Vault-13

MIRATI THERAPEUTICS INC MRTX

COM · Common Stock · CUSIP 60468T105 · ISIN US60468T1051

233 institutional holders -11 vs Q3 2022
65,427,38665.4m shares reported held*
$3.0bnreported value*
35 new 98 added 71 reduced 47 sold out net bought ≈ $35.1m (+775.5k shares)

* Summed across managers. Shares that two managers' reports both contain – a subsidiary's holdings that its parent's report includes too, or a sub-adviser's in its client's – are counted once ($1.4m this quarter). Holder counts are more reliable. Implied quarter-end price ≈ $45.31. Options: 25 managers hold calls ($86.2m notional), 14 hold puts ($34.1m).

Trends to Q4 2022

Institutional holders

Managers reporting a position, each quarter

0100200300Q3 22: 244Q4 22: 233233Q3 22Q4 22
Numbers
QuarterHolders
Q3 2022244
Q4 2022233

Calls vs puts

Options held, notional value, last 4 quarters. P/C = puts ÷ calls

CallsPuts
$0$25m$50m$75m$100mQ3 22 calls: $71.0mQ3 22 puts: $87.9mQ3 22P/C 1.24Q4 22 calls: $86.2mQ4 22 puts: $34.1mQ4 22P/C 0.40
Numbers
QuarterCallsPutsP/C
Q3 2022$71.0m$87.9m1.24
Q4 2022$86.2m$34.1m0.40

Biggest buyers

RTW INVESTMENTS, LP Added +1,760,451+1.8m
ARMISTICE CAPITAL, LLC Added +1,588,000+1.6m
STATE STREET CORP Added +974,037+974.0k
MORGAN STANLEY Added +702,556+702.6k
Point72 Asset Management, L.P. Added +651,753+651.8k
California Public Employees Retirement System Added +560,034+560.0k
Octagon Capital Advisors LP Added +529,000+529.0k
Artal Group S.A. Added +507,758+507.8k
Paradigm Biocapital Advisors LP Added +417,585+417.6k
Woodline Partners LP Added +414,209+414.2k

Biggest sellers

FMR LLC Reduced -1,454,594-1.5m
ADAGE CAPITAL PARTNERS GP, L.L.C. Sold out -1,418,747-1.4m
EcoR1 Capital, LLC Sold out -1,015,572-1.0m
JANUS HENDERSON GROUP PLC Reduced -924,507-924.5k
AMERIPRISE FINANCIAL INC Reduced -832,704-832.7k
FRANKLIN RESOURCES INC Reduced -723,425-723.4k
Camber Capital Management LP Reduced -600,000-600.0k
PERCEPTIVE ADVISORS LLC Reduced -593,371-593.4k
ArrowMark Colorado Holdings LLC Sold out -453,643-453.6k
WELLINGTON MANAGEMENT GROUP LLP Reduced -452,976-453.0k

Biggest calls

Artal Group S.A. New $22.7m500.0k shares
JPMORGAN CHASE & CO Added $13.5m297.5k shares
CITADEL ADVISORS LLC Added $5.9m130.8k shares
Caption Management, LLC Added $5.8m128.0k shares
PURA VIDA INVESTMENTS, LLC New $5.5m122.2k shares
SG3 Management, LLC Added $5.0m110.5k shares
Hudson Bay Capital Management LP New $4.5m100.0k shares
Casdin Capital, LLC Unchanged $4.5m100.0k shares
SIMPLEX TRADING, LLC Added $4.2m93.2k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $3.9m85.3k shares

Biggest puts

Caption Management, LLC Reduced $9.2m203.6k shares
CITADEL ADVISORS LLC Added $7.1m156.7k shares
GROUP ONE TRADING LLC Added $5.5m121.3k shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Reduced $5.0m111.2k shares
SIMPLEX TRADING, LLC Added $3.2m69.6k shares
Jefferies Financial Group Inc. New $1.7m36.6k shares
JANE STREET GROUP, LLC Reduced $1.1m23.7k shares
PURA VIDA INVESTMENTS, LLC New $566.4k12.5k shares
HAP Trading, LLC New $280.0k26.3k shares
SG3 Management, LLC Reduced $226.6k5.0k shares

Options at notional value: the value of the shares the contracts control, as filers report them, not what the options cost. Not included in the holders, shares or buying above.

