Vault-13

KYVERNA THERAPEUTICS INC KYTX

COM · Common Stock · CUSIP 501976104

91 institutional holders
31,710,55431.7m shares reported held*
73.5% of all shares outstanding*
$787.6mreported value*

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.7m this quarter). Holder counts are more reliable. Shares outstanding: 43.1m as of 2024-05-10, from the company's own SEC filing; the percentage can still exceed 100%: lent-out shares are counted by the lender and the buyer, and some reports overlap without saying so. Implied quarter-end price ≈ $24.84. Options: 2 managers hold calls ($5.0k notional), 4 hold puts ($514.2k).

Trends to Q1 2024

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$200k$400k$600kQ2 23 calls: $0Q2 23 puts: $0Q2 23P/C —Q3 23 calls: $0Q3 23 puts: $0Q3 23P/C —Q4 23 calls: $0Q4 23 puts: $0Q4 23P/C —Q1 24 calls: $5.0kQ1 24 puts: $514.2kQ1 24P/C 103.50
Numbers
QuarterCallsPutsP/C
Q2 2023$0$0—
Q3 2023$0$0—
Q4 2023$0$0—
Q1 2024$5.0k$514.2k103.50

Biggest buyers

Vida Ventures Advisors, LLC New +4,523,924+4.5m
Northpond Ventures, LLC New +3,255,426+3.3m
Bain Capital Life Sciences Investors, LLC New +3,163,868+3.2m
RTW INVESTMENTS, LP New +1,852,711+1.9m
JPMORGAN CHASE & CO New +1,688,930+1.7m
DEERFIELD MANAGEMENT COMPANY, L.P. New +1,462,337+1.5m
JENNISON ASSOCIATES LLC New +1,398,659+1.4m
PRICE T ROWE ASSOCIATES INC /MD/ New +929,634+929.6k
Insight Holdings Group, LLC New +912,915+912.9k
Commodore Capital LP New +912,189+912.2k

Biggest sellers

None

Biggest calls

Biggest puts

SUSQUEHANNA INTERNATIONAL GROUP, LLP New $325.4k13.1k shares
CITADEL ADVISORS LLC New $181.3k7.3k shares
BANK OF AMERICA CORP /DE/ New $7.5k300 shares
CONCOURSE FINANCIAL GROUP SECURITIES, INC. New $00 shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Major shareholders (over 5%)

Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.

HolderStakeChangeShares Last filed
Westlake BioPartners Fund I, L.P. 13G · exempt (held before listing) filed 2026-02-06 7.8% 4.7m≈ $41.5m 2026-02-06
GordonMD Global Investments LP 13G · passive investor new · filed 2025-11-17 7.0% new 3.1m≈ $27.3m 2025-11-17
Northpond Ventures III, LP 13G · passive investor filed 2026-02-17 6.1% 3.5m≈ $30.9m 2026-02-17
HIRSCHMAN ORIN 13G · institution new · filed 2026-10-19 5.9% new 3.6m≈ $32.5m 2026-10-19
BlackRock, Inc. 13G · institution new · filed 2026-07-29 5.1% new 3.1m≈ $27.7m 2026-07-29

Fell to 5% or below in the last year: Bain Capital Life Sciences Opportunities III, LP (4.8%, 2026-08-14)

Insider purchases and sales in Q1 2024

Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.

DateInsiderTradeSharesPrice ValueTheir holding
2024-02-12 GILEAD SCIENCES, INC. 10% owner Bought 910,000 $22.00 $20.0m910.0k shares +28%
2024-02-12 Rubin Michael P. +2 Former 10% Owner · By: Northpond Ventures, LP Bought 450,000 $22.00 $9.9m450.0k shares new
2024-02-12 Bain Capital Life Sciences Investors, LLC +4 10% owner · See footnotes Bought 450,000 $22.00 $9.9m450.0k shares +17%
2024-02-12 Vida Ventures, LLC +3 10% owner · By Vida Ventures III, L.P. Bought 252,553 $22.00 $5.6m252.6k shares new
2024-02-12 Vida Ventures, LLC +3 10% owner · By Vida Ventures III-A, L.P. Bought 583 $22.00 $12.8k583 shares new

Their holding: how much the trade added to or took from the insider's holding (direct, or the trust or fund named). The same trade is sometimes reported by more than one insider, such as a fund and the director who represents it; totals count it once. A value is left blank where the reported price is far from the market price (usually a typo).

