Vault-13

Paradigm Biocapital Advisors LP

NEW YORK, NY · CIK 1855655 · 13F filing filed 2023-02-14

SEC-registered investment adviser since 2021 · limited partnership

$851.9m reported value +20.0% vs Q3 2022
23positions
62.8%in top 10
4 new 14 added 5 reduced 8 sold out vs Q3 2022

Holdings, Q4 2022

The small lines show how much was held over the last 4 quarters (adjusted for stock splits).

#SecurityTickerShares Value% of portfolioChangeShares change
1 INCYTE CORP COM INCY INCY 852,830 $68.5m8.04% 8.04% AddedShares held: Q3 2022 773.1k, Q4 2022 852.8k +79.7k +79,748 10.3%
2 BIOGEN INC COM BIIB BIIB 238,772 $66.1m7.76% 7.76% AddedShares held: Q3 2022 154.6k, Q4 2022 238.8k +84.2k +84,167 54.4%
3 MIRATI THERAPEUTICS INC COM MRTX MRTX 1,267,970 $57.5m6.74% 6.74% AddedShares held: Q3 2022 850.4k, Q4 2022 1.3m +417.6k +417,585 49.1%
4 HORIZON THERAPEUTICS PUB L SHS HZNP HZNP 477,585 $54.3m6.38% 6.38% AddedShares held: Q3 2022 351.4k, Q4 2022 477.6k +126.2k +126,180 35.9%
5 LEGEND BIOTECH CORP SPONSORED ADS LEGN LEGN 1,054,870 $52.7m6.18% 6.18% ReducedShares held: Q3 2022 1.1m, Q4 2022 1.1m -21.7k -21,721 -2.0%
6 VIRIDIAN THERAPEUTICS INC COM VRDN VRDN 1,751,167 $51.2m6.00% 6.00% AddedShares held: Q3 2022 1.6m, Q4 2022 1.8m +115.0k +114,956 7.0%
7 SYNDAX PHARMACEUTICALS INC COM SNDX SNDX 1,954,512 $49.7m5.84% 5.84% AddedShares held: Q3 2022 1.1m, Q4 2022 2.0m +869.4k +869,370 80.1%
8 IMMUNOCORE HLDGS PLC ADS IMCR IMCR 857,925 $49.0m5.75% 5.75% AddedShares held: Q3 2022 773.1k, Q4 2022 857.9k +84.8k +84,846 11.0%
9 ASCENDIS PHARMA A/S SPONSORED ADR SPONSORED ADR 352,808 $43.1m5.06% 5.06% ReducedShares held: Q3 2022 497.3k, Q4 2022 352.8k -144.5k -144,539 -29.1%
10 VOR BIOPHARMA INC COM COM 6,442,825 $42.8m5.03% 5.03% AddedShares held: Q3 2022 1.7m, Q4 2022 6.4m +4.7m +4,739,180 278.2%
11 UNITED THERAPEUTICS CORP DEL COM UTHR UTHR 148,892 $41.4m4.86% 4.86% AddedShares held: Q3 2022 140.6k, Q4 2022 148.9k +8.3k +8,331 5.9%
12 SEAGEN INC COM SGEN SGEN 286,288 $36.8m4.32% 4.32% NewShares held: Q3 2022 0, Q4 2022 286.3k
13 BICYCLE THERAPEUTICS PLC SPONSORED ADS BCYC BCYC 1,233,280 $36.5m4.29% 4.29% AddedShares held: Q3 2022 1.2m, Q4 2022 1.2m +74.6k +74,594 6.4%
14 ARGENX SE SPONSORED ADR ARGX ARGX 89,556 $33.9m3.98% 3.98% ReducedShares held: Q3 2022 90.3k, Q4 2022 89.6k -741 -741 -0.8%
15 AKERO THERAPEUTICS INC COM AKRO AKRO 604,544 $33.1m3.89% 3.89% ReducedShares held: Q3 2022 833.3k, Q4 2022 604.5k -228.7k -228,721 -27.4%
16 ARCELLX INC COMMON STOCK ACLX ACLX 882,101 $27.3m3.21% 3.21% NewShares held: Q3 2022 0, Q4 2022 882.1k
17 KARUNA THERAPEUTICS INC COM COM 106,210 $20.9m2.45% 2.45% NewShares held: Q3 2022 0, Q4 2022 106.2k
18 ARVINAS INC COM ARVN ARVN 599,599 $20.5m2.41% 2.41% AddedShares held: Q3 2022 283.8k, Q4 2022 599.6k +315.8k +315,822 111.3%
19 ALPINE IMMUNE SCIENCES INC COM NVLS NVLS 2,317,634 $17.0m2.00% 2.00% AddedShares held: Q3 2022 2.2m, Q4 2022 2.3m +102.9k +102,912 4.7%
20 CRINETICS PHARMACEUTICALS IN COM CRNX CRNX 890,105 $16.3m1.91% 1.91% AddedShares held: Q3 2022 519.3k, Q4 2022 890.1k +370.8k +370,849 71.4%
21 ZAI LAB LTD ADR ZLAB ZLAB 515,274 $15.8m1.86% 1.86% NewShares held: Q3 2022 0, Q4 2022 515.3k
22 POSEIDA THERAPEUTICS INC COM PSTX PSTX 2,434,816 $12.9m1.51% 1.51% AddedShares held: Q3 2022 2.1m, Q4 2022 2.4m +364.7k +364,708 17.6%
23 PROTHENA CORP PLC SHS PRTA PRTA 75,000 $4.5m0.53% 0.53% ReducedShares held: Q3 2022 235.8k, Q4 2022 75.0k -160.8k -160,826 -68.2%

