ARGENX SE ARGX
SPONSORED ADR · ADR · CUSIP 04016X101 · ISIN US04016X1019
- SectorHealth care
- IndustryBiological Products, (No Diagnostic Substances)
- FilingsSEC EDGAR
* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($2.0m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $378.84. Options: 11 managers hold calls ($108.3m notional), 10 hold puts ($72.4m).
Trends to Q4 2022
Institutional holders
Managers reporting a position, each quarter
Numbers
| Quarter | Holders |
|---|---|
| Q3 2022 | 255 |
| Q4 2022 | 271 |
Calls vs puts
Options held, notional value, last 4 quarters. P/C = puts ÷ calls
Numbers
| Quarter | Calls | Puts | P/C |
|---|---|---|---|
| Q3 2022 | $77.6m | $45.3m | 0.58 |
| Q4 2022 | $108.3m | $72.4m | 0.67 |
Biggest buyers
| MORGAN STANLEY | Added | +443.2k |
| Darwin Global Management, Ltd. | New | +297.7k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | New | +287.4k |
| Avidity Partners Management LP | Added | +133.2k |
| Assenagon Asset Management S.A. | Added | +123.4k |
| CITADEL ADVISORS LLC | Added | +91.8k |
| RENAISSANCE TECHNOLOGIES LLC | Added | +73.5k |
| BANK OF MONTREAL /CAN/ | New | +63.7k |
| PRINCIPAL FINANCIAL GROUP INC | Added | +51.0k |
| ARMISTICE CAPITAL, LLC | Added | +50.0k |
Biggest sellers
| T. Rowe Price Investment Management, Inc. | Reduced | -791.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ | Reduced | -279.0k |
| Point72 Asset Management, L.P. | Sold out | -263.3k |
| ORBIMED ADVISORS LLC | Reduced | -253.5k |
| Artisan Partners Limited Partnership | Reduced | -213.3k |
| Artal Group S.A. | Sold out | -150.0k |
| JANUS HENDERSON GROUP PLC | Reduced | -149.8k |
| Redmile Group, LLC | Reduced | -131.5k |
| LORD, ABBETT & CO. LLC | Reduced | -85.9k |
| D. E. Shaw & Co., Inc. | Reduced | -71.2k |
Biggest calls
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $29.7m78.3k shares |
| GROUP ONE TRADING LLC | Reduced | $19.6m51.7k shares |
| MILLENNIUM MANAGEMENT LLC | New | $18.8m49.5k shares |
| Optiver Holding B.V. | Reduced | $18.7m49.4k shares |
| CITADEL ADVISORS LLC | Added | $10.6m27.9k shares |
| SIMPLEX TRADING, LLC | Added | $6.7m17.6k shares |
| JPMORGAN CHASE & CO | New | $1.5m4.0k shares |
| Walleye Trading LLC | New | $1.3m3.5k shares |
| JANE STREET GROUP, LLC | Reduced | $1.3m3.5k shares |
| Walleye Capital LLC | New | $189.4k500 shares |
Biggest puts
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | Added | $34.2m90.2k shares |
| CITADEL ADVISORS LLC | Added | $12.9m34.0k shares |
| Optiver Holding B.V. | Reduced | $9.0m23.8k shares |
| GROUP ONE TRADING LLC | Added | $6.4m16.9k shares |
| MILLENNIUM MANAGEMENT LLC | New | $3.7m9.8k shares |
| SIMPLEX TRADING, LLC | Added | $3.7m9.8k shares |
| Walleye Trading LLC | New | $1.4m3.7k shares |
| Walleye Capital LLC | New | $871.3k2.3k shares |
| JANE STREET GROUP, LLC | Reduced | $227.3k600 shares |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | Unchanged | $00 shares |
Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.
Major shareholders (over 5%)
Anyone who owns more than 5% of a class of the company's shares has to say so: on Schedule 13D if they may try to influence or control the company, on 13G if they're a passive investor, and update it as the stake changes. Each holder's latest filing, from 19 Dec 2024 on; percentages are of the share class, as the holder worked them out.
No one currently above 5% in the filings since 19 Dec 2024.