Holders, Q4 2022

#ManagerLocationShares Value% of their portfolioChangeShares change
1 Avoro Capital Advisors LLC 3.76% of their portfolio NEW YORK, NY 5,555,5555.6m $251.7m $251.7m 3.76% Added +5.0k +5,000
2 VANGUARD GROUP INC 0.01% of their portfolio Valley Forge, PA 4,973,8885.0m $225.4m $225.4m 0.01% Added +245.6k +245,589
3 RTW INVESTMENTS, LP 3.37% of their portfolio NEW YORK, NY 3,643,1143.6m $165.1m $165.1m 3.37% Added +1.8m +1,760,451
4 ARMISTICE CAPITAL, LLC 4.25% of their portfolio NEW YORK, NY 3,488,0003.5m $158.0m $158.0m 4.25% Added +1.6m +1,588,000
5 Aviva Holdings Ltd. 81.47% of their portfolio NEW PROVIDENCE, C5 3,135,9663.1m $142.1m $142.1m 81.47% Unchanged
6 WELLINGTON MANAGEMENT GROUP LLP 0.03% of their portfolio Boston, MA 3,016,3353.0m $136.7m $136.7m 0.03% Reduced -453.0k -452,976
7 BlackRock Inc. 0.00% of their portfolio New York, NY 2,662,9222.7m $120.7m $120.7m 0.00% Added +235.2k +235,171
8 STATE STREET CORP 0.01% of their portfolio BOSTON, MA 2,545,5762.5m $115.3m $115.3m 0.01% Added +974.0k +974,037
9 PERCEPTIVE ADVISORS LLC 2.86% of their portfolio NEW YORK, NY 2,191,4252.2m $99.3m $99.3m 2.86% Reduced -593.4k -593,371
10 Boxer Capital, LLC 4.78% of their portfolio San Diego, CA 2,000,0002.0m $90.6m $90.6m 4.78% Unchanged
11 Artal Group S.A. 4.79% of their portfolio LUXEMBOURG, N4 1,832,7581.8m $83.0m $83.0m 4.79% Added +507.8k +507,758
12 MORGAN STANLEY 0.01% of their portfolio NEW YORK, NY 1,689,7111.7m $76.6m $76.6m 0.01% Added +702.6k +702,556
13 PRICE T ROWE ASSOCIATES INC /MD/ 0.01% of their portfolio BALTIMORE, MD 1,416,7281.4m $64.2m $64.2m 0.01% Added +274.0k +273,973
14 BAKER BROS. ADVISORS LP 0.38% of their portfolio NEW YORK, NY 1,409,7841.4m $63.9m $63.9m 0.38% Unchanged
15 Camber Capital Management LP 2.22% of their portfolio BOSTON, MA 1,400,0001.4m $63.4m $63.4m 2.22% Reduced -600.0k -600,000
16 ORBIMED ADVISORS LLC 1.11% of their portfolio New York, NY 1,283,6921.3m $58.2m $58.2m 1.11% Reduced -135.2k -135,200
17 Paradigm Biocapital Advisors LP 6.74% of their portfolio NEW YORK, NY 1,267,9701.3m $57.5m $57.5m 6.74% Added +417.6k +417,585
18 Rock Springs Capital Management LP 0.88% of their portfolio Baltimore, MD 805,024805.0k $36.5m $36.5m 0.88% Reduced -61.8k -61,752
19 Candriam S.C.A. 0.23% of their portfolio STRASSEN, N4 767,596767.6k $34.8m $34.8m 0.23% Added +105.1k +105,095
20 Point72 Asset Management, L.P. 0.13% of their portfolio STAMFORD, CT 753,600753.6k $34.1m $34.1m 0.13% Added +651.8k +651,753
21 Octagon Capital Advisors LP 5.29% of their portfolio NEW YORK, NY 750,000750.0k $34.0m $34.0m 5.29% Added +529.0k +529,000
22 FRANKLIN RESOURCES INC 0.02% of their portfolio San Mateo, CA 736,768736.8k $33.4m $33.4m 0.02% Reduced -723.4k -723,425
23 GEODE CAPITAL MANAGEMENT, LLC 0.00% of their portfolio BOSTON, MA 707,345707.3k $32.0m $32.0m 0.00% Added +51.4k +51,395
24 Fiera Capital Corp 0.10% of their portfolio MONTREAL, A8 692,657692.7k $31.4m $31.4m 0.10% Added +159.3k +159,307
