Vault-13

ASCENDIS PHARMA A/S

SPONSORED ADR · CUSIP 04351P101 · ISIN US04351P1012

190 institutional holders +4 vs Q4 2023
61,125,77961.1m shares reported held*
$9.2bnreported value*
37 new 74 added 50 reduced 33 sold out net bought ≈ $196.5m (+1.3m shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($632.0k this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $151.16. Options: 12 managers hold calls ($48.3m notional), 13 hold puts ($51.8m).

Trends to Q1 2024

Institutional holders

Managers reporting a position, each quarter

0100200Q3 22: 183Q4 22: 187Q1 23: 165Q2 23: 159Q3 23: 161Q4 23: 186Q1 24: 190190Q3 22Q1 23Q3 23Q1 24
Numbers
QuarterHolders
Q3 2022183
Q4 2022187
Q1 2023165
Q2 2023159
Q3 2023161
Q4 2023186
Q1 2024190

Buyers vs sellers

Managers adding to or starting a position, vs cutting or selling out

Bought or addedCut or sold out
2000200Q4 22: 94 bought or addedQ4 22: 91 cut or sold outQ4 22Q1 23: 75 bought or addedQ1 23: 100 cut or sold outQ1 23Q2 23: 87 bought or addedQ2 23: 88 cut or sold outQ2 23Q3 23: 71 bought or addedQ3 23: 78 cut or sold outQ3 23Q4 23: 90 bought or addedQ4 23: 86 cut or sold outQ4 23Q1 24: 111 bought or addedQ1 24: 83 cut or sold outQ1 24
Numbers
QuarterBought or addedCut or sold out
Q4 20229491
Q1 202375100
Q2 20238788
Q3 20237178
Q4 20239086
Q1 202411183

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$20m$40m$60mQ2 23 calls: $43.5mQ2 23 puts: $26.7mQ2 23P/C 0.61Q3 23 calls: $17.4mQ3 23 puts: $23.0mQ3 23P/C 1.32Q4 23 calls: $26.8mQ4 23 puts: $20.7mQ4 23P/C 0.77Q1 24 calls: $48.3mQ1 24 puts: $51.8mQ1 24P/C 1.07
Numbers
QuarterCallsPutsP/C
Q2 2023$43.5m$26.7m0.61
Q3 2023$17.4m$23.0m1.32
Q4 2023$26.8m$20.7m0.77
Q1 2024$48.3m$51.8m1.07

Biggest buyers

FRANKLIN RESOURCES INC Added +917,064+917.1k
MILLENNIUM MANAGEMENT LLC Added +339,669+339.7k
PRICE T ROWE ASSOCIATES INC /MD/ Added +336,976+337.0k
CITADEL ADVISORS LLC Added +285,933+285.9k
ACADIAN ASSET MANAGEMENT LLC Added +234,446+234.4k
VOLORIDGE INVESTMENT MANAGEMENT, LLC Added +234,164+234.2k
SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC New +225,111+225.1k
MORGAN STANLEY Added +212,404+212.4k
Avoro Capital Advisors LLC Added +211,111+211.1k
TWO SIGMA INVESTMENTS, LP New +210,325+210.3k

Biggest sellers

T. Rowe Price Investment Management, Inc. Reduced -1,420,927-1.4m
WELLINGTON MANAGEMENT GROUP LLP Reduced -502,421-502.4k
JANUS HENDERSON GROUP PLC Reduced -227,582-227.6k
TimesSquare Capital Management, LLC Reduced -217,247-217.2k
EVENTIDE ASSET MANAGEMENT, LLC Sold out -180,857-180.9k
FMR LLC Reduced -175,908-175.9k
Camber Capital Management LP Sold out -165,000-165.0k
PERCEPTIVE ADVISORS LLC Sold out -132,176-132.2k
ALLIANCEBERNSTEIN L.P. Reduced -115,183-115.2k
DEUTSCHE BANK AG\ Reduced -111,385-111.4k

Biggest calls

BARCLAYS PLC Added $18.1m119.7k shares
MILLENNIUM MANAGEMENT LLC New $11.3m75.0k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $10.1m67.1k shares
CITIGROUP INC Reduced $3.7m24.8k shares
CITADEL ADVISORS LLC Reduced $2.3m15.4k shares
SIMPLEX TRADING, LLC Added $876.0k5.8k shares
JANE STREET GROUP, LLC Added $710.5k4.7k shares
Walleye Capital LLC Added $453.5k3.0k shares
Walleye Trading LLC Reduced $362.8k2.4k shares
GROUP ONE TRADING LLC Added $211.6k1.4k shares