Fell to 5% or below in the last year: PRICE T ROWE ASSOCIATES INC /MD/ (4.3%, 2026-08-14)
Insider purchases and sales in Q4 2022
Shares bought or sold by the company's own officers, directors and 10% owners, in the open market or privately, as they reported to the SEC on Form 4 (due within two business days of the trade). Grants, option exercises, shares withheld for tax and gifts aren't included.
None reported in Q4 2022.
Holders, Q4 2022
| Manager | Shares | Change |
|---|---|---|
| FMR LLC 0.20% of their portfolio | 5.2m $2.0bn | Added +23.4k |
| PRICE T ROWE ASSOCIATES INC /MD/ 0.24% of their portfolio | 4.0m $1.5bn | Reduced -279.0k |
| Artisan Partners Limited Partnership 1.76% of their portfolio | 2.6m $990.8m | Reduced -213.3k |
| JENNISON ASSOCIATES LLC 0.57% of their portfolio | 1.5m $561.8m | Reduced -66.2k |
| Avoro Capital Advisors LLC 7.16% of their portfolio | 1.3m $479.4m | Unchanged |
| T. Rowe Price Investment Management, Inc. 0.36% of their portfolio | 1.2m $464.8m | Reduced -791.4k |
| JANUS HENDERSON GROUP PLC 0.26% of their portfolio | 974.7k $369.2m | Reduced -149.8k |
| Bellevue Group AG 4.58% of their portfolio | 911.1k $345.2m | Reduced -8.2k |
| BlackRock Inc. 0.01% of their portfolio | 761.2k $288.4m | Reduced -43.5k |
| Capital World Investors 0.06% of their portfolio | 740.9k $280.7m | Added +936 |
| MORGAN STANLEY 0.03% of their portfolio | 630.3k $238.8m | Added +443.2k |
| Avidity Partners Management LP 5.53% of their portfolio | 625.0k $236.8m | Added +133.2k |
| Holocene Advisors, LP 1.19% of their portfolio | 510.6k $193.4m | Reduced -2.5k |
| RTW INVESTMENTS, LP 3.73% of their portfolio | 482.2k $182.7m | Added +15.0k |
| PICTET ASSET MANAGEMENT SA 0.25% of their portfolio | 449.9k $170.4m | Reduced -51.0k |
| DEUTSCHE BANK AG\ 0.09% of their portfolio | 431.3k $163.4m | Added +10.5k |
| FEDERATED HERMES, INC. 0.40% of their portfolio | 379.0k $143.6m | Reduced -64.6k |
| BAMCO INC /NY/ 0.46% of their portfolio | 364.3k $138.0m | Reduced -52.9k |
| Rock Springs Capital Management LP 3.19% of their portfolio | 350.0k $132.6m | Unchanged |
| EVENTIDE ASSET MANAGEMENT, LLC 2.46% of their portfolio | 328.9k $124.6m | Added +9.5k |
| Darwin Global Management, Ltd. 70.21% of their portfolio | 297.7k $112.8m | New |
| LORD, ABBETT & CO. LLC 0.20% of their portfolio | 290.0k $109.8m | Reduced -85.9k |
| ADAGE CAPITAL PARTNERS GP, L.L.C. 0.26% of their portfolio | 287.4k $108.9m | New |
| BAKER BROS. ADVISORS LP 0.64% of their portfolio | 280.2k $106.1m | Unchanged |
| D. E. Shaw & Co., Inc. 0.16% of their portfolio | 257.0k $97.4m | Reduced -71.2k |
| 1832 Asset Management L.P. 0.17% of their portfolio | 221.2k $83.8m | Added +40.4k |
| WELLINGTON MANAGEMENT GROUP LLP 0.02% of their portfolio | 220.7k $83.6m | Added +5.1k |
| AMERICAN CENTURY COMPANIES INC 0.07% of their portfolio | 213.0k $80.7m | Reduced -4.6k |
| FRANKLIN RESOURCES INC 0.04% of their portfolio | 211.1k $80.0m | Reduced -261 |