25 FMR LLC 0.00% of their portfolio BOSTON, MA 686,028686.0k $31.1m $31.1m 0.00% Reduced -1.5m -1,454,594
26 California Public Employees Retirement System 0.03% of their portfolio Sacramento, CA 652,619652.6k $29.6m $29.6m 0.03% Added +560.0k +560,034
27 AMERIPRISE FINANCIAL INC 0.01% of their portfolio MINNEAPOLIS, MN 637,130637.1k $28.9m $28.9m 0.01% Reduced -832.7k -832,704
28 Woodline Partners LP 0.40% of their portfolio San Francisco, CA 636,717636.7k $28.8m $28.8m 0.40% Added +414.2k +414,209
29 JANUS HENDERSON GROUP PLC 0.02% of their portfolio LONDON, X0 527,709527.7k $23.9m $23.9m 0.02% Reduced -924.5k -924,507
30 CREDIT SUISSE AG/ 0.03% of their portfolio ZURICH, V8 521,084521.1k $23.6m $23.6m 0.03% Added +78.7k +78,711
31 NORGES BANK 0.01% of their portfolio OSLO, Q8 475,992476.0k $21.6m $21.6m 0.01% Added +38.4k +38,362
32 Casdin Capital, LLC 1.68% of their portfolio New York, NY 475,000475.0k $21.5m $21.5m 1.68% Added +225.0k +225,000
33 Invesco Ltd. 0.01% of their portfolio ATLANTA, GA 433,576433.6k $19.6m $19.6m 0.01% Reduced -147.3k -147,332
34 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 0.01% of their portfolio SAN FRANCISCO, CA 431,963432.0k $19.6m $19.6m 0.01% Added +27.8k +27,789
35 BRAIDWELL LP 0.63% of their portfolio STAMFORD, CT 413,600413.6k $18.7m $18.7m 0.63% First filing
36 BANK OF NOVA SCOTIA 0.05% of their portfolio TORONTO, A6 413,333413.3k $18.7m $18.7m 0.05% Added +92.6k +92,569
37 Cormorant Asset Management, LP 1.22% of their portfolio BOSTON, MA 400,000400.0k $18.1m $18.1m 1.22% Reduced -175.0k -175,000
38 NATIONAL BANK OF CANADA /FI/ 0.04% of their portfolio MONTREAL, A8 367,300367.3k $16.6m $16.6m 0.04% Added +115.3k +115,300
39 BNP PARIBAS FINANCIAL MARKETS 0.04% of their portfolio PARIS, I0 351,547351.5k $15.9m $15.9m 0.04% Added +289.0k +289,019
40 BANK OF AMERICA CORP /DE/ 0.00% of their portfolio CHARLOTTE, NC 303,118303.1k $13.7m $13.7m 0.00% Added +42.2k +42,229
41 Rhenman & Partners Asset Management AB 1.42% of their portfolio Stockholm, V7 300,000300.0k $13.6m $13.6m 1.42% Added +102.9k +102,933
42 GOLDMAN SACHS GROUP INC 0.00% of their portfolio NEW YORK, NY 292,698292.7k $13.3m $13.3m 0.00% Added +74.4k +74,440
43 DIMENSIONAL FUND ADVISORS LP 0.00% of their portfolio AUSTIN, TX 290,859290.9k $13.2m $13.2m 0.00% Added +84.4k +84,355
44 Nextech Invest Ltd. 4.76% of their portfolio Zurich, V8 263,914263.9k $12.0m $12.0m 4.76% Unchanged
45 INTERNATIONAL BIOTECHNOLOGY TRUST PLC 3.41% of their portfolio London, X0 244,000244.0k $11.1m $11.1m 3.41% Added +108.0k +108,000
46 UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC 0.01% of their portfolio NEW YORK, NY 239,902239.9k $10.9m $10.9m 0.01% Added +38.0k +37,976
47 Allspring Global Investments Holdings, LLC 0.02% of their portfolio CHARLOTTE, NC 238,282238.3k $10.8m $10.8m 0.02% Reduced -8.6k -8,637
48 Nuveen Asset Management, LLC 0.00% of their portfolio CHICAGO, IL 237,274237.3k $10.8m $10.8m 0.00% Added +96.9k +96,877
49 NEW YORK STATE COMMON RETIREMENT FUND 0.01% of their portfolio ALBANY, NY 231,382231.4k $10.5m $10.5m 0.01% Added +50.6k +50,650