Biggest puts

SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC New $11.4m75.1k shares
BARCLAYS PLC Added $11.0m72.5k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Added $9.1m60.0k shares
Caption Management, LLC New $7.6m50.0k shares
JANE STREET GROUP, LLC Reduced $5.9m38.9k shares
CITIGROUP INC Unchanged $3.7m24.8k shares
TORNO CAPITAL, LLC New $1.5m10.0k shares
CITADEL ADVISORS LLC Added $1.2m7.9k shares
Walleye Capital LLC Reduced $272.1k1.8k shares
Walleye Trading LLC Reduced $120.9k800 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
T. Rowe Price Investment Management, Inc. 13G · institution +0.6 pts · filed 2026-05-07 10.5% +0.6 pts 6.5m 2026-05-07
WESTFIELD CAPITAL MANAGEMENT CO LP 13G · institution -0.7 pts · filed 2026-02-11 8.5% -0.7 pts 5.2m 2026-02-11
FMR LLC 13G · institution filed 2025-05-12 8.0% 4.6m 2025-05-12
JANUS HENDERSON GROUP PLC 13G · institution -1.8 pts · filed 2026-05-15 6.0% -1.8 pts 3.7m 2026-05-15
Artisan Partners Limited Partnership 13G · institution filed 2026-02-03 5.2% 3.2m 2026-02-03

Fell to 5% or below in the last year: Capital International Investors (3.2%, 2026-05-14)