| GOLDMAN SACHS GROUP INC 0.02% of their portfolio | 189.9k $71.9m | Reduced -55.5k |
| SEI INVESTMENTS CO 0.14% of their portfolio | 171.4k $64.9m | Reduced -8.1k |
| ARMISTICE CAPITAL, LLC 1.73% of their portfolio | 170.0k $64.4m | Added +50.0k |
| Fiera Capital Corp 0.19% of their portfolio | 164.2k $62.2m | Reduced -963 |
| Redmile Group, LLC 2.30% of their portfolio | 148.5k $56.3m | Reduced -131.5k |
| Clearbridge Investments, LLC 0.05% of their portfolio | 142.2k $53.9m | Reduced -21.3k |
| Assenagon Asset Management S.A. 0.21% of their portfolio | 135.2k $51.2m | Added +123.4k |
| TimesSquare Capital Management, LLC 0.71% of their portfolio | 130.8k $49.6m | Reduced -2.5k |
| MARSHALL WACE, LLP 0.13% of their portfolio | 130.7k $49.5m | Added +29.4k |
| TD Asset Management Inc 0.06% of their portfolio | 129.1k $48.9m | Reduced -66.3k |
| CITADEL ADVISORS LLC 0.05% of their portfolio | 123.1k $46.6m | Added +91.8k |
| NEW YORK STATE COMMON RETIREMENT FUND 0.06% of their portfolio | 117.9k $44.7m | Reduced -2.3k |
| PFM Health Sciences, LP 1.67% of their portfolio | 104.7k $39.7m | Unchanged |
| BANK OF AMERICA CORP /DE/ 0.00% of their portfolio | 104.5k $39.6m | Added +34.7k |
| MILLENNIUM MANAGEMENT LLC 0.04% of their portfolio | 99.5k $37.7m | Reduced -3.7k |
| Public Sector Pension Investment Board 0.27% of their portfolio | 89.7k $34.0m | Reduced -8.5k |
| Paradigm Biocapital Advisors LP 3.98% of their portfolio | 89.6k $33.9m | Reduced -741 |
| Artia Global Partners LP 12.39% of their portfolio | 85.2k $32.3m | First filing |
| RENAISSANCE TECHNOLOGIES LLC 0.04% of their portfolio | 84.1k $31.9m | Added +73.5k |
| Tekla Capital Management LLC 1.20% of their portfolio | 84.0k $31.8m | Added +7.4k |
| Thrivent Financial for Lutherans 0.07% of their portfolio | 76.1k $28.8m | Reduced -584 |
| BNP PARIBAS FINANCIAL MARKETS 0.07% of their portfolio | 75.8k $28.7m | Added +29.0k |
| Fairmount Funds Management LLC 4.42% of their portfolio | 73.5k $27.9m | Unchanged |
| Allspring Global Investments Holdings, LLC 0.05% of their portfolio | 73.5k $27.8m | Added +4.2k |
| Invesco Ltd. 0.01% of their portfolio | 72.8k $27.6m | Added +24.8k |
| Balyasny Asset Management L.P. 0.09% of their portfolio | 70.4k $26.7m | Reduced -25.7k |
| Nicholas Investment Partners, LP 2.20% of their portfolio | 66.1k $25.1m | Reduced -104 |
| AXA S.A. 0.09% of their portfolio | 64.2k $24.3m | Reduced -64.6k |
| BANK OF MONTREAL /CAN/ 0.01% of their portfolio | 63.7k $25.1m | New |
| Eagle Health Investments LP 5.27% of their portfolio | 60.3k $22.8m | Unchanged |
| PRINCIPAL FINANCIAL GROUP INC 0.01% of their portfolio | 52.2k $19.8m | Added +51.0k |
| JPMORGAN CHASE & CO 0.00% of their portfolio | 50.6k $19.2m | Added +10.3k |
| AWM Investment Company, Inc. 2.73% of their portfolio | 50.0k $18.9m | Unchanged |
| VAN ECK ASSOCIATES CORP 0.05% of their portfolio | 49.5k $18.7m | Reduced -235 |
| Legal & General Group Plc 0.01% of their portfolio | 49.4k $18.7m | Added +9.5k |