50 BARCLAYS PLC 0.01% of their portfolio LONDON, X0 228,425228.4k $10.3m $10.3m 0.01% First filing
51 DEUTSCHE BANK AG\ 0.01% of their portfolio FRANKFURT AM MAIN, 2M 227,321227.3k $10.3m $10.3m 0.01% Added +24.7k +24,688
52 D. E. Shaw & Co., Inc. 0.02% of their portfolio New York, NY 213,301213.3k $9.7m $9.7m 0.02% Reduced -353.1k -353,129
53 EVENTIDE ASSET MANAGEMENT, LLC 0.18% of their portfolio Boston, MA 203,600203.6k $9.2m $9.2m 0.18% Unchanged
54 Ghost Tree Capital, LLC 3.87% of their portfolio NEW YORK, NY 200,000200.0k $9.1m $9.1m 3.87% Added +25.0k +25,000
55 NORTHERN TRUST CORP 0.00% of their portfolio CHICAGO, IL 194,033194.0k $8.8m $8.8m 0.00% Reduced -3.5k -3,486
56 Rafferty Asset Management, LLC 0.07% of their portfolio New York, NY 193,073193.1k $8.7m $8.7m 0.07% Added +111.4k +111,361
57 Kynam Capital Management, LP 1.33% of their portfolio PRINCETON, NJ 191,158191.2k $8.7m $8.7m 1.33% New
58 JANE STREET GROUP, LLC 0.02% of their portfolio NEW YORK, NY 190,220190.2k $8.6m $8.6m 0.02% Added +159.2k +159,188
59 Assenagon Asset Management S.A. 0.03% of their portfolio SENNINGERBERG, N4 169,785169.8k $7.7m $7.7m 0.03% Reduced -23.6k -23,643
60 EDMOND DE ROTHSCHILD HOLDING S.A. 0.18% of their portfolio CHAMBESY, V8 169,060169.1k $7.7m $7.7m 0.18% Added +10.0k +10,000
61 Bank of New York Mellon Corp 0.00% of their portfolio NEW YORK, NY 168,956169.0k $7.7m $7.7m 0.00% Reduced -6.2k -6,247
62 VOLORIDGE INVESTMENT MANAGEMENT, LLC 0.04% of their portfolio JUPITER, FL 154,620154.6k $7.0m $7.0m 0.04% Added +130.4k +130,363
63 MILLENNIUM MANAGEMENT LLC 0.01% of their portfolio NEW YORK, NY 148,800148.8k $6.7m $6.7m 0.01% Added +137.6k +137,588
64 Caption Management, LLC 1.13% of their portfolio OKLAHOMA CITY, OK 147,900147.9k $6.7m $6.7m 1.13% Added +73.7k +73,661
65 UBS Group AG 0.00% of their portfolio ZURICH, V8 139,732139.7k $6.3m $6.3m 0.00% Added +118.3k +118,286
66 Thrivent Financial for Lutherans 0.02% of their portfolio Minneapolis, MN 133,333133.3k $6.0m $6.0m 0.02% New
67 GREAT POINT PARTNERS LLC 1.25% of their portfolio Greenwich, CT 133,000133.0k $6.0m $6.0m 1.25% New
68 CITIGROUP INC 0.01% of their portfolio NEW YORK, NY 122,714122.7k $5.6m $5.6m 0.01% Added +43.6k +43,552
69 CITADEL ADVISORS LLC 0.01% of their portfolio MIAMI, FL 120,503120.5k $5.5m $5.5m 0.01% Added +31.6k +31,617
70 Ikarian Capital, LLC 2.03% of their portfolio DALLAS, TX 108,100108.1k $4.9m $4.9m 2.03% New
71 Tri Locum Partners LP 2.10% of their portfolio NEW YORK, NY 104,598104.6k $4.7m $4.7m 2.10% Reduced -46.9k -46,936
72 Skandinaviska Enskilda Banken AB (publ) 0.03% of their portfolio STOCKHOLM, V7 95,49595.5k $4.3m $4.3m 0.03% Reduced -40 -40
73 Swiss National Bank 0.00% of their portfolio ZURICH, V8 94,00094.0k $4.3m $4.3m 0.00% Added +1.8k +1,800
74 Granahan Investment Management, LLC 0.13% of their portfolio WALTHAM, MA 91,90091.9k $4.2m $4.2m 0.13% New
75 Handelsbanken Fonder AB 0.02% of their portfolio STOCKHOLM, V7 75,60075.6k $3.4m $3.4m 0.02% Reduced -100 -100