Holders, Q1 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 RA CAPITAL MANAGEMENT, L.P. 19.44% of their portfolio BOSTON, MA 10,108,40010.1m $1.5bn $1.5bn 19.44% Added +1.0k +1,000
2 Artisan Partners Limited Partnership 1.25% of their portfolio Milwaukee, WI 5,671,9345.7m $857.4m $857.4m 1.25% Reduced -77.3k -77,293
3 FMR LLC 0.05% of their portfolio BOSTON, MA 4,938,4614.9m $746.5m $746.5m 0.05% Reduced -175.9k -175,908
4 WESTFIELD CAPITAL MANAGEMENT CO LP 3.23% of their portfolio BOSTON, MA 4,075,2144.1m $616.1m $616.1m 3.23% Added +44.6k +44,580
5 Avoro Capital Advisors LLC 6.99% of their portfolio NEW YORK, NY 3,966,6664.0m $599.6m $599.6m 6.99% Added +211.1k +211,111
6 JANUS HENDERSON GROUP PLC 0.31% of their portfolio LONDON, X0 3,767,2033.8m $569.4m $569.4m 0.31% Reduced -227.6k -227,582
7 WELLINGTON MANAGEMENT GROUP LLP 0.07% of their portfolio Boston, MA 2,745,8722.7m $415.1m $415.1m 0.07% Reduced -502.4k -502,421
8 T. Rowe Price Investment Management, Inc. 0.24% of their portfolio BALTIMORE, MD 2,568,9032.6m $388.3m $388.3m 0.24% Reduced -1.4m -1,420,927
9 Capital International Investors 0.07% of their portfolio Los Angeles, CA 2,191,3122.2m $331.3m $331.3m 0.07% Added +10.0k +10,044
10 FRANKLIN RESOURCES INC 0.09% of their portfolio San Mateo, CA 1,981,8692.0m $299.6m $299.6m 0.09% Added +917.1k +917,064
11 PRICE T ROWE ASSOCIATES INC /MD/ 0.03% of their portfolio BALTIMORE, MD 1,781,9261.8m $269.4m $269.4m 0.03% Added +337.0k +336,976
12 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 0.07% of their portfolio Boston, MA 1,617,8301.6m $244.6m $244.6m 0.07% Added +98.6k +98,611
13 Invesco Ltd. 0.03% of their portfolio ATLANTA, GA 964,663964.7k $145.8m $145.8m 0.03% Added +56.8k +56,752
14 Sofinnova Investments, Inc. 6.73% of their portfolio Menlo Park, CA 754,032754.0k $114.0m $114.0m 6.73% Unchanged
15 BROWN ADVISORY INC 0.14% of their portfolio BALTIMORE, MD 684,072684.1k $103.4m $103.4m 0.14% Added +178.1k +178,125
16 Spyglass Capital Management LLC 6.18% of their portfolio Greenbrae, CA 614,107614.1k $92.8m $92.8m 6.18% Added +74.2k +74,159
17 TimesSquare Capital Management, LLC 1.27% of their portfolio NEW YORK, NY 575,698575.7k $87.0m $87.0m 1.27% Reduced -217.2k -217,247
18 Vestal Point Capital, LP 6.56% of their portfolio NEW YORK, NY 525,000525.0k $79.4m $79.4m 6.56% Reduced -100.0k -100,000
19 Paradigm Biocapital Advisors LP 2.70% of their portfolio NEW YORK, NY 507,952508.0k $76.8m $76.8m 2.70% Added +156.3k +156,252
20 ALLIANCEBERNSTEIN L.P. 0.03% of their portfolio NASHVILLE, TN 473,753473.8k $71.6m $71.6m 0.03% Reduced -115.2k -115,183
21 CITADEL ADVISORS LLC 0.07% of their portfolio MIAMI, FL 457,504457.5k $69.2m $69.2m 0.07% Added +285.9k +285,933
22 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 456,156456.2k $69.0m $69.0m 0.00% Added +212.4k +212,404
23 GOLDMAN SACHS GROUP INC 0.01% of their portfolio NEW YORK, NY 437,092437.1k $66.1m $66.1m 0.01% Added +14.2k +14,238
24 BlackRock Inc. 0.00% of their portfolio New York, NY 405,169405.2k $61.2m $61.2m 0.00% Added +56.1k +56,147
25 MILLENNIUM MANAGEMENT LLC 0.05% of their portfolio NEW YORK, NY 362,060362.1k $54.7m $54.7m 0.05% Added +339.7k +339,669
26 SEI INVESTMENTS CO 0.08% of their portfolio OAKS, PA 346,186346.2k $52.3m $52.3m 0.08% Reduced -15.6k -15,644
27 D. E. Shaw & Co., Inc. 0.07% of their portfolio New York, NY 340,118340.1k $51.4m $51.4m 0.07% Added +75.0k +74,961
28 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.17% of their portfolio JUPITER, FL 307,499307.5k $46.5m $46.5m 0.17% Added +234.2k +234,164
29 AMERICAN CENTURY COMPANIES INC 0.03% of their portfolio KANSAS CITY, MO 306,141306.1k $46.3m $46.3m 0.03% Reduced -1.6k -1,596
30 Rock Springs Capital Management LP 1.11% of their portfolio Baltimore, MD 290,000290.0k $43.8m $43.8m 1.11% Unchanged
31 Q Global Advisors, LLC 16.34% of their portfolio FORT WORTH, TX 285,000285.0k $43.1m $43.1m 16.34% Unchanged