| BRAIDWELL LP 0.62% of their portfolio | 49.2k $18.6m | First filing |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE 0.01% of their portfolio | 41.1k $15.5m | Reduced -6.7k |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio | 40.1k $15.2m | Added +87 |
| Senator Investment Group LP 1.36% of their portfolio | 40.0k $15.2m | Not comparable |
| Qube Research & Technologies Ltd 0.09% of their portfolio | 37.6k $14.3m | Added +24.2k |
| NEUBERGER BERMAN GROUP LLC 0.01% of their portfolio | 34.5k $13.1m | Added +7 |
| Driehaus Capital Management LLC 0.19% of their portfolio | 33.6k $12.7m | Reduced -5.4k |
| Russell Investments Group, Ltd. 0.03% of their portfolio | 32.6k $12.4m | Reduced -8.2k |
| QVT Financial LP 0.73% of their portfolio | 32.5k $12.3m | Unchanged |
| LMR Partners LLP 0.22% of their portfolio | 30.0k $11.4m | Unchanged |
| TOBAM 0.74% of their portfolio | 29.5k $11.2m | Added +12.0k |
| Atika Capital Management LLC 1.59% of their portfolio | 27.5k $10.4m | Reduced -8.5k |
| AMERIPRISE FINANCIAL INC 0.00% of their portfolio | 27.0k $10.2m | Reduced -10.2k |
| Schonfeld Strategic Advisors LLC 0.08% of their portfolio | 26.9k $10.2m | New |
| WELLS FARGO & COMPANY/MN 0.00% of their portfolio | 26.1k $9.9m | Reduced -210 |
| DCF Advisers, LLC 7.32% of their portfolio | 25.0k $9.5m | Unchanged |
| GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio | 24.2k $9.2m | Reduced -6.6k |
| Aquilo Capital Management, LLC 4.05% of their portfolio | 24.0k $9.1m | Unchanged |
| Ensign Peak Advisors, Inc 0.02% of their portfolio | 23.7k $9.0m | Unchanged |
| MCKINLEY CAPITAL MANAGEMENT LLC 1.08% of their portfolio | 21.2k $8.0m | Reduced -3.2k |
| NORTHERN TRUST CORP 0.00% of their portfolio | 21.1k $8.0m | Reduced -1.8k |
| Brookfield Corp /ON/ 0.03% of their portfolio | 20.3k $7.7m | Reduced -16.0k |
| Handelsbanken Fonder AB 0.05% of their portfolio | 20.0k $7.6m | New |
| VOYA INVESTMENT MANAGEMENT LLC 0.01% of their portfolio | 20.0k $7.6m | Reduced -375 |
| ROYAL BANK OF CANADA 0.00% of their portfolio | 19.7k $7.5m | Reduced -699 |
| SG Americas Securities, LLC 0.10% of their portfolio | 18.5k $7.0m | Added +10.4k |
| ExodusPoint Capital Management, LP 0.10% of their portfolio | 17.4k $6.6m | Added +6.7k |
| SCHRODER INVESTMENT MANAGEMENT GROUP 0.01% of their portfolio | 17.4k $6.6m | Added +606 |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.03% of their portfolio | 16.3k $6.2m | New |
| ORBIMED ADVISORS LLC 0.12% of their portfolio | 16.2k $6.1m | Reduced -253.5k |
| PARTNERS CAPITAL INVESTMENT GROUP, LLP 0.29% of their portfolio | 16.1k $6.1m | Added +6.8k |
| EFG Asset Management (North America) Corp. 1.31% of their portfolio | 15.5k $5.8m | Reduced -1.6k |
| Weiss Multi-Strategy Advisers LLC 0.17% of their portfolio | 15.2k $5.8m | Added +2.3k |
| ENVESTNET ASSET MANAGEMENT INC 0.00% of their portfolio | 15.2k $5.8m | Reduced -15 |
| FIRST TRUST ADVISORS LP 0.01% of their portfolio | 13.6k $5.2m | New |
| PINEBRIDGE INVESTMENTS, L.P. 0.06% of their portfolio | 13.4k $5.1m | New |