Holders, Q1 2024

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Vida Ventures Advisors, LLC 62.43% of their portfolio BOSTON, MA 4,523,9244.5m $112.4m $112.4m 62.43% New
2 Northpond Ventures, LLC 78.80% of their portfolio Bethesda, MD 3,255,4263.3m $80.9m $80.9m 78.80% New
3 Bain Capital Life Sciences Investors, LLC 6.32% of their portfolio Boston, MA 3,163,8683.2m $78.6m $78.6m 6.32% New
4 RTW INVESTMENTS, LP 0.68% of their portfolio NEW YORK, NY 1,852,7111.9m $46.0m $46.0m 0.68% New
5 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 1,688,9301.7m $42.0m $42.0m 0.00% New
6 DEERFIELD MANAGEMENT COMPANY, L.P. 0.63% of their portfolio New York, NY 1,462,3371.5m $36.3m $36.3m 0.63% New
7 JENNISON ASSOCIATES LLC 0.02% of their portfolio NEW YORK, NY 1,398,6591.4m $34.7m $34.7m 0.02% New
8 PRICE T ROWE ASSOCIATES INC /MD/ 0.00% of their portfolio BALTIMORE, MD 929,634929.6k $23.1m $23.1m 0.00% New
9 Insight Holdings Group, LLC 0.63% of their portfolio NEW YORK, NY 912,915912.9k $22.7m $22.7m 0.63% New
10 Commodore Capital LP 1.52% of their portfolio NEW YORK, NY 912,189912.2k $22.7m $22.7m 1.52% New
11 BlackRock Inc. 0.00% of their portfolio New York, NY 749,966750.0k $18.6m $18.6m 0.00% New
12 NOVO HOLDINGS A/S 1.20% of their portfolio HELLERUP, G7 700,000700.0k $17.4m $17.4m 1.20% New
13 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 695,094695.1k $17.3m $17.3m 0.01% New
14 JANUS HENDERSON GROUP PLC 0.01% of their portfolio LONDON, X0 606,500606.5k $15.0m $15.0m 0.01% New
15 WELLINGTON MANAGEMENT GROUP LLP 0.00% of their portfolio Boston, MA 601,436601.4k $14.9m $14.9m 0.00% New
16 ADAGE CAPITAL PARTNERS GP, L.L.C. 0.03% of their portfolio Boston, MA 575,000575.0k $14.3m $14.3m 0.03% New
17 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 523,743523.7k $13.0m $13.0m 0.01% New
18 Logos Global Management LP 1.31% of their portfolio San Francisco, CA 500,000500.0k $12.4m $12.4m 1.31% New
19 ALLIANCEBERNSTEIN L.P. 0.00% of their portfolio NASHVILLE, TN 475,827475.8k $11.8m $11.8m 0.00% New
20 Avoro Capital Advisors LLC 0.14% of their portfolio NEW YORK, NY 475,000475.0k $11.8m $11.8m 0.14% New
21 FRANKLIN RESOURCES INC 0.00% of their portfolio San Mateo, CA 460,561460.6k $11.4m $11.4m 0.00% New
22 EcoR1 Capital, LLC 0.28% of their portfolio San Francisco, CA 450,000450.0k $11.2m $11.2m 0.28% New
23 Cormorant Asset Management, LP 0.48% of their portfolio BOSTON, MA 440,000440.0k $10.9m $10.9m 0.48% New
24 Woodline Partners LP 0.09% of their portfolio San Francisco, CA 392,928392.9k $9.8m $9.8m 0.09% New
25 Cutter Capital Management, LP 1.59% of their portfolio NEW YORK, NY 333,028333.0k $8.3m $8.3m 1.59% New
26 VANGUARD GROUP INC 0.00% of their portfolio Valley Forge, PA 264,215264.2k $6.6m $6.6m 0.00% New
27 Avidity Partners Management LP 0.18% of their portfolio DALLAS, TX 202,333202.3k $5.0m $5.0m 0.18% New
28 Artal Group S.A. 0.13% of their portfolio LUXEMBOURG, N4 200,000200.0k $5.0m $5.0m 0.13% New
29 Rock Springs Capital Management LP 0.11% of their portfolio Baltimore, MD 178,963179.0k $4.4m $4.4m 0.11% New
30 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 172,236172.2k $4.3m $4.3m 0.00% New