Sold out since Q3 2022

SecurityTickerShares held beforeValue then
GLOBAL BLOOD THERAPEUTICS IN GBT GBT 1,175,879 $80.1m1.2m shares
AXSOME THERAPEUTICS INC AXSM AXSM 520,080 $23.2m520.1k shares
ESPERION THERAPEUTICS INC NE ESPR ESPR 1,719,831 $11.5m1.7m shares
MERUS N V MRUS MRUS 564,214 $11.3m564.2k shares
G1 THERAPEUTICS INC GTHX GTHX 884,574 $11.0m884.6k shares
OYSTER PT PHARMA INC OYST OYST 1,648,316 $9.3m1.6m shares
TG THERAPEUTICS INC TGTX TGTX 1,505,479 $8.9m1.5m shares
MILESTONE PHARMACEUTICALS IN MIST MIST 634,211 $5.8m634.2k shares

Stakes above 5%

Companies where this manager has reported owning more than 5% of a class of shares, on Schedule 13D (may seek influence) or 13G (passive): its latest filing for each, from 19 Dec 2024 on.

CompanyTickerStakeChange ScheduleLast filed
OLEMA PHARMACEUTICALS INC OLMA · 13G · filed 2025-02-14 OLMA 10.0%≈ $92.9m 13G 2025-02-14
EDGEWISE THERAPEUTICS INC EWTX · 13G · filed 2026-08-14 EWTX 9.5%≈ $415.1m +3.3 pts 13G 2026-08-14
ACHIEVE LIFE SCIENCES INC ACHV · 13G · filed 2026-04-24 ACHV 9.2%≈ $64.7m new 13G 2026-04-24
ASSEMBLY BIOSCIENCES INC ASMB · 13G · filed 2026-08-14 ASMB 7.8%≈ $42.7m +2.4 pts 13G 2026-08-14
VIRIDIAN THERAPEUTICS INC VRDN · 13G · filed 2026-08-14 VRDN 6.1%≈ $123.5m +1.0 pts 13G 2026-08-14
TYRA BIOSCIENCES INC TYRA · 13G · filed 2026-09-17 TYRA 5.8%≈ $110.9m new 13G 2026-09-17
LEXEO THERAPEUTICS INC LXEO · 13G · filed 2026-08-14 LXEO 5.3%≈ $19.4m -3.0 pts 13G 2026-08-14
MBX BIOSCIENCES INC MBX · 13G · filed 2026-06-24 MBX 5.2%≈ $137.6m new 13G 2026-06-24
SPYRE THERAPEUTICS INC SYRE · 13G · filed 2026-10-01 SYRE 5.1%≈ $395.7m new 13G 2026-10-01
JADE BIOSCIENCES INC JBIO · 13G · filed 2026-07-17 JBIO 5.1%≈ $69.0m new 13G 2026-07-17