76 WELLS FARGO & COMPANY/MN 0.00% of their portfolio SAN FRANCISCO, CA 73,64273.6k $3.3m $3.3m 0.00% Added +8.0k +7,966
77 DAFNA Capital Management LLC 0.94% of their portfolio LOS ANGELES, CA 73,60073.6k $3.3m $3.3m 0.94% Added +2.0k +2,000
78 ORACLE INVESTMENT MANAGEMENT INC 2.78% of their portfolio GREENWICH, CT 70,45370.5k $3.2m $3.2m 2.78% Reduced -235.2k -235,176
79 Lombard Odier Asset Management (Switzerland) SA 0.25% of their portfolio PETIT-LANCY, V8 69,95370.0k $3.2m $3.2m 0.25% Added +2.4k +2,439
80 SUSQUEHANNA INTERNATIONAL GROUP, LLP 0.01% of their portfolio BALA CYNWYD, PA 67,69167.7k $3.1m $3.1m 0.01% Reduced -12.1k -12,088
81 SECTORAL ASSET MANAGEMENT INC 0.59% of their portfolio MONTREAL, A8 66,84666.8k $3.0m $3.0m 0.59% Added +7.3k +7,330
82 Tekla Capital Management LLC 0.11% of their portfolio Boston, MA 65,49065.5k $3.0m $3.0m 0.11% Reduced -56.9k -56,900
83 STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 0.01% of their portfolio TALLAHASSEE, FL 63,87263.9k $2.9m $2.9m 0.01% Reduced -1.5k -1,470
84 Russell Investments Group, Ltd. 0.01% of their portfolio Seattle, WA 60,02660.0k $2.7m $2.7m 0.01% Added +33.2k +33,186
85 TANG CAPITAL MANAGEMENT LLC 0.39% of their portfolio SAN DIEGO, CA 60,00060.0k $2.7m $2.7m 0.39% Added +40.0k +40,000
86 MACQUARIE GROUP LTD 0.00% of their portfolio Sydney, NSW 2000, C3 60,00060.0k $2.7m $2.7m 0.00% Reduced -638 -638
87 NOMURA HOLDINGS INC 0.03% of their portfolio TOKYO, M0 54,55054.5k $2.5m $2.5m 0.03% Added +27.8k +27,827
88 TD Asset Management Inc 0.00% of their portfolio Toronto, A6 54,10554.1k $2.5m $2.5m 0.00% Added +23.0k +22,970
89 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 0.00% of their portfolio WEST SACRAMENTO, CA 51,76951.8k $2.3m $2.3m 0.00% Added +1.2k +1,228
90 RHUMBLINE ADVISERS 0.00% of their portfolio BOSTON, MA 49,25449.3k $2.2m $2.2m 0.00% Added +3.1k +3,091
91 Ally Bridge Group (NY) LLC 2.09% of their portfolio NEW YORK, NY 47,52047.5k $2.2m $2.2m 2.09% New
92 Balyasny Asset Management L.P. 0.01% of their portfolio Chicago, IL 45,54145.5k $2.1m $2.1m 0.01% New
93 GUGGENHEIM CAPITAL LLC 0.02% of their portfolio CHICAGO, IL 45,31345.3k $2.1m $2.1m 0.02% Added +21.0k +20,973
94 SEVEN EIGHT CAPITAL, LP 0.51% of their portfolio New York, NY 43,26443.3k $2.0m $2.0m 0.51% New
95 JPMORGAN CHASE & CO 0.00% of their portfolio NEW YORK, NY 43,00643.0k $1.9m $1.9m 0.00% Reduced -116.9k -116,870
96 Walleye Capital LLC 0.04% of their portfolio NEW YORK, NY 42,09842.1k $1.9m $1.9m 0.04% New
97 CAPITAL FUND MANAGEMENT S.A. 0.04% of their portfolio PARIS, I0 42,05642.1k $1.9m $1.9m 0.04% Reduced -10.1k -10,094
98 JACOBS LEVY EQUITY MANAGEMENT, INC 0.01% of their portfolio FLORHAM PARK, NJ 42,02242.0k $1.9m $1.9m 0.01% New
99 GROUP ONE TRADING LLC 0.06% of their portfolio CHICAGO, IL 39,87039.9k $1.8m $1.8m 0.06% Reduced -31.7k -31,713
100 ALPS ADVISORS INC 0.02% of their portfolio Denver, CO 38,84038.8k $1.8m $1.8m 0.02% Added +8.5k +8,461