31 MARSHALL WACE, LLP 0.01% of their portfolio LONDON, X0 155,755155.8k $3.9m $3.9m 0.01% New
32 PERCEPTIVE ADVISORS LLC 0.07% of their portfolio NEW YORK, NY 150,000150.0k $3.7m $3.7m 0.07% New
33 GREAT POINT PARTNERS LLC 0.58% of their portfolio Greenwich, CT 150,000150.0k $3.7m $3.7m 0.58% New
34 Casdin Capital, LLC 0.28% of their portfolio New York, NY 150,000150.0k $3.7m $3.7m 0.28% New
35 Walleye Capital LLC 0.04% of their portfolio NEW YORK, NY 150,000150.0k $3.7m $3.7m 0.04% New
36 MORGAN STANLEY 0.00% of their portfolio NEW YORK, NY 119,793119.8k $3.0m $3.0m 0.00% New
37 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.00% of their portfolio NEW YORK, NY 105,900105.9k $2.6m $2.6m 0.00% New
38 LMR Partners LLP 0.07% of their portfolio LONDON, X0 104,814104.8k $2.6m $2.6m 0.07% New
39 Blackstone Inc. 0.01% of their portfolio NEW YORK, NY 100,000100.0k $2.5m $2.5m 0.01% New
40 Pictet Asset Management Holding SA 0.00% of their portfolio CAROUGE, V8 100,000100.0k $2.5m $2.5m 0.00% New
41 Squarepoint Ops LLC 0.01% of their portfolio NEW YORK, NY 88,42388.4k $2.2m $2.2m 0.01% New
42 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.00% of their portfolio SAN FRANCISCO, CA 84,88084.9k $2.1m $2.1m 0.00% New
43 Invesco Ltd. 0.00% of their portfolio ATLANTA, GA 75,86575.9k $1.9m $1.9m 0.00% New
44 ArrowMark Colorado Holdings LLC 0.02% of their portfolio Denver, CO 70,00070.0k $1.7m $1.7m 0.02% New
45 Qube Research & Technologies Ltd 0.00% of their portfolio LONDON, X0 69,23769.2k $1.7m $1.7m 0.00% New
46 Alyeska Investment Group, L.P. 0.01% of their portfolio CHICAGO, IL 65,00065.0k $1.6m $1.6m 0.01% New
47 Point72 (DIFC) Ltd 0.12% of their portfolio DUBAI, C0 60,80060.8k $1.5m $1.5m 0.12% First filing
48 CITIGROUP INC 0.00% of their portfolio NEW YORK, NY 59,66659.7k $1.5m $1.5m 0.00% New
49 STATE STREET CORP 0.00% of their portfolio BOSTON, MA 50,40050.4k $1.3m $1.3m 0.00% New
50 Hudson Bay Capital Management LP 0.01% of their portfolio STAMFORD, CT 50,00050.0k $1.2m $1.2m 0.01% New
51 Paradigm Biocapital Advisors LP 0.04% of their portfolio NEW YORK, NY 50,00050.0k $1.2m $1.2m 0.04% New
52 BARCLAYS PLC 0.00% of their portfolio LONDON, X0 43,09443.1k $1.1m $1.1m 0.00% New
53 STEMPOINT CAPITAL LP 0.27% of their portfolio NEW YORK, NY 41,00041.0k $1.0m $1.0m 0.27% New
54 Polar Asset Management Partners Inc. 0.03% of their portfolio TORONTO, A6 40,00040.0k $993.6k $993.6k 0.03% New
55 NORGES BANK 0.00% of their portfolio OSLO, Q8 40,00040.0k $993.6k $993.6k 0.00% New
56 Ghisallo Capital Management LLC 0.11% of their portfolio BOSTON, MA 40,00040.0k $993.6k $993.6k 0.11% New
57 Laurion Capital Management LP 0.03% of their portfolio NEW YORK, NY 37,50037.5k $931.5k $931.5k 0.03% New
58 JANE STREET GROUP, LLC 0.00% of their portfolio NEW YORK, NY 37,04137.0k $920.1k $920.1k 0.00% New
59 AMERIPRISE FINANCIAL INC 0.00% of their portfolio MINNEAPOLIS, MN 36,58336.6k $908.7k $908.7k 0.00% New
60 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 28,79328.8k $715.2k $715.2k 0.00% New
61 MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.00% of their portfolio Toronto, A6 28,49428.5k $707.8k $707.8k 0.00% New