32 Pictet Asset Management Holding SA 0.04% of their portfolio CAROUGE, V8 270,770270.8k $40.9m $40.9m 0.04% Added +67.1k +67,116
33 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 264,445264.4k $40.0m $40.0m 0.00% Added +112.6k +112,607
34 DEUTSCHE BANK AG\ 0.02% of their portfolio FRANKFURT AM MAIN, 2M 261,029261.0k $39.5m $39.5m 0.02% Reduced -111.4k -111,385
35 ARS Investment Partners, LLC 3.84% of their portfolio New York, NY 254,967255.0k $38.5m $38.5m 3.84% Reduced -27.8k -27,777
36 ACADIAN ASSET MANAGEMENT LLC 0.13% of their portfolio Boston, MA 250,492250.5k $37.8m $37.8m 0.13% Added +234.4k +234,446
37 TD Asset Management Inc 0.03% of their portfolio Toronto, A6 236,870236.9k $35.8m $35.8m 0.03% Reduced -7.7k -7,708
38 SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC 1.63% of their portfolio Boston, MA 225,111225.1k $34.0m $34.0m 1.63% New
39 TWO SIGMA INVESTMENTS, LP 0.08% of their portfolio NEW YORK, NY 210,325210.3k $31.8m $31.8m 0.08% New
40 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.06% of their portfolio Boston, MA 209,512209.5k $31.7m $31.7m 0.06% Added +65.5k +65,512
41 NEW YORK STATE COMMON RETIREMENT FUND 0.04% of their portfolio ALBANY, NY 196,079196.1k $29.6m $29.6m 0.04% Reduced -8.5k -8,469
42 Woodline Partners LP 0.27% of their portfolio San Francisco, CA 196,030196.0k $29.6m $29.6m 0.27% Added +179.9k +179,881
43 Allspring Global Investments Holdings, LLC 0.04% of their portfolio CHARLOTTE, NC 189,208189.2k $28.6m $28.6m 0.04% Reduced -14.0k -13,964
44 FRED ALGER MANAGEMENT, LLC 0.14% of their portfolio NEW YORK, NY 186,121186.1k $28.1m $28.1m 0.14% Reduced -7.4k -7,381
45 Finepoint Capital LP 6.81% of their portfolio BOSTON, MA 175,672175.7k $26.6m $26.6m 6.81% Added +11.9k +11,900
46 TWO SIGMA ADVISERS, LP 0.06% of their portfolio NEW YORK, NY 163,400163.4k $24.7m $24.7m 0.06% New
47 RICE HALL JAMES & ASSOCIATES, LLC 1.40% of their portfolio San Diego, CA 162,412162.4k $24.6m $24.6m 1.40% Reduced -6.5k -6,471
48 First Turn Management, LLC 3.43% of their portfolio DEL MAR, CA 151,587151.6k $22.9m $22.9m 3.43% Unchanged
49 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 150,944150.9k $22.8m $22.8m 0.00% Reduced -62.2k -62,225
50 Aberdeen Group plc 0.04% of their portfolio EDINBURGH, X0 138,791138.8k $21.0m $21.0m 0.04% Unchanged
51 VICTORY CAPITAL MANAGEMENT INC 0.02% of their portfolio San Antonio, TX 134,564134.6k $20.3m $20.3m 0.02% New
52 Thrivent Financial for Lutherans 0.03% of their portfolio Minneapolis, MN 114,401114.4k $17.3m $17.3m 0.03% Added +1.1k +1,137
53 Tri Locum Partners LP 5.91% of their portfolio NEW YORK, NY 112,670112.7k $17.0m $17.0m 5.91% Added +13.1k +13,120
54 BIT Capital GmbH 1.46% of their portfolio BERLIN, 2M 109,638109.6k $16.6m $16.6m 1.46% Added +48.1k +48,108
55 FARALLON CAPITAL MANAGEMENT, L.L.C. 0.10% of their portfolio SAN FRANCISCO, CA 109,000109.0k $16.5m $16.5m 0.10% Not comparable
56 Saturn V Capital Management LP 6.27% of their portfolio AUSTIN, TX 103,428103.4k $15.6m $15.6m 6.27% Reduced -28.3k -28,331
57 Schonfeld Strategic Advisors LLC 0.12% of their portfolio NEW YORK, NY 102,000102.0k $15.4m $15.4m 0.12% Reduced -22.9k -22,901
58 Driehaus Capital Management LLC 0.15% of their portfolio Chicago, IL 100,320100.3k $15.2m $15.2m 0.15% New
59 Candriam S.C.A. 0.10% of their portfolio STRASSEN, N4 99,37599.4k $15.0m $15.0m 0.10% Unchanged
60 DAFNA Capital Management LLC 3.18% of their portfolio LOS ANGELES, CA 92,47292.5k $14.0m $14.0m 3.18% Reduced -31.0k -31,000
61 BNP PARIBAS ASSET MANAGEMENT Holding S.A. 0.03% of their portfolio Paris, I0 86,20286.2k $13.0m $13.0m 0.03% New
62 BAILLIE GIFFORD & CO 0.01% of their portfolio EDINBURGH, X0 81,20681.2k $12.3m $12.3m 0.01% Reduced -464 -464
63 BNP PARIBAS FINANCIAL MARKETS 0.01% of their portfolio PARIS, I0 75,54075.5k $11.4m $11.4m 0.01% Added +73.8k +73,796
64 Ensign Peak Advisors, Inc 0.02% of their portfolio SALT LAKE CITY, UT 67,54467.5k $10.2m $10.2m 0.02% Unchanged
