
| UBS Group AG 0.00% of their portfolio | 10.0k $248.6k | Reduced -1.2k |
| SIMPLEX TRADING, LLC 0.01% of their portfolio | 9.8k $244.0k | New |
| Cubist Systematic Strategies, LLC 0.00% of their portfolio | 9.4k $234.6k | Reduced -104.5k |
| FISHMAN JAY A LTD/MI 0.02% of their portfolio | 9.0k $224.1k | Reduced -25.5k |
| PEAK6 Investments LLC 0.01% of their portfolio | 9.0k $224.1k | Unchanged |
| BNP PARIBAS FINANCIAL MARKETS 0.00% of their portfolio | 8.8k $220.0k | Reduced -28.0k |
| PDS Planning, Inc 0.02% of their portfolio | 8.4k $210.4k | New |
| DEUTSCHE BANK AG\ 0.00% of their portfolio | 8.1k $200.9k | Reduced -302 |
| PNC Financial Services Group, Inc. 0.00% of their portfolio | 7.7k $191.7k | Added +140 |
| China Universal Asset Management Co., Ltd. 0.02% of their portfolio | 6.9k $170.8k | Added +2.9k |
| VIRTUS ADVISERS, LLC 0.08% of their portfolio | 5.8k $143.8k | Reduced -398 |
| Leonteq Securities AG 0.02% of their portfolio | 5.0k $124.5k | Unchanged |
| HighMark Wealth Management LLC 0.07% of their portfolio | 4.4k $110.4k | Unchanged |
| NATIXIS 0.00% of their portfolio | 2.6k $63.2k | Reduced -61 |
| FIRST MANHATTAN CO. LLC. 0.00% of their portfolio | 2.2k $54.8k | Unchanged |
| OSAIC HOLDINGS, INC. 0.00% of their portfolio | 1.4k $34.6k | Reduced -594 |
| GAMMA Investing LLC 0.00% of their portfolio | 871 $21.7k | Added +349 |
| RHUMBLINE ADVISERS 0.00% of their portfolio | 639 $15.9k | Added +229 |
| Tower Research Capital LLC (TRC) 0.00% of their portfolio | 411 $10.2k | Reduced -1.9k |
| US BANCORP \DE\ 0.00% of their portfolio | 300 $7.5k | New |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 287 $7.0k | Reduced -59 |
| CITIGROUP INC 0.00% of their portfolio | 128 $3.2k | Reduced -15.5k |
| MACROVIEW INVESTMENT MANAGEMENT LLC 0.00% of their portfolio | 126 $3.1k | Unchanged |
| Daiwa Securities Group Inc. 0.00% of their portfolio | 103 $3.0k | Unchanged |
| GROUP ONE TRADING LLC 0.00% of their portfolio | 91 $2.3k | Reduced -26.2k |
| BARCLAYS PLC 0.00% of their portfolio | 84 $2.1k | Reduced -14.9k |
| Gen-Wealth Partners Inc 0.00% of their portfolio | 39 $971 | First filing |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 0.00% of their portfolio | 5 $125 | Unchanged |
| Zurcher Kantonalbank (Zurich Cantonalbank) 0.00% of their portfolio | 4 $100 | Reduced -454 |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio | 0 $0 | Unchanged |