62 DISCOVERY CAPITAL MANAGEMENT, LLC / CT 0.08% of their portfolio SOUTH NORWALK, CT 25,00025.0k $621.0k $621.0k 0.08% New
63 UBS Group AG 0.00% of their portfolio ZURICH, V8 24,89824.9k $618.5k $618.5k 0.00% New
64 Point72 Asset Management, L.P. 0.00% of their portfolio STAMFORD, CT 20,90020.9k $519.2k $519.2k 0.00% New
65 TWO SIGMA INVESTMENTS, LP 0.00% of their portfolio NEW YORK, NY 20,84220.8k $517.7k $517.7k 0.00% New
66 Davidson Kempner Capital Management LP 0.01% of their portfolio New York, NY 20,00020.0k $495.2k $495.2k 0.01% Not comparable
67 Skandinaviska Enskilda Banken AB (publ) 0.00% of their portfolio STOCKHOLM, V7 16,81016.8k $417.6k $417.6k 0.00% New
68 Balyasny Asset Management L.P. 0.00% of their portfolio Chicago, IL 16,72116.7k $415.4k $415.4k 0.00% New
69 CAXTON CORP 2.24% of their portfolio Princeton, NJ 15,84615.8k $393.6k $393.6k 2.24% Not comparable
70 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 13,01613.0k $323.3k $323.3k 0.00% New
71 TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY 0.00% of their portfolio FRANKFORT, KY 12,61412.6k $313.0k $313.0k 0.00% New
72 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 11,90611.9k $295.7k $295.7k 0.00% New
73 PRUDENTIAL FINANCIAL INC 0.00% of their portfolio NEWARK, NJ 11,50011.5k $285.7k $285.7k 0.00% New
74 Brevan Howard Capital Management LP 0.03% of their portfolio ST. HELIER, Y9 11,43511.4k $284.0k $284.0k 0.03% New
75 Point72 Asia (Singapore) Pte. Ltd. 0.07% of their portfolio SINGAPORE, U0 10,13310.1k $251.7k $251.7k 0.07% New
76 Sofinnova Investments, Inc. 0.01% of their portfolio Menlo Park, CA 10,00010.0k $248.4k $248.4k 0.01% New
77 Greenland Capital Management LP 0.04% of their portfolio NEW YORK, NY 10,00010.0k $248.4k $248.4k 0.04% New
78 Legal & General Group Plc 0.00% of their portfolio London, X0 9,5859.6k $237.7k $237.7k 0.00% New
79 Diametric Capital, LP 0.13% of their portfolio BOSTON, MA 9,3009.3k $231.0k $231.0k 0.13% New
80 TUDOR INVESTMENT CORP ET AL 0.00% of their portfolio STAMFORD, CT 8,4928.5k $210.9k $210.9k 0.00% New
81 DekaBank Deutsche Girozentrale 0.00% of their portfolio FRANKFURT, 2M 7,5007.5k $181.0k $181.0k 0.00% New
82 SECTORAL ASSET MANAGEMENT INC 0.07% of their portfolio MONTREAL, A8 7,0007.0k $173.9k $173.9k 0.07% New
83 Cubist Systematic Strategies, LLC 0.00% of their portfolio STAMFORD, CT 2,7752.8k $68.9k $68.9k 0.00% New
84 OSAIC HOLDINGS, INC. 0.00% of their portfolio SCOTTSDALE, AZ 2,0002.0k $49.7k $49.7k 0.00% New
85 MACQUARIE GROUP LTD 0.00% of their portfolio Sydney, NSW 2000, C3 950950 $24 $24 0.00% New
86 Tower Research Capital LLC (TRC) 0.00% of their portfolio NEW YORK, NY 766766 $19.0k $19.0k 0.00% New
87 NEW YORK STATE COMMON RETIREMENT FUND 0.00% of their portfolio ALBANY, NY 183183 $4.5k $4.5k 0.00% New
88 COMERICA BANK 0.00% of their portfolio DALLAS, TX 6363 $1.6k $1.6k 0.00% New
89 Washington Trust Advisors, Inc. 0.00% of their portfolio WELLESLEY, MA 6060 $1.5k $1.5k 0.00% New
90 ROYAL BANK OF CANADA 0.00% of their portfolio TORONTO, A6 44 $0 $0 0.00% New
91 CONCOURSE FINANCIAL GROUP SECURITIES, INC. 0.00% of their portfolio BIRMINGHAM, AL 00 $0 $0 0.00% New