65 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 56,10256.1k $8.5m $8.5m 0.00% Added +1.0k +1,012
66 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 56,01256.0k $8.5m $8.5m 0.00% Reduced -67.7k -67,716
67 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 55,16655.2k $8.3m $8.3m 0.00% Reduced -7.1k -7,144
68 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio Toronto, A6 54,52654.5k $8.2m $8.2m 0.01% Added +31.7k +31,738
69 Gray Foundation 2.44% of their portfolio Cohoes, NY 51,70051.7k $7.8m $7.8m 2.44% Unchanged
70 ADAR1 Capital Management, LLC 2.01% of their portfolio AUSTIN, TX 48,58448.6k $7.3m $7.3m 2.01% Added +2.7k +2,700
71 Atika Capital Management LLC 0.82% of their portfolio NEW YORK, NY 48,50048.5k $7.3m $7.3m 0.82% New
72 Cinctive Capital Management LP 0.38% of their portfolio New York, NY 48,38348.4k $7.3m $7.3m 0.38% New
73 Resolute Capital Asset Partners LLC 3.71% of their portfolio DENVER, CO 47,00047.0k $7.1m $7.1m 3.71% Added +10.6k +10,600
74 Polar Asset Management Partners Inc. 0.18% of their portfolio TORONTO, A6 44,08944.1k $6.7m $6.7m 0.18% New
75 Matisse Capital 2.58% of their portfolio PORTLAND, OR 35,54035.5k $5.4m $5.4m 2.58% Added +905 +905
76 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 34,35234.4k $5.2m $5.2m 0.00% Added +3.1k +3,100
77 Cubist Systematic Strategies, LLC 0.06% of their portfolio STAMFORD, CT 33,66133.7k $5.1m $5.1m 0.06% Added +14.8k +14,770
78 DekaBank Deutsche Girozentrale 0.01% of their portfolio FRANKFURT, 2M 30,00030.0k $4.4m $4.4m 0.01% Unchanged
79 UBS Group AG 0.00% of their portfolio ZURICH, V8 27,75527.8k $4.2m $4.2m 0.00% Reduced -172 -172
80 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 25,08425.1k $3.8m $3.8m 0.01% New
81 Altium Capital Management LLC 1.69% of their portfolio NEW YORK, NY 25,00025.0k $3.8m $3.8m 1.69% Unchanged
82 Henry James International Management Inc. 1.14% of their portfolio NEW YORK, NY 24,52124.5k $3.7m $3.7m 1.14% Added +26 +26
83 Jefferies Financial Group Inc. 0.07% of their portfolio NEW YORK, NY 24,15124.2k $3.7m $3.7m 0.07% Reduced -3.8k -3,849
84 HARBOR CAPITAL ADVISORS, INC. 0.43% of their portfolio CHICAGO, IL 22,00622.0k $3.3m $3.3m 0.43% Added +9.9k +9,921
85 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 21,07221.1k $3.2m $3.2m 0.00% Added +3.7k +3,747
86 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 20,39420.4k $3.1m $3.1m 0.00% Reduced -11.1k -11,074
87 Trexquant Investment LP 0.06% of their portfolio STAMFORD, CT 20,28920.3k $3.1m $3.1m 0.06% Added +10.4k +10,421
88 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 19,97620.0k $3.0m $3.0m 0.00% Added +952 +952
89 VOYA INVESTMENT MANAGEMENT LLC 0.00% of their portfolio ATLANTA, GA 19,58019.6k $3.0m $3.0m 0.00% Unchanged
90 Penserra Capital Management LLC 0.04% of their portfolio ORINDA, CA 19,41219.4k $2.9m $2.9m 0.04% Added +16.0k +15,964
91 Erste Asset Management GmbH 0.04% of their portfolio VIENNA, C4 18,50018.5k $2.7m $2.7m 0.04% Unchanged
92 Nicholas Investment Partners, LP 0.28% of their portfolio RANCHO SANTA FE, CA 17,98418.0k $2.7m $2.7m 0.28% Added +13.7k +13,717
93 Artia Global Partners LP 0.59% of their portfolio MIAMI, FL 15,89415.9k $2.4m $2.4m 0.59% New
94 NOMURA ASSET MANAGEMENT CO LTD 0.01% of their portfolio TOKYO, M0 13,92913.9k $2.1m $2.1m 0.01% Added +1.3k +1,261
95 Evolutionary Tree Capital Management, LLC 2.08% of their portfolio ALEXANDRIA, VA 13,63913.6k $2.1m $2.1m 2.08% Reduced -3.1k -3,087
96 Nan Fung Group Holdings Ltd 1.90% of their portfolio KAI TAK, K3 13,60013.6k $2.1m $2.1m 1.90% New
97 Mirae Asset Global Investments Co., Ltd. 0.00% of their portfolio SEOUL, M5 13,27613.3k $1.7m $1.7m 0.00% Reduced -713 -713
98 STIFEL FINANCIAL CORP 0.00% of their portfolio ST. LOUIS, MO 13,16013.2k $2.0m $2.0m 0.00% Added +579 +579
99 SUPERSTRING CAPITAL MANAGEMENT LP 1.27% of their portfolio NEW YORK, NY 12,75412.8k $1.9m $1.9m 1.27% New
100 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 12,32512.3k $1.9m $1.9m 0.00% Added +11.5